Publications by authors named "Leigh Murphy"

88Publications

Paracrine Crosstalk between Fibroblasts and ER Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.

iScience 2019 Sep 24;19:388-401. Epub 2019 Jul 24.

Department of Immunology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada; Research Institute of Oncology & Hematology, CancerCareManitoba, Winnipeg, MB R3E 0V9, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2019.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706609PMC
September 2019

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.

Transl Oncol 2019 Mar 15;12(3):561-575. Epub 2019 Jan 15.

Department of Pathology, University of Manitoba; Department of Physiology and Pathophysiology, University of Manitoba; Research Institute of Oncology and Hematology, Winnipeg, Manitoba, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tranon.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349319PMC
March 2019

Long Non-Coding RNA H19 Acts as an Estrogen Receptor Modulator that is Required for Endocrine Therapy Resistance in ER+ Breast Cancer Cells.

Cell Physiol Biochem 2018 29;51(4):1518-1532. Epub 2018 Nov 29.

Research Institute of Oncology and Hematology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495643
Publisher Site
http://dx.doi.org/10.1159/000495643DOI Listing
January 2019

A robust cell culture system for large scale feeder cell-free expansion of human breast epithelial progenitors.

Stem Cell Res Ther 2018 10 4;9(1):264. Epub 2018 Oct 4.

Department of Immunology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada.

View Article

Download full-text PDF

Source
https://stemcellres.biomedcentral.com/articles/10.1186/s1328
Publisher Site
http://dx.doi.org/10.1186/s13287-018-0994-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172804PMC
October 2018

Androgen Receptor and Ki67 Expression and Survival Outcomes in Non-small Cell Lung Cancer.

Horm Cancer 2018 08 18;9(4):288-294. Epub 2018 Jun 18.

Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12672-018-0336-7
Publisher Site
http://dx.doi.org/10.1007/s12672-018-0336-7DOI Listing
August 2018

Genes and functions from breast cancer signatures.

BMC Cancer 2018 04 27;18(1):473. Epub 2018 Apr 27.

Research Institute of Oncology and Hematology, CancerCare Manitoba, 675 McDermot Ave, Winnipeg, Manitoba, R3E 0V9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-018-4388-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921990PMC
April 2018

Recurrent copy number alterations in young women with breast cancer.

Oncotarget 2018 Feb 29;9(14):11541-11558. Epub 2018 Jan 29.

Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.24336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837756PMC
February 2018

The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC).

BMC Cancer 2018 01 4;18(1):22. Epub 2018 Jan 4.

Research Institute of Oncology and Hematology, CancerCare Manitoba & University of Manitoba, Winnipeg, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-017-3939-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753474PMC
January 2018

Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue.

Stem Cell Reports 2018 01 7;10(1):196-211. Epub 2017 Dec 7.

Department of Immunology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada; Research Institute of Oncology & Hematology, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22136711173048
Publisher Site
http://dx.doi.org/10.1016/j.stemcr.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768884PMC
January 2018

A 16 Yin Yang gene expression ratio signature for ER+/node- breast cancer.

Int J Cancer 2017 03;140(6):1413-1424

Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.30556DOI Listing
March 2017

Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada.

Cancer Epidemiol 2016 12 19;45:82-90. Epub 2016 Oct 19.

Rady Faculty of Health Sciences, University of Manitoba, Canada; CancerCare Manitoba, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canep.2016.10.006DOI Listing
December 2016

A 10-Gene Yin Yang Expression Ratio Signature for Stage IA and IB Non-Small Cell Lung Cancer.

J Thorac Oncol 2016 12 4;11(12):2150-2160. Epub 2016 Aug 4.

Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada; Section of Hematology and Oncology, Department of Internal Medicine, Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2016.07.023DOI Listing
December 2016

Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.

Cancer Lett 2016 08 6;378(2):69-79. Epub 2016 May 6.

Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, United States; UC Davis Comprehensive Cancer Center, University of California, Davis, Sacramento, CA 95817, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505026PMC
August 2016

Regulation of steroid hormone receptors and coregulators during the cell cycle highlights potential novel function in addition to roles as transcription factors.

Nucl Recept Signal 2016 13;14:e001. Epub 2016 Jan 13.

Department of Biochemistry and Medical Genetics (YZ, LCM), University of Manitoba; Manitoba Institute of Cell Biology (YZ, LCM), CancerCare Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1621/nrs.14001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714463PMC
October 2016

The steroid receptor RNA activator protein (SRAP) controls cancer cell migration/motility.

FEBS Lett 2015 Dec 17;589(24 Pt B):4010-8. Epub 2015 Nov 17.

Manitoba Institute of Cell Biology, 675 McDermot Ave., R3E0V9 Winnipeg, Manitoba, Canada; Department of Biochemistry and Medical Genetics, University of Manitoba, 770 Bannatyne Avenue, R3E0W3 Winnipeg, Manitoba, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2015.11.007DOI Listing
December 2015

Estrogen regulates luminal progenitor cell differentiation through H19 gene expression.

Endocr Relat Cancer 2015 Aug 5;22(4):505-17. Epub 2015 May 5.

Department of ImmunologyUniversity of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5Manitoba Institute of Cell Biology675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9Department of Biochemistry and Medical GeneticsUniversity of Manitoba, Winnipeg, Manitoba, Canada R3E 0W2 Department of ImmunologyUniversity of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5Manitoba Institute of Cell Biology675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9Department of Biochemistry and Medical GeneticsUniversity of Manitoba, Winnipeg, Manitoba, Canada R3E 0W2

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-15-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498491PMC
August 2015

Intratumoural inflammation and endocrine resistance in breast cancer.

Endocr Relat Cancer 2015 Feb 17;22(1):R51-67. Epub 2014 Nov 17.

Deeley Research CentreBritish Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5Translational Gastroenterology UnitNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UKDepartment of Biochemistry and Medical Genetics and the Manitoba Institute of Cell BiologyUniversity of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, CanadaDepartment of Biochemistry and MicrobiologyUniversity of Victoria, Victoria, British Columbia, CanadaDepartment of Pathology and Laboratory MedicineUniversity of British Columbia, Vancouver, British Columbia, Canada Deeley Research CentreBritish Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5Translational Gastroenterology UnitNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UKDepartment of Biochemistry and Medical Genetics and the Manitoba Institute of Cell BiologyUniversity of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, CanadaDepartment of Biochemistry and MicrobiologyUniversity of Victoria, Victoria, British Columbia, CanadaDepartment of Pathology and Laboratory MedicineUniversity of British Columbia, Vancouver, British Columbia, Canada Deeley Research CentreBritish Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5Translational Gastroenterology UnitNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UKDepartment of Biochemistry and Medical Genetics and the Manitoba Institute of Cell BiologyUniversity of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, CanadaDepartment of Biochemistry and MicrobiologyUniversity of Victoria, Victoria, British Columbia, CanadaDepartment of Pathology and Laboratory MedicineUniversity of British Columbia, Vancouver, British Columbia, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-14-0096DOI Listing
February 2015

Differential regulation of estrogen receptors α and β by 4-(E)-{(4-hydroxyphenylimino)-methylbenzene,1,2-diol}, a novel resveratrol analog.

J Steroid Biochem Mol Biol 2014 Oct 19;144 Pt B:500-12. Epub 2014 Sep 19.

Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2014.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195806PMC
October 2014

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Mol Oncol 2015 Jan 8;9(1):115-27. Epub 2014 Aug 8.

Cancer Research UK, Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK; Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK; Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molonc.2014.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286124PMC
January 2015

A practical tool for modeling biospecimen user fees.

Biopreserv Biobank 2014 Aug;12(4):234-9

1 University of British Columbia Office of Biobank Education and Research , Vancouver, British Columbia, Canada .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/bio.2014.0008DOI Listing
August 2014

The kinome associated with estrogen receptor-positive status in human breast cancer.

Endocr Relat Cancer 2014 Oct 23;21(5):R357-70. Epub 2014 Jul 23.

Department of Biochemistry and Medical GeneticsManitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-14-0232DOI Listing
October 2014

ERβ splice variant expression in four large cohorts of human breast cancer patient tumors.

Breast Cancer Res Treat 2014 Aug 10;146(3):657-67. Epub 2014 Jul 10.

Department of Pathology, Yale University School of Medicine, BML116, 310 Cedar Street, PO Box 208023, New Haven, CT, 06520-8023, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-014-3050-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939385PMC
August 2014

Steroid receptor RNA activator protein (SRAP) expression as a prognostic factor in ER+ human breast tumors.

J Cancer Res Clin Oncol 2013 Oct 2;139(10):1637-47. Epub 2013 Aug 2.

Manitoba Institute of Cell Biology, 675 McDermot Ave., Winnipeg, MB, R3E0V9, Canada,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-013-1485-2DOI Listing
October 2013

Claudin 1 expression in basal-like breast cancer is related to patient age.

BMC Cancer 2013 May 30;13:268. Epub 2013 May 30.

Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-13-268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674926PMC
May 2013

A bi-faceted role of estrogen receptor β in breast cancer.

Endocr Relat Cancer 2013 Jun 30;20(3):R127-39. Epub 2013 May 30.

Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-12-0389DOI Listing
June 2013

Product inhibition of five Hypocrea jecorina cellulases.

Enzyme Microb Technol 2013 Mar 14;52(3):163-9. Epub 2013 Jan 14.

Roskilde University, NSM, Research Unit for Functional Biomaterials, 1 Universitetsvej, DK-4000 Roskilde, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.enzmictec.2013.01.002DOI Listing
March 2013

Post-translational modifications of nuclear receptors and human disease.

Nucl Recept Signal 2012 27;10:e001. Epub 2012 Feb 27.

Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1621/nrs.10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309075PMC
May 2012

The role of estrogen receptor-β in breast cancer.

Semin Reprod Med 2012 Jan 23;30(1):5-13. Epub 2012 Jan 23.

Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0031-1299592DOI Listing
January 2012

Oncostatin M suppresses oestrogen receptor-α expression and is associated with poor outcome in human breast cancer.

Endocr Relat Cancer 2012 Apr 10;19(2):181-95. Epub 2012 Apr 10.

Deeley Research Centre, BC Cancer Agency, Victoria, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-11-0326DOI Listing
April 2012

Comparative evaluation of ERα and ERβ significance in breast cancer: state of the art.

Expert Rev Endocrinol Metab 2011 May;6(3):333-343

a Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Ave, Winnipeg, Manitoba, R3E 0V9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/eem.11.27DOI Listing
May 2011

A kinetic model for the burst phase of processive cellulases.

FEBS J 2011 May 28;278(9):1547-60. Epub 2011 Mar 28.

Roskilde University, NSM, Research Unit for Biomaterials, Roskilde, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2011.08078.xDOI Listing
May 2011

Clinical significance of estrogen receptor phosphorylation.

Endocr Relat Cancer 2011 Feb 19;18(1):R1-14. Epub 2011 Jan 19.

Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/ERC-10-0070DOI Listing
February 2011

Advantages of isothermal titration calorimetry for xylanase kinetics in comparison to chemical-reducing-end assays.

Anal Biochem 2011 Mar 11;410(1):19-26. Epub 2010 Nov 11.

Department of Science, Systems, and Models (NSM), Biomaterials, Roskilde University, DK-4000 Roskilde, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2010.11.001DOI Listing
March 2011

Assay development for the determination of phosphorylation stoichiometry using multiple reaction monitoring methods with and without phosphatase treatment: application to breast cancer signaling pathways.

Anal Chem 2010 Jul;82(13):5610-20

Genome BC - UVic Proteomics Centre and Department of Biochemistry and Microbiology, University of Victoria, #3101-4464 Markham Street, Victoria, British Columbia, Canada V8Z-7X8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac1005553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909760PMC
July 2010

An enzymatic signal amplification system for calorimetric studies of cellobiohydrolases.

Anal Biochem 2010 Sep 10;404(2):140-8. Epub 2010 May 10.

Department of Science, Systems, and Models (NSM), Biomaterials, Roskilde University, DK-4000 Roskilde, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2010.04.020DOI Listing
September 2010

A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer.

Endocr Relat Cancer 2010 Sep 3;17(3):589-97. Epub 2010 Jun 3.

Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/ERC-10-0030DOI Listing
September 2010

Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice.

Can J Physiol Pharmacol 2009 Oct;87(10):831-8

Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0W3, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/Y09-073DOI Listing
October 2009

Estrogen receptor alpha phosphorylated at tyrosine 537 is associated with poor clinical outcome in breast cancer patients treated with tamoxifen.

Horm Cancer 2010 Aug;1(4):215-21

Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, R3E 0V9, MB, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12672-010-0049-zDOI Listing
August 2010

Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides.

Nucleic Acids Res 2009 Jul 29;37(13):4518-31. Epub 2009 May 29.

Department of Biochemistry & Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E0W3, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkp441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715257PMC
July 2009

The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo.

J Steroid Biochem Mol Biol 2009 Mar 6;114(1-2):90-5. Epub 2009 Feb 6.

Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2009.01.017DOI Listing
March 2009

Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype.

Virchows Arch 2009 Jun 23;454(6):647-56. Epub 2009 Apr 23.

Department of Pathology, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E0W3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-009-0770-6DOI Listing
June 2009

Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas.

Breast Cancer Res Treat 2009 Dec 23;118(3):443-53. Epub 2008 Dec 23.

Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-008-0267-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448371PMC
December 2009

Influence of evolution in tumor biobanking on the interpretation of translational research.

Cancer Epidemiol Biomarkers Prev 2008 Dec;17(12):3344-50

Tumour Tissue Repository and Deeley Research Center, BC Cancer Agency, Victoria, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
Publisher Site
http://dx.doi.org/10.1158/1055-9965.EPI-08-0622DOI Listing
December 2008

Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha.

Breast Cancer Res Treat 2009 Nov 21;118(2):269-79. Epub 2008 Oct 21.

Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Ave, Winnipeg, MB, Canada R3E 0V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-008-0221-0DOI Listing
November 2009

Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target.

J Steroid Biochem Mol Biol 2008 Mar 8;109(1-2):1-10. Epub 2007 Dec 8.

Manitoba Institute of Cell Biology, Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2007.12.010DOI Listing
March 2008

Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors.

Mol Cell Biochem 2007 Dec 28;306(1-2):33-42. Epub 2007 Jul 28.

Manitoba Institute of Cell Biology, Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB, Canada R3E 0V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-007-9551-1DOI Listing
December 2007

S100A7 (psoriasin) influences immune response genes in human breast cancer.

Exp Cell Res 2007 Aug 30;313(14):3016-25. Epub 2007 Mar 30.

Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2007.03.020DOI Listing
August 2007

Targeting the EGFR pathway for cancer therapy.

Curr Med Chem 2006 ;13(29):3483-92

Department of Internal Medicine, Manitoba Institute of Cell Biology, ON6010-675 McDermot Ave. , University of Manitoba, Winnipeg, MB, R3E 0V9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/092986706779026174DOI Listing
February 2007

Potential role of estrogen receptor alpha (ERalpha) phosphorylated at Serine118 in human breast cancer in vivo.

J Steroid Biochem Mol Biol 2006 Dec 7;102(1-5):139-46. Epub 2006 Nov 7.

Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Man. R3E 0V9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2006.09.021DOI Listing
December 2006

Estrogen receptor-alpha phosphorylated at Ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression.

Cancer Res 2006 Oct;66(20):10162-70

Department of Biochemistry and Medical Genetics and Department of Pathology, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-05-4111DOI Listing
October 2006

Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer.

Breast Cancer Res Treat 2007 Jul 29;104(1):75-85. Epub 2006 Sep 29.

Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-006-9390-xDOI Listing
July 2007

The Prohibitins: emerging roles in diverse functions.

J Cell Mol Med 2006 Apr-Jun;10(2):353-63

Department of Physiology, University of Manitoba, Winnipeg, Canada.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933126PMC
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00404.xDOI Listing
August 2006

Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?

Endocr Relat Cancer 2006 Jun;13(2):327-34

Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, and Cancer Care Manitoba Winnipeg, Canada R3E 0V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/erc.1.01141DOI Listing
June 2006

Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions.

Breast Cancer Res Treat 2006 Nov 17;100(1):23-31. Epub 2006 May 17.

Manitoba Institute of Cell Biology, Department of Biochemistry & Medical Genetics, University of Manitoba, 675 McDermot Avenue, R3E 0V9 Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-006-9229-5DOI Listing
November 2006

Prohibitin: a potential target for new therapeutics.

Trends Mol Med 2005 Apr;11(4):192-7

Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2005.02.004DOI Listing
April 2005

Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor alpha in human breast carcinoma.

Clin Cancer Res 2004 Dec;10(24):8720-7

Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-04-1235DOI Listing
December 2004

Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen.

Clin Cancer Res 2004 Sep;10(17):5902-6

Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-04-0191DOI Listing
September 2004

S100 proteins and their influence on pro-survival pathways in cancer.

Biochem Cell Biol 2004 Aug;82(4):508-15

Manitoba Institute of Cell Biology, Winnipeg, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/o04-052DOI Listing
August 2004

S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast.

Breast Cancer Res 2004 26;6(4):R308-15. Epub 2004 Apr 26.

Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/bcr791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC468627PMC
November 2004

S100A7 and the progression of breast cancer.

Breast Cancer Res 2004 4;6(4):153-9. Epub 2004 Jun 4.

Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/bcr816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC468668PMC
November 2004

Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.

Clin Cancer Res 2004 Feb;10(4):1354-9

Manitoba Institute of Cell Biology, Department of Biochemistry, University of Manitoba, Winnipeg, Manitoba, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.ccr-03-0112DOI Listing
February 2004

New insights into estrogen receptor function in human breast cancer.

Ann Med 2003 ;35(8):614-31

Manitoba Institute of Cell Biology, Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07853890310014579DOI Listing
April 2004

Relationship between mammaglobin expression and estrogen receptor status in breast tumors.

Endocrine 2003 Aug;21(3):245-50

Departments of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3EOW3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/ENDO:21:3:245DOI Listing
August 2003

Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer.

Clin Cancer Res 2003 Jul;9(7):2627-31

Departments of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada.

View Article

Download full-text PDF

Source
July 2003

Psoriasin interacts with Jab1 and influences breast cancer progression.

Cancer Res 2003 Apr;63(8):1954-61

Department of Pathology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada.

View Article

Download full-text PDF

Source
April 2003

Identification of new human coding steroid receptor RNA activator isoforms.

Biochem Biophys Res Commun 2003 Feb;301(2):509-15

Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3EOW3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0006-291x(02)03070-xDOI Listing
February 2003

Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer.

Clin Cancer Res 2003 Jan;9(1):207-14

Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada.

View Article

Download full-text PDF

Source
January 2003

Analysis of gene expression in ductal carcinoma in situ of the breast.

Clin Cancer Res 2002 Dec;8(12):3788-95

Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada.

View Article

Download full-text PDF

Source
December 2002

Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression.

Clin Cancer Res 2002 Jun;8(6):1747-53

Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, R3E 0W3 Canada.

View Article

Download full-text PDF

Source
June 2002

Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium.

Cancer Res 2002 May;62(10):2736-40

Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.

View Article

Download full-text PDF

Source
May 2002