Leighton J Core

Leighton J Core

UNVERIFIED PROFILE

Are you Leighton J Core?   Register this Author

Register author
Leighton J Core

Leighton J Core

Publications by authors named "Leighton J Core"

Are you Leighton J Core?   Register this Author

25Publications

714Reads

47Profile Views

Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation.

Genes Dev 2016 08 4;30(15):1731-46. Epub 2016 Aug 4.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14835, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.284430.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002978PMC
August 2016

Identification of active transcriptional regulatory elements from GRO-seq data.

Nat Methods 2015 May 23;12(5):433-8. Epub 2015 Mar 23.

Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507281PMC
May 2015

Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers.

Nat Genet 2014 Dec 10;46(12):1311-20. Epub 2014 Nov 10.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254663PMC
December 2014

Nuclear stability and transcriptional directionality separate functionally distinct RNA species.

Nat Commun 2014 Nov 12;5:5336. Epub 2014 Nov 12.

The Bioinformatics Centre, Department of Biology and Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms6336
Publisher Site
http://dx.doi.org/10.1038/ncomms6336DOI Listing
November 2014

RNA-DNA differences are generated in human cells within seconds after RNA exits polymerase II.

Cell Rep 2014 Mar 20;6(5):906-15. Epub 2014 Feb 20.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Departments of Pediatrics and Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918108PMC
March 2014

Pol II docking and pausing at growth and stress genes in C. elegans.

Cell Rep 2014 Feb 30;6(3):455-66. Epub 2014 Jan 30.

Department of Biology, Duke Center for Systems Biology, Duke University, Durham, NC 27708, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026043PMC
February 2014

Condensin controls recruitment of RNA polymerase II to achieve nematode X-chromosome dosage compensation.

Elife 2013 Jun 18;2:e00808. Epub 2013 Jun 18.

Department of Molecular and Cell Biology , Howard Hughes Medical Institute, University of California, Berkeley , Berkeley , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.00808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687364PMC
June 2013

Extensive polymerase pausing during Drosophila axis patterning enables high-level and pliable transcription.

Genes Dev 2013 May;27(10):1146-58

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.215459.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672648PMC
May 2013

Precise maps of RNA polymerase reveal how promoters direct initiation and pausing.

Science 2013 Feb;339(6122):950-3

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1229386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974810PMC
February 2013

Defining the status of RNA polymerase at promoters.

Cell Rep 2012 Oct 10;2(4):1025-35. Epub 2012 Oct 10.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2012.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483431PMC
October 2012

Bacillus subtilis RapA phosphatase domain interaction with its substrate, phosphorylated Spo0F, and its inhibitor, the PhrA peptide.

J Bacteriol 2012 Mar 20;194(6):1378-88. Epub 2012 Jan 20.

The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.06747-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294843PMC
March 2012

The polycomb group mutant esc leads to augmented levels of paused Pol II in the Drosophila embryo.

Mol Cell 2011 Jun;42(6):837-44

Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, University of California, Berkeley, Berkeley, CA 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2011.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130001PMC
June 2011

X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila.

Nature 2011 Mar;471(7336):115-8

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature09757
Publisher Site
http://dx.doi.org/10.1038/nature09757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076316PMC
March 2011

Divergent transcription: a new feature of active promoters.

Cell Cycle 2009 Aug 19;8(16):2557-64. Epub 2009 Aug 19.

Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.8.16.9305DOI Listing
August 2009

Paused Pol II captures enhancer activity and acts as a potent insulator.

Genes Dev 2009 Jul;23(14):1606-12

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1827709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959990PMC
July 2009

Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes.

Mol Cell Biol 2009 Mar 22;29(5):1123-33. Epub 2008 Dec 22.

Department of Molecular Biology and Genetics, Cornell University, 465 Biotechnology Building, Ithaca, NY 14853, USA.

View Article

Download full-text PDF

Source
http://mcb.asm.org/cgi/doi/10.1128/MCB.00841-08
Publisher Site
http://dx.doi.org/10.1128/MCB.00841-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643830PMC
March 2009

Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters.

Science 2008 Dec 4;322(5909):1845-8. Epub 2008 Dec 4.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1162228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833333PMC
December 2008

Transcription regulation through promoter-proximal pausing of RNA polymerase II.

Science 2008 Mar;319(5871):1791-2

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/cgi/doi/10.1126/science.1150843
Publisher Site
http://dx.doi.org/10.1126/science.1150843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833332PMC
March 2008

Breaking barriers to transcription elongation.

Nat Rev Mol Cell Biol 2006 Aug;7(8):557-67

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm1981DOI Listing
August 2006