Leonard H van den Berg

Leonard H van den Berg

UNVERIFIED PROFILE

Are you Leonard H van den Berg?   Register this Author

Register author
Leonard H van den Berg

Leonard H van den Berg

Publications by authors named "Leonard H van den Berg"

Are you Leonard H van den Berg?   Register this Author

100Publications

3005Reads

43Profile Views

Two heads are better than one: benefits of joint models for ALS trials.

J Neurol Neurosurg Psychiatry 2019 Sep 11;90(9):1071-1072. Epub 2019 Apr 11.

Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2019-320553
Publisher Site
http://dx.doi.org/10.1136/jnnp-2019-320553DOI Listing
September 2019

Warming nerves for excitability testing.

Muscle Nerve 2019 Sep 10;60(3):279-285. Epub 2019 Jul 10.

Department of Neurology, University Medical Center Utrecht, Brain Center, Utrecht University, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26621DOI Listing
September 2019

Neuropathy associated with immunoglobulin M monoclonal gammopathy: A combined sonographic and nerve conduction study.

Muscle Nerve 2019 Sep 24;60(3):263-270. Epub 2019 Jul 24.

Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26626DOI Listing
September 2019

Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk.

J Neurol Neurosurg Psychiatry 2019 Aug 8;90(8):854-860. Epub 2019 Mar 8.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2018-319779DOI Listing
August 2019

A neuropsychological and behavioral study of PLS.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Aug 28;20(5-6):376-384. Epub 2019 May 28.

a Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1620284DOI Listing
August 2019

The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Aug;20(5-6):432-440

a Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1606244DOI Listing
August 2019

Natural course of scoliosis and lifetime risk of scoliosis surgery in spinal muscular atrophy.

Neurology 2019 Jul 4;93(2):e149-e158. Epub 2019 Jun 4.

From the Department of Neurology and Neurosurgery (C.A.W., F.A.S.d.K., M.S., L.A.M.O., F.-L.A., R.P.A.v.E., J.S., I.C., L.H.v.d.B., R.I.W., W-L.v.d.P), Department of Rehabilitation (M.V.), Department of Orthopedic Surgery (R.C.B., R.M.C.), Department of Pediatrics, Child Development and Exercise Centre (B.B), and Biostatistics & Research Support Julius Centre for Health Sciences and Primary Care (R.P.A.v.E.), University Medical Centre Utrecht, Utrecht University, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007742DOI Listing
July 2019

Implications of spirometric reference values for amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Jul 4:1-8. Epub 2019 Jul 4.

a Department of Neurology, Brain Centre Rudolf Magnus , University Medical Centre Utrecht , Utrecht , the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1634736DOI Listing
July 2019

Amyotrophic lateral sclerosis as a multi-step process: an Australia population study.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Jul 8:1-6. Epub 2019 Jul 8.

f Brain and Mind Centre , University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital , Sydney , Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2018.1556697DOI Listing
July 2019

A case of ALS with posterior cortical atrophy.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Jul 8:1-5. Epub 2019 Jul 8.

c Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1632348DOI Listing
July 2019

Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Jul 8:1-10. Epub 2019 Jul 8.

b King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience , London , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1632899DOI Listing
July 2019

Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials.

J Neurol Neurosurg Psychiatry 2019 Jul 10. Epub 2019 Jul 10.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2019-320998DOI Listing
July 2019

Nerve ultrasound can identify treatment-responsive chronic neuropathies without electrodiagnostic features of demyelination.

Muscle Nerve 2019 Jul 11. Epub 2019 Jul 11.

Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26629DOI Listing
July 2019

Human immune globulin 10% with recombinant human hyaluronidase in multifocal motor neuropathy.

J Neurol 2019 Jul 19. Epub 2019 Jul 19.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center Rudolf Magnus, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-019-09475-xDOI Listing
July 2019

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy.

Muscle Nerve 2019 Jun 22;59(6):694-698. Epub 2019 Mar 22.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26462DOI Listing
June 2019

Accelerometry for remote monitoring of physical activity in amyotrophic lateral sclerosis: a longitudinal cohort study.

J Neurol 2019 Jun 11. Epub 2019 Jun 11.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-019-09427-5DOI Listing
June 2019

User perspectives on a psychosocial blended support program for partners of patients with amyotrophic lateral sclerosis and progressive muscular atrophy: a qualitative study.

BMC Psychol 2019 Jun 15;7(1):35. Epub 2019 Jun 15.

Center of Excellence in Rehabilitation Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40359-019-0308-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570885PMC
June 2019

Psychological distress and coping styles of caregivers of patients with amyotrophic lateral sclerosis: a longitudinal study.

Amyotroph Lateral Scler Frontotemporal Degener 2019 May 18;20(3-4):235-241. Epub 2019 Jan 18.

a Center of Excellence for Rehabilitation Medicine , Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University and De Hoogstraat Rehabilitation , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1
Publisher Site
http://dx.doi.org/10.1080/21678421.2018.1534976DOI Listing
May 2019

10Kin1day: A Bottom-Up Neuroimaging Initiative.

Authors:
Martijn P van den Heuvel Lianne H Scholtens Hannelore K van der Burgh Federica Agosta Clara Alloza Celso Arango Bonnie Auyeung Simon Baron-Cohen Silvia Basaia Manon J N L Benders Frauke Beyer Linda Booij Kees P J Braun Geraldo Busatto Filho Wiepke Cahn Dara M Cannon Tiffany M Chaim-Avancini Sandra S M Chan Eric Y H Chen Benedicto Crespo-Facorro Eveline A Crone Udo Dannlowski Sonja M C de Zwarte Bruno Dietsche Gary Donohoe Stefan Du Plessis Sarah Durston Covadonga M Díaz-Caneja Ana M Díaz-Zuluaga Robin Emsley Massimo Filippi Thomas Frodl Martin Gorges Beata Graff Dominik Grotegerd Dariusz Gąsecki Julie M Hall Laurena Holleran Rosemary Holt Helene J Hopman Andreas Jansen Joost Janssen Krzysztof Jodzio Lutz Jäncke Vasiliy G Kaleda Jan Kassubek Shahrzad Kharabian Masouleh Tilo Kircher Martijn G J C Koevoets Vladimir S Kostic Axel Krug Stephen M Lawrie Irina S Lebedeva Edwin H M Lee Tristram A Lett Simon J G Lewis Franziskus Liem Michael V Lombardo Carlos Lopez-Jaramillo Daniel S Margulies Sebastian Markett Paulo Marques Ignacio Martínez-Zalacaín Colm McDonald Andrew M McIntosh Genevieve McPhilemy Susanne L Meinert José M Menchón Christian Montag Pedro S Moreira Pedro Morgado David O Mothersill Susan Mérillat Hans-Peter Müller Leila Nabulsi Pablo Najt Krzysztof Narkiewicz Patrycja Naumczyk Bob Oranje Victor Ortiz-Garcia de la Foz Jiska S Peper Julian A Pineda Paul E Rasser Ronny Redlich Jonathan Repple Martin Reuter Pedro G P Rosa Amber N V Ruigrok Agnieszka Sabisz Ulrich Schall Soraya Seedat Mauricio H Serpa Stavros Skouras Carles Soriano-Mas Nuno Sousa Edyta Szurowska Alexander S Tomyshev Diana Tordesillas-Gutierrez Sofie L Valk Leonard H van den Berg Theo G M van Erp Neeltje E M van Haren Judith M C van Leeuwen Arno Villringer Christiaan H Vinkers Christian Vollmar Lea Waller Henrik Walter Heather C Whalley Marta Witkowska A Veronica Witte Marcus V Zanetti Rui Zhang Siemon C de Lange

Front Neurol 2019 9;10:425. Epub 2019 May 9.

Connectome Lab, CTG, CNCR, VU Amsterdam, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fneur.2019.00425
Publisher Site
http://dx.doi.org/10.3389/fneur.2019.00425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524614PMC
May 2019

Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 May 30:1-9. Epub 2019 May 30.

a Australian Institute for Bioengineering and Nanotechnology , The University of Queensland , Brisbane , Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1621346DOI Listing
May 2019

Statins do not increase risk of polyneuropathy: A case-control study and literature review.

Neurology 2019 Apr 8;92(18):e2136-e2144. Epub 2019 Feb 8.

From the UMC Utrecht Brain Center (J.K.W., A.F.J.E.V., N.A.V., L.H.v.d.B., N.C.N.), Department of Neurology, UMC Utrecht; and Biostatistics & Research Support (R.P.A.v.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007148DOI Listing
April 2019

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

Neurology 2019 Apr 8;92(14):e1610-e1623. Epub 2019 Mar 8.

From the Department of Neurology (L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.S.), Mayo Clinic, Rochester, MN; Department of Neurology (G.G.), University of Kansas Medical Center, Kansas City; Department of Medicine (E.A.M.), Massachusetts General Hospital, Biostatistics Center, Harvard Medical School, Boston; Department of Neurology (J.A., H.M.), Columbia University, Eleanor and Lou Gehrig ALS Center, New York, NY; Department of Neurology (R.H.B.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (M.B.), University of Miami, FL; Neurological Clinical Research Institute (J.D.B.), Massachusetts General Hospital, Boston; Rita Levi Montalcini Department of Neuroscience (A.C.), University of Torino, Italy; Centre Constitutif SLA (P.C.), Université de Tours, France; Department of Neurology (A.G.), Clinical Research Unit, Montreal Neurological Institute, Neurosurgery, McGill University, Montreal, Canada; National Institute of Neurological Disorders and Stroke (A.K.G.), National Institutes of Health, Bethesda, MD; ALS Center (C.L.-H.), University of California San Francisco; Department of Neuroscience (C.J.M.), Sheffield Institute for Translational Neuroscience, University of Sheffield, UK; Department of Neurology (E.P.P.), Section of ALS & Related Disorders, Cleveland Clinic, OH; Department of Neurology (J.R.), The Center for Restorative Neurology, Loma Linda University School of Medicine, CA; Department of Neurology and Laboratory of Neuroscience (V.S.), Istituto Auxologico Italiano, IRCCS, Milan; Department of Pathophysiology and Transplantation (V.S.), "Dino Ferrari" Centre, Università degli Studi di Milano, Milan, Italy; Nuffield Department of Clinical Neurosciences (M.R.T.), University of Oxford, UK; Neuromuscular Diseases Unit/ALS Clinic (M.W.), Kantonsspital St. Gallen, Switzerland; Carolinas Neuromuscular/ALS-MDA Care Center (B.R.B.), Charlotte; Department of Neurology (B.R.B.), Carolinas Medical Center, University of North Carolina School of Medicine, Charlotte; Forbes Norris ALS Treatment and Research Center (R.G.M.), California Pacific Medical Center San Francisco; and Department of Neurosciences (R.G.M.), Stanford University, CA.

View Article

Download full-text PDF

Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000007242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448453PMC
April 2019

Evidence for a multimodal effect of riluzole in patients with ALS?

J Neurol Neurosurg Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2018-320211DOI Listing
March 2019

Cognitive and behavioural changes in PLS and PMA:challenging the concept of restricted phenotypes.

J Neurol Neurosurg Psychiatry 2019 Feb 3;90(2):141-147. Epub 2018 Aug 3.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2018-318788DOI Listing
February 2019

Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Feb 12;20(1-2):19-27. Epub 2018 Oct 12.

a Department of Neurology , Brain Centre Rudolf Magnus, University Medical Centre Utrecht , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2018.1522352DOI Listing
February 2019

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study.

J Neurol Neurosurg Psychiatry 2019 Jan 3;90(1):11-19. Epub 2018 Aug 3.

'Rita Levi Montalcini' Department of Neurosciences, University of Turin, Turin, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2018-318559DOI Listing
January 2019

Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials.

Neurology 2019 Jan 9. Epub 2019 Jan 9.

From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369899PMC
January 2019

Social participation of adult patients with spinal muscular atrophy: Frequency, restrictions, satisfaction, and correlates.

Muscle Nerve 2018 12 15;58(6):805-811. Epub 2018 Nov 15.

Center of Excellence for Rehabilitation Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26201DOI Listing
December 2018

Nerve ultrasound: A reproducible diagnostic tool in peripheral neuropathy.

Neurology 2018 Dec 28. Epub 2018 Dec 28.

From the Department of Neurology and Clinical Neurophysiology (J.A.T., I.J.T.H., J.-T.H.v.A., L.H.V.), Elisabeth-Tweesteden Hospital, Tilburg; Department of Neurology and Neurosurgery (J.A.T., I.J.T.H., H.S.G., W.L.v.d.P., L.H.v.d.B.), Brain Center Rudolf Magnus, UMC Utrecht; Department of Neurology and Clinical Neurophysiology (C.V.), Academic Medical Center, Amsterdam; and Department of Biostatistics (S.N.), Julius Center for Health Sciences and Primary Care, UMC Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006856DOI Listing
December 2018

"ALS reversals": demographics, disease characteristics, treatments, and co-morbidities.

Amyotroph Lateral Scler Frontotemporal Degener 2018 11 2;19(7-8):495-499. Epub 2018 Apr 2.

f Department of Neurology , Duke University and Durham VA Medical Center , Durham , NC , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2018.1457059DOI Listing
November 2018

Nerve ultrasound and magnetic resonance imaging in the diagnosis of neuropathy.

Curr Opin Neurol 2018 10;31(5):526-533

Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WCO.0000000000000607DOI Listing
October 2018

Microglia innately develop within cerebral organoids.

Nat Commun 2018 10 9;9(1):4167. Epub 2018 Oct 9.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University, P.O. Box 85500, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-06684-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177485PMC
October 2018

A continuous repetitive task to detect fatigability in spinal muscular atrophy.

Orphanet J Rare Dis 2018 09 12;13(1):160. Epub 2018 Sep 12.

Department of Neurology, Brain Center Rudolf Magnus Institute of Neuroscience, Utrecht University, University Medical Center Utrecht, Heidelberglaan 100, F02.230, 3508 GA, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0
Publisher Site
http://dx.doi.org/10.1186/s13023-018-0904-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134509PMC
September 2018

Respiratory measures in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 23;19(5-6):321-330. Epub 2018 Mar 23.

f Eleanor and Lou Gehrig ALS Center, The Neurological Institute, Columbia University , New York , NY , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2018.1452945DOI Listing
August 2018

Understanding the use of NIV in ALS: results of an international ALS specialist survey.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 16;19(5-6):331-341. Epub 2018 Apr 16.

k Department of Neurology, Brain Centre Rudolf Magnus , University Medical Centre Utrecht , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2018.1457058DOI Listing
August 2018

Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 08 23;89(8):797-803. Epub 2018 Apr 23.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2017-317724DOI Listing
August 2018

The life expectancy of Stephen Hawking, according to the ENCALS model.

Lancet Neurol 2018 08 17;17(8):662-663. Epub 2018 Jul 17.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht 3584 CX, Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(18)30241-2DOI Listing
August 2018

The multistep hypothesis of ALS revisited: The role of genetic mutations.

Neurology 2018 08 25;91(7):e635-e642. Epub 2018 Jul 25.

From the "Rita Levi Montalcini" Department of Neuroscience (A. Chiò, A. Canosa, C.M., U.M., M.B., M.B., A. Calvo), University of Torino; Institute of Cognitive Sciences and Technologies (A. Chiò), National Research Council, Rome; ALS Center (L.M., E.B.), Department of Neurology, Azienda Ospedaliera Universitaria Maggiore della Carità; Department of Health Sciences (S.D., L.C.), Interdisciplinary Research Center of Autoimmune Diseases, "Amedeo Avogadro" University of Eastern Piedmont, Novara, Italy; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, UK; Centre for Public Health Research (N.P.), Massey University Wellington Campus, New Zealand; Department of Neurology and Neurosurgery (J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Academic Unit of Neurology (R.M., A.V., O.H., J.R.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Istituti Clinici Scientifici Maugeri (G.M.), IRCCS Milano, Italy (Gabriele Mora); and King's College London (W.S., A.A.-C.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000005996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105040PMC
August 2018

Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs.

J Clin Epidemiol 2018 Jun 24;98:80-88. Epub 2018 Feb 24.

Department of Neurology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinepi.2018.02.013DOI Listing
June 2018

A blended psychosocial support program for partners of patients with amyotrophic lateral sclerosis and progressive muscular atrophy: protocol of a randomized controlled trial.

BMC Psychol 2018 May 2;6(1):20. Epub 2018 May 2.

Center of Excellence in Rehabilitation Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University and De Hoogstraat Rehabilitation, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40359-018-0232-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930742PMC
May 2018

Sodium-potassium pump assessment by submaximal electrical nerve stimulation.

Clin Neurophysiol 2018 04 31;129(4):809-814. Epub 2018 Jan 31.

Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2018.01.016DOI Listing
April 2018

Author Correction: A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study.

Sci Rep 2018 Apr 11;8(1):6057. Epub 2018 Apr 11.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-22952-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895799PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis.

Clin Epidemiol 2018 19;10:333-341. Epub 2018 Mar 19.

Department of Biostatistics, University Medical Center Utrecht, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CLEP.S153196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865572PMC
March 2018

Patterns of symptom development in patients with motor neuron disease.

Amyotroph Lateral Scler Frontotemporal Degener 2018 02 16;19(1-2):21-28. Epub 2017 Oct 16.

a Department of Neurology, Brain Center Rudolf Magnus , University Medical Center Utrecht , Utrecht , The Netherlands and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2017.1386688DOI Listing
February 2018

Monitoring disease progression with plasma creatinine in amyotrophic lateral sclerosis clinical trials.

J Neurol Neurosurg Psychiatry 2018 02 30;89(2):156-161. Epub 2017 Oct 30.

Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2017-317077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800333PMC
February 2018

Support needs of caregivers of patients with amyotrophic lateral sclerosis: A qualitative study.

Palliat Support Care 2018 Feb 5:1-7. Epub 2018 Feb 5.

Center of Excellence in Rehabilitation Medicine,Brain Center Rudolf Magnus,University Medical Center Utrecht, andDe Hoogstraat Rehabilitation,Utrecht,The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1478951517001213DOI Listing
February 2018

Caregiver burden in amyotrophic lateral sclerosis: A systematic review.

Palliat Med 2018 01 3;32(1):231-245. Epub 2017 Jul 3.

3 Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0269216317709965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784458PMC
January 2018

High-resolution ultrasound in patients with Wartenberg's migrant sensory neuritis, a case-control study.

Clin Neurophysiol 2018 01 21;129(1):232-237. Epub 2017 Nov 21.

Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2017.10.040DOI Listing
January 2018

The role of nutrition as risk factor for polyneuropathy: a case-control study.

J Peripher Nerv Syst 2017 12 31;22(4):455-459. Epub 2017 Aug 31.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jns.12233DOI Listing
December 2017

Deep learning predictions of survival based on MRI in amyotrophic lateral sclerosis.

Neuroimage Clin 2017 11;13:361-369. Epub 2016 Oct 11.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA, Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2016.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219634PMC
November 2017

Participation restrictions in ambulatory amyotrophic lateral sclerosis patients: Physical and psychological factors.

Muscle Nerve 2017 Nov 26;56(5):912-918. Epub 2017 Mar 26.

Center of Excellence in Rehabilitation Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/mus.25574
Publisher Site
http://dx.doi.org/10.1002/mus.25574DOI Listing
November 2017

Amyotrophic lateral sclerosis.

Lancet 2017 Nov 25;390(10107):2084-2098. Epub 2017 May 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(17)31287-4DOI Listing
November 2017

A case series of PLS patients with frontotemporal dementia and overview of the literature.

Amyotroph Lateral Scler Frontotemporal Degener 2017 11 26;18(7-8):534-548. Epub 2017 Jul 26.

a Department of Neurology , Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2017.1354996DOI Listing
November 2017

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.

Neurology 2017 Oct 4;89(18):1915-1922. Epub 2017 Oct 4.

From the Department of Neurology, Brain Centre Rudolf Magnus (R.P.A.v.E., F.P.D., W.v.R., J.H.V., L.H.v.d.B., M.A.v.E.), and Department of Biostatistics and Research Support (M.J.C.E.), University Medical Centre Utrecht, the Netherlands; Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute Centre (A.R.J., W.S., A.S., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London; Sheffield Institute for Translational Neuroscience (SITraN) (P.J.S.), University of Sheffield, South Yorkshire; Department of Clinical Neuroscience (P.N.L.), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton; The Walton Centre NHS Trust (C.A.Y.), Liverpool, UK; Istituti Clinici Scientifici Maugeri IRCSS (G.M.), Milan; Department of Neuroscience (J.M.), Sant'Agostino-Estense Hospital and University of Modena and Reggio Emilia, Modena; Department of Neurology (G.B.), Azienda Universitario Ospedaliera di Cagliari and University of Cagliari; Istituti Clinici Scientifici Maugeri IRCSS (P.V.), Mistretta, Italy; Rijnstate Ziekenhuis (E.V.), Arnhem, the Netherlands; Rita Levi Montalcini' Department of Neuroscience (A.C.), ALS Centre, University of Torino; and Azienda Ospedaliera Città della Salute e della Scienza (A.C.), Turin, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664299PMC
October 2017

Amyotrophic lateral sclerosis.

Nat Rev Dis Primers 2017 Oct 5;3:17071. Epub 2017 Oct 5.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrdp.2017.71DOI Listing
October 2017

A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR.

Neurology 2017 Sep 23;89(12):1283-1290. Epub 2017 Aug 23.

From the Academic Unit of Neurology (J.P.K.R., O.H.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Department of Neurology and Neurosurgery (A.E.V., J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neuroscience (F.D., A.C.), ALS Centre, University of Torino, Turin, Italy; Institute for Risk Assessment Sciences (R.V.), Department of Environmental Epidemiology, University of Utrecht, the Netherlands; Department of Neurosciences (E.B.), IRCSS, Mario Negri Institute of Pharmacological Research, Milan; and Department of Neuroscience (G.L.), University of Bari, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004390DOI Listing
September 2017

A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study.

Sci Rep 2017 09 22;7(1):12175. Epub 2017 Sep 22.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-07404-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610184PMC
September 2017

Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case-control Study.

Environ Health Perspect 2017 09 27;125(9):097023. Epub 2017 Sep 27.

Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1289/EHP1115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915195PMC
September 2017

Critical issues in ALS case-control studies: the case of the Euro-MOTOR study.

Amyotroph Lateral Scler Frontotemporal Degener 2017 08 10;18(5-6):411-418. Epub 2017 Feb 10.

f Neurological Diseases Laboratory, Department of Neurosciences , IRCCS Mario Negri , Milano , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2017.1285939DOI Listing
August 2017

The changing picture of amyotrophic lateral sclerosis: lessons from European registers.

J Neurol Neurosurg Psychiatry 2017 07 11;88(7):557-563. Epub 2017 Mar 11.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2016-314495DOI Listing
July 2017

Exploring the fitness hypothesis in ALS: a population-based case-control study of parental cause of death and lifespan.

J Neurol Neurosurg Psychiatry 2017 07 14;88(7):550-556. Epub 2017 Mar 14.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2016-315071DOI Listing
July 2017

Edaravone: a new treatment for ALS on the horizon?

Lancet Neurol 2017 07 15;16(7):490-491. Epub 2017 May 15.

University Medical Center Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(17)30163-1DOI Listing
July 2017

Assessment of the factorial validity and reliability of the ALSFRS-R: a revision of its measurement model.

J Neurol 2017 Jul 12;264(7):1413-1420. Epub 2017 Jun 12.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-017-8538-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502060PMC
July 2017

Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 29;18(3-4):210-220. Epub 2016 Nov 29.

h Department of Neurology and Neurosurgery , Brain Centre Rudolf Magnus, University Medical Centre Utrecht , Utrecht , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2016.1245757DOI Listing
May 2017

Association of motor milestones, SMN2 copy and outcome in spinal muscular atrophy types 0-4.

J Neurol Neurosurg Psychiatry 2017 04 20;88(4):365-367. Epub 2017 Jan 20.

Department of Neurology and Neurosurgery, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2016-314292DOI Listing
April 2017

No association between gluten sensitivity and amyotrophic lateral sclerosis.

J Neurol 2017 Apr 6;264(4):694-700. Epub 2017 Feb 6.

Department of Neurology, Brain Center Rudolf Magnus, F02.230, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-017-8400-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374172PMC
April 2017

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.

Nat Commun 2017 03 21;8:14774. Epub 2017 Mar 21.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms14774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364411PMC
March 2017

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management.

Nat Rev Neurol 2017 Feb 16;13(2):96-104. Epub 2016 Dec 16.

UMC Utrecht Brain Center Rudolf Magnus, Universiteitsweg 100, 3584 CG, Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2016.182DOI Listing
February 2017

Diagnostic value of sonography in treatment-naive chronic inflammatory neuropathies.

Neurology 2017 Jan 7;88(2):143-151. Epub 2016 Dec 7.

From the Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery (H.S.G., W.L.v.d.P., H.F., N.C.N., A.J.F.E.V., M.A.v.E., L.H.v.d.B.), and Department of Biostatistics, Julius Center for Health Sciences and Primary Care (S.N.), UMC Utrecht; and Department of Neurology and Clinical Neurophysiology (J-T.H.v.A., L.H.V.), St. Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003483DOI Listing
January 2017

The Åstrand-Ryhming Test is not a Feasible Measure in Ambulatory Patients with Amyotrophic Lateral Sclerosis.

J Neuromuscul Dis 2016 11;3(4):539-544

Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JND-160182DOI Listing
November 2016