Publications by authors named "Leila Moradi"

21 Publications

  • Page 1 of 1

The Epidemiology of Aggression and Associated Factors among Iranian Adult Population: A National Survey.

J Res Health Sci 2020 Nov 25;20(4):e00499. Epub 2020 Nov 25.

Department of Public Health, School of Public Health, Ilam University of Medical Sciences, Ilam, Iran.

Background: This survey was conducted to determine the level of aggression among the Iranian adult population and underlying predisposing factors.

Study Design: A cross-sectional study.

Methods: This cross-sectional study included 10,957 participants, involving 23 out of the 31 provinces of Iran in 2019. The outcome of interest was aggression, evaluated by the Buss & Perry aggression questionnaire. The association between aggression and 34 demographic, behavioral, social, and cultural characteristics was assessed using simple and multiple linear regression.

Results: The overall mean (SD) score of aggression was 77.10 (22.53). Based on the severity of aggression, the participants were categorized into four groups as follows: 2,464 (23.1%) nonaggressive, 4,692 (43.9%) mild, 3,071 (28.8%) moderate, and 454 (4.2%) severe aggressive. Aggression was more likely to occur in people with the following characteristics: younger ages, having several siblings, lower ranks of birth, having an intimate friend of the opposite sex, having an aggressive father/mother, history of parental divorce, interest in watching action/porn movies, listening to music, history of escape from home/school, using neuropsychiatric drugs, using illicit drugs, history of suicidal thoughts/attempt, and family conflict and hostility. Aggression was less likely to occur with the following characteristics: reading, regular physical exercise, the ability to control anger, regular prayer, adherence to avoid lying, respect to other people's rights, sexual satisfaction, and attachment to parents.

Conclusion: A majority of the population has some degree of aggression. Aggression is a multifactorial behavior corresponding with several demographical, social, cultural, and religious factors, some of which back to early childhood events.
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http://dx.doi.org/10.34172/jrhs.2020.34DOI Listing
November 2020

Invasive Rasamsonia argillacea infection in chronic granulomatous disease: Report of a new case and literature review.

J Mycol Med 2020 Dec 31;31(1):101106. Epub 2020 Dec 31.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Invasive Rasamsonia spp. infections are rare and usually associated with chronic granulomatous disease (CGD). We present a case of pulmonary and possible cerebral infection due to Rasamsonia argillacea in a girl with CGD receiving no primary antifungal prophylaxis. There was a fatal outcome despite the combination of antifungal therapy and surgical interventions. We also conducted a literature review on reported invasive Rasamsonia spp. infections in the setting of CGD.
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http://dx.doi.org/10.1016/j.mycmed.2020.101106DOI Listing
December 2020

Fates of aflatoxin B from wheat flour to Iranian traditional cookies: Managing procedures to aflatoxin B reduction during traditional processing.

Food Sci Nutr 2020 Nov 19;8(11):6014-6022. Epub 2020 Sep 19.

Student Research Committee Department of Food Science and Technology School of Nutrition Sciences and Food Technology Kermanshah University of Medical Science Kermanshah Iran.

Aflatoxin B (AFB) incidence in cereal, especially in wheat products, is a serious worldwide challenge for human health. The objective of the current study was to survey the effect of various factors, including fermentation times, yeast levels, ingredients, and time/temperature combinations of the baking process on aflatoxin B (AFB) reduction in order to modify parameters of the traditional cookie-making process. AFB levels were analyzed by an HPLC-fluorescence detector. The results revealed AFB levels significantly decreased during fermentation (%23.7), depending on an increase in the yeast level (2%) and fermentation time (90 min). Furthermore, there was a significant correlation between pH reduction and AFB decomposition. However, the formulation of the recipe did not show a significant effect on the detoxification of AFB. The baking temperature increase in an admissible technological range (280°C for 15 min) more effectively reduced AFB content (%53.9). As a result, the exact control of the traditional process was able to significantly decreased AFB content as a serious health-threatening toxin in the final product (%75.9). However, AFB toxicity reduction should be considered seriously in the raw materials and such products.
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http://dx.doi.org/10.1002/fsn3.1888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684617PMC
November 2020

Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial.

Diabetes Metab Syndr Obes 2020 18;13:753-761. Epub 2020 Mar 18.

Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background And Aim: The imbalance between pro-oxidant and antioxidant systems often leads to further oxidative damage in the pathogenesis of both diabetes and periodontal disease. This study aimed to investigate the antioxidant and anti-inflammatory properties of melatonin in type 2 diabetes mellitus (T2DM) patients with periodontal disease (PD) under non-surgical periodontal therapy (NSPT).

Materials And Methods: In this double-blind clinical trial study, 50 T2DM patients with PD were randomly allocated to intervention and control groups and received 250 mg/day (2 tablets) either melatonin or placebo 1 h before bedtime for 8 weeks. The NSPT was performed for all patients in both groups at the beginning of the study. The serum levels of interleukin-1b (IL-1b), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured pre- and post-intervention.

Results: Supplementation with melatonin in adjunct to NSPT significantly increased the serum levels of TAC, SOD, CAT, and GPx in the intervention group (P = 0.02, 0.008, 0.004 and 0.004, respectively). The mean changes of SOD, CAT, and GPx were significantly (P = 0.02, 0.04 and 0.04, respectively) greater in the intervention group compared with the control group. Also, after adjusting for confounding factors, the results did not change in terms of significance (P < 0.05). After the intervention, serum levels of MDA and IL-1b were significantly reduced in the intervention group (P < 0.001 and P = 0.008, respectively). The intervention group exhibited lower mean changes of MDA compared with the control group, and these changes were statistically significant (P = 0.008). In addition, after adjusting for confounding factors, the results did not change in terms of significance.

Conclusion: The adjunctive effects of melatonin and NSPT may improve inflammatory and antioxidant parameters in T2DM patients with PD.
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http://dx.doi.org/10.2147/DMSO.S242208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090208PMC
March 2020

Clinical and Genetic Analysis of Nine Suspected Familial Haemophagocytic Lymphohistiocytosis Patients for MUNC13-4 Deficiency and Introducing Four Novel Mutations in UNC13D.

Iran J Allergy Asthma Immunol 2019 Oct 23;18(5):487-492. Epub 2019 Oct 23.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Familial haemophagocytic lymphohistiocytosis (FHL) is a rare disorder of immune dysregulation. FHL inherited in an autosomal recessive pattern is classified into five subtypes based on underlying genetic defects. Mutations in four genes including PRF1, UNC13D, STX11 and STXBP2 are responsible for FHL2 to FHL5 respectively. The cause of FHL1 is associated with mutations in an unknown gene located at 9q21.3-22. This study aims to report the clinical features and genetic results of nine Iranian patients suffering from -haemophagocytic lymphohistiocytosis. Nine patients (five males and four females) suspected to FHL whose genetic evaluation of PRF1 and STX11 revealed no mutations, were entered the study to investigate UNC13D mutations. Primers were designed to amplify all coding regions and exon-intron boundaries of the gene. PCR products were then sequenced and analyzed by sequence analysis tools including BLAST. The most frequent clinical manifestations observed in the patients were fever and hepatosplenomegaly. In this study, five mutations were detected in UNC13D including four novel mutations (c.1434_1446delACCCATGGTGCAGinsTGGTGCT, c.1933C>T, c.1389+1G>C and c.2091+1G>A) besides to a previously reported deletion (c.627delT). The pathogenicity of the missense mutation was assessed using online prediction tools including SIFT and PolyPhen2. The study results may provide valuable information for genetic counseling especially for those who have a history of immunodeficiency diseases in their family and can be used for prenatal diagnosis.
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http://dx.doi.org/10.18502/ijaai.v18i5.1911DOI Listing
October 2019

Behavioral factors influencing childhood obesity: a systematic review and meta-analysis.

Obes Res Clin Pract 2020 Mar - Apr;14(2):109-118. Epub 2020 Mar 19.

Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: This report provides information on 14 behavioral and nutritional factors that can be addressed in childhood overweight/obesity prevention programs.

Methods: Web of Science, PubMed, and Scopus were searched through November 2018. Reference lists were also screened for additional references. Observational studies addressing the associations between overweight/obesity in children/adolescents aged between 5 to 19 years and associated risk factors were analyzed. Between-studies heterogeneity was assessed by χ, τ, and I statistics. The likelihood of publication bias was evaluated using the Begg and Egger tests and trim & fill analysis. Effect sizes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model.

Results: Of 34,537 retrieved studies, 199 including 1,636,049 participants were eligible. The ORs (95% CI) of factors associated with childhood overweight/obesity were as follows: sufficient physical activity 0.70 (0.66, 0.75); eating breakfast every day 0.66 (0.59, 0.74); sufficient consumption of fruits/vegetables 0.92 (0.84, 1.01); breastfeeding <4 months 1.24 (1.16, 1.33); inadequate sleep 1.26 (1.13, 1.40); watching TV >1-2 h/day 1.42 (1.35, 1.49); playing computer games >2 h/day 1.08 (0.95, 1.23); eating sweets ≥3 times/week 0.78 (0.71, 0.85); eating snack ≥4 times/week 0.84 (0.71, 1.00); drinking sugar-sweetened beverages ≥4 times/week 1.24 (1.07, 1.43); eating fast-food ≥3 times/week 1.03 (0.89, 1.18); eating fried-food ≥3 times/week 1.09 (0.90, 1.33); smoking 1.17 (1.07, 1.29); and drinking alcohol 1.05 (0.95, 1.16).

Conclusions: This meta-analysis provided a clear picture of the behavioral and nutritional factors associated with weight gain in children.
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http://dx.doi.org/10.1016/j.orcp.2020.03.002DOI Listing
March 2020

Risk factors for stomach cancer: a systematic review and meta-analysis.

Epidemiol Health 2020 2;42:e2020004. Epub 2020 Feb 2.

Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Objectives: This report provides information on 14 behavioral and nutritional factors that can be addressed in stomach cancer prevention programs.

Methods: PubMed, Web of Science, and Scopus were searched through December 2018. Reference lists were also screened. Observational studies addressing the associations between stomach cancer and behavioral factors were analyzed. Between-study heterogeneity was investigated using the χ2, τ2, and I2 statistics. The likelihood of publication bias was explored using the Begg and Egger tests and trim-and-fill analysis. Effect sizes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model.

Results: Of 52,916 identified studies, 232 (including 33,831,063 participants) were eligible. The OR (95% CI) of factors associated with stomach cancer were as follows: Helicobacter pylori infection, 2.56 (95% CI, 2.18 to 3.00); current smoking, 1.61 (95% CI, 1.49 to 1.75); former smoking 1.43 (95% CI, 1.29 to 1.59); current drinking, 1.19 (95% CI, 1.10 to 1.29); former drinking, 1.73 (95% CI, 1.17 to 2.56); overweight/obesity, 0.89 (95% CI, 0.74 to 1.08); sufficient physical activity, 0.83 (95% CI, 0.68 to 1.02); consumption of fruits ≥3 times/wk, 0.48 (95% CI, 0.37 to 0.63); consumption of vegetables ≥3 times/wk, 0.62 (95% CI, 0.49 to 0.79); eating pickled vegetables, 1.28 (95% CI, 1.09 to 1.51); drinking black tea, 1.00 (95% CI, 0.84 to 1.20); drinking green tea, 0.88 (95% CI, 0.80 to 0.97); drinking coffee, 0.99 (95% CI, 0.88 to 1.11); eating fish ≥1 time/wk 0.79 (95% CI, 0.61 to 1.03); eating red meat ≥4 times/wk 1.31 (95% CI, 0.87 to 1.96), and high salt intake 3.78 (95% CI, 1.74 to 5.44) and 1.34 (95% CI, 0.88 to 2.03), based on two different studies.

Conclusions: This meta-analysis provided a clear picture of the behavioral and nutritional factors associated with the development of stomach cancer. These results may be utilized for ranking and prioritizing preventable risk factors to implement effective prevention programs.
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http://dx.doi.org/10.4178/epih.e2020004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056944PMC
March 2020

The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial.

Diabetes Metab Syndr Obes 2020 6;13:19-29. Epub 2020 Jan 6.

Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Aim: The aim of the current study was to investigate that combination of the synbiotic supplementation in adjunct with non-surgical periodontal therapy (NSPT) is useful in treating periodontitis and biomarkers of oxidative stress in type 2 diabetes mellitus (T2DM) patients.

Methods: In this study, 47 patients suffering from DM and CP were recruited and randomly assigned to two groups. The intervention (n= 23) and control (n=24) groups received either multispecies probiotic supplement plus 100 mg fructo-oligosaccharide (500 mg in each capsule) or placebo capsule containing 500 mg wheat flour, respectively, every day for 8 weeks. All subjects were treated with NSPT during the intervention period. Serum levels of interleukin-1β (IL-1β), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and periodontal indices including clinical attachment loss (CAL), pocket depth (PD) (main outcome), BOP, and plaque index were measured before and after the intervention.

Results: Supplementation with the synbiotic with NSPT led to a significant decrease in the levels of IL-1β, MDA, plaque index, PD, and CAL in the intervention group post-intervention (p < 0.05). The serum levels of TAC, SOD, and GPx were significantly increased in the intervention group compared with the baseline (p < 0.05). Consumption of synbiotic with NSPT, compared to the control, resulted in a significant decrease in the mean changes of IL-1β, MDA, and CAL (p < 0.05). Also, the mean changes of TAC and GPx were significantly higher in the intervention group compared with the control group (p < 0.05). Also, in the intervention group was seen a significant reduction in plaque index (p = 0.035) and BOP (p = 0.04) compared with the control group.

Conclusion: It was observed that synbiotic supplementation with NSPT may be beneficial in improving inflammatory, antioxidant, and periodontal status in T2DM patients with CP.
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http://dx.doi.org/10.2147/DMSO.S230060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954633PMC
January 2020

The chromene derivative 4-Clpgc inhibits cell proliferation and induces apoptosis in the K562 cell line.

J Cell Commun Signal 2020 Mar 6;14(1):77-91. Epub 2019 Sep 6.

National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.

Chronic myeloid leukemia (CML) is a malignant blood disease with a particular chromosomal aberration that is known as a common form of leukemia. The chromene family exhibits strong anti-cancer effects. Therefore, the effects of six members of the dihydropyrano [2,3-g] chromene family on cell toxicity and apoptosis induction in K562 cancer cells were investigated and compared with those of normal peripheral blood mononuclear cells (PBMCs). The K562 cells were cultured in the presence of the aforementioned chromene derivatives at concentrations of 40 to 200 μM for 24 to 72 h. The effects of these compounds on the growth and viability of the K562 cell line and PBMCs were studied through MTT assay. Furthermore, apoptosis induction was investigated using flow cytometry. Real-time PCR was used for relative quantification of BCL2, Bax, TP53 and BCR- ABL genes after 48 h of exposing K562 cells and PBMCs to 4-Clpgc. Based on the results, these chromene derivatives inhibited the growth of K562 cells. According to the obtained data, 4-Clpgc was the strongest compound with IC50 values of 102 ± 1.6 μM and 143 ± 9.41 μM in K562 cells and PBMCs, while pgc was the weakest one with IC50 levels of 278 ± 2.7 μM and 366 ± 47 μM in K562 cells and PBMCs (after 72 h), respectively. The results demonstrated that the apoptotic cell percentage in the control group increased from 6.09% to 84.10% and 17.2% to 20.06% in K562 cells and PBMCs after 48 h of treatment, respectively. Moreover, 4-Clpgc treatment increased the expression of Bax and TP53 genes by 42.74 and 35.88 folds in K562 cells and 9.60 and 7.75 folds in PBMCs, respectively. On the other hand, the expression of BCL2 was reduced by 1.47 and 1.38 folds in K562 cells and PBMCs, respectively. These compounds were associated with less toxic effects on normal cells, compared to the cancer cells. In conclusion, these derivatives can be considered as appropriate candidates for leukemia treatment.
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http://dx.doi.org/10.1007/s12079-019-00530-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176807PMC
March 2020

Insulin resistance and pseudoacromegaly: A case report.

Diabetes Metab Syndr 2019 Mar - Apr;13(2):901-903. Epub 2018 Dec 20.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Patients with acromegaly have soft tissue overgrowth that induced characteristic clinical presentation. A growth hormone-secreting adenoma of the anterior pituitary gland is the most common cause of acromegaly. Metabolic and somatic features of acromegaly caused by high serum concentrations of insulin-like growth factor-I (IGF-I) and excess growth hormone (GH) production. we present a case of 'pseudoacromegaly' with an acromegaloid features, suppressed IGF-I levels and marked elevation of serum insulin. Endocrinologists should consider this diagnosis when assessing patients with clinical features of acromegaly and insulin resistance, in the absence of elevated levels of GH and IGF-I.
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http://dx.doi.org/10.1016/j.dsx.2018.12.009DOI Listing
December 2019

Frequency of type I and II diabetes in newly diagnosed diabetic patients: Measuring C-Peptide level.

Diabetes Metab Syndr 2019 May - Jun;13(3):1833-1835. Epub 2019 Apr 17.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Aims: Diabetes mellitus is a metabolic disease that manifested as hyperglycemia due to the defect in secretion or function of insulin. This study aimed was to survey about frequency type I and II diabetes in newly diagnosed diabetic patients base on c-peptide and anti-glutamate acid decarboxylase (GAD) tests.

Materials & Methods: This study was conducted as a prospective study on 70 diabetic patients aged 15-45 years old who referred to diabetes clinics in Ahvaz city during 2012-2014 and their diabetes was diagnosed for the first time, but their type of diabetes was not clinically definitive. Patients with anti-GAD positive and fasting C-peptide level of less than 0.65 were diagnosed as type I diabetes. Patients with anti-GAD negative fasting C-peptide level of greater than or equal to 0.65 were considered as type II diabetes.

Results: Eighty two patients (49 males and 33 females) with a mean age of 21.64 ± 4.36 years (range 15-34) and a mean BMI of 22.05 ± 4.41 kg/m (range 14-18) were studied. Twenty three patients (28.5%) had type I diabetes and 59 patients (71.95%) had type II diabetes. In patients with type I diabetes, the mean BMI was 24.86 ± 2.36 kg/m and the number of patients with family history (56.22%) was higher. In type II diabetic patients, the number of women (62.71%) was higher than that of men.

Conclusion: Anti-GAD test can be used as a predictive test for early diagnosis of disease and screening of people with a diagnosis of diabetes based on the type of diabetes.
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http://dx.doi.org/10.1016/j.dsx.2019.04.018DOI Listing
December 2019

The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial.

Inflammopharmacology 2019 Feb 16;27(1):67-76. Epub 2018 Oct 16.

Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Diabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in the pathogenesis of these two diseases. The aim of this study was to investigate the effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 DM patients with chronic periodontitis (CP).

Materials And Methods: In this double-blind clinical trial study, 50 type 2 DM patients with CP were randomly allocated to the intervention and control groups. The intervention and control groups received either 6 mg melatonin or placebo (2 tablets) once a day. Serum levels of melatonin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), hs-C-reactive protein (hs-CRP), clinical attachment loss (CAL), pocket depth (PD), bleeding on probing (BOP) and plaque index were evaluated in all subjects pre- and post-intervention.

Results: Melatonin supplementation significantly increased the mean serum levels of melatonin after intervention. The mean changes of melatonin were significantly higher in intervention group compared with control group. IL-6 and hs-CRP levels were significantly (p = 0.008 and p = 0.017, respectively) reduced in the intervention group. The mean changes of IL-6 were significantly lower in the intervention group compared with the control group (p = 0.04). In the intervention group, PD and CAL were significantly decreased after intervention (p < 0.001). There were significant differences in the mean change of PD and CAL between the intervention and control groups after intervention (p < 0.001).

Conclusions: Melatonin supplementation in adjunct with non-surgical periodontal therapy might improve inflammatory and periodontal status in T2DM with CP.
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http://dx.doi.org/10.1007/s10787-018-0539-0DOI Listing
February 2019

Sodium Saccharin as an Effective Catalyst for Rapid One-pot Pseudo-five Component Synthesis of Dihydropyrano[2,3-g]chromenes under Microwave Irradiation.

Acta Chim Slov 2017 06;64(2):506-512

One-pot microwave-assisted synthesis of dihydropyrano[2,3-g]chromenes catalyzed by sodium saccharin as an efficient, mild and green catalyst was studied. The method presented is a safe and eco-friendly approach for the multicomponent synthesis of dihydropyrano[2,3-g]chromene derivatives with many merits including short reaction times (in comparison with other reported results), high yields and easy work up.
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http://dx.doi.org/10.17344/acsi.2017.3417DOI Listing
June 2017

A study of the prevalence of dyslipidemia among the adult population of Ahvaz, Iran.

Diabetes Metab Syndr 2016 Oct - Dec;10(4):190-193. Epub 2016 Jun 8.

Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Hypercholesterolemia is one of the main causes of the disease burden in developed and developing countries. The present study is planned to access the prevalence of dyslipidemia and its risk factors among the general population of Ahvaz over 20 years of age.

Method: In this descriptive-analytic study, using multi-stage cluster method, out of the 25 existing health centers in the city of Ahvaz (four health centers in the Eastern Ahvaz and two centers in the west were chosen based on the population they covered). The blood samples of the participants were taken after 12h of fasting for measure FBS, TG, Chol, HDLand LDL level their heights, and weights were measured using the standard methods. Interviewing the participants, the research questionnaires were filled by the trained health workers.

Results: Out of 2505 participants, 1155 samples (%46.1) were male with mean age of 42.9±14.5years and 1350 samples (%53.9) were women with the mean age of 39.9±12.6 years. The prevalence of dyslipidemia among the individuals over 20 years of age in Ahvaz was %80.9 (%75.9 in male and %85.1 in female). Age and BMI were positively correlated with increase in the risk of dyslipidemia. Women had a higher risk of dyslipidemia CONCLUSION: This study showed that more than %80 over 20 years old Ahvazian population had dyslipidemia(female more than male). Age and BMI are positively correlated with increasing dyslipidemia in my population.
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http://dx.doi.org/10.1016/j.dsx.2016.06.003DOI Listing
March 2017

Femtomolar level detection of RASSF1A tumor suppressor gene methylation by electrochemical nano-genosensor based on Fe3O4/TMC/Au nanocomposite and PT-modified electrode.

Biosens Bioelectron 2016 Mar 4;77:1095-103. Epub 2015 Nov 4.

Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The alterations in DNA methylation pattern have been identified as one of the most frequent molecular phenomenon in human cancers. The RASSF1A tumor suppressor gene was shown to be often inactivated by hypermethylation of its promoter region. In the present study, a novel chip format sandwich electrochemical genosensor has been developed for the analysis of gene-specific methylation using Fe3O4/N-trimethyl chitosan/gold (Fe3O4/TMC/Au) nanocomposite as tracing tag to label DNA probe and polythiophene (PT) as immobilization platform of sensing element. However, no attempt has yet been made to conjugate DNA probe to Fe3O4/TMC/Au nanocomposite as electrochemical label for strip-based genosensing. Cyclic voltammetric (CV) analysis indicated that modification procedure was well performed. Differential pulse voltammetry (DPV) was employed for quantitative assessment of RASSF1A DNA promoter methylation. The electrochemical measurements accomplished using non-specific DNA fragments mixed with samples, revealed the high specificity and selectivity in methylation analysis by means of this DNA nanobiosensor. With the linear range of concentration from 1 × 10(-14)M to 5 × 10(-9)M and the detection limit of 2 × 10(-15)M, this new strategy has shown such a promising application to be used for universal analysis of any DNA sequence.
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http://dx.doi.org/10.1016/j.bios.2015.11.007DOI Listing
March 2016

A survey of the effective factors in students' adherence to university dress code policy, using the theory of reasoned action.

J Adv Med Educ Prof 2015 Jul;3(3):133-41

Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Recognizing the determinants of behavior plays a major role in identification and application of effective strategies for encouraging individuals to follow the intended pattern of behavior. The present study aimed to analyze the university students' behaviors regarding the amenability to dress code, using the theory of reasoned action (TRA).

Methods: In this cross sectional study, 472 students were selected through multi-stage random sampling. The data were collected using a researcher-made questionnaire whose validity was confirmed by specialists. Besides, its reliability was confirmed by conducting a pilot study revealing Cronbach's alpha coefficients of 0.93 for attitude, 0.83 for subjective norms, 0.94 for behavioral intention and 0.77 for behavior. The data were entered into the SPSS statistical software and analyzed using descriptive and inferential statistics (Mann-Whitney, correlation and regression analysis).

Results: Based on the students' self-reports, conformity of clothes to the university's dress code was below the expected level in 28.87% of the female students and 28.55% of the male ones. The mean scores of attitude, subjective norms, and behavioral intention to comply with dress code policy were 28.78±10.08, 28.51±8.25 and 11.12±3.84, respectively. The students of different colleges were different from each other concerning TRA constructs. Yet, subjective norms played a more critical role in explaining the variance of dress code behavior among the students.

Conclusion: Theory of reasoned action explained the students' dress code behaviors relatively well. The study results suggest paying attention to appropriate approaches in educational, cultural activities, including promotion of student-teacher communication.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530003PMC
July 2015

Effect of a parenting education program on girls' life satisfaction in governmental guidance schools of Shiraz.

J Adv Med Educ Prof 2014 Jan;2(1):12-9

Department of Epidemiology, Faculty of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: One of the main determinants of adolescents' life satisfaction is parenting skills. Due to the lack of educational trials in this field, this research was done to evaluate the effect of a parenting education program on girls' life satisfaction in governmental guidance schools of Shiraz. 

Methods: This study is an educational randomized controlled trial. At first, 152 female students in 2nd grade of governmental guidance schools and 304 parents (152 mother and 152 father) were selected by multistage random cluster sampling method. Then, they were categorized into experimental and control groups. Before and after the intervention, data were collected from two groups using multidimensional students' life satisfaction scale with stability (Cronbach's alpha=0.89), test-retest and correlation coefficient (r=0.70). Educational intervention for parents was performed in the experimental group through presentations with question and answer, discussion in small groups and distribution of educational booklets in 5 volumes. Finally, the data were analyzed using SPSS 14 and through Mann-Whitney test, Chi-square test, Fisher's Exact test, Wilcoxon test.

Results: Before the intervention, the experimental and control groups did not show a statistically significant difference based on the demographic variables. Thetotal of life satisfaction scores and also its subscales in the experimental and controlgroup, before and six weeks afterthe educational interventiondid showstatisticallysignificant difference (p<0.001). The scores of differences (pre-test/post-test) in total life satisfaction between the experimental and control groups were statistically significant difference (p<0.001).

Conclusion: According to low scores of the students in the pre-test, especially in the control group which didn't undergo any educational program, holding scheduled educational intervention is necessary. This study not only supports the effectiveness of educational intervention but also recommends further educational research to develop knowledge regarding patterns of parenting education.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235541PMC
January 2014

Amidation of multiwalled carbon nanotubes in mild and efficient conditions.

J Nanosci Nanotechnol 2013 Mar;13(3):1923-6

Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, PO. Box 87317, Kashan, I. R. Iran.

Functionalization of Multi Walled Carbon Nanotubes (MWCNTs) with amines under a two step reaction is studied. In the first step, maleic anhydride graft to the MWCNT (Mah-g-MWCNTs) surfaces via a polymerization process with benzoylproxide as initiator. Active anhydride groups on the surfaces of MWCNTs, react with amines to give a polyamido chain attached to the MWCNTs surfaces. The reaction products have high solubility and disperse stability in organic solvents. FTIR, TGA and elemental analysis (CHN) were used to characterization of the achieved products.
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http://dx.doi.org/10.1166/jnn.2013.7104DOI Listing
March 2013

Solubilization of multi walled carbon nanotubes under a facile and mild condition.

J Nanosci Nanotechnol 2011 Oct;11(10):8903-6

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 87317, Kashan, I.R. Iran.

Multi-walled carbon nanotubes (MWCNTs) functionalized with amino groups was prepared via chemical modification of carboxyl groups introduced on the carbon nanotube surfaces. Oxidation of MWCNTs was performed with ozone in aqueous phase and amidation of generated carboxylic groups, was occurred with amines in the presence of HATU as a coupling agent. Obtained functionalized MWCNTs are soluble in many common organic solvents. The functionalized MWCNTs were characterized in detail using FTIR-ATR, Raman CHN and SEM methods.
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http://dx.doi.org/10.1166/jnn.2011.3454DOI Listing
October 2011

Effect of functionalized carbon nanotubes on the synthesis of hydroxyapatite nanoparticles.

J Nanosci Nanotechnol 2011 Jun;11(6):5423-8

Faculty of Biomaterial Science, Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Ponak, Tehran, PO Box 14176766981, Iran.

The purpose of this study was to investigate the effect of the functionalized carbon nanotubes (CNT) on the nucleation of the HA nanoparticles. In this work, solutions of calcium nitrate tetra hydrate and diamonium hydrogen phosphate in water were used as Ca, P precursors. The former solution was added to an aqueous suspension of MWNTs-COOH. Different CNT functionalization percentage ratios of 1%, 2%, 3%, 4% and 5% were examined. X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR) experiments confirmed that the resulting powders were composed of hydroxyapatite. The Scanning Electron Microscopy (SEM) images illustrated a short distance effect of CNTs on the formation of the HA nanoparticles. In addition, a more detailed observation performed by Transmission Electron Microscopy (TEM) depicted the flake-like morphology of the nanoparticles. Based on the results of this research, the crystallinity decreased due to the CNT addition to the synthesis media. The sample containing a CNT functionality percentage of 5% revealed a preferred crystalline orientation compared with the samples composed of less CNT functionality percentage of 1%, 2%, 3% and 4%.
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http://dx.doi.org/10.1166/jnn.2011.3782DOI Listing
June 2011

The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.

Curr Pharm Des 2010 ;16(26):2935-47

Endocrinology and Metabolism Research Center, and Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: This review focuses on the efficacy and safety of effective herbal medicines in the management of hyperlipidemia in human.

Methods: PubMed, Scopus, Google Scholar, Web of Science, and IranMedex databases were searched up to 11th May 2010. The search terms were "hyperlipidemia" and ("herbal medicine" or "medicine traditional", "extract plant") without narrowing or limiting search elements. All of the human studies on the effects of herbs with the key outcome of change in lipid profiles were included.

Results: Fifty three relevant clinical trials were reviewed for efficacy of plants. This study showed significant decrease in total cholesterol and LDL cholesterol after treatment with Daming capsule (DMC), chunghyul-dan, Glycyrrhiza glabra, garlic powder (Allicor), black tea, green tea, soy drink enriched with plant sterols, licorice, Satureja khuzestanica, Monascus purpureus Went rice, Fenugreek, Commiphora mukul (guggul), Achillea wilhelmsii C. Koch, Ningzhi capsule (NZC), cherry, compositie salviae dropping pill (CSDP), shanzha xiaozhi capsule, Ba-wei-wan (hachimijiogan), rhubarb stalk, Silybum marianum, Rheum Ribes and Jingmingdan granule (primrose oil). Conflicting data exist for red yeast rice, garlic and guggul. No significant adverse effect or mortality were observed except in studies with DMC, guggul, and Terminalia belerica, Terminalia chebula, Emblica officinalis, ginger, and garlic powder (Allium sativum).

Conclusion: Amongst reviewed studies, 22 natural products were found effective in the treatment of hyperlipidemia that deserve further works to isolate and characterization of their constituents to reach novel therapeutic and more effective agents.
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http://dx.doi.org/10.2174/138161210793176464DOI Listing
August 2011