Leon De Windt

Leon De Windt

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Leon De Windt

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Comparison of different chemically modified inhibitors of miR-199b in vivo.

Biochem Pharmacol 2019 Jan 16;159:106-115. Epub 2018 Nov 16.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952183049
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http://dx.doi.org/10.1016/j.bcp.2018.11.013DOI Listing
January 2019

If you like it, put a ring on it!

Cardiovasc Res 2018 Oct;114(12):1575-1577

Department of Cardiology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, ER Maastricht, the Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy190DOI Listing
October 2018

The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy.

Cardiovasc Res 2018 Sep;114(11):1474-1486

Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy091DOI Listing
September 2018

RNA therapeutics for heart disease.

Biochem Pharmacol 2018 Sep 29;155:468-478. Epub 2018 Jul 29.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences; Maastricht University, Maastricht, The Netherlands; Faculty of Science and Engineering; Maastricht University, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.07.037DOI Listing
September 2018

Non-coding RNA function in stem cells and Regenerative Medicine.

Noncoding RNA Res 2018 Jun 20;3(2):39-41. Epub 2018 Apr 20.

International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

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http://dx.doi.org/10.1016/j.ncrna.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096417PMC
June 2018

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure.

Hypertension 2018 02 18;71(2):280-288. Epub 2017 Dec 18.

From the Department of Cardiology (R.V., T.P., R.v.L., W.V., M.H., L.J.d.W., S.H., B.S.), Department of Physiology (C.M., F.A.v.N., M.v.B.), and Department of Internal Medicine (M.B.), CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands; Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain (F.J.B., J.D., A.G.); Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain (F.J.B., J.D., A.G.); CIBERCV, Carlos III Institute of Health, Madrid, Spain (F.J.B., J.D., A.G.); Department of Molecular Cell Biology, Leiden University Medical Biology Center, The Netherlands (T.v.H., M.J.G.); Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain (J.D.); Netherlands Heart Institute (ICIN), Utrecht; and Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology (CMVB), KU Leuven, Belgium (S.H.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10094DOI Listing
February 2018

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

Mol Metab 2017 11 31;6(11):1429-1442. Epub 2017 Aug 31.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6200MD, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681243PMC
November 2017

Wnt/β-catenin pathway in arrhythmogenic cardiomyopathy.

Oncotarget 2017 Sep 27;8(36):60640-60655. Epub 2017 Apr 27.

University of Padua, Department of Biology, Padua, Italy.

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http://dx.doi.org/10.18632/oncotarget.17457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601168PMC
September 2017

Translational Perspective on Epigenetics in Cardiovascular Disease.

J Am Coll Cardiol 2017 Aug;70(5):590-606

Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2017.05.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543329PMC
August 2017

miR-199b-5p is a regulator of left ventricular remodeling following myocardial infarction.

Noncoding RNA Res 2017 Mar 13;2(1):18-26. Epub 2017 Jan 13.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.ncrna.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096423PMC
March 2017

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.

J Am Coll Cardiol 2016 10;68(14):1557-71

Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.07.739DOI Listing
October 2016

Exosomes: scytales in the damaged heart.

Ann Transl Med 2016 Jun;4(11):222

1 Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands ; 2 Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.21037/atm.2016.05.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916351PMC
June 2016

MicroRNAs in heart failure: from biomarker to target for therapy.

Eur J Heart Fail 2016 05 11;18(5):457-68. Epub 2016 Feb 11.

Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

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http://dx.doi.org/10.1002/ejhf.495DOI Listing
May 2016

Targeting microRNAs in heart failure.

Trends Cardiovasc Med 2016 Feb 30;26(2):99-110. Epub 2015 May 30.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2015.05.008DOI Listing
February 2016

Long noncoding RNA Chast promotes cardiac remodeling.

Sci Transl Med 2016 Feb;8(326):326ra22

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany. Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany. National Heart and Lung Institute, Imperial College London, SW3 6NP London, UK.

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http://dx.doi.org/10.1126/scitranslmed.aaf1475DOI Listing
February 2016

Non-coding RNA in control of gene regulatory programs in cardiac development and disease.

J Mol Cell Cardiol 2015 Dec 27;89(Pt A):51-8. Epub 2015 Mar 27.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828150010
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http://dx.doi.org/10.1016/j.yjmcc.2015.03.014DOI Listing
December 2015

Antisense MicroRNA Therapeutics in Cardiovascular Disease: Quo Vadis?

Mol Ther 2015 Dec 28;23(12):1810-8. Epub 2015 Jul 28.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/mt.2015.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700106PMC
December 2015

Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases.

J Mol Cell Cardiol 2015 Dec 9;89(Pt A):27-34. Epub 2015 Nov 9.

Department of Biology, University of Padua, Via G. Colombo 3, 35131, Padua, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.10.028DOI Listing
December 2015

State-of-the-art on non-coding RNA bioinformatics, diagnostics and therapeutics in cardiovascular diseases: Preface to SI Non-coding RNAs in cardiovascular disease.

J Mol Cell Cardiol 2015 Dec;89(Pt A):1-2

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.11.021DOI Listing
December 2015

Longing for Naiades in Heart Failure.

J Am Coll Cardiol 2015 Nov;66(18):2016-2018

Department of Cardiology, School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.08.868DOI Listing
November 2015

HypoxamiRs: regulators of cardiac hypoxia and energy metabolism.

Trends Endocrinol Metab 2015 Sep 18;26(9):502-8. Epub 2015 Jul 18.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.06.008DOI Listing
September 2015

Supplementing exposure to hypoxia with a copper depleted diet does not exacerbate right ventricular remodeling in mice.

PLoS One 2014 15;9(4):e92983. Epub 2014 Apr 15.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988035PMC
January 2015

Nuclear calcium transients: Hermes Propylaios in the heart.

Circulation 2014 Jul 13;130(3):221-3. Epub 2014 Jun 13.

From the Department of Cardiology, School for Cardiovascular Diseases, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010675DOI Listing
July 2014

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.

Eur J Heart Fail 2014 May 23;16(5):509-18. Epub 2014 Feb 23.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200 319, Porto, Portugal.

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http://dx.doi.org/10.1002/ejhf.66DOI Listing
May 2014

Regulation of fetal gene expression in heart failure.

Biochim Biophys Acta 2013 Dec 10;1832(12):2414-24. Epub 2013 Sep 10.

Dept of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands; ICIN-Netherlands Heart Institute, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S09254439130027
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http://dx.doi.org/10.1016/j.bbadis.2013.07.023DOI Listing
December 2013

miR-223: sailing to terra incognita for microRNAs in platelets.

Thromb Haemost 2013 Dec 7;110(6):1112-3. Epub 2013 Nov 7.

Dr. Leon J. De Windt, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands, Tel.: +31 43 388 4308, Fax: +31 43 387 1055, E-mail:

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http://www.cmcardio.com/upload/090-Halkein-TH-2013.pdf
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http://www.schattauer.de/index.php?id=1214&doi=10.1160/T
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http://dx.doi.org/10.1160/TH13-10-0882DOI Listing
December 2013

Towards modern genetics, diagnostics and therapeutics of heart failure in a new era.

Biochim Biophys Acta 2013 Dec;1832(12):2401-2

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2013.10.010DOI Listing
December 2013

A deep sequencing approach to uncover the miRNOME in the human heart.

PLoS One 2013 27;8(2):e57800. Epub 2013 Feb 27.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057800PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583901PMC
September 2013

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

Circulation 2013 Sep 16;128(13):1420-32. Epub 2013 Aug 16.

Center for Heart Failure Research, Department of Cardiology (S.H., M.F.C., W.V., P.C., R.E.W.v.L., K.C., T.P., M.H., M.v.B., A.-P.P., B.S.), Department of Molecular Genetics (L.S., M.P.J.d.W.), Department of Pathology (E.W., E.L.), Department of Pharmacology (B.J.J.), Department of Cardiology (L.J.d.W.), and Department of Internal Medicine (K.W.), Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands (S.H.); Center for Molecular and Cardiovascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium (S.H., P.C., A.-P.P.); Department of Medical Biochemistry (L.S., E.L., M.P.J.d.W.) and Heart Failure Research Center (E.E.C., Y.M.P.), Academic Medical Center, Amsterdam, the Netherlands; Cluster of Excellence Cell Networks, Department of Infectious Diseases/Virology, Virus Host Interactions, Heidelberg University, Heidelberg, Germany (D.G., N.S.); Laboratory of Lymphocyte Signaling and Development, Babraham Institute, Cambridge, UK (E.V.); Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany (T.T.); Medical Microbiology, Maastricht University, Maastricht, the Netherlands (F.S.); King's BHF Centre, King's College London, London UK (X.Y., M.M.); Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany (E.L.); and Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy (S.Z., M.G.).

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http://circ.ahajournals.org/content/early/2013/08/16/CIRCULA
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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001357DOI Listing
September 2013

An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart.

Cardiovasc Res 2013 Jun 22;98(3):372-80. Epub 2013 Feb 22.

Department of Aging, Stress and Inflammation , UPMC Univ Paris 6, 7, quai Saint Bernard - BP 256, Paris 75005, France.

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http://dx.doi.org/10.1093/cvr/cvt042DOI Listing
June 2013

MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization.

PLoS One 2012 19;7(6):e36799. Epub 2012 Jun 19.

Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036799PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378550PMC
December 2012

Circulating miRNAs: reflecting or affecting cardiovascular disease?

Curr Hypertens Rep 2012 Dec;14(6):498-509

Department of Cardiology, Heart Vessel Center, Maastricht University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1007/s11906-012-0310-7DOI Listing
December 2012

Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.

Heart Rhythm 2012 Nov 27;9(11):1875-83. Epub 2012 Jul 27.

Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.hrthm.2012.07.023DOI Listing
November 2012

MicroRNAs as biomarkers for myocardial infarction.

Curr Atheroscler Rep 2012 Jun;14(3):193-200

Department of Cardiology, Cardiovascular Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands.

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http://dx.doi.org/10.1007/s11883-012-0238-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348461PMC
June 2012

Apoptosis-inducing factor regulates skeletal muscle progenitor cell number and muscle phenotype.

PLoS One 2011 4;6(11):e27283. Epub 2011 Nov 4.

Centre d'Etude de la Sensori-Motricité, UMR 8194 CNRS, Université Paris Descartes, Centre Universitaire des Saints-Pères, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027283PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208607PMC
March 2012

MicroRNAs in control of cardiac hypertrophy.

Cardiovasc Res 2012 Mar 19;93(4):563-72. Epub 2012 Jan 19.

Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvs013DOI Listing
March 2012

Small changes can make a big difference - microRNA regulation of cardiac hypertrophy.

J Mol Cell Cardiol 2012 Jan 24;52(1):74-82. Epub 2011 Sep 24.

Dept. of Cardiology, Cardiovascular Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00222828110041
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http://dx.doi.org/10.1016/j.yjmcc.2011.09.015DOI Listing
January 2012

Quaero muneris: exploring microRNA function in cardiovascular disease.

J Mol Cell Cardiol 2012 Jan 28;52(1):1-2. Epub 2011 Oct 28.

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http://dx.doi.org/10.1016/j.yjmcc.2011.10.017DOI Listing
January 2012

Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.

Circ Res 2012 Jan 17;110(2):211-9. Epub 2011 Nov 17.

Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.249482DOI Listing
January 2012

Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load.

Eur J Heart Fail 2011 Dec 24;13(12):1275-82. Epub 2011 Oct 24.

Department of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands.

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http://doi.wiley.com/10.1093/eurjhf/hfr134
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http://dx.doi.org/10.1093/eurjhf/hfr134DOI Listing
December 2011

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process.

Am J Physiol Heart Circ Physiol 2010 Nov 10;299(5):H1283-99. Epub 2010 Sep 10.

Department of Thorax and Vascular Surgery, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1152/ajpheart.00251.2010DOI Listing
November 2010

miR-21: a miRaculous Socratic paradox.

Cardiovasc Res 2010 Aug 18;87(3):397-400. Epub 2010 Jun 18.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvq196DOI Listing
August 2010

Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.

Hypertension 2010 Apr 15;55(4):932-8. Epub 2010 Feb 15.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, 1 Baylor Plaza, BCM 335, Houston, TX 77030, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.146449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843393PMC
April 2010

MiR423-5p as a circulating biomarker for heart failure.

Circ Res 2010 Apr 25;106(6):1035-9. Epub 2010 Feb 25.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.218297DOI Listing
April 2010

MEF2 transcriptional activity maintains mitochondrial adaptation in cardiac pressure overload.

Eur J Heart Fail 2010 Jan;12(1):4-12

Department of Cardiology, Faculty of Health, Medicine and Life Sciences, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hfp165DOI Listing
January 2010

NF-kappaB activation is required for adaptive cardiac hypertrophy.

Cardiovasc Res 2009 Dec 20;84(3):416-24. Epub 2009 Jul 20.

Department of Cardiology, Franz Volhard Klinik, Experimental Clinical Research Center, Charité Campus Buch, Berlin, Germany.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvp237DOI Listing
December 2009

Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation.

Proc Natl Acad Sci U S A 2008 Dec 10;105(50):19762-7. Epub 2008 Dec 10.

Department of Cardiology, Campus-Buch and Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Franz Volhard Klinik, Germany.

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http://dx.doi.org/10.1073/pnas.0808393105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604963PMC
December 2008

Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis.

J Biol Chem 2008 Oct 1;283(43):29004-10. Epub 2008 Aug 1.

The Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CT Utrecht, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M801297200
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http://dx.doi.org/10.1074/jbc.M801297200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662004PMC
October 2008

Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.

Circulation 2008 Oct 22;118(15):1567-76. Epub 2008 Sep 22.

Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.7
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http://dx.doi.org/10.1161/CIRCULATIONAHA.108.769984DOI Listing
October 2008

In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.

J Mol Cell Cardiol 2008 Sep 11;45(3):373-84. Epub 2008 Jul 11.

Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2008.06.011DOI Listing
September 2008

NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure.

J Biol Chem 2008 Aug 12;283(32):22295-303. Epub 2008 May 12.

Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M801296200
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http://dx.doi.org/10.1074/jbc.M801296200DOI Listing
August 2008

Heart spotting.

Basic Res Cardiol 2008 May 15;103(3):228-31. Epub 2008 Feb 15.

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http://dx.doi.org/10.1007/s00395-008-0698-zDOI Listing
May 2008

Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.

Cardiovasc Res 2007 Aug 3;75(3):519-29. Epub 2007 May 3.

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.

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http://dx.doi.org/10.1016/j.cardiores.2007.04.026DOI Listing
August 2007

Reparative myocardial mechanisms in adult C57BL/6 and MRL mice following injury.

Physiol Genomics 2007 Jun 27;30(1):44-52. Epub 2007 Feb 27.

Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00070.2006DOI Listing
June 2007

Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.

Proc Natl Acad Sci U S A 2007 Mar 2;104(11):4377-82. Epub 2007 Mar 2.

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1073/pnas.0611726104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838610PMC
March 2007

Controlling cardiomyocyte survival.

Novartis Found Symp 2006 ;274:41-51; discussion 51-7, 152-5, 272-6

Department of Cardiology, Heart Lung Center Utrecht, UMC Utrecht, The Netherlands.

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January 2007

EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.

J Am Coll Cardiol 2006 Aug 25;48(4):824-32. Epub 2006 Jul 25.

Hubrecht Laboratory and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2006.02.075DOI Listing
August 2006

MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure.

Circulation 2006 Jul 17;114(4):298-308. Epub 2006 Jul 17.

Hubrecht Laboratory, and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, Netherlands.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.6
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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.608968DOI Listing
July 2006

Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.

Proc Natl Acad Sci U S A 2006 May 28;103(19):7327-32. Epub 2006 Apr 28.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1073/pnas.0509340103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464340PMC
May 2006

TOLL-erating cardiac hypertrophy following pressure overload.

Cardiovasc Res 2005 Nov 26;68(2):178-9. Epub 2005 Sep 26.

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http://dx.doi.org/10.1016/j.cardiores.2005.08.007DOI Listing
November 2005

Myocyte apoptosis in heart failure.

Cardiovasc Res 2005 Jul;67(1):21-9

Hubrecht Laboratory and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1016/j.cardiores.2005.04.012DOI Listing
July 2005

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

Proc Natl Acad Sci U S A 2005 Jul 22;102(27):9607-12. Epub 2005 Jun 22.

Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0500353102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172237PMC
July 2005

Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice.

Am J Transplant 2005 Jun;5(6):1204-15

Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, the Netherlands.

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http://doi.wiley.com/10.1111/j.1600-6143.2005.00821.x
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http://dx.doi.org/10.1111/j.1600-6143.2005.00821.xDOI Listing
June 2005

Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation.

Circ Res 2005 Jun 2;96(12):e92-e101. Epub 2005 Jun 2.

Hubrecht Laboratory and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/01.RES.0000172081.30327.28DOI Listing
June 2005

Myocyte hypertrophy and apoptosis: a balancing act.

Cardiovasc Res 2004 Aug;63(3):487-99

Hubrecht Laboratory and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.cardiores.2004.02.013DOI Listing
August 2004

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.

Circulation 2004 Apr 19;109(16):1938-41. Epub 2004 Apr 19.

Department of Cardiology, Maastricht University, and Heart Lung Center Utrecht, Maastricht and Utrecht, Netherlands.

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http://dx.doi.org/10.1161/01.CIR.0000127126.73759.23DOI Listing
April 2004

MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction.

Circ Res 2004 Feb 22;94(3):e18-26. Epub 2004 Jan 22.

Hubrecht Laboratory and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/01.RES.0000118597.54416.00DOI Listing
February 2004