Publications by authors named "Leona A Doyle"

64Publications

Radiation-associated sarcomas other than malignant peripheral nerve sheath tumours demonstrate loss of histone H3K27 trimethylation.

Histopathology 2020 Jul 31. Epub 2020 Jul 31.

Departments of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/his.14223DOI Listing
July 2020

Primary intra-abdominal melanoma arising in association with extracutaneous blue naevus: a report of two cases.

Histopathology 2020 Jul 22. Epub 2020 Jul 22.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.14219DOI Listing
July 2020

MYC expression has limited utility in the distinction of undifferentiated radiation-associated sarcomas from sporadic sarcomas and sarcomatoid carcinoma.

Histopathology 2020 Oct 28;77(4):667-672. Epub 2020 Jul 28.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.14168DOI Listing
October 2020

Secondary Sarcomas: Biology, Presentation, and Clinical Care.

Am Soc Clin Oncol Educ Book 2020 Mar;40:1-12

Division of Medical Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1200/EDBK_280985DOI Listing
March 2020

Characteristics of mismatch repair deficiency in sarcomas.

Mod Pathol 2019 07 14;32(7):977-987. Epub 2019 Feb 14.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41379-019-0202-3
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http://dx.doi.org/10.1038/s41379-019-0202-3DOI Listing
July 2019

Radiation-Associated Sarcomas: An Update on Clinical, Histologic, and Molecular Features.

Surg Pathol Clin 2019 Mar 20;12(1):139-148. Epub 2018 Dec 20.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18759181183008
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http://dx.doi.org/10.1016/j.path.2018.10.010DOI Listing
March 2019

A Comparison of Outcomes and Prognostic Features for Radiation-Associated Angiosarcoma of the Breast and Other Radiation-Associated Sarcomas.

Int J Radiat Oncol Biol Phys 2019 06 29;104(2):425-435. Epub 2019 Jan 29.

Department of Pathology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.082DOI Listing
June 2019

A Breath-Taking Diagnosis.

N Engl J Med 2019 01;380(1):81-87

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1807721DOI Listing
January 2019

Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.

Am J Clin Pathol 2017 Aug;148(2):179-189

Department of Pathology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1093/ajcp/aqx060DOI Listing
August 2017

Fumarate hydratase expression is retained in atypical intradermal smooth muscle neoplasms and cutaneous leiomyosarcomas.

Histopathology 2017 12 6;71(6):1023-1025. Epub 2017 Oct 6.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1111/his.13308
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http://dx.doi.org/10.1111/his.13308DOI Listing
December 2017

Advances in the Genetic Characterization of Cutaneous Mesenchymal Neoplasms: Implications for Tumor Classification and Novel Diagnostic Markers.

Surg Pathol Clin 2017 Jun 18;10(2):299-317. Epub 2017 Mar 18.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2017.01.005DOI Listing
June 2017

Genomic Characterization of Low- and High-Grade Pancreatic Mucinous Cystic Neoplasms Reveals Recurrent KRAS Alterations in "High-Risk" Lesions.

Pancreas 2017 May/Jun;46(5):665-671

From the *Department of Pathology, Brigham and Women's Hospital; †Harvard Medical School; and ‡Department of Pathology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/MPA.0000000000000805DOI Listing
March 2018

Spindle Cell Lipomas Arising at Atypical Locations.

Am J Clin Pathol 2016 Oct;146(4):487-95

Department of Laboratory Medicine and Pathology

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http://dx.doi.org/10.1093/ajcp/aqw137DOI Listing
October 2016

Refinements in Sarcoma Classification in the Current 2013 World Health Organization Classification of Tumours of Soft Tissue and Bone.

Surg Oncol Clin N Am 2016 10 30;25(4):621-43. Epub 2016 Jul 30.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.soc.2016.05.001DOI Listing
October 2016

Advances in the clinicopathological and molecular classification of cutaneous mesenchymal neoplasms.

Histopathology 2016 May 1;68(6):776-95. Epub 2016 Mar 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.12930DOI Listing
May 2016

Anorectal Cancer: Critical Anatomic and Staging Distinctions That Affect Use of Radiation Therapy.

Radiographics 2015 Nov-Dec;35(7):2090-107

From the Departments of Radiology (S.A.M., S.H.T., N.H.R., M.H.R.), Radiation Oncology (H.J.M.), and Pathology (L.A.D.), Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass (H.J.M., C.S.F., L.A.D., S.H.T., N.H.R., M.H.R.); and Departments of Medical Oncology (C.S.F.) and Imaging (S.H.T., N.H.R., M.H.R.), Dana-Farber Cancer Institute, Boston, Mass.

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http://dx.doi.org/10.1148/rg.2015150037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664281PMC
September 2016

Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics.

Am J Surg Pathol 2016 Jan;40(1):94-102

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0000000000000511DOI Listing
January 2016

Diagnostic Challenges and Recent Developments in Soft Tissue Pathology. Preface.

Surg Pathol Clin 2015 Sep;8(3):ix

Mayo Clinic, Department of Anatomic Pathology, Hilton 11, 200 First Street, Southwest, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2015.07.001DOI Listing
September 2015

Non-mesenchymal Mimics of Sarcoma.

Authors:
Leona A Doyle

Surg Pathol Clin 2015 Sep;8(3):493-513

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2015.05.010DOI Listing
September 2015

Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing.

Lab Invest 2015 Sep 29;95(9):1071-6. Epub 2015 Jun 29.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1038/labinvest.2015.83DOI Listing
September 2015

Ipilimumab-associated Hepatitis: Clinicopathologic Characterization in a Series of 11 Cases.

Am J Surg Pathol 2015 Aug;39(8):1075-84

*Department of Pathology, Brigham and Women's Hospital and Harvard Medical School Departments of †Pathology ‡Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0000000000000453DOI Listing
August 2015

ALK rearrangement and overexpression in epithelioid fibrous histiocytoma.

Mod Pathol 2015 Jul 10;28(7):904-12. Epub 2015 Apr 10.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2015.49DOI Listing
July 2015

Soft tissue tumor pathology: New diagnostic immunohistochemical markers.

Authors:
Leona A Doyle

Semin Diagn Pathol 2015 Sep 4;32(5):370-80. Epub 2015 Feb 4.

Department of Pathology, Brigham and Women׳s Hospital and Harvard Medical School, 75 Francis St, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.semdp.2015.02.012DOI Listing
September 2015

An update on the application of newly described immunohistochemical markers in soft tissue pathology.

Arch Pathol Lab Med 2015 Jan;139(1):106-21

From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania (Dr Lin); and the Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (Dr Doyle).

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http://dx.doi.org/10.5858/arpa.2014-0488-RADOI Listing
January 2015

Ewing sarcoma mimicking atypical carcinoid tumor: detection of unexpected genomic alterations demonstrates the use of next generation sequencing as a diagnostic tool.

Cancer Genet 2014 Jul-Aug;207(7-8):335-9. Epub 2014 Aug 29.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.cancergen.2014.08.004DOI Listing
January 2015

DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma.

J Am Acad Dermatol 2014 Aug 19;71(2):256-63. Epub 2014 Apr 19.

Pathology Department, University of California, San Francisco, California; Dermatology Department, University of California, San Francisco, California; Helen A. Diller Family Comprehensive Cancer Center, University of California, San Francisco, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622140124
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http://dx.doi.org/10.1016/j.jaad.2014.03.015DOI Listing
August 2014

Pathology of extramedullary mastocytosis.

Immunol Allergy Clin North Am 2014 May;34(2):323-39

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 USA; Mastocytosis Center, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.iac.2014.01.010DOI Listing
May 2014

Sarcoma classification: an update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone.

Authors:
Leona A Doyle

Cancer 2014 Jun 19;120(12):1763-74. Epub 2014 Mar 19.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28657DOI Listing
June 2014

A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients.

Am J Surg Pathol 2014 Jun;38(6):832-43

Departments of *Pathology †Medicine, Brigham and Women's Hospital and Harvard Medical School ‡Mastocytosis Center, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0000000000000190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086834PMC
June 2014

Investigating MicroRNA Expression Profiles in Pancreatic Cystic Neoplasms.

Clin Transl Gastroenterol 2014 Jan 30;5:e47. Epub 2014 Jan 30.

1] Center for Pancreatic Disease, Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Interdisciplinary Management of Pancreatic Cystic Tumors (IMPACT) Clinic, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ctg201318
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http://dx.doi.org/10.1038/ctg.2013.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912316PMC
January 2014

STAT6 is amplified in a subset of dedifferentiated liposarcoma.

Mod Pathol 2014 Sep 24;27(9):1231-7. Epub 2014 Jan 24.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2013.247DOI Listing
September 2014

GRIA2 is a novel diagnostic marker for solitary fibrous tumour identified through gene expression profiling.

Histopathology 2014 Jul 2;65(1):71-80. Epub 2014 Apr 2.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.12377DOI Listing
July 2014

Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms.

Gynecol Oncol 2014 Feb 14;132(2):328-33. Epub 2013 Dec 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Department of Pathology, Boston, MA, USA; Brigham and Women's Hospital, Division of Women's and Perinatal Pathology, Boston, MA, USA. Electronic address:

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http://research4.dfci.harvard.edu/drapkin_lab/PDFs/EliasGynO
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http://linkinghub.elsevier.com/retrieve/pii/S009082581301375
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http://dx.doi.org/10.1016/j.ygyno.2013.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929430PMC
February 2014

Cytokeratin 17: an adjunctive marker of invasion in squamous neoplastic lesions of the anus.

Am J Surg Pathol 2014 Jan;38(1):78-85

*Pathology Service, Massachusetts General Hospital and Harvard Medical School †Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0000000000000111DOI Listing
January 2014

Peripheral hemangioblastoma: clinicopathologic characterization in a series of 22 cases.

Am J Surg Pathol 2014 Jan;38(1):119-27

*Department of Pathology, Brigham and Women's Hospital †Department of Pathology, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0b013e3182a266c1DOI Listing
January 2014

Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase.

Histopathology 2014 Jan 28;64(1):53-67. Epub 2013 Nov 28.

Department of Pathology, Brigham and Women's Hospital , Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1111/his.12302
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http://dx.doi.org/10.1111/his.12302DOI Listing
January 2014

PEComa of the gastrointestinal tract: clinicopathologic study of 35 cases with evaluation of prognostic parameters.

Am J Surg Pathol 2013 Dec;37(12):1769-82

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0b013e31829caab3DOI Listing
December 2013

Predicting behavior of solitary fibrous tumor: are we getting closer to more accurate risk assessment?

Ann Surg Oncol 2013 Dec 19;20(13):4055-6. Epub 2013 Sep 19.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-013-3243-8DOI Listing
December 2013

Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics.

Mod Pathol 2014 Mar 13;27(3):390-5. Epub 2013 Sep 13.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2013.164DOI Listing
March 2014

EWSR1 rearrangements in sclerosing epithelioid fibrosarcoma.

Am J Surg Pathol 2013 Oct;37(10):1630-1

Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston, MA.

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http://dx.doi.org/10.1097/PAS.0b013e3182a05a6bDOI Listing
October 2013

Mesenchymal Tumors of the Gastrointestinal Tract Other than GIST.

Surg Pathol Clin 2013 Sep 23;6(3):425-73. Epub 2013 Jul 23.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2013.05.003DOI Listing
September 2013

Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases.

Am J Surg Pathol 2013 Apr;37(4):484-95

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/PAS.0b013e31827070d4DOI Listing
April 2013

Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors.

Mod Pathol 2013 Feb 7;26(2):289-94. Epub 2012 Sep 7.

Dana-Farber Cancer Institute, Center for Sarcoma and Bone Oncology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2012.153DOI Listing
February 2013

Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study.

Histopathology 2012 Nov 17;61(5):801-9. Epub 2012 Jul 17.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1365-2559.2012.04300.xDOI Listing
November 2012

Severe pazopanib-induced hepatotoxicity: clinical and histologic course in two patients.

J Clin Oncol 2012 Sep 16;30(27):e264-8. Epub 2012 Jul 16.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://ascopubs.org/doi/10.1200/JCO.2011.41.0332
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http://dx.doi.org/10.1200/JCO.2011.41.0332DOI Listing
September 2012

EMA positivity in epithelioid fibrous histiocytoma: a potential diagnostic pitfall.

J Cutan Pathol 2011 Sep 14;38(9):697-703. Epub 2011 Jul 14.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1111/j.1600-0560.2011.01747.x
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http://dx.doi.org/10.1111/j.1600-0560.2011.01747.xDOI Listing
September 2011

MUC4 is a highly sensitive and specific marker for low-grade fibromyxoid sarcoma.

Am J Surg Pathol 2011 May;35(5):733-41

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/PAS.0b013e318210c268DOI Listing
May 2011