Leona D Samson

Leona D Samson

UNVERIFIED PROFILE

Are you Leona D Samson?   Register this Author

Register author
Leona D Samson

Leona D Samson

Publications by authors named "Leona D Samson"

Are you Leona D Samson?   Register this Author

98Publications

1070Reads

7Profile Views

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.

PLoS One 2019 27;14(2):e0208341. Epub 2019 Feb 27.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208341PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392231PMC
October 2019

H. John F. Cairns (1922-2018).

Authors:
Leona D Samson

Nat Struct Mol Biol 2019 03;26(3):149-150

Department of Biological Engineering and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41594-019-0194-1DOI Listing
March 2019

Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation.

Cell Rep 2019 02;26(6):1668-1678.e4

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247193008
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.01.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431241PMC
February 2019

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.

Sci Signal 2019 02 12;12(568). Epub 2019 Feb 12.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aau9216DOI Listing
February 2019

A target to suppress inflammation.

Authors:
Leona D Samson

Science 2018 11;362(6416):748-749

Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aav4744DOI Listing
November 2018

Nitric oxide induced S-nitrosation causes base excision repair imbalance.

DNA Repair (Amst) 2018 08 5;68:25-33. Epub 2018 May 5.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436541PMC
August 2018

In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities.

Proc Natl Acad Sci U S A 2017 11 9;114(48):E10379-E10388. Epub 2017 Nov 9.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1712032114
Publisher Site
http://dx.doi.org/10.1073/pnas.1712032114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715766PMC
November 2017

Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms.

PLoS One 2017 8;12(9):e0184619. Epub 2017 Sep 8.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590993PMC
October 2017

PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration.

Oncotarget 2017 Sep 3;8(40):68707-68720. Epub 2017 Aug 3.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.19844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620290PMC
September 2017

A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine.

Nucleic Acids Res 2017 04;45(6):3242-3252

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkx015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389632PMC
April 2017

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

Cancer Res 2017 01 28;77(1):198-206. Epub 2016 Oct 28.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-1151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100738PMC
January 2017

Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response.

PLoS One 2016 1;11(4):e0152684. Epub 2016 Apr 1.

Department of Chemistry, Stanford University, Stanford, CA, 94305, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818092PMC
August 2016

The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.

Oncotarget 2016 May;7(19):28624-36

Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053750PMC
http://dx.doi.org/10.18632/oncotarget.8721DOI Listing
May 2016

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.

DNA Repair (Amst) 2015 Nov 14;35:13-8. Epub 2015 Sep 14.

Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2015.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206904PMC
November 2015

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

Cancer Res 2015 Aug 29;75(15):3127-38. Epub 2015 May 29.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-3616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526337PMC
August 2015

DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo.

Carcinogenesis 2014 Nov 25;35(11):2495-502. Epub 2014 Aug 25.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Singapore-MIT Alliance for Research and Technology, Singapore 138602, Singapore

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgu177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216056PMC
November 2014

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Proc Natl Acad Sci U S A 2014 Nov 27;111(45):E4878-86. Epub 2014 Oct 27.

Departments of Biological Engineering and Biology, Center for Environmental Health Sciences, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1413582111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234618PMC
November 2014

Repair of endogenous DNA base lesions modulate lifespan in mice.

DNA Repair (Amst) 2014 Sep 30;21:78-86. Epub 2014 Jun 30.

Biological Engineering Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Biology Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Rodent Histopathology Core, Harvard Medical School, 126 Goldenson Building, Boston, MA 02115, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2014.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125484PMC
September 2014

Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposure.

PLoS One 2013 9;8(9):e73736. Epub 2013 Sep 9.

Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America ; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America ; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073736PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767620PMC
July 2014

Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.

DNA Repair (Amst) 2014 Jul 26;19:199-213. Epub 2014 Apr 26.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2014.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071454PMC
July 2014

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.

Proc Natl Acad Sci U S A 2014 May 22;111(18):E1823-32. Epub 2014 Apr 22.

Department of Biological Engineering, Center for Environmental Health Sciences, Department of Biology, and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1401182111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020053PMC
May 2014

Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.

Nucleic Acids Res 2013 Nov 9;41(20):9310-24. Epub 2013 Aug 9.

Department of Biological Engineering, Center for Environmental Health Sciences, Laboratory for Computational Biology and Biophysics, Department of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814357PMC
November 2013

Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae.

Lab Chip 2013 Jul;13(14):2754-63

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3lc50162kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686985PMC
July 2013

Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.

Genes Dev 2013 May 10;27(10):1089-100. Epub 2013 May 10.

Department of Biological Engineering, Department of Biology, Center for Environmental Health Sciences, David H. Koch Center for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.215533.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672644PMC
May 2013

Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1.

PLoS Genet 2013 Apr 4;9(4):e1003413. Epub 2013 Apr 4.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617098PMC
April 2013

Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).

DNA Repair (Amst) 2013 Mar 3;12(3):177-87. Epub 2013 Jan 3.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2012.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998512PMC
March 2013

Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.

Mol Cell Biol 2013 Feb 26;33(3):635-42. Epub 2012 Nov 26.

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01020-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554213PMC
February 2013

O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.

Integr Biol (Camb) 2012 Oct;4(10):1237-55

Biological Engineering Department, Biology Department, Center for Environmental Health Sciences, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=c2ib20091k
Publisher Site
http://dx.doi.org/10.1039/c2ib20091kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574819PMC
October 2012

Identification of novel human damage response proteins targeted through yeast orthology.

PLoS One 2012 16;7(5):e37368. Epub 2012 May 16.

Biological Engineering Department, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353887PMC
September 2012

Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.

DNA Repair (Amst) 2012 Jan 11;11(1):46-52. Epub 2011 Nov 11.

Department of Biological Engineering, and Biology, Center for Environmental Health Sciences, David H. Koch Center for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2011.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253959PMC
January 2012

A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects.

DNA Repair (Amst) 2012 Jan 30;11(1):92-8. Epub 2011 Nov 30.

Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2011.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408220PMC
January 2012

Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.

Biochemistry 2012 Jan 20;51(1):382-90. Epub 2011 Dec 20.

Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi201484kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254189PMC
January 2012

Balancing repair and tolerance of DNA damage caused by alkylating agents.

Nat Rev Cancer 2012 Jan 12;12(2):104-20. Epub 2012 Jan 12.

Department of Biological Engineering, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc3185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586545PMC
January 2012

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.

Mol Syst Biol 2012 Jan 31;8:568. Epub 2012 Jan 31.

Department of Biology, David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/msb.2012.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296916PMC
January 2012

Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.

BMC Syst Biol 2011 Oct 6;5:157. Epub 2011 Oct 6.

Biological Engineering Department, Center for Environmental Health Sciences, Biology Department, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1752-0509-5-157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213080PMC
October 2011

Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA.

J Biol Chem 2011 Apr 24;286(15):13205-13. Epub 2011 Feb 24.

Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.192435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075667PMC
April 2011

Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

Carcinogenesis 2010 Dec 23;31(12):2111-7. Epub 2010 Aug 23.

Department of Molecular Medicine, University of Erlangen-Nuremberg, D-91052 Erlangen, German.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgq174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994278PMC
December 2010

DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.

PLoS One 2010 Aug 18;5(8):e12229. Epub 2010 Aug 18.

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012229PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923601PMC
August 2010

Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase.

Mol Cell 2010 Mar;37(6):843-53

Department of Biological Engineering, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2010.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894629PMC
March 2010

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).

Biochemistry 2009 Mar;48(9):1850-61

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi8018898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883313PMC
March 2009

O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.

Proc Natl Acad Sci U S A 2009 Jan 5;106(2):576-81. Epub 2009 Jan 5.

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0811991106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613938PMC
January 2009

Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.

Proc Natl Acad Sci U S A 2009 Jan 12;106(3):888-93. Epub 2009 Jan 12.

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0807030106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621254PMC
January 2009

Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival.

DNA Repair (Amst) 2008 Oct 29;7(10):1731-45. Epub 2008 Aug 29.

Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S156878640800252
Publisher Site
http://dx.doi.org/10.1016/j.dnarep.2008.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073691PMC
October 2008

Genomic predictors of interindividual differences in response to DNA damaging agents.

Genes Dev 2008 Oct 19;22(19):2621-6. Epub 2008 Sep 19.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1688508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559901PMC
October 2008

Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.

Mutagenesis 2008 Sep 13;23(5):341-6. Epub 2008 May 13.

Department of Pediatrics, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mutage/gen018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527341PMC
September 2008

Base excision repair.

Adv Exp Med Biol 2005 ;570:125-73

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/1-4020-3764-3_5DOI Listing
September 2008

3-Methyladenine DNA glycosylase is important for cellular resistance to psoralen interstrand cross-links.

DNA Repair (Amst) 2008 Aug 20;7(8):1399-406. Epub 2008 Jun 20.

Biological Engineering Department and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2008.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583468PMC
August 2008

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice.

J Clin Invest 2008 Jul;118(7):2516-25

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://www.jci.org/articles/view/35073
Publisher Site
http://dx.doi.org/10.1172/JCI35073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423313PMC
July 2008

Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag).

DNA Repair (Amst) 2008 Jun 12;7(6):970-82. Epub 2008 May 12.

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S156878640800128
Publisher Site
http://dx.doi.org/10.1016/j.dnarep.2008.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494847PMC
June 2008

AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.

Cancer Res 2008 Jun;68(11):4142-9

Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Rikshospitalet HF and University of Oslo, Blindern, Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-0796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725713PMC
June 2008

Oxanine DNA glycosylase activities in mammalian systems.

DNA Repair (Amst) 2008 Jan 22;7(1):128-34. Epub 2007 Oct 22.

Department of Genetics and Biochemistry, South Carolina Experiment Station, Clemson University, Room 219, Biosystems Research Complex, 51 New Cherry Street, Clemson, SC 29634, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2007.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211726PMC
January 2008

Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.

DNA Repair (Amst) 2007 Dec 6;6(12):1764-73. Epub 2007 Aug 6.

Committee on Immunology, University of Chicago, Chicago, IL 60637, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2007.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196218PMC
December 2007

The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents.

Chem Res Toxicol 2007 Dec 20;20(12):1843-53. Epub 2007 Nov 20.

Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx700126e
Publisher Site
http://dx.doi.org/10.1021/tx700126eDOI Listing
December 2007

Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.

PLoS One 2007 Nov 28;2(11):e1252. Epub 2007 Nov 28.

Center for Environmental Health Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080756PMC
November 2007

Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes.

FASEB J 2007 Aug 10;21(10):2564-79. Epub 2007 Apr 10.

Department of Mechanical Engineering, MIT, 77 Mass. Ave., Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.06-7473comDOI Listing
August 2007

Genetic association and functional studies of major polymorphic variants of MGMT.

DNA Repair (Amst) 2007 Aug 13;6(8):1116-26. Epub 2007 Jun 13.

Biological Engineering Division, Biology Department, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2007.03.023DOI Listing
August 2007

Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.

Carcinogenesis 2007 May 20;28(5):1111-6. Epub 2006 Nov 20.

Committee on Cancer Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgl218DOI Listing
May 2007

The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.

BMC Genomics 2006 Dec 12;7:313. Epub 2006 Dec 12.

Department of Biological Engineering, Massachusetts Institute of Technology, NE47-277, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
Publisher Site
http://dx.doi.org/10.1186/1471-2164-7-313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764021PMC
December 2006

Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk.

Pharmacogenet Genomics 2006 Jul;16(7):469-74

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=01213011-200607000-000
Publisher Site
http://dx.doi.org/10.1097/01.fpc.0000215065.21718.4cDOI Listing
July 2006

Genome-wide responses to DNA-damaging agents.

Annu Rev Microbiol 2005 ;59:357-77

Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://www.annualreviews.org/doi/10.1146/annurev.micro.59.03
Publisher Site
http://dx.doi.org/10.1146/annurev.micro.59.031805.133658DOI Listing
January 2006

Comparative modeling and analysis of microfluidic and conventional DNA microarrays.

Anal Biochem 2006 Jan 8;348(2):284-93. Epub 2005 Nov 8.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2005.10.033DOI Listing
January 2006

AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo.

Nat Struct Mol Biol 2005 Oct 2;12(10):855-60. Epub 2005 Oct 2.

Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nsmb996
Publisher Site
http://dx.doi.org/10.1038/nsmb996DOI Listing
October 2005

Network responses to DNA damaging agents.

DNA Repair (Amst) 2004 Aug-Sep;3(8-9):1123-32

Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S156878640400072
Publisher Site
http://dx.doi.org/10.1016/j.dnarep.2004.03.013DOI Listing
February 2005

Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae.

Proc Natl Acad Sci U S A 2004 Dec 17;101(52):18006-11. Epub 2004 Dec 17.

Digital Signal Processing Group, Department of Electrical Engineering and Computer Science, and Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0405996101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539745PMC
December 2004

Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping.

Mol Cell 2004 Oct;16(1):117-25

Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2004.09.005DOI Listing
October 2004

Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase.

J Biol Chem 2004 Sep 7;279(37):38177-83. Epub 2004 Jul 7.

Department of Genetics, Biochemistry & Life Science Studies, South Carolina Experiment Station, Clemson University, Clemson, South Carolina 29634, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M405882200
Publisher Site
http://dx.doi.org/10.1074/jbc.M405882200DOI Listing
September 2004

Reversing DNA damage with a directional bias.

Nat Struct Mol Biol 2004 Aug;11(8):688-90

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nsmb0804-688
Publisher Site
http://dx.doi.org/10.1038/nsmb0804-688DOI Listing
August 2004

Polymorphisms in DNA double-strand break repair genes and skin cancer risk.

Cancer Res 2004 May;64(9):3009-13

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.can-04-0246DOI Listing
May 2004

Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

Mol Cell 2004 Apr;14(1):105-16

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1097-2765(04)00162-5DOI Listing
April 2004

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

J Biol Chem 2003 Oct 25;278(41):39951-9. Epub 2003 Jul 25.

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M306592200DOI Listing
October 2003

Molecular biology: A fix for RNA.

Nature 2003 Feb;421(6925):795-6

View Article

Download full-text PDF

Source
http://www.nature.com/articles/421795a
Publisher Site
http://dx.doi.org/10.1038/421795aDOI Listing
February 2003

AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism.

Trends Biochem Sci 2003 Jan;28(1):2-5

Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0968-0004(02)00010-5DOI Listing
January 2003

Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping.

Mol Cancer Res 2002 Dec;1(2):103-12

Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
December 2002

Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress.

Proc Natl Acad Sci U S A 2002 May 30;99(10):6860-5. Epub 2002 Apr 30.

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.092662499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124494PMC
May 2002

3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance.

Cancer Res 2002 Feb;62(3):656-60

Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
February 2002