Publications by authors named "Leo Luznik"

100Publications

Shortened-Duration Immunosuppressive Therapy after Nonmyeloablative, Related HLA-Haploidentical or Unrelated Peripheral Blood Grafts and Post-Transplantation Cyclophosphamide.

Biol Blood Marrow Transplant 2020 Aug 18. Epub 2020 Aug 18.

Department of Oncology, Sidney Kimmel Cancer Center, Baltimore, Maryland; Division of Hematology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Division of Pediatric Oncology, Sidney Kimmel Cancer Center, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2020.07.037DOI Listing
August 2020

Non-Myeloablative Allogeneic Transplantation with Post-Transplant Cyclophosphamide after Immune Checkpoint Inhibition for Classic Hodgkin Lymphoma: A Retrospective Cohort Study.

Biol Blood Marrow Transplant 2020 Sep 24;26(9):1679-1688. Epub 2020 Jun 24.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2020.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486273PMC
September 2020

How we perform haploidentical stem cell transplantation with posttransplant cyclophosphamide.

Hematology Am Soc Hematol Educ Program 2019 12;2019(1):513-521

Department of Oncology and.

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http://dx.doi.org/10.1182/hematology.2019001323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913422PMC
December 2019

Allogeneic Haploidentical Blood or Marrow Transplantation with Post-Transplantation Cyclophosphamide in Chronic Lymphocytic Leukemia.

Biol Blood Marrow Transplant 2020 Mar 12;26(3):502-508. Epub 2019 Nov 12.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.11.008DOI Listing
March 2020

PTCY keeps on giving!

Blood 2019 09;134(11):848-849

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.

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http://dx.doi.org/10.1182/blood.2019002284DOI Listing
September 2019

Post-transplantation cyclophosphamide for chimerism-based tolerance.

Bone Marrow Transplant 2019 08;54(Suppl 2):769-774

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41409-019-0615-0DOI Listing
August 2019

Immune reconstitution after T-cell replete HLA-haploidentical transplantation.

Semin Hematol 2019 07 26;56(3):221-226. Epub 2019 Mar 26.

Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1053/j.seminhematol.2019.03.005DOI Listing
July 2019

Post-transplant cyclophosphamide use in matched HLA donors: a review of literature and future application.

Bone Marrow Transplant 2020 01 14;55(1):40-47. Epub 2019 May 14.

Department of Adult Hematology & Stem Cell Transplant, King Faisal Hospital & Research Center, Riyadh, KSA, Saudi Arabia.

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http://dx.doi.org/10.1038/s41409-019-0547-8DOI Listing
January 2020

Mechanism of action of posttransplantation cyclophosphamide: more than meets the eye.

J Clin Invest 2019 05 6;129(6):2189-2191. Epub 2019 May 6.

Division of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.

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https://www.jci.org/articles/view/128710
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http://dx.doi.org/10.1172/JCI128710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546449PMC
May 2019

Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial.

Lancet Haematol 2019 Apr 14;6(4):e183-e193. Epub 2019 Mar 14.

Hematologic Malignancies and Bone Marrow Transplantation Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/S2352-3026(19)30031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506220PMC
April 2019

Activated Allogeneic Donor-derived Marrow-infiltrating Lymphocytes Display Measurable In Vitro Antitumor Activity.

J Immunother 2019 04;42(3):73-80

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

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http://dx.doi.org/10.1097/CJI.0000000000000256DOI Listing
April 2019

Teaching a Young Dog New Tricks: Modifications to the Post-Transplantation Cyclophosphamide Haploidentical Transplantation Platform.

Biol Blood Marrow Transplant 2018 06 10;24(6):1108-1110. Epub 2018 Apr 10.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2018.04.004DOI Listing
June 2018

Have haploidentical transplants replaced umbilical cord transplants for acute leukemias?

Curr Opin Hematol 2018 03;25(2):103-111

Division of Hematologic Malignancies, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000412DOI Listing
March 2018

Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8 T Cells During Relapse after Allogeneic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2018 04 26;24(4):666-677. Epub 2017 Dec 26.

Department of Laboratory Medicine-Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.11.027DOI Listing
April 2018

Notching up B-cell pathology in chronic GVHD.

Blood 2017 11;130(19):2053-2054

JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2017-09-805366DOI Listing
November 2017

Major Histocompatibility Mismatch and Donor Choice for Second Allogeneic Bone Marrow Transplantation.

Biol Blood Marrow Transplant 2017 Nov 25;23(11):1887-1894. Epub 2017 Jul 25.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Division of Hematologic Malignancies, Bunting Blaustein Cancer Research Bldg., 1650 Orleans Street, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881910PMC
November 2017

Post-Transplantation Cyclophosphamide after Bone Marrow Transplantation Is Not Associated with an Increased Risk of Donor-Derived Malignancy.

Biol Blood Marrow Transplant 2017 Apr 3;23(4):612-617. Epub 2017 Jan 3.

Blood and Marrow Transplantation Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.12.640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632950PMC
April 2017

For Whom the Bell Tolls: Programmed Death 1 as a Marker of Post-Transplantation Mortality.

Biol Blood Marrow Transplant 2016 12 13;22(12):2115-2116. Epub 2016 Sep 13.

Division of Hematologic Malignancies, Department of Oncology, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2016.09.009DOI Listing
December 2016

Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide.

JCI Insight 2016;1(5). Epub 2016 Apr 21.

Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1172/jci.insight.86252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874509PMC
April 2016

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

J Hematol Oncol 2016 Apr 12;9:35. Epub 2016 Apr 12.

Peking University People's Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Beijing, Xicheng District, 100044, China.

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http://dx.doi.org/10.1186/s13045-016-0265-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830035PMC
April 2016

Haploidentical bone marrow and stem cell transplantation: experience with post-transplantation cyclophosphamide.

Semin Hematol 2016 Apr 15;53(2):90-7. Epub 2016 Jan 15.

Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Department of Oncology; Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806368PMC
April 2016

Might haplo "be the (better) match"?

Blood 2016 Feb;127(7):799-800

JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2016-01-689042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760085PMC
February 2016

Modern approaches to HLA-haploidentical blood or marrow transplantation.

Nat Rev Clin Oncol 2016 Feb 31;13(2):132. Epub 2015 Dec 31.

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http://dx.doi.org/10.1038/nrclinonc.2015.234DOI Listing
February 2016

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment.

Blood 2016 Jan 17;127(3):352-9. Epub 2015 Nov 17.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA; and.

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http://dx.doi.org/10.1182/blood-2014-12-617019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722286PMC
January 2016

Modern approaches to HLA-haploidentical blood or marrow transplantation.

Nat Rev Clin Oncol 2016 Jan 25;13(1):10-24. Epub 2015 Aug 25.

Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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https://www.nature.com/articles/nrclinonc.2015.128.pdf
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http://www.nature.com/articles/nrclinonc.2015.128
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http://dx.doi.org/10.1038/nrclinonc.2015.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695979PMC
January 2016

Alternative Donor Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia.

Semin Hematol 2015 Jul 18;52(3):232-42. Epub 2015 Mar 18.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1053/j.seminhematol.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483196PMC
July 2015

Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.

Curr Drug Targets 2017 ;18(3):315-331

Cancer Research Building I, Room 346, 1650 Orleans Street, Baltimore, MD 21287, United States.

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http://dx.doi.org/10.2174/1389450116666150518095346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729661PMC
September 2017

Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent.

Oncoimmunology 2015 Mar 20;4(3):e974393. Epub 2015 Mar 20.

Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine ; Baltimore, MD, USA.

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http://dx.doi.org/10.4161/2162402X.2014.974393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404790PMC
March 2015

Multi-institutional study of post-transplantation cyclophosphamide as single-agent graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation using myeloablative busulfan and fludarabine conditioning.

J Clin Oncol 2014 Nov 29;32(31):3497-505. Epub 2014 Sep 29.

Christopher G. Kanakry, Marta Medeot, Richard J. Jones, Leo Luznik, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD; Paul V. O'Donnell, Terry Furlong, Marco Mielcarek, Fred Hutchinson Cancer Research Center, Seattle, WA; Marcos J. de Lima, Wei Wei, Richard E. Champlin, Peter F. Thall, Borje S. Andersson, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://ascopubs.org/doi/10.1200/JCO.2013.54.0625
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http://dx.doi.org/10.1200/JCO.2013.54.0625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209101PMC
November 2014

Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice.

Blood 2014 Sep 18;124(13):2131-41. Epub 2014 Aug 18.

Division of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD;

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http://dx.doi.org/10.1182/blood-2013-10-525873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186542PMC
September 2014

Are alternative donors really still "alternative?".

Biol Blood Marrow Transplant 2014 Oct 31;20(10):1463-4. Epub 2014 Jul 31.

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596228PMC
October 2014

Sustained CD4 T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide.

Oncoimmunology 2014 Jan 3;3(1):e27357. Epub 2014 Jan 3.

Department of Medical Oncology; Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center; Baltimore, MD USA ; James Buchanan Brady Urological Institute; Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center; Baltimore, MD USA.

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http://dx.doi.org/10.4161/onci.27357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004618PMC
January 2014

HLA-haploidentical donor lymphocyte infusions for patients with relapsed hematologic malignancies after related HLA-haploidentical bone marrow transplantation.

Biol Blood Marrow Transplant 2014 Mar 1;20(3):314-8. Epub 2013 Dec 1.

The Sidney Kimmel Comprehensive Cancer Center, Department of Oncology at the Johns Hopkins University, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2013.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010132PMC
March 2014

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide.

Sci Transl Med 2013 Nov;5(211):211ra157

The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155575PMC
November 2013

Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies.

Biol Blood Marrow Transplant 2013 Apr 22;19(4):647-52. Epub 2013 Jan 22.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.bbmt.2013.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768172PMC
April 2013

Lymphocyte phenotype during therapy for acute graft-versus-host disease: a brief report from BMT-CTN 0302.

Biol Blood Marrow Transplant 2013 Mar 12;19(3):481-5. Epub 2012 Dec 12.

Hematologic Malignancies, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653300PMC
March 2013

HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease.

Blood 2012 Nov 6;120(22):4285-91. Epub 2012 Sep 6.

Hematologic Malignancies and Bone Marrow Transplantation Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-07-43
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http://dx.doi.org/10.1182/blood-2012-07-438408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507140PMC
November 2012

New treatment approaches in acute myeloid leukemia: review of recent clinical studies.

Rev Recent Clin Trials 2012 Aug;7(3):224-37

University of Maryland, Department of Medicine, Baltimore, MD 21287-0013, USA.

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http://dx.doi.org/10.2174/157488712802281303DOI Listing
August 2012

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.

Blood 2012 Feb 9;119(6):1570-80. Epub 2011 Nov 9.

Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1182/blood-2011-07-364414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286218PMC
February 2012