Leo A B Joosten

Leo A B Joosten

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Leo A B Joosten

Leo A B Joosten

Publications by authors named "Leo A B Joosten"

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Differential effects of BCG vaccine on immune responses induced by vi polysaccharide typhoid fever vaccination: an explorative randomized trial.

Eur J Clin Microbiol Infect Dis 2020 Jun 17;39(6):1177-1184. Epub 2020 Feb 17.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6526, GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s10096-020-03813-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225183PMC
June 2020

IL-15 enhances the capacity of primary human macrophages to control Leishmania braziliensis infection by IL-32/vitamin D dependent and independent pathways.

Parasitol Int 2020 Jun 27;76:102097. Epub 2020 Feb 27.

Instituto de Patologia Tropical e Saúde Pública/Laboratório de Imunidade Natural (LIN), Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2020.102097DOI Listing
June 2020

Borrelia burgdorferi hijacks cellular metabolism of immune cells: Consequences for host defense.

Ticks Tick Borne Dis 2020 May 3;11(3):101386. Epub 2020 Feb 3.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ttbdis.2020.101386DOI Listing
May 2020

Author Correction: Training the trainable cells of the immune system and beyond.

Nat Immunol 2020 May;21(5):588

Department of Internal Medicine and Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1038/s41590-020-0647-zDOI Listing
May 2020

Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity.

Arterioscler Thromb Vasc Biol 2020 May 28:ATVBAHA120314508. Epub 2020 May 28.

From the Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands (R.t.H., I.C.L.v.d.M., K.S., R.A.-G., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.H., N.P.R.).

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http://dx.doi.org/10.1161/ATVBAHA.120.314508DOI Listing
May 2020

Advances in understanding molecular regulation of innate immune memory.

Curr Opin Cell Biol 2020 Apr 25;63:68-75. Epub 2020 Jan 25.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500HB, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.

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http://dx.doi.org/10.1016/j.ceb.2019.12.006DOI Listing
April 2020

The role of Toll-like receptor 10 in modulation of trained immunity.

Immunology 2020 03 26;159(3):289-297. Epub 2019 Nov 26.

Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/imm.13145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011636PMC
March 2020

Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia.

Immunol Rev 2020 03 19;294(1):92-105. Epub 2019 Dec 19.

Department of Medical Genetics, Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

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http://dx.doi.org/10.1111/imr.12833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065123PMC
March 2020

A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.

Immunol Rev 2020 03 13;294(1):63-79. Epub 2020 Jan 13.

Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud Institute of Molecular Life Sciences (RIMLS), Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/imr.12837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065069PMC
March 2020

Aldosterone induces trained immunity: the role of fatty acid synthesis.

Cardiovasc Res 2020 Feb;116(2):317-328

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

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https://academic.oup.com/cardiovascres/advance-article/doi/1
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http://dx.doi.org/10.1093/cvr/cvz137DOI Listing
February 2020

Asymptomatic hyperuricaemia: a silent activator of the innate immune system.

Nat Rev Rheumatol 2020 02 10;16(2):75-86. Epub 2019 Dec 10.

Department of Medicine of the University of Colorado School of Medicine of the University Hospital, Aurora, CO, USA.

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http://dx.doi.org/10.1038/s41584-019-0334-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075706PMC
February 2020

Training the trainable cells of the immune system and beyond.

Nat Immunol 2020 02;21(2):115-119

Department of Internal Medicine and Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1038/s41590-019-0583-yDOI Listing
February 2020

Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guérin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial.

Clin Infect Dis 2020 Jan;70(3):455-463

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cid/ciz246DOI Listing
January 2020

IL-32 and its splice variants are associated with protection against Mycobacterium tuberculosis infection and skewing of Th1/Th17 cytokines.

J Leukoc Biol 2020 Jan 4;107(1):113-118. Epub 2019 Aug 4.

Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS), and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/JLB.4AB0219-071RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972663PMC
January 2020

Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes.

Cytokine 2020 Jan 6;125:154793. Epub 2019 Aug 6.

Department of Internal Medicine and Radboud Centre for Infectious Diseases (RCI), 6525GA Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.cyto.2019.154793DOI Listing
January 2020

Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.

Inflammation 2020 Jan 30. Epub 2020 Jan 30.

Department of Internal Medicine, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s10753-020-01190-4DOI Listing
January 2020

Sixteen-Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State.

J Am Heart Assoc 2019 11 18;8(21):e013764. Epub 2019 Oct 18.

Department of Internal Medicine Radboud Institute for Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands.

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http://dx.doi.org/10.1161/JAHA.119.013764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898840PMC
November 2019

Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration.

Cell Oncol (Dordr) 2019 Oct 14;42(5):691-703. Epub 2019 Jun 14.

Department of Internal Medicine (463), Division of Endocrinology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525, GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s13402-019-00457-9DOI Listing
October 2019

β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32.

Cell Rep 2019 Sep;28(10):2659-2672.e6

Radboud Institute for Molecular Sciences (RILMS), Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.004DOI Listing
September 2019

Gout.

Nat Rev Dis Primers 2019 09 26;5(1):69. Epub 2019 Sep 26.

Department of Medicine, University of Otago, Christchurch, New Zealand.

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http://dx.doi.org/10.1038/s41572-019-0115-yDOI Listing
September 2019

Therapeutic targeting of trained immunity.

Nat Rev Drug Discov 2019 07;18(7):553-566

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.1038/s41573-019-0025-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069501PMC
July 2019

A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome.

Eur J Immunol 2019 07 9;49(7):1015-1022. Epub 2019 May 9.

Radboud Expertise Center for Q fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184801
Publisher Site
http://dx.doi.org/10.1002/eji.201848012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163623PMC
July 2019

Immunometabolism orchestrates training of innate immunity in atherosclerosis.

Cardiovasc Res 2019 07;115(9):1416-1424

Department of Internal Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein Zuid 8, GA, HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvz107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910162PMC
July 2019

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Cell Metab 2019 07 13;30(1):1-2. Epub 2019 Jun 13.

Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.05.014DOI Listing
July 2019

Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells.

Nat Commun 2019 07 22;10(1):3266. Epub 2019 Jul 22.

Department of Biological Regulation, Weizmann Institute of Science, 7610001, Rehovot, Israel.

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http://dx.doi.org/10.1038/s41467-019-11257-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646406PMC
July 2019

Cytokine profiles in patients with Q fever fatigue syndrome.

J Infect 2019 05 23;78(5):349-357. Epub 2019 Jan 23.

Radboud Expertise Center for Q Fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.01.006DOI Listing
May 2019

Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Clin Exp Rheumatol 2019 May-Jun;37(3):367-372. Epub 2019 Feb 7.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

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May 2019

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

J Transl Med 2019 05 14;17(1):157. Epub 2019 May 14.

Radboud Expertise Center for Q Fever, Department of Internal Medicine, Division of Infectious Diseases 463, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12967-019-1906-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518812PMC
May 2019

Role of Glutamine Metabolism in Host Defense Against Mycobacterium tuberculosis Infection.

J Infect Dis 2019 04;219(10):1662-1670

Department of Internal Medicine, Radboud University Medical Center, Nijmegen.

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http://dx.doi.org/10.1093/infdis/jiy709DOI Listing
April 2019

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders.

Front Immunol 2018 20;9:298. Epub 2018 Feb 20.

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.00298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826224PMC
March 2019

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Cell Metab 2019 01 4;29(1):211-220.e5. Epub 2018 Oct 4.

Department of Internal Medicine (463) and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183056
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http://dx.doi.org/10.1016/j.cmet.2018.09.003DOI Listing
January 2019

Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens.

Cell Host Microbe 2019 01;25(1):13-26

Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.12.006DOI Listing
January 2019

Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

Stroke 2018 12;49(12):2910-2917

From the Department of Internal Medicine, Radboud University Medical Center Behaviour, (M.P.N., L.A.B.J., M.G.N., N.P.R.), Nijmegen, the Netherlands.

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http://dx.doi.org/10.1161/STROKEAHA.118.023192DOI Listing
December 2018

Trained Immunity and Local Innate Immune Memory in the Lung.

Cell 2018 11;175(6):1463-1465

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183149
Publisher Site
http://dx.doi.org/10.1016/j.cell.2018.11.007DOI Listing
November 2018

Epigenetics and Trained Immunity.

Antioxid Redox Signal 2018 10 21;29(11):1023-1040. Epub 2017 Nov 21.

1 Department of Internal Medicine, Radboud University Medical Center , Nijmegen, The Netherlands .

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http://dx.doi.org/10.1089/ars.2017.7310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121175PMC
October 2018

Non-specific effects of vaccines: Current evidence and potential implications.

Semin Immunol 2018 10 11;39:35-43. Epub 2018 Jul 11.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.06.002DOI Listing
October 2018

The impact of sex hormones on BCG-induced trained immunity.

J Leukoc Biol 2018 09;104(3):573-578

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/JLB.5MA0118-027RDOI Listing
September 2018

Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients.

Sci Rep 2018 09 19;8(1):14050. Epub 2018 Sep 19.

Department of Internal Medicine, Radboud Centre for Infectious Diseases (RCI) and Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-32485-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145899PMC
September 2018

Induction of Trained Innate Immunity in Human Monocytes by Bovine Milk and Milk-Derived Immunoglobulin G.

Nutrients 2018 Sep 27;10(10). Epub 2018 Sep 27.

Cell Biology and Immunology, Wageningen University, Wageningen, P.O. Box 338, 6708 WD Wageningen, The Netherlands.

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http://dx.doi.org/10.3390/nu10101378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213000PMC
September 2018

Interleukin-32: An endogenous danger signal or master regulator of intracellular pathogen infections-Focus on leishmaniases.

Semin Immunol 2018 08 15;38:15-23. Epub 2018 Mar 15.

Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.02.010DOI Listing
August 2018

A role for TLR10 in obesity and adipose tissue morphology.

Cytokine 2018 08 23;108:205-212. Epub 2018 Apr 23.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.

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http://dx.doi.org/10.1016/j.cyto.2018.03.021DOI Listing
August 2018

Insights into the role of IL-32 in cancer.

Semin Immunol 2018 08 8;38:24-32. Epub 2018 May 8.

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.03.004DOI Listing
August 2018

Intracellular Alarmins: Hidden dangers signals crucial for cancer, host defense and inflammatory processes.

Semin Immunol 2018 08 26;38:1-2. Epub 2018 Oct 26.

Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Medical Center, 6525GA Nijmegen, the Netherlands; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.

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http://dx.doi.org/10.1016/j.smim.2018.10.007DOI Listing
August 2018

Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.

Eur J Clin Microbiol Infect Dis 2018 Jul 26;37(7):1385-1391. Epub 2018 May 26.

Radboud Expertise Center for Q fever, Department of Internal Medicine, Division of Infectious Diseases 463, Radboud University Medical Center, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s10096-018-3265-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015096PMC
July 2018

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis.

Cardiovasc Res 2018 06;114(7):944-953

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy092DOI Listing
June 2018

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies.

Trends Mol Med 2018 05 14;24(5):458-471. Epub 2018 Apr 14.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; R&D Department, Hycult Biotech, Uden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939989PMC
May 2018

Ex vivo inhibited cytokine profiling may explain inferior treatment response to golimumab after adalimumab failure in rheumatoid arthritis.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):140-143. Epub 2017 Oct 18.

Department of Rheumatology, Sint Maartenskliniek; Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.

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April 2018

Differential Cytokine Induction by the Species of Cryptococcus gattii Complex.

Infect Immun 2018 04 22;86(4). Epub 2018 Mar 22.

Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil

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http://dx.doi.org/10.1128/IAI.00958-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865019PMC
April 2018

Physiological and Genetic Adaptations to Diving in Sea Nomads.

Cell 2018 04;173(3):569-580.e15

Centre for GeoGenetics, University of Copenhagen, Copenhagen 1350, Denmark; Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK; Wellcome Trust, Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.054DOI Listing
April 2018

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis.

Circ Res 2018 03 24;122(5):664-669. Epub 2018 Jan 24.

From the Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (J.L., S.B., L.A.B.J., M.G.N., N.P.R.); Department of Medical Genetics, University of Medicine and Pharmacy, Iuliu Haţieganu, Cluj-Napoca, Romania (L.A.B.J.); Department for Genomics & Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Germany (M.G.N.); Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia (D.P.B.); and Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia (D.P.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312465DOI Listing
March 2018

Role of glutathione metabolism in host defense against infection.

Proc Natl Acad Sci U S A 2018 03 14;115(10):E2320-E2328. Epub 2018 Feb 14.

Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1720833115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877983PMC
March 2018

Monocyte and macrophage immunometabolism in atherosclerosis.

Semin Immunopathol 2018 02 2;40(2):203-214. Epub 2017 Oct 2.

Department of Internal Medicine (463) and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00281-017-0656-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809534PMC
February 2018

Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents.

Front Physiol 2018 27;9:139. Epub 2018 Feb 27.

Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2018.00139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835230PMC
February 2018

Exploring the Role of IL-32 in HIV-Related Kaposi Sarcoma.

Am J Pathol 2018 01 14;188(1):196-203. Epub 2017 Oct 14.

Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands; Radboud Center of Infectious Diseases, Radboud University Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.ajpath.2017.08.033DOI Listing
January 2018

The role of the interleukin-1 family in trained immunity.

Immunol Rev 2018 01;281(1):28-39

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/imr.12617DOI Listing
January 2018

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.

Cell Host Microbe 2018 Jan;23(1):89-100.e5

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.12.010DOI Listing
January 2018

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Cell 2018 01;172(1-2):135-146.e9

Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.025DOI Listing
January 2018

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Cell 2018 01;172(1-2):162-175.e14

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324559PMC
January 2018

Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer.

J Leukoc Biol 2017 12 10;102(6):1323-1332. Epub 2017 Oct 10.

Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1189/jlb.5RI0217-064RRDOI Listing
December 2017

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment.

J Transl Med 2017 12 29;15(1):267. Epub 2017 Dec 29.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12967-017-1371-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747240PMC
December 2017

The NOD2 receptor is crucial for immune responses towards New World Leishmania species.

Sci Rep 2017 11 9;7(1):15219. Epub 2017 Nov 9.

Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-15412-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680260PMC
November 2017

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.

Sci Rep 2017 09 13;7(1):11500. Epub 2017 Sep 13.

Department of Experimental Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Medical Center, Geert Grooteplein zuid 8, 6525GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-11738-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597613PMC
September 2017

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis.

PLoS Pathog 2017 Sep 18;13(9):e1006632. Epub 2017 Sep 18.

Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1006632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619837PMC
September 2017