Publications by authors named "Leo Kager"

46Publications

Pathological Fracture and Prognosis of High-Grade Osteosarcoma of the Extremities: An Analysis of 2,847 Consecutive Cooperative Osteosarcoma Study Group (COSS) Patients.

J Clin Oncol 2020 03 13;38(8):823-833. Epub 2020 Jan 13.

Department of Pediatrics, Kinderklinik München Schwabing, Technical University of Munich School of Medicine, CCCM Munich Comprehensive Cancer Center and German Translational Cancer Research Consortium DKTK, Munich, Germany.

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http://dx.doi.org/10.1200/JCO.19.00827DOI Listing
March 2020

Outcome of two patients with bilateral nephroblastomatosis/Wilms tumour treated with an add-on 13-cis retinoic acid therapy - Case report.

Pediatr Hematol Oncol 2018 Apr 27;35(3):218-224. Epub 2018 Sep 27.

a Department of Pediatric Hematology and Oncology , St. Anna Children's Hospital, Medical University of Vienna , Vienna , Austria.

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http://dx.doi.org/10.1080/08880018.2018.1515284DOI Listing
April 2018

Thoracic Actinomycosis With Infiltration of the Spine: An Oncological Pitfall.

J Pediatr Hematol Oncol 2018 08;40(6):468-471

Pediatric Hematology and Oncology, St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna.

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http://Insights.ovid.com/crossref?an=00043426-201808000-0001
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http://dx.doi.org/10.1097/MPH.0000000000001035DOI Listing
August 2018

Advances in the management of osteosarcoma.

F1000Res 2016 25;5:2767. Epub 2016 Nov 25.

St. Anna Children's Hospital, Department of Paediatrics, Medical University Vienna and Children's Cancer Research Institute CCRI, Vienna, Austria.

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http://dx.doi.org/10.12688/f1000research.9465.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130082PMC
November 2016

Reduced-intensity conditioning and stem cell transplantation in infants with Diamond Blackfan anemia.

Haematologica 2017 03 7;102(3):e73-e75. Epub 2016 Dec 7.

St. Anna Children's Hospital, Department of Pediatrics, Medical University Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.2016.157149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394961PMC
March 2017

Band 3 null , a novel homozygous SLC4A1 p.Ser477X variant causing severe hemolytic anemia, dyserythropoiesis and complete distal renal tubular acidosis.

Pediatr Blood Cancer 2017 03 8;64(3). Epub 2016 Oct 8.

Department of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/pbc.26227DOI Listing
March 2017

Novel insights and therapeutic interventions for pediatric osteosarcoma.

Future Oncol 2017 Feb 21;13(4):357-368. Epub 2016 Sep 21.

Klinikum Stuttgart, Olgahospital, Pediatrics 5 - Oncology, Hematology, Immunology, Stuttgart, Germany.

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http://dx.doi.org/10.2217/fon-2016-0261DOI Listing
February 2017

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study.

J Clin Oncol 2016 09 18;34(26):3195-203. Epub 2016 Jul 18.

Tasnim Chagtai, William Mifsud, Neil Sebire, Richard Dafydd Williams, and Kathy Pritchard-Jones, University College London Institute of Child Health, London; Sergey Popov, University Hospital of Wales; Gordan Vujanić, Cardiff University School of Medicine, Cardiff, United Kingdom; Christina Zill, Jenny Wegert, and Manfred Gessler, Wuerzburg University, Wuerzburg; Marcel Kool, German Cancer Research Center, Heidelberg; Norbert Graf, Saarland University Hospital, Homburg, Germany; Linda Dainese, Yves Le Bouc, Annick Blaise, and Aurore Coulomb, Sorbonne Universités; Linda Dainese, Yves Le Bouc, and Aurore Coulomb, Assistance Publique Hôpitaux de Paris-Hôpital Armand Trousseau, Paris; Christophe Bergeron, Centre Léon Bérard, Lyon, France; Suvi Savola, MRC-Holland; Harm van Tinteren, Netherlands Cancer Institute, Amsterdam; Godelieve A.M. Tytgat and Marry M. van den Heuvel-Eibrink, Princess Maxima Center for Pediatric Oncology/Hematology, Utrecht, the Netherlands; Peter F. Ambros and Leo Kager, Children's Cancer Research Institute; Leo Kager, St Anna Children's Hospital, Vienna, Austria; Maureen J. O'Sullivan, Our Lady's Children's Hospital, Dublin, Ireland; and Linda Holmquist Mengelbier and David Gisselsson, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1200/JCO.2015.66.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505170PMC
September 2016

NF-κB1 Haploinsufficiency Causing Immunodeficiency and EBV-Driven Lymphoproliferation.

J Clin Immunol 2016 08 23;36(6):533-40. Epub 2016 Jun 23.

St. Anna Kinderspital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1007/s10875-016-0306-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940442PMC
August 2016

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.

J Clin Oncol 2015 Jul 1;33(20):2279-87. Epub 2015 Jun 1.

Stefan S. Bielack, Klinikum Stuttgart-Olgahospital, Stuttgart; Mathias Werner, Helios Klinikum Emil von Behring; Per-Ulf Tunn, Helios Klinikum Berlin-Buch, Berlin; Knut Helmke, Altonaer Kinderkrankenhaus, Hamburg; Heribert Jürgens, Gabriele Calaminus, Joachim Gerss, and Trude Butterfass-Bahloul, Universitätsklinikum Münster, Münster; Peter Reichardt, Klinik für Interdisziplinäre Onkologie, Bad Saarow, Germany; Sigbjørn Smeland and Kirsten Sundby Hall, Oslo University Hospital; Kirsten Sundby Hall, Norwegian Radium Hospital, Oslo, Norway; Jeremy S. Whelan, University College London Hospitals; Gordana Jovic, Jane M. Hook, and Matthew R. Sydes, University College London; Beatrice Seddon and Maria Michelagnoli, University College Hospital, London; Bernadette Brennan, Christie Hospital and Royal Manchester Children's Hospital, Manchester; Susan Picton, Leeds University Hospital, Leeds, United Kingdom; Neyssa Marina, Stanford University Medical Center; Claudia Deffenbaugh, Lucille Salter Packard Children's Hospital, Palo Alto; Mark D. Krailo, Children's Oncology Group, Arcadia, CA; Mark Gebhardt and Allen Goorin, Dana-Farber Cancer Institute; Mark Gebhardt and Lisa A. Teot, Children's Hospital Boston, Boston, MA; Zsuzsanna Pápai, National Medical Center, Budapest, Hungary; James Meyer, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA; Helen Nadel, British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia; Mark Bernstein, Dalhousie University, Halifax, Nova Scotia, Canada; R. Lor Randall, University of Utah, Salt Lake City, UT; Rajaram Nagarajan, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; G. Douglas Letson, H. Lee Moffit Cancer Center and Research Institute, Tampa, FL; Daniel Baumhoer, Universitätsspital Basel; Thomas Kühne, University Children's Hospital Basel, Basel, Switzerland; Leo Kager, St Anna's Children Hospital; Reinhard Windhager, Medica

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http://dx.doi.org/10.1200/JCO.2014.60.0734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486345PMC
July 2015

Can pharmacogenomics help to improve therapy in patients with high-grade osteosarcoma?

Expert Opin Drug Metab Toxicol 2015 Jul 16;11(7):1025-8. Epub 2015 Apr 16.

St. Anna Children's Hospital, Department of Pediatrics, Medical University Vienna , Kinderspitalgasse 6, A-1090 Vienna , Austria +43 1 401702800 ; +43 1 401707280 ;

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http://dx.doi.org/10.1517/17425255.2015.1038237DOI Listing
July 2015

Multiple relapses in high-grade osteosarcoma: when to stop aggressive therapy?

Pediatr Blood Cancer 2015 Mar 8;62(3):529-30. Epub 2014 Dec 8.

Department of Pediatrics, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/pbc.25360DOI Listing
March 2015

Malignant rhabdoid tumor of the kidney: significantly improved response to pre-operative treatment intensified with doxorubicin.

Cancer Genet 2014 Sep 18;207(9):434-6. Epub 2014 Jul 18.

Saarland University Hospital, Pediatric Hematology and Oncology, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.cancergen.2014.07.001DOI Listing
September 2014

Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein.

PLoS One 2014 4;9(2):e87602. Epub 2014 Feb 4.

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087602PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913655PMC
December 2014

Thiamine-responsive megaloblastic anemia (TRMA) in an Austrian boy with compound heterozygous SLC19A2 mutations.

Eur J Pediatr 2012 Nov 11;171(11):1711-5. Epub 2012 May 11.

Pediatric Hematology and Oncology, St. Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1007/s00431-012-1730-8DOI Listing
November 2012

Review of mifamurtide in the treatment of patients with osteosarcoma.

Ther Clin Risk Manag 2010 Jun 24;6:279-86. Epub 2010 Jun 24.

St. Anna Children's Hospital, Vienna, Austria;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893760PMC
http://dx.doi.org/10.2147/tcrm.s5688DOI Listing
June 2010

Old drug--new insights--better treatment?

Leuk Res 2010 Dec 1;34(12):1558-9. Epub 2010 Jul 1.

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http://dx.doi.org/10.1016/j.leukres.2010.05.033DOI Listing
December 2010

Synchronous and metachronous lung metastases in high-grade osteosarcoma.

Jpn J Clin Oncol 2010 Jan 13;40(1):94-5. Epub 2009 Nov 13.

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http://dx.doi.org/10.1093/jjco/hyp148DOI Listing
January 2010

Pharmacogenetics in acute lymphoblastic leukemia.

Semin Hematol 2009 Jan;46(1):39-51

Jean-Pierre Aubert Research Center, INSERM U837, Genomics Core IRCL-IMPRT, Lille, France.

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http://dx.doi.org/10.1053/j.seminhematol.2008.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665795PMC
January 2009

Antileukemic drug effects in childhood acute lymphoblastic leukemia.

Expert Rev Clin Pharmacol 2008 May;1(3):401-13

EA2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France.

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http://dx.doi.org/10.1586/17512433.1.3.401DOI Listing
May 2008

Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children.

Haematologica 2007 Nov;92(11):1561-4

Department of Hematology and Oncology, St. Anna Children's Hospital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.11239DOI Listing
November 2007

Cutting edge: a hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development.

J Immunol 2007 Aug;179(4):2055-9

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2055DOI Listing
August 2007

Pharmacogenomics of acute lymphoblastic leukemia.

Curr Opin Hematol 2006 Jul;13(4):260-5

St Anna Children's Hospital, Department of Hematology/Oncology, Children's Cancer Research Institute, Vienna, Austria.

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http://dx.doi.org/10.1097/01.moh.0000231424.46148.f9DOI Listing
July 2006

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.

J Clin Invest 2005 Jan;115(1):110-7

Hematological Malignancies Program, and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.jci.org/articles/view/22477
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http://dx.doi.org/10.1172/JCI22477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539195PMC
January 2005

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.

Pharmacogenetics 2004 Aug;14(8):557-67

Department of Pharmaceutical Sciences, Hematological Malignancies Program, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/01.fpc.0000114761.78957.7eDOI Listing
August 2004

Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis.

Blood 2004 Sep 13;104(5):1435-41. Epub 2004 May 13.

St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1182/blood-2003-12-4306DOI Listing
September 2004

Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.

J Clin Oncol 2003 May;21(10):2011-8

Cooperative German-Austrian-Swiss Osteosarcoma Study Center, Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Albert-Schweitzer Str 33, 48129 Muenster, Germany;

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http://ascopubs.org/doi/10.1200/JCO.2003.08.132
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http://dx.doi.org/10.1200/JCO.2003.08.132DOI Listing
May 2003