Leon J Thal

Leon J Thal

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Leon J Thal

Leon J Thal

Publications by authors named "Leon J Thal"

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Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI.

Neurobiol Aging 2008 Sep 23;29(9):1285-95. Epub 2007 Apr 23.

Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768818PMC
September 2008

Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease.

Neuropsychology 2007 Nov;21(6):696-705

Department of Psychology, University of California, San Diego, CA 92093-0109, USA.

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http://dx.doi.org/10.1037/0894-4105.21.6.696DOI Listing
November 2007

ADCS Prevention Instrument Project: overview and initial results.

Alzheimer Dis Assoc Disord 2006 Oct-Dec;20(4 Suppl 3):S109-23

Alzheimer's Disease Center, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1097/01.wad.0000213870.40300.21DOI Listing
May 2007

ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials.

Alzheimer Dis Assoc Disord 2006 Oct-Dec;20(4 Suppl 3):S139-46

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0948, USA.

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http://dx.doi.org/10.1097/01.wad.0000213871.40300.68DOI Listing
May 2007

Density of the brain, decline of the mind: an atypical case of Fahr disease.

Arch Neurol 2007 May;64(5):756-7

Alzheimer's Disease Cooperative Study, La Jolla, CA 92037-1712, USA.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archneur.64.5.756DOI Listing
May 2007

Nerve growth factor promotes survival of new neurons in the adult hippocampus.

Neurobiol Dis 2007 Apr 20;26(1):47-55. Epub 2006 Dec 20.

Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.

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http://dx.doi.org/10.1016/j.nbd.2006.11.015DOI Listing
April 2007

Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease.

Neuropsychology 2007 Jan;21(1):20-30

Department of Neurosciences, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1037/0894-4105.21.1.20DOI Listing
January 2007

Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia.

Arch Neurol 2007 Jan;64(1):108-15

Department of Neurology and Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California at Davis, Sacramento 95817, USA.

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http://dx.doi.org/10.1001/archneur.64.1.108DOI Listing
January 2007

Robert Katzman honored.

Alzheimer Dis Assoc Disord 2006 Jul-Sep;20(3 Suppl 2):S27-8

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http://dx.doi.org/10.1097/00002093-200607001-00001DOI Listing
November 2006

Prevention of Alzheimer disease.

Authors:
Leon J Thal

Alzheimer Dis Assoc Disord 2006 Jul-Sep;20(3 Suppl 2):S97-9

Department of Neurosciences, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.

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http://dx.doi.org/10.1097/00002093-200607001-00015DOI Listing
November 2006

Utility of the telephone interview for cognitive status for enrollment in clinical trials.

Alzheimers Dement 2006 Apr;2(2):104-9

Department of Neurosciences, University of California-San Diego, La Jolla, CA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155252600600044
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http://dx.doi.org/10.1016/j.jalz.2006.02.004DOI Listing
April 2006

The septohippocampal cholinergic system and spatial working memory in the Morris water maze.

Behav Brain Res 2006 Mar 5;168(1):37-46. Epub 2005 Dec 5.

Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.

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https://www2.uef.fi/documents/1085457/1371730/54the.pdf/32aa
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http://linkinghub.elsevier.com/retrieve/pii/S016643280500437
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http://dx.doi.org/10.1016/j.bbr.2005.10.008DOI Listing
March 2006

What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?

Brain 2006 Mar 9;129(Pt 3):729-35. Epub 2006 Jan 9.

Dipartimento di Scienze Neurologiche, Ospedale Niguarda Ca' Granda, Milano, Italy.

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http://dx.doi.org/10.1093/brain/awh725DOI Listing
March 2006

Regulatable acetylcholine-producing fibroblasts enhance cognitive performance.

Mol Ther 2006 Jan 26;13(1):175-82. Epub 2005 Sep 26.

Department of Neurosciences, University of California at San Diego, VA Medical Center MC 9151, La Jolla, CA 92093-9157, USA.

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http://dx.doi.org/10.1016/j.ymthe.2005.08.001DOI Listing
January 2006

Identification of Alzheimer disease risk by functional magnetic resonance imaging.

Arch Neurol 2005 Dec;62(12):1881-8

Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA.

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http://dx.doi.org/10.1001/archneur.62.12.1881DOI Listing
December 2005

The Alzheimer's disease neuroimaging initiative.

Neuroimaging Clin N Am 2005 Nov;15(4):869-77, xi-xii

Department of Radiology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.nic.2005.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376747PMC
November 2005

Reminiscences: Robert Katzman and Robert Terry.

Authors:
Leon J Thal

Alzheimers Dement 2005 Jul;1(1):73

Department of Neurosciences, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2005.06.009DOI Listing
July 2005

Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role.

Neurobiol Aging 2005 May;26(5):625-35

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.06.016DOI Listing
May 2005

The Alzheimer's Disease Cooperative Study in 2004.

Authors:
Leon J Thal

Alzheimer Dis Assoc Disord 2004 Oct-Dec;18(4):183-5

Department of Neurosciences, University of California San Diego, La Jolla, CA 92093-0624, USA.

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April 2005

Reliability of monitoring the clinical dementia rating in multicenter clinical trials.

Alzheimer Dis Assoc Disord 2004 Oct-Dec;18(4):219-22

Department of Neurosciences, University of California, San Diego, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367865PMC
April 2005

Independence of changes in behavior from cognition and function in community-dwelling persons with Alzheimer's disease: a factor analytic approach.

J Neuropsychiatry Clin Neurosci 2005 ;17(1):51-60

Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, 7 East Main, M702, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1176/jnp.17.1.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377284PMC
April 2005

Regression to the mean: implications for clinical trials of psychotropic agents in dementia.

Curr Alzheimer Res 2004 Nov;1(4):323-8

Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371726PMC
http://dx.doi.org/10.2174/1567205043332027DOI Listing
November 2004

A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease.

J Int Neuropsychol Soc 2004 Sep;10(5):689-97

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0948, USA.

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http://dx.doi.org/10.1017/S1355617704105043DOI Listing
September 2004

Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector.

Brain Res Mol Brain Res 2004 Jul;126(1):1-13

Department of Neurosciences, University of California San Diego, La Jolla, CA 92023, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2004.03.006DOI Listing
July 2004

Executive dysfunction in Alzheimer disease.

Arch Neurol 2004 Apr;61(4):556-60

Department of Neurology, David Geffen School of Medicine at UCLA, 90095-1769, USA.

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http://dx.doi.org/10.1001/archneur.61.4.556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419376PMC
April 2004

The Sleep Disorders Inventory: an instrument for studies of sleep disturbance in persons with Alzheimer's disease.

J Sleep Res 2003 Dec;12(4):331-7

Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Washington, DC 20057, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418643PMC
http://dx.doi.org/10.1046/j.0962-1105.2003.00374.xDOI Listing
December 2003

Therapeutics and mild cognitive impairment: current status and future directions.

Authors:
Leon J Thal

Alzheimer Dis Assoc Disord 2003 Apr-Jun;17 Suppl 2:S69-71

Department of Neuroscience, University of California, San Diego School of Medicine, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1097/00002093-200304002-00012DOI Listing
August 2003

Comorbidity of psychopathological domains in community-dwelling persons with Alzheimer's disease.

J Geriatr Psychiatry Neurol 2003 Jun;16(2):94-9

Center for Population and Health, Georgetown University, Washington, DC 20057-1197, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418652PMC
http://dx.doi.org/10.1177/0891988703016002006DOI Listing
June 2003

NSAIDs and hypertension.

Arch Intern Med 2003 May;163(9):1115; author reply 1115-6

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http://dx.doi.org/10.1001/archinte.163.9.1115-aDOI Listing
May 2003

Estrogen levels do not correlate with improvement in cognition.

Arch Neurol 2003 Feb;60(2):209-12

Department of Neurosciences, University of California, San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1001/archneur.60.2.209DOI Listing
February 2003

Emergent psychopathology in Alzheimer's disease patients over 12 months associated with functional, not cognitive, changes.

J Geriatr Psychiatry Neurol 2002 ;15(2):110-7

Department of Neurosciences, University of California, San Diego, La Jolla 92093-0949, USA.

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http://dx.doi.org/10.1177/089198870201500210DOI Listing
January 2003

No long-term effect of behavioral treatment on psychotropic drug use for agitation in Alzheimer's disease patients.

J Geriatr Psychiatry Neurol 2002 ;15(2):95-8

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1177/089198870201500208DOI Listing
January 2003

Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice.

J Neurosci 2003 Jan;23(2):539-49

Laboratory of Genetics and Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741871PMC
January 2003

Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype.

J Int Neuropsychol Soc 2002 Nov;8(7):943-55

Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621042PMC
http://dx.doi.org/10.1017/s1355617702870096DOI Listing
November 2002

Modulation of sensory inputs and ectopic presence of Schwann cells depend upon the route and duration of nerve growth factor administration.

Exp Neurol 2002 Nov;178(1):91-103

Department of Neurosciences, University of California-San Diego, La Jolla, CA 92093-0624, USA.

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http://dx.doi.org/10.1006/exnr.2002.8010DOI Listing
November 2002

Growth factor gene therapy for Alzheimer disease.

Neurosurg Focus 2002 Nov 15;13(5):e5. Epub 2002 Nov 15.

Department of Neurosciences, Division of Neurosurgery, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.3171/foc.2002.13.5.6DOI Listing
November 2002

Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease.

Neuroreport 2002 Oct;13(14):1825-8

Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093-0624, USA.

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http://dx.doi.org/10.1097/00001756-200210070-00028DOI Listing
October 2002

Investigating emergent symptomatology as an outcome measure in a behavioral study of Alzheimer's disease.

J Neuropsychiatry Clin Neurosci 2002 ;14(3):303-10

Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California, San Diego 92093-0949, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371727PMC
http://dx.doi.org/10.1176/jnp.14.3.303DOI Listing
September 2002

Mnemonic deficits in animals depend upon the degree of cholinergic deficit and task complexity.

Exp Neurol 2002 Sep;177(1):292-305

Department of Neurosciences, University of California San Diego, La Jolla, California 92093-0624 , USA.

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http://dx.doi.org/10.1006/exnr.2002.7993DOI Listing
September 2002

Estimating the prevalence of agitation in community-dwelling persons with Alzheimer's disease.

J Neuropsychiatry Clin Neurosci 2002 ;14(1):11-8

Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California, San Diego, La Jolla 92093-0949, USA.

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http://dx.doi.org/10.1176/jnp.14.1.11DOI Listing
May 2002

How to define treatment success using cholinesterase inhibitors.

Authors:
Leon J Thal

Int J Geriatr Psychiatry 2002 Apr;17(4):388-90

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http://doi.wiley.com/10.1002/gps.612
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http://dx.doi.org/10.1002/gps.612DOI Listing
April 2002

Assessing Alzheimer's disease patients with the Cohen-Mansfield Agitation Inventory: scoring and clinical implications.

J Psychiatr Res 2002 Jan-Feb;36(1):19-25

Departments of Psychiatry and Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9070, USA.

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http://dx.doi.org/10.1016/s0022-3956(01)00047-4DOI Listing
February 2002

Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdala.

Proc Natl Acad Sci U S A 2002 Feb 5;99(4):2315-9. Epub 2002 Feb 5.

Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.022627799
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http://dx.doi.org/10.1073/pnas.022627799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122362PMC
February 2002