Leonard Guarente

Leonard Guarente

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Leonard Guarente

Publications by authors named "Leonard Guarente"

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NAD supplementation rejuvenates aged gut adult stem cells.

Aging Cell 2019 Jun 27;18(3):e12935. Epub 2019 Mar 27.

Department of Biology, Glenn Labs for the Science of Aging, and Koch Institute, MIT, Cambridge, Massachusetts.

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http://dx.doi.org/10.1111/acel.12935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516145PMC
June 2019

Rate of brain aging and are synergistic risk factors for Alzheimer's disease.

Life Sci Alliance 2019 06 27;2(3). Epub 2019 May 27.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

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http://dx.doi.org/10.26508/lsa.201900303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537750PMC
June 2019

Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging.

Cell 2018 03;173(1):74-89.e20

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884172PMC
March 2018

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

PLoS One 2017 22;12(9):e0185236. Epub 2017 Sep 22.

Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609767PMC
October 2017

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.

PLoS One 2017 25;12(5):e0178520. Epub 2017 May 25.

Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444833PMC
September 2017

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.

Nat Cell Biol 2017 May 24;19(5):445-456. Epub 2017 Apr 24.

Molecular Neurobiology Laboratory, Department of Psychiatry and McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1038/ncb3517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545746PMC
May 2017

The brain, sirtuins, and ageing.

Nat Rev Neurosci 2017 05;18(6):362-374

Department of Biology, The Paul F. Glenn Center for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 68-280 Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrn.2017.42DOI Listing
May 2017

Mutations that Allow SIR2 Orthologs to Function in a NAD-Depleted Environment.

Cell Rep 2017 03;18(10):2310-2319

Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173021
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http://dx.doi.org/10.1016/j.celrep.2017.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407064PMC
March 2017

The unexpected role of mTORC1 in intestinal stem cells during calorie restriction.

Cell Cycle 2017 01 11;16(1):1-2. Epub 2016 Aug 11.

a Department of Biology , Glenn Labs for the Science of Aging, and Koch Institute, MIT , Cambridge, MA , USA.

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http://dx.doi.org/10.1080/15384101.2016.1221210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270518PMC
January 2017

Overcoming ATM Deficiency by Activating the NAD/SIRT1 Axis.

Authors:
Leonard Guarente

Cell Metab 2016 10;24(4):526-528

Novartis Professor, Koch Institute Affiliate and Director of the Paul F. Glenn Center for the Science of Aging Research, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.019DOI Listing
October 2016

Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency.

Cell Rep 2016 10;17(3):809-820

Glenn Laboratory for the Science of Aging and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081691PMC
http://dx.doi.org/10.1016/j.celrep.2016.09.046DOI Listing
October 2016

Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers.

Trends Mol Med 2016 08 5;22(8):633-634. Epub 2016 Jul 5.

Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.06.011DOI Listing
August 2016

It takes two to tango: NAD and sirtuins in aging/longevity control.

NPJ Aging Mech Dis 2016 18;2:16017. Epub 2016 Aug 18.

Department of Biology and Glenn Laboratories for the Science of Aging, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/npjamd.2016.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514996PMC
August 2016

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.

Cell 2016 Jul 23;166(2):436-450. Epub 2016 Jun 23.

Department of Biology, Glenn Labs for the Science of Aging and Koch Institute, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30595-5.pdf
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http://www.cell.com/cms/attachment/2061046803/2062833216/mmc
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http://dx.doi.org/10.1016/j.cell.2016.05.044DOI Listing
July 2016

CELL METABOLISM. The resurgence of NAD⁺.

Authors:
Leonard Guarente

Science 2016 Jun;352(6292):1396-7

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.aag1718DOI Listing
June 2016

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

Nat Commun 2016 05 11;7:11445. Epub 2016 May 11.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Coimbra 3004-504, Portugal.

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http://dx.doi.org/10.1038/ncomms11445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865854PMC
May 2016

The multifaceted functions of sirtuins in cancer.

Nat Rev Cancer 2015 Oct 18;15(10):608-24. Epub 2015 Sep 18.

Department of Biology, The Paul F. Glenn Center for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 68-280 Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrc3985DOI Listing
October 2015

Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.

PLoS One 2013 26;8(12):e84481. Epub 2013 Dec 26.

Department of Pediatrics, University of California San Diego, San Diego, California, United States of America ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873454PMC
February 2015

Linking DNA damage, NAD(+)/SIRT1, and aging.

Authors:
Leonard Guarente

Cell Metab 2014 Nov 4;20(5):706-707. Epub 2014 Nov 4.

Novartis Professor of Biology, Director of the Glenn Labs for the Science of Aging, and Affiliate of the Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.10.015DOI Listing
November 2014

Small-molecule allosteric activators of sirtuins.

Annu Rev Pharmacol Toxicol 2014 16;54:363-80. Epub 2013 Oct 16.

Glenn Laboratories for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018738PMC
September 2014

SirT1 is required in the male germ cell for differentiation and fecundity in mice.

Development 2014 Sep 19;141(18):3495-504. Epub 2014 Aug 19.

Massachusetts Institute of Technology, Department of Biology, Glenn Laboratory for the Science of Aging, Cambridge, MA 02139, USA Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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http://dx.doi.org/10.1242/dev.110627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197722PMC
September 2014

Aging research-where do we stand and where are we going?

Authors:
Leonard Guarente

Cell 2014 Sep;159(1):15-19

Department of Biology, Koch Institute for Integrative Cancer Research and Paul F. Glenn Laboratories for the Science of Aging, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.041DOI Listing
September 2014

NAD+ and sirtuins in aging and disease.

Trends Cell Biol 2014 Aug 29;24(8):464-71. Epub 2014 Apr 29.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Glenn Laboratory for the Science of Aging, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112140PMC
August 2014

SnapShot: sirtuins, NAD, and aging.

Cell Metab 2014 Jul;20(1):192-192.e1

Paul F. Glenn Laboratory for the Science of Aging and Department of Biology, and The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cmet.2014.06.001DOI Listing
July 2014

Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.

PLoS Genet 2014 Jul 17;10(7):e1004490. Epub 2014 Jul 17.

Glenn Laboratory for the Science of Aging and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102452PMC
July 2014

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Am J Physiol Lung Cell Mol Physiol 2014 May 14;306(9):L816-28. Epub 2014 Mar 14.

Dept. of Environmental Medicine, Univ. of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY 14642.

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http://dx.doi.org/10.1152/ajplung.00323.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010647PMC
May 2014

Introduction: sirtuins in aging and diseases.

Authors:
Leonard Guarente

Methods Mol Biol 2013 ;1077:3-10

Glenn Lab for the Science of Aging and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-637-5_1DOI Listing
April 2014

SIRT1 and other sirtuins in metabolism.

Trends Endocrinol Metab 2014 Mar 30;25(3):138-45. Epub 2013 Dec 30.

Glenn Laboratory for the Science of Aging, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10432760130020
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http://dx.doi.org/10.1016/j.tem.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943707PMC
March 2014

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Gastroenterology 2014 Feb 1;146(2):539-49.e7. Epub 2013 Nov 1.

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.10.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228483PMC
February 2014

SIRT1 in neurodevelopment and brain senescence.

Neuron 2014 Feb;81(3):471-83

Department of Biology and Glenn Laboratories for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68-280, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040287PMC
February 2014

The many faces of sirtuins: Sirtuins and the Warburg effect.

Authors:
Leonard Guarente

Nat Med 2014 Jan;20(1):24-5

Department of Biology, Glenn Laboratory for the Science of Aging and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nm.3438
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http://dx.doi.org/10.1038/nm.3438DOI Listing
January 2014

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

Am J Physiol Lung Cell Mol Physiol 2013 Nov 13;305(9):L615-24. Epub 2013 Sep 13.

Dept. of Environmental Medicine, Univ. of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY 14642.

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http://dx.doi.org/10.1152/ajplung.00249.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840276PMC
November 2013

Calorie restriction and sirtuins revisited.

Authors:
Leonard Guarente

Genes Dev 2013 Oct;27(19):2072-85

Department of Biology, Glenn Laboratory for the Science of Aging, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.227439.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850092PMC
October 2013

Sirtuins and ageing--new findings.

Authors:
Leonard Guarente

EMBO Rep 2013 Sep 9;14(9):750. Epub 2013 Aug 9.

Department of Biology and Glenn Laboratory for the Science of Aging, MIT, Cambridge, USA.

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http://dx.doi.org/10.1038/embor.2013.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790060PMC
September 2013

Metabolic and neuropsychiatric effects of calorie restriction and sirtuins.

Annu Rev Physiol 2013 1;75:669-84. Epub 2012 Oct 1.

Glenn Laboratory for the Science of Aging, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1146/annurev-physiol-030212-183800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570673PMC
August 2013

Sirtuin deacetylases in neurodegenerative diseases of aging.

Cell Res 2013 Jun 21;23(6):746-58. Epub 2013 May 21.

Department of Pathology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/cr.2013.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674397PMC
June 2013

SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging.

Cell 2013 Jun;153(7):1448-60

Glenn Laboratory for the Science of Aging, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2013.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748806PMC
June 2013

SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.

Cell Rep 2013 Apr 11;3(4):1175-86. Epub 2013 Apr 11.

Glenn Laboratory for the Science of Aging and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881428PMC
April 2013

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

EMBO Mol Med 2013 Mar 30;5(3):430-40. Epub 2013 Jan 30.

Glenn Laboratory for the Science of Aging, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/emmm.201201606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598082PMC
March 2013

Sirtuins, aging, and metabolism.

Authors:
Leonard Guarente

Cold Spring Harb Symp Quant Biol 2011 23;76:81-90. Epub 2011 Nov 23.

Paul F Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://symposium.cshlp.org/cgi/doi/10.1101/sqb.2011.76.01062
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http://dx.doi.org/10.1101/sqb.2011.76.010629DOI Listing
October 2012

Deviation of innate circadian period from 24 h reduces longevity in mice.

Aging Cell 2012 Oct 12;11(5):794-800. Epub 2012 Jul 12.

Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2012.00846.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526942PMC
October 2012

High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.

Cell Metab 2012 Aug;16(2):180-8

Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539750PMC
August 2012

The place of genetics in ageing research.

Nat Rev Genet 2012 07 10;13(8):589-94. Epub 2012 Jul 10.

Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer Building, #701, Bronx, New York City, New York 10461, USA.

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http://dx.doi.org/10.1038/nrg3290DOI Listing
July 2012

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

J Clin Invest 2012 Jun 1;122(6):2032-45. Epub 2012 May 1.

Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1172/JCI60132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366403PMC
June 2012

Sirtuins and calorie restriction.

Authors:
Leonard Guarente

Nat Rev Mol Cell Biol 2012 Feb 29;13(4):207. Epub 2012 Feb 29.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/articles/nrm3308
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http://dx.doi.org/10.1038/nrm3308DOI Listing
February 2012

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.

J Neurosci 2012 Jan;32(1):124-32

Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3442-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263206PMC
January 2012

Sirtuins mediate mammalian metabolic responses to nutrient availability.

Nat Rev Endocrinol 2012 Jan 17;8(5):287-96. Epub 2012 Jan 17.

Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 68, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/nrendo.2011.225DOI Listing
January 2012

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

Nat Med 2011 Dec 18;18(1):159-65. Epub 2011 Dec 18.

Department of Neurology, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://www.nature.com/articles/nm.2559
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http://dx.doi.org/10.1038/nm.2559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509213PMC
December 2011

SIRT1-mediated acute cardioprotection.

Am J Physiol Heart Circ Physiol 2011 Oct 19;301(4):H1506-12. Epub 2011 Aug 19.

Department of Anesthesiology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00587.2011
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http://dx.doi.org/10.1152/ajpheart.00587.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197366PMC
October 2011

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes.

Nature 2011 Sep 21;477(7365):E1-2. Epub 2011 Sep 21.

Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/articles/nature10440
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http://dx.doi.org/10.1038/nature10440DOI Listing
September 2011

Metabolic signals regulate SIRT1 expression.

EMBO Rep 2011 Sep 30;12(10):985-6. Epub 2011 Sep 30.

Paul F. Glenn Lab and Department of Biology, MIT, Cambridge, Massachusetts, USA.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2011.179
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http://dx.doi.org/10.1038/embor.2011.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185348PMC
September 2011

The logic linking protein acetylation and metabolism.

Authors:
Leonard Guarente

Cell Metab 2011 Aug;14(2):151-3

Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.07.007DOI Listing
August 2011

Franklin H. Epstein Lecture: Sirtuins, aging, and medicine.

Authors:
Leonard Guarente

N Engl J Med 2011 Jun;364(23):2235-44

Paul F. Glenn Lab and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1056/NEJMra1100831DOI Listing
June 2011

The SirT3 divining rod points to oxidative stress.

Mol Cell 2011 Jun;42(5):561-8

Paul F Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765110034
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http://dx.doi.org/10.1016/j.molcel.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526939PMC
June 2011

Sirtuins at a glance.

J Cell Sci 2011 Mar;124(Pt 6):833-8

Paul F. Glenn Laboratory for the Science of Aging, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 68-280, Cambridge, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/jcs.081067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048886PMC
March 2011

Roles of SIRT1 in the acute and restorative phases following induction of inflammation.

J Biol Chem 2010 Dec 21;285(53):41391-401. Epub 2010 Oct 21.

Department of Surgery, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.174482
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http://dx.doi.org/10.1074/jbc.M110.174482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009865PMC
December 2010

3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.

Proc Natl Acad Sci U S A 2010 Nov 18;107(44):18927-32. Epub 2010 Oct 18.

Department of Biology, Paul F Glenn Laboratory, Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

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November 2010

Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.

J Biol Chem 2010 Jul 29;285(28):21581-9. Epub 2010 Apr 29.

Novartis Institute for Biomedical Research, Cardiovascular and Metabolism Disease Area, Cambridge, Massachusetts 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898407PMC
July 2010

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

Cell 2010 Jul;142(2):320-32

Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2010.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911635PMC
July 2010

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.

Trends Pharmacol Sci 2010 May 11;31(5):212-20. Epub 2010 Mar 11.

Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.tips.2010.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526941PMC
May 2010

Aging and disease: connections to sirtuins.

Aging Cell 2010 Apr;9(2):285-90

Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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April 2010

Forever young.

Authors:
Leonard Guarente

Cell 2010 Jan;140(2):176-8

Paul F. Glenn Lab, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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January 2010

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.

Genes Dev 2009 Dec;23(24):2812-7

Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1839209
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800085PMC
December 2009

Cell biology. Hypoxic hookup.

Authors:
Leonard Guarente

Science 2009 Jun;324(5932):1281-2

Paul F. Glenn Lab and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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June 2009

Urea cycle regulation by mitochondrial sirtuin, SIRT5.

Aging (Albany NY) 2009 Jun 29;1(6):578-81. Epub 2009 Jun 29.

Paul F. Glenn Laboratory for the Science of Aging and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.18632/aging.100062DOI Listing
June 2009

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Cell 2009 May;137(3):560-70

Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698666PMC
May 2009

SIRT1 promotes differentiation of normal human keratinocytes.

J Invest Dermatol 2009 Jan 19;129(1):41-9. Epub 2008 Jun 19.

Genstruct Inc., One Alewife Center, Cambridge, Massachusetts 2140, USA.

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http://dx.doi.org/10.1038/jid.2008.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526938PMC
January 2009

Tissue-specific regulation of SIRT1 by calorie restriction.

Genes Dev 2008 Jul 11;22(13):1753-7. Epub 2008 Jun 11.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492662PMC
July 2008

Neurogenesis directed by Sirt1.

Nat Cell Biol 2008 Apr;10(4):373-4

Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703710PMC
April 2008

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

PLoS One 2008 Apr 16;3(4):e2020. Epub 2008 Apr 16.

Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289879PMC
April 2008

Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

Authors:
Leonard Guarente

Cell 2008 Jan;132(2):171-6

Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680180PMC
January 2008

SIRT1 transgenic mice show phenotypes resembling calorie restriction.

Aging Cell 2007 Dec 17;6(6):759-67. Epub 2007 Sep 17.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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December 2007

Genetic links between diet and lifespan: shared mechanisms from yeast to humans.

Nat Rev Genet 2007 Nov;8(11):835-44

Department of Biology, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrg2188DOI Listing
November 2007

SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

Mol Cell 2007 Oct;28(1):91-106

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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October 2007

Two neurons mediate diet-restriction-induced longevity in C. elegans.

Nature 2007 May;447(7144):545-9

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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May 2007

SIR2: a potential target for calorie restriction mimetics.

Trends Mol Med 2007 Feb 4;13(2):64-71. Epub 2007 Jan 4.

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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February 2007

A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins.

Cell Cycle 2006 Nov 15;5(22):2588-91. Epub 2006 Nov 15.

Department of Biology, Massachusetts Insitute of Technology, Cambridge, Massachusetts 02139, USA.

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November 2006