Publications by authors named "Leonard C Schalkwyk"

82Publications

5-hydroxymethylcytosine is highly dynamic across human fetal brain development.

BMC Genomics 2017 Sep 18;18(1):738. Epub 2017 Sep 18.

University of Exeter Medical School, RILD Building, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1186/s12864-017-4091-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604137PMC
September 2017

Paternal Age Alters Social Development in Offspring.

J Am Acad Child Adolesc Psychiatry 2017 May 6;56(5):383-390. Epub 2017 Mar 6.

Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, UK.

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http://dx.doi.org/10.1016/j.jaac.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409803PMC
May 2017

Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice.

Sci Rep 2017 02 1;7:41204. Epub 2017 Feb 1.

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1038/srep41204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286500PMC
February 2017

Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish.

Am J Med Genet B Neuropsychiatr Genet 2016 09 19;171(6):827-38. Epub 2016 Apr 19.

King's College London, Social, Genetic and Developmental Psychiatry Centre (MRC), Institute of Psychiatry, Psychology and Neuroscience, United Kingdom.

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http://dx.doi.org/10.1002/ajmg.b.32451DOI Listing
September 2016

Comparative mRNA analysis of behavioral and genetic mouse models of aggression.

Am J Med Genet B Neuropsychiatr Genet 2016 Apr 17;171B(3):427-36. Epub 2016 Feb 17.

King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, United Kingdom.

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http://dx.doi.org/10.1002/ajmg.b.32424DOI Listing
April 2016

Tissue-specific patterns of allelically-skewed DNA methylation.

Epigenetics 2016 19;11(1):24-35. Epub 2016 Jan 19.

a Institute of Psychiatry, Psychology and Neuroscience, King's College London , London , UK.

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http://dx.doi.org/10.1080/15592294.2015.1127479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846124PMC
December 2016

Methylomic trajectories across human fetal brain development.

Genome Res 2015 Mar 3;25(3):338-52. Epub 2015 Feb 3.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, United Kingdom;

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http://dx.doi.org/10.1101/gr.180273.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352878PMC
March 2015

Genes and gene networks implicated in aggression related behaviour.

Neurogenetics 2014 Oct 22;15(4):255-66. Epub 2014 Aug 22.

King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK,

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http://dx.doi.org/10.1007/s10048-014-0417-xDOI Listing
October 2014

Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder.

Psychoneuroendocrinology 2015 Jan 23;51:506-12. Epub 2014 Jul 23.

Research Centre Military Mental Healthcare, Ministry of Defence, Utrecht, The Netherlands; Department Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.psyneuen.2014.07.011DOI Listing
January 2015

The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder.

BMC Med 2014 May 7;12:73. Epub 2014 May 7.

King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, at Institute of Psychiatry, SGDP Research Centre (PO80), De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1186/1741-7015-12-73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046519PMC
May 2014

Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse.

PPAR Res 2014 1;2014:349525. Epub 2014 Apr 1.

Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia ; Centre of Excellence for Translational Medicine, 19 Ravila Street, 50411 Tartu, Estonia.

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http://downloads.hindawi.com/journals/ppar/2014/349525.pdf
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http://dx.doi.org/10.1155/2014/349525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995169PMC
May 2014

Mood-stabilizers differentially affect housekeeping gene expression in human cells.

Int J Methods Psychiatr Res 2014 Jun 12;23(2):279-88. Epub 2014 Feb 12.

King's College London, MRC Social Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1002/mpr.1435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878232PMC
June 2014

Transcriptomic changes in the frontal cortex associated with paternal age.

Mol Autism 2014 Mar 23;5(1):24. Epub 2014 Mar 23.

Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1186/2040-2392-5-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998024PMC
March 2014

The inflammatory cytokines: molecular biomarkers for major depressive disorder?

Biomark Med 2015 14;9(2):169-80. Epub 2014 Feb 14.

MRC Social, Genetic & Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, King's College London, PO 80, Denmark Hill, London, SE5 8AF, UK.

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http://dx.doi.org/10.2217/bmm.14.29DOI Listing
December 2015

Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder.

Pharmacogenomics 2013 Dec;14(16):1979-90

King's College London, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.2217/pgs.13.154DOI Listing
December 2013

ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway.

J Psychopharmacol 2013 Jul 29;27(7):609-15. Epub 2013 May 29.

MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.

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http://dx.doi.org/10.1177/0269881113490329DOI Listing
July 2013

A data-driven approach to preprocessing Illumina 450K methylation array data.

BMC Genomics 2013 May 1;14:293. Epub 2013 May 1.

Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.

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http://dx.doi.org/10.1186/1471-2164-14-293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769145PMC
May 2013

Peripheral blood RNA gene expression profiling in patients with bacterial meningitis.

Front Neurosci 2013 18;7:33. Epub 2013 Mar 18.

Department of Neurology and Neurosurgery, University of Tartu Tartu, Estonia.

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http://dx.doi.org/10.3389/fnins.2013.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600829PMC
March 2013

DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice.

Mol Brain 2012 Dec 6;5:42. Epub 2012 Dec 6.

Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1186/1756-6606-5-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541153PMC
December 2012

TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease.

Am J Med Genet B Neuropsychiatr Genet 2013 Jan 5;162B(1):1-16. Epub 2012 Nov 5.

Social, Genetic and Developmental Psychiatry Centre, King's College London, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1002/ajmg.b.32109DOI Listing
January 2013

Stochastic choice of allelic expression in human neural stem cells.

Stem Cells 2012 Sep;30(9):1938-47

King's College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, Department of Neuroscience, London, United Kingdom.

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http://dx.doi.org/10.1002/stem.1155DOI Listing
September 2012

Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains.

Proteomics 2012 Aug;12(14):2355-65

King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1002/pmic.201100306DOI Listing
August 2012

Depression-Related Behavioral Tests.

Curr Protoc Mouse Biol 2012 Jun 1;2(2):119-27. Epub 2012 Jun 1.

Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1002/9780470942390.mo110176DOI Listing
June 2012

Hypothalamic gene expression profile indicates a reduction in G protein signaling in the Wfs1 mutant mice.

Physiol Genomics 2011 Dec 25;43(24):1351-8. Epub 2011 Oct 25.

Department of Physiology, Centre of Translational Medicine, Institute of Technology, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1152/physiolgenomics.00117.2011DOI Listing
December 2011

Antidepressants and the resilience to early-life stress in inbred mouse strains.

Pharmacogenet Genomics 2011 Dec;21(12):779-89

INSERM U862, Avenir group Physiopathology of Energy Balance and Obesity, Université de Bordeaux 2, Bordeaux, France.

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http://dx.doi.org/10.1097/FPC.0b013e32834b3f35DOI Listing
December 2011

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder.

Hum Mol Genet 2011 Dec 9;20(24):4786-96. Epub 2011 Sep 9.

MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1093/hmg/ddr416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221539PMC
December 2011

Gene set enrichment; a problem of pathways.

Brief Funct Genomics 2010 Dec 22;9(5-6):385-90. Epub 2010 Sep 22.

Institute of Psychiatry, Kings College London, UK.

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http://dx.doi.org/10.1093/bfgp/elq021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080747PMC
December 2010

Allele-specific methylation in the human genome: implications for genetic studies of complex disease.

Epigenetics 2010 Oct 1;5(7):578-82. Epub 2010 Oct 1.

King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK.

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http://dx.doi.org/10.4161/epi.5.7.12960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052843PMC
October 2010

A three-stage genome-wide association study of general cognitive ability: hunting the small effects.

Behav Genet 2010 Nov 21;40(6):759-67. Epub 2010 Mar 21.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1007/s10519-010-9350-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992848PMC
November 2010

Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model.

PLoS One 2009 Dec 30;4(12):e8456. Epub 2009 Dec 30.

Medical Research Council Social Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008456PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794376PMC
December 2009

Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months.

Twin Res Hum Genet 2009 Aug;12(4):372-80

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom.

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http://www.journals.cambridge.org/abstract_S1832427400009981
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http://dx.doi.org/10.1375/twin.12.4.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819565PMC
August 2009

To What Extent is Blood a Reasonable Surrogate for Brain in Gene Expression Studies: Estimation from Mouse Hippocampus and Spleen.

Front Neurosci 2009 9;3:54. Epub 2009 Oct 9.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London London, UK.

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http://dx.doi.org/10.3389/neuro.15.002.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858613PMC
July 2011

The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays.

Bioinformatics 2009 Jan 12;25(2):281-3. Epub 2008 Nov 12.

Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/btn587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639010PMC
January 2009

The 21st International Mammalian Genome Conference meeting report.

Mamm Genome 2008 Sep 24;19(9):618-22. Epub 2008 Oct 24.

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, School of Medicine and Public Health, 1400 University Avenue, Madison, WI, 53706-1599, USA.

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http://dx.doi.org/10.1007/s00335-008-9147-4DOI Listing
September 2008

Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function.

Mamm Genome 2008 Aug 2;19(7-8):552-60. Epub 2008 Jul 2.

Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, KCL, PO82, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1007/s00335-008-9116-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755775PMC
August 2008

Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry.

Am J Med Genet B Neuropsychiatr Genet 2009 Apr;150B(3):309-17

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.b.30815DOI Listing
April 2009

Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice.

Behav Brain Res 2008 Mar 26;188(1):62-70. Epub 2007 Oct 26.

Department of Physiology, Centre of Molecular and Clinical Medicine, University of Tartu, Tartu 50411, Estonia.

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http://dx.doi.org/10.1016/j.bbr.2007.10.020DOI Listing
March 2008

Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism.

Proc Natl Acad Sci U S A 2007 Nov 5;104(47):18860-5. Epub 2007 Nov 5.

Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London SE5 8AF, England.

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http://dx.doi.org/10.1073/pnas.0704292104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141867PMC
November 2007

Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping.

Mamm Genome 2007 Jul 7;18(6-7):482-91. Epub 2007 Jul 7.

Social, Genetic and Developmental Psychiatry Centre (PO82), Institute of Psychiatry, King's College London, London, SE5 8AF, United Kingdom.

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http://link.springer.com/content/pdf/10.1007/s00335-007-9029
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http://link.springer.com/10.1007/s00335-007-9029-1
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http://dx.doi.org/10.1007/s00335-007-9029-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1998875PMC
July 2007

Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies.

BMC Genomics 2007 Jul 4;8:214. Epub 2007 Jul 4.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK.

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http://dx.doi.org/10.1186/1471-2164-8-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925094PMC
July 2007

Microarrays.

Dev Sci 2007 Jan;10(1):19-23

Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1111/j.1467-7687.2007.00558.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776927PMC
January 2007

Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans.

Nucleic Acids Res 2006 Feb 14;34(4):e27. Epub 2006 Feb 14.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK.

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http://dx.doi.org/10.1093/nar/gnj027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368655PMC
February 2006

Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice.

Behav Genet 2005 Sep;35(5):675-92

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1007/s10519-005-3423-9DOI Listing
September 2005

Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs.

BMC Genomics 2005 Apr 5;6:52. Epub 2005 Apr 5.

Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-6-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079828PMC
April 2005

SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children.

Hum Mol Genet 2005 May 30;14(10):1315-25. Epub 2005 Mar 30.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.

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http://academic.oup.com/hmg/article/14/10/1315/632685/SNPs-m
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http://dx.doi.org/10.1093/hmg/ddi142DOI Listing
May 2005

Behavioral characterization of wild derived male mice (Mus musculus musculus) of the PWD/Ph inbred strain: high exploration compared to C57BL/6J.

Behav Genet 2004 Nov;34(6):621-30

Social, Genetic and Developmental Psychiatry Centre, PO 82, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. c.

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http://dx.doi.org/10.1007/s10519-004-5589-yDOI Listing
November 2004

The Collaborative Cross, a community resource for the genetic analysis of complex traits.

Authors:
Gary A Churchill David C Airey Hooman Allayee Joe M Angel Alan D Attie Jackson Beatty William D Beavis John K Belknap Beth Bennett Wade Berrettini Andre Bleich Molly Bogue Karl W Broman Kari J Buck Ed Buckler Margit Burmeister Elissa J Chesler James M Cheverud Steven Clapcote Melloni N Cook Roger D Cox John C Crabbe Wim E Crusio Ariel Darvasi Christian F Deschepper R W Doerge Charles R Farber Jiri Forejt Daniel Gaile Steven J Garlow Hartmut Geiger Howard Gershenfeld Terry Gordon Jing Gu Weikuan Gu Gerald de Haan Nancy L Hayes Craig Heller Heinz Himmelbauer Robert Hitzemann Kent Hunter Hui-Chen Hsu Fuad A Iraqi Boris Ivandic Howard J Jacob Ritsert C Jansen Karl J Jepsen Dabney K Johnson Thomas E Johnson Gerd Kempermann Christina Kendziorski Malak Kotb R Frank Kooy Bastien Llamas Frank Lammert Jean-Michel Lassalle Pedro R Lowenstein Lu Lu Aldons Lusis Kenneth F Manly Ralph Marcucio Doug Matthews Juan F Medrano Darla R Miller Guy Mittleman Beverly A Mock Jeffrey S Mogil Xavier Montagutelli Grant Morahan David G Morris Richard Mott Joseph H Nadeau Hiroki Nagase Richard S Nowakowski Bruce F O'Hara Alexander V Osadchuk Grier P Page Beverly Paigen Kenneth Paigen Abraham A Palmer Huei-Ju Pan Leena Peltonen-Palotie Jeremy Peirce Daniel Pomp Michal Pravenec Daniel R Prows Zhonghua Qi Roger H Reeves John Roder Glenn D Rosen Eric E Schadt Leonard C Schalkwyk Ze'ev Seltzer Kazuhiro Shimomura Siming Shou Mikko J Sillanpää Linda D Siracusa Hans-Willem Snoeck Jimmy L Spearow Karen Svenson Lisa M Tarantino David Threadgill Linda A Toth William Valdar Fernando Pardo-Manuel de Villena Craig Warden Steve Whatley Robert W Williams Tim Wiltshire Nengjun Yi Dabao Zhang Min Zhang Fei Zou

Nat Genet 2004 Nov;36(11):1133-7

The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/ng1104-1133DOI Listing
November 2004

Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour.

Eur J Neurosci 2004 May;19(9):2576-82

Social, Genetic and Developmental Psychiatry Centre, PO 82, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1111/j.0953-816X.2004.03358.xDOI Listing
May 2004

Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes.

Eur J Hum Genet 2004 Aug;12(8):639-46

SGDP Centre, Institute of Psychiatry, Box PO 82, Denmark Hill, London SE5, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5201212DOI Listing
August 2004

The nature and identification of quantitative trait loci: a community's view.

Nat Rev Genet 2003 Nov;4(11):911-6

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http://dx.doi.org/10.1038/nrg1206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063446PMC
November 2003

Genetic analysis of the mouse brain proteome.

Nat Genet 2002 Apr 25;30(4):385-93. Epub 2002 Mar 25.

Institut für Humangenetik, Humboldt-Universität zu Berlin, Charité, Campus Virchow-Klinikum, Augustenburger Platz 1, D-13353 Berlin, Germany.

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http://www.buessow.com/pdf/Klose02_Nature_Genetics.pdf
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http://www.nature.com/doifinder/10.1038/ng861
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http://dx.doi.org/10.1038/ng861DOI Listing
April 2002