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Publications Authored by Leonard M Neckers | PubFacts
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Leonard M Neckers

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Publications by authors named "Leonard M Neckers"

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22Publications

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Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer.

Pharm Dev Technol 2016 7;21(1):121-6. Epub 2014 Nov 7.

a Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , Texas Southern University , Houston , TX , USA .

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http://dx.doi.org/10.3109/10837450.2014.979946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428990PMC
October 2016

Computational polypharmacology analysis of the heat shock protein 90 interactome.

J Chem Inf Model 2015 Mar 23;55(3):676-86. Epub 2015 Feb 23.

†Life Sciences Department, University of Modena and Reggio Emilia, Via Campi 183, 41125 Modena, Italy.

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http://dx.doi.org/10.1021/ci5006959DOI Listing
March 2015

Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity.

Clin Cancer Res 2014 Sep 8;20(18):4873-81. Epub 2014 Apr 8.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology;

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167185PMC
September 2014

Quantification of a New Anti-Cancer Molecule MJC13 Using a Rapid, Sensitive, and Reliable Liquid Chromatography-Tandem Mass Spectrometry Method.

Am J Mod Chromatogr 2014;1(1):1-11

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292881PMC
January 2014

Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.

Breast Cancer Res 2012 Apr 17;14(2):R62. Epub 2012 Apr 17.

Department of Surgery, Duke University Medical Center, Box 2606, 203 Research Drive, Durham, NC 27710, USA.

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http://dx.doi.org/10.1186/bcr3168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446397PMC
April 2012

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity.

Proc Natl Acad Sci U S A 2012 Feb 6;109(8):2937-42. Epub 2012 Feb 6.

Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1114414109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287002PMC
February 2012

STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.

Curr Opin Investig Drugs 2010 Dec;11(12):1466-76

Center for Cancer Research, Medical Oncology Branch & Urologic Oncology Branch, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA.

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December 2010

Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.

Cell Cycle 2007 Jun 13;6(11):1393-402. Epub 2007 Jun 13.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1107, USA.

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http://dx.doi.org/10.4161/cc.6.11.4296DOI Listing
June 2007

Measuring ubiquitin conjugation in cells.

Methods Mol Biol 2005 ;301:223-41

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

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http://link.springer.com/10.1385/1-59259-895-1:223
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http://dx.doi.org/10.1385/1-59259-895-1:223DOI Listing
June 2005

Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin.

Cancer Res 2004 Jan;64(1):286-91

British Columbia Research Institute for Children's and Women's Health, Department of Pediatrics, Laboratory for Oncogenomic Research, University of British Columbia, Vancouver British Columbia, Canada.

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January 2004

The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function.

Curr Cancer Drug Targets 2003 Oct;3(5):343-7

Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Rockville, MD 20850, USA.

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October 2003

Immunoblotting methods for the study of protein ubiquitination.

Methods Mol Biol 2002 ;194:179-203

National Cancer Institute, NIH, Rockville, MD, USA.

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http://dx.doi.org/10.1385/1-59259-181-7:179DOI Listing
August 2003

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.

J Biol Chem 2002 Aug 6;277(33):29936-44. Epub 2002 Jun 6.

Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1074/jbc.M204733200DOI Listing
August 2002

Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2.

Cell Stress Chaperones 2002 Jan;7(1):91-6

Department of Cell and Cancer Biology, Medicine Branch, National Cancer Institute, Rockville, MD 20850, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514806PMC
http://dx.doi.org/10.1379/1466-1268(2002)007<0091:hngrti>2.0.co;2DOI Listing
January 2002

Can the heat shock protein 90 inhibitor geldanamycin be designed to specifically inhibit HER-2 tyrosine kinase?

Drug Resist Updat 2000 Aug;3(4):203-205

Department of cell and Cancer Biology, National Cancer Institute, Rockville, USA

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http://dx.doi.org/10.1054/drup.2000.0149DOI Listing
August 2000