Len A Pennacchio

Len A Pennacchio

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Len A Pennacchio

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Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation.

Genome Biol 2019 07 15;20(1):140. Epub 2019 Jul 15.

Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s13059-019-1750-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631995PMC
July 2019

TIMELESS mutation alters phase responsiveness and causes advanced sleep phase.

Proc Natl Acad Sci U S A 2019 Jun 28;116(24):12045-12053. Epub 2019 May 28.

Department of Neurology, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1819110116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575169PMC
June 2019

Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.

Am J Hum Genet 2018 12 29;103(6):874-892. Epub 2018 Nov 29.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288322PMC
December 2018

Ultraconserved Enhancers Are Required for Normal Development.

Cell 2018 01 18;172(3):491-499.e15. Epub 2018 Jan 18.

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA; U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California Merced, Merced, CA 95343, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786478PMC
January 2018

Genomic Patterns of De Novo Mutation in Simplex Autism.

Cell 2017 Oct 28;171(3):710-722.e12. Epub 2017 Sep 28.

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679715PMC
October 2017

Improved regulatory element prediction based on tissue-specific local epigenomic signatures.

Proc Natl Acad Sci U S A 2017 02 13;114(9):E1633-E1640. Epub 2017 Feb 13.

Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1618353114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338528PMC
February 2017

Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease.

Cell 2016 Oct 29;167(2):355-368.e10. Epub 2016 Sep 29.

Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113733PMC
October 2016

Progressive Loss of Function in a Limb Enhancer during Snake Evolution.

Cell 2016 Oct;167(3):633-642.e11

MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, CA 95343, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)31310-1.pdf
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http://www.cell.com/cms/attachment/2073022832/2068642346/mmc
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http://dx.doi.org/10.1016/j.cell.2016.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484524PMC
October 2016

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

A Cryptochrome 2 mutation yields advanced sleep phase in humans.

Elife 2016 08 16;5. Epub 2016 Aug 16.

Department of Neurology, University of California, San Francisco, San Francisco, United States.

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http://dx.doi.org/10.7554/eLife.16695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398888PMC
August 2016

Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.

Development 2015 Dec;142(23):4092-106

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA

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http://dev.biologists.org/content/develop/142/23/4092.full.p
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http://dev.biologists.org/cgi/doi/10.1242/dev.124800
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http://dx.doi.org/10.1242/dev.124800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712833PMC
December 2015

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Epigenetics Chromatin 2015 23;8:16. Epub 2015 Apr 23.

Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 304 Wartik Laboratory, University Park, PA 16802 USA.

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http://dx.doi.org/10.1186/s13072-015-0009-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432502PMC
May 2015

Brg1 modulates enhancer activation in mesoderm lineage commitment.

Development 2015 Apr 26;142(8):1418-30. Epub 2015 Mar 26.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA Department of Pediatrics, University of California, San Francisco, CA 94143, USA Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA

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http://dx.doi.org/10.1242/dev.109496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392595PMC
April 2015

Tissue-specific RNA expression marks distant-acting developmental enhancers.

PLoS Genet 2014 Sep 4;10(9):e1004610. Epub 2014 Sep 4.

Lawrence Berkeley National Laboratory, Berkeley, California, United States of America; U.S. Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America; School of Natural Sciences, University of California, Merced, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154669PMC
September 2014

Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease.

Nat Commun 2014 Sep 24;5:4907. Epub 2014 Sep 24.

1] Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA [2] Harvard Stem Cell Institute, Harvard University, 1350 Massachusetts Avenue, Suite 727W, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/ncomms5907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236193PMC
September 2014

Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.

Genome Res 2014 Jun 21;24(6):920-9. Epub 2014 Apr 21.

Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA; US Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA;

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http://dx.doi.org/10.1101/gr.168930.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032856PMC
June 2014

Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex.

Neuron 2014 Jun 8;82(5):989-1003. Epub 2014 May 8.

Department of Psychiatry, Program in Neuroscience, Rock Hall, University of California at San Francisco, San Francisco, CA 94158-2324, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104757PMC
June 2014

Function-based identification of mammalian enhancers using site-specific integration.

Nat Methods 2014 May 23;11(5):566-71. Epub 2014 Mar 23.

1] Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. [2] US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.

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http://dx.doi.org/10.1038/nmeth.2886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008384PMC
May 2014

Rapid and pervasive changes in genome-wide enhancer usage during mammalian development.

Cell 2013 Dec;155(7):1521-31

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, CA 95343, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989111PMC
December 2013

Enhancers: five essential questions.

Nat Rev Genet 2013 04;14(4):288-95

Genomics Division, One Cyclotron Road, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nrg3458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445073PMC
April 2013

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.

Neuron 2013 Jan;77(1):83-98

Department of Psychiatry, Neuroscience Program, and the Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco (UCSF), San Francisco, CA 94158-2324, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547499PMC
January 2013

Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression.

BMC Genomics 2012 Dec 19;13:713. Epub 2012 Dec 19.

Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Ctra. Utrera Km 1, Seville 41013, Spain.

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http://dx.doi.org/10.1186/1471-2164-13-713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541358PMC
December 2012

Generation of long insert pairs using a Cre-LoxP Inverse PCR approach.

PLoS One 2012 9;7(1):e29437. Epub 2012 Jan 9.

Joint Genome Institute, United States Department of Energy, Walnut Creek, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029437PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253782PMC
May 2012

1001 Proteomes: a functional proteomics portal for the analysis of Arabidopsis thaliana accessions.

Bioinformatics 2012 May 25;28(10):1303-6. Epub 2012 Mar 25.

Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1093/bioinformatics/bts133DOI Listing
May 2012

A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis.

PLoS One 2011 30;6(11):e28408. Epub 2011 Nov 30.

Department of Molecular and Cellular Biology, California Institute for Quantitative Biosciences, University of California, Berkeley, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227667PMC
April 2012

Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers.

Genome Res 2010 May 2;20(5):565-77. Epub 2010 Apr 2.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.

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http://dx.doi.org/10.1101/gr.104471.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860159PMC
May 2010

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice.

Nature 2010 Mar 21;464(7287):409-12. Epub 2010 Feb 21.

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nature08801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938076PMC
March 2010

Genomic views of distant-acting enhancers.

Nature 2009 Sep;461(7261):199-205

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nature08451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923221PMC
September 2009

Contrasting patterns of sequence evolution at the functionally redundant bric à brac paralogs in Drosophila melanogaster.

J Mol Evol 2009 Aug 29;69(2):194-202. Epub 2009 Jul 29.

Department of Biological Sciences, University of Southern California, Los Angeles, 90089, USA.

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http://dx.doi.org/10.1007/s00239-009-9265-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722720PMC
August 2009

Functional autonomy of distant-acting human enhancers.

Genomics 2009 Jun 5;93(6):509-13. Epub 2009 Mar 5.

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA.

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http://dx.doi.org/10.1016/j.ygeno.2009.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683195PMC
June 2009

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

J Clin Invest 2009 Jan 15;119(1):70-9. Epub 2008 Dec 15.

Donald W. Reynolds Cardiovascular Clinical Research Center and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1172/JCI37118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613476PMC
January 2009

Association of common variants in the Joubert syndrome gene (AHI1) with autism.

Hum Mol Genet 2008 Dec 9;17(24):3887-96. Epub 2008 Sep 9.

Center for Autism Research and Treatment Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/hmg/ddn291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638573PMC
December 2008

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.

Nat Genet 2008 Dec 25;40(12):1461-5. Epub 2008 Sep 25.

Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1038/ng.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597056PMC
December 2008

Ultraconservation identifies a small subset of extremely constrained developmental enhancers.

Nat Genet 2008 Feb 6;40(2):158-60. Epub 2008 Jan 6.

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/ng.2007.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647775PMC
February 2008

In vivo characterization of human APOA5 haplotypes.

Genomics 2007 Dec 23;90(6):674-9. Epub 2007 Oct 23.

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.ygeno.2007.08.003DOI Listing
December 2007

Deletion of ultraconserved elements yields viable mice.

PLoS Biol 2007 Sep;5(9):e234

Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0050234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964772PMC
September 2007

Comparative genomics: a tool to functionally annotate human DNA.

Methods Mol Biol 2007 ;366:229-51

Genomics Division, Lawrence Berkeley National Laboratory, CA, USA.

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http://link.springer.com/10.1007/978-1-59745-030-0_13
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http://dx.doi.org/10.1007/978-1-59745-030-0_13DOI Listing
July 2007

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

Nat Genet 2007 Apr 25;39(4):513-6. Epub 2007 Feb 25.

Donald W. Reynolds Cardiovascular Clinical Research Center, the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ng1984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762948PMC
April 2007

Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.

Am J Hum Genet 2007 Apr 8;80(4):727-39. Epub 2007 Mar 8.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02125, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970761104
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http://dx.doi.org/10.1086/513473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852724PMC
April 2007

Predicting tissue-specific enhancers in the human genome.

Genome Res 2007 Feb 8;17(2):201-11. Epub 2007 Jan 8.

Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1101/gr.5972507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781352PMC
February 2007

Enhancer identification through comparative genomics.

Semin Cell Dev Biol 2007 Feb 5;18(1):140-52. Epub 2007 Jan 5.

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.semcdb.2006.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855162PMC
February 2007

VISTA Enhancer Browser--a database of tissue-specific human enhancers.

Nucleic Acids Res 2007 Jan 27;35(Database issue):D88-92. Epub 2006 Nov 27.

Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA.

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http://dx.doi.org/10.1093/nar/gkl822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716724PMC
January 2007

Array comparative genomic hybridization in patients with congenital diaphragmatic hernia: mapping of four CDH-critical regions and sequencing of candidate genes at 15q26.1-15q26.2.

Eur J Hum Genet 2006 Sep 31;14(9):999-1008. Epub 2006 May 31.

Department of Pediatrics, Division of Genetics, University of California, San Francisco, Room U585P, 533 Parnassus St, San Francisco, CA 94143-0748, USA.

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http://dx.doi.org/10.1038/sj.ejhg.5201652DOI Listing
September 2006

Close sequence comparisons are sufficient to identify human cis-regulatory elements.

Genome Res 2006 Jul 12;16(7):855-63. Epub 2006 Jun 12.

Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1101/gr.4717506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1484452PMC
July 2006

Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice.

Biol Chem 2006 Jul;387(7):885-91

Institut für Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1515/BC.2006.112DOI Listing
July 2006

A PYY Q62P variant linked to human obesity.

Hum Mol Genet 2006 Feb 20;15(3):387-91. Epub 2005 Dec 20.

Genomics Division, One Cyclotron Road, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1093/hmg/ddi455DOI Listing
February 2006

SNP-VISTA: an interactive SNP visualization tool.

BMC Bioinformatics 2005 Dec 8;6:292. Epub 2005 Dec 8.

Institute for Data Analysis and Visualization, (IDAV), Department of Computer Science, University of California, Davis, One ShieldsAve., Davis, CA 95616, USA.

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http://dx.doi.org/10.1186/1471-2105-6-292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325058PMC
December 2005