Publications by authors named "Leon van Gurp"

15Publications

A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas.

Authors:
Léon van Gurp Mauro J Muraro Tim Dielen Lina Seneby Gitanjali Dharmadhikari Gerard Gradwohl Alexander van Oudenaarden Eelco J P de Koning

Development 2019 06 24;146(12). Epub 2019 Jun 24.

Hubrecht Institute/KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands

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June 2019

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Authors:
Kenichiro Furuyama Simona Chera Léon van Gurp Daniel Oropeza Luiza Ghila Nicolas Damond Heidrun Vethe Joao A Paulo Antoinette M Joosten Thierry Berney Domenico Bosco Craig Dorrell Markus Grompe Helge Ræder Bart O Roep Fabrizio Thorel Pedro L Herrera

Nature 2019 03 13;567(7746):43-48. Epub 2019 Feb 13.

Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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March 2019

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells.

Authors:
Valentina Cigliola Luiza Ghila Fabrizio Thorel Léon van Gurp Delphine Baronnier Daniel Oropeza Simone Gupta Takeshi Miyatsuka Hideaki Kaneto Mark A Magnuson Anna B Osipovich Maike Sander Christopher E V Wright Melissa K Thomas Kenichiro Furuyama Simona Chera Pedro L Herrera

Nat Cell Biol 2018 11 22;20(11):1267-1277. Epub 2018 Oct 22.

Department of Genetic Medicine and Development, iGE3 and Centre facultaire du diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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November 2018

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Authors:
Cindy J M Loomans Nerys Williams Giuliani Jeetindra Balak Femke Ringnalda Léon van Gurp Meritxell Huch Sylvia F Boj Toshiro Sato Lennart Kester Susana M Chuva de Sousa Lopes Matthias S Roost Susan Bonner-Weir Marten A Engelse Ton J Rabelink Harry Heimberg Robert G J Vries Alexander van Oudenaarden Françoise Carlotti Hans Clevers Eelco J P de Koning

Stem Cell Reports 2018 03;10(3):712-724

Hubrecht Institute/KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Department of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands. Electronic address:

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March 2018

Development, Use, and Impact of a Global Laboratory Database During the 2014 Ebola Outbreak in West Africa.

Authors:
Kara N Durski Shalini Singaravelu Junxiong Teo Dhamari Naidoo Luke Bawo Amara Jambai Sakoba Keita Ali Ahmed Yahaya Beatrice Muraguri Brice Ahounou Victoria Katawera Fredson Kuti-George Yacouba Nebie T Henry Kohar Patrick Jowlehpah Hardy Mamoudou Harouna Djingarey David Kargbo Nuha Mahmoud Yewondwossen Assefa Orla Condell Magassouba N'Faly Leon Van Gurp Margaret Lamanu Julia Ryan Boubacar Diallo Foday Daffae Dikena Jackson Fayyaz Ahmed Malik Philomena Raftery Pierre Formenty

J Infect Dis 2017 06;215(12):1799-1806

World Health Organization, Geneva, Switzerland.

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June 2017

A Single-Cell Transcriptome Atlas of the Human Pancreas.

Authors:
Mauro J Muraro Gitanjali Dharmadhikari Dominic Grün Nathalie Groen Tim Dielen Erik Jansen Leon van Gurp Marten A Engelse Francoise Carlotti Eelco J P de Koning Alexander van Oudenaarden

Cell Syst 2016 10 29;3(4):385-394.e3. Epub 2016 Sep 29.

Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Cancer Genomics Netherlands, 3584 CT Utrecht, the Netherlands. Electronic address:

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October 2016

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice.

Authors:
Léon van Gurp Cindy J M Loomans Pim P van Krieken Gitanjali Dharmadhikari Erik Jansen Femke C A S Ringnalda Evelyne Beerling Jacco van Rheenen Eelco J P de Koning

Diabetologia 2016 11 21;59(11):2387-2392. Epub 2016 Jul 21.

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT, Utrecht, the Netherlands.

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November 2016

Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis.

Authors:
Laila Ritsma Ernst J A Steller Evelyne Beerling Cindy J M Loomans Anoek Zomer Carmen Gerlach Nienke Vrisekoop Daniëlle Seinstra Leon van Gurp Ronny Schäfer Daniëlle A Raats Anko de Graaff Ton N Schumacher Eelco J P de Koning Inne H Borel Rinkes Onno Kranenburg Jacco van Rheenen

Sci Transl Med 2012 Oct;4(158):158ra145

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht 3584 CT, Netherlands.

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October 2012

Induced Wnt5a expression perturbs embryonic outgrowth and intestinal elongation, but is well-tolerated in adult mice.

Authors:
Elvira R M Bakker Lalini Raghoebir Patrick F Franken Werner Helvensteijn Léon van Gurp Frits Meijlink Martin A van der Valk Robbert J Rottier Ernst J Kuipers Wendy van Veelen Ron Smits

Dev Biol 2012 Sep 9;369(1):91-100. Epub 2012 Jun 9.

Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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September 2012

An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.

Authors:
Carolien Wansleeben Léon van Gurp Harma Feitsma Carla Kroon Ester Rieter Marlies Verberne Victor Guryev Edwin Cuppen Frits Meijlink

PLoS One 2011 Apr 29;6(4):e19357. Epub 2011 Apr 29.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, The Netherlands.

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April 2011

An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.

Authors:
Carolien Wansleeben Léon van Gurp Petra de Graaf Florence Mousson H Th Marc Timmers Frits Meijlink

Mech Dev 2011 May-Jun;128(5-6):279-88. Epub 2011 Mar 16.

Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan, Netherlands.

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October 2011

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis.

Authors:
Wendy van Veelen Ngoc H Le Werner Helvensteijn Lau Blonden Myrte Theeuwes Elvira R M Bakker Patrick F Franken Léon van Gurp Frits Meijlink Martin A van der Valk Ernst J Kuipers Riccardo Fodde Ron Smits

Gut 2011 Sep 9;60(9):1204-12. Epub 2011 Feb 9.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, room L-63, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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September 2011

Duodenal pain and spinal morphine induce conditioned taste aversion in rats.

Authors:
Gert-Jan Geerse Léon C A van Gurp Diane C W A van Wijk Victor M Wiegant Rianne Stam

Physiol Behav 2007 Jun 16;91(2-3):310-7. Epub 2007 Mar 16.

Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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June 2007

Individual reactivity to the open-field predicts the expression of cardiovascular and behavioural sensitisation to novel stress.

Authors:
Gert-Jan Geerse Léon C A van Gurp Victor M Wiegant Rianne Stam

Behav Brain Res 2006 Nov 22;175(1):9-17. Epub 2006 Aug 22.

Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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November 2006

Individual reactivity to the open-field predicts the expression of stress-induced behavioural and somatic pain sensitisation.

Authors:
Gert-Jan Geerse Léon C A van Gurp Victor M Wiegant Rianne Stam

Behav Brain Res 2006 Nov 22;174(1):112-8. Epub 2006 Aug 22.

Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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November 2006