Leif Bertilsson

Leif Bertilsson

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Leif Bertilsson

Publications by authors named "Leif Bertilsson"

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Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin.

Eur J Clin Pharmacol 2018 Nov 12;74(11):1405-1415. Epub 2018 Jul 12.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-018-2499-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182598PMC
November 2018

Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype.

Sci Rep 2018 11 5;8(1):16316. Epub 2018 Nov 5.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://www.nature.com/articles/s41598-018-34674-3
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http://dx.doi.org/10.1038/s41598-018-34674-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218524PMC
November 2018

N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians.

Eur J Clin Pharmacol 2018 Jul 27;74(7):903-911. Epub 2018 Mar 27.

Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.

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http://link.springer.com/10.1007/s00228-018-2448-y
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http://dx.doi.org/10.1007/s00228-018-2448-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999125PMC
July 2018

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients.

BMC Pharmacol Toxicol 2018 06 25;19(1):33. Epub 2018 Jun 25.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, SE-141 86, Stockholm, Sweden.

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https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40360-018-0221-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020207PMC
June 2018

Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.

Basic Clin Pharmacol Toxicol 2017 Oct;121(4):266-271

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/bcpt.12710DOI Listing
October 2017

Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients.

J Clin Pharmacol 2016 12 29;56(12):1538-1549. Epub 2016 May 29.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.756DOI Listing
December 2016

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study.

Medicine (Baltimore) 2016 Aug;95(34):e4631

aDepartment of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden bDepartment of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia cDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden dDepartment of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/MD.0000000000004631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400328PMC
August 2016

Is there a need to increase the dose of efavirenz during concomitant rifampicin-based antituberculosis therapy in sub-Saharan Africa? The HIV-TB pharmagene study.

Pharmacogenomics 2015 1;16(10):1047-64. Epub 2015 Apr 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, C-168, Karolinska Institutet, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.15.35DOI Listing
June 2016

The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.

J Clin Psychopharmacol 2015 Dec;35(6):694-9

From the *Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; †CICAB Clinical Research Centre, Extremadura University Hospital and Medical School, Badajoz, Spain; and ‡Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital-Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1097/JCP.0000000000000413DOI Listing
December 2015

Genetic and Clinical Factors Affecting Plasma Clozapine Concentration.

Prim Care Companion CNS Disord 2015 19;17(1). Epub 2015 Feb 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, and Department of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB, Stockholm (Dr Olsson); Department of Psychiatry, Tiohundra AB, Norrtälje (Drs Edman and Ösby and Ms Hukic); Department of Neurobiology, Care Sciences and Society, Centre of Family Medicine, Karolinska Institutet, Stockholm (Drs Edman and Ösby); Center for Molecular Medicine, Karolinska University Hospital, Stockholm (Drs Edman, Lavebratt, and Ösby); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm (Dr Bertilsson); Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Drs Hukic and Lavebratt); and Department of Cardiology, Danderyd University Hospital, Karolinska Institutet, Stockholm (Dr Eriksson), Sweden.

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http://dx.doi.org/10.4088/PCC.14m01704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468884PMC
July 2015

Differences in CYP2C9 Genotype and Enzyme Activity Between Swedes and Koreans of Relevance for Personalized Medicine: Role of Ethnicity, Genotype, Smoking, Age, and Sex.

OMICS 2015 Jun 15;19(6):346-53. Epub 2015 May 15.

1 Department of Laboratory Medicine, Karolinska Institutet, Division of Clinical Pharmacology, Karolinska University Hospital , Huddinge, Sweden .

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http://dx.doi.org/10.1089/omi.2015.0022DOI Listing
June 2015

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.

Drug Metab Pharmacokinet 2014 11;29(4):352-5. Epub 2014 Feb 11.

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge.

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May 2015

Plasma levels of 25-hydroxyvitamin D3 and in vivo markers of cytochrome P450 3A activity in Swedes and Koreans: effects of a genetic polymorphism and oral contraceptives.

Basic Clin Pharmacol Toxicol 2014 Oct 11;115(4):366-71. Epub 2014 Apr 11.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12230DOI Listing
October 2014

Comparisons of CYP2A6 genotype and enzyme activity between Swedes and Koreans.

Drug Metab Pharmacokinet 2013 24;28(2):93-7. Epub 2012 Jul 24.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden.

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July 2014

High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.

OMICS 2014 Jul 31;18(7):446-53. Epub 2013 Dec 31.

1 Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital , Karolinska Institutet, Stockholm, Sweden .

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http://dx.doi.org/10.1089/omi.2013.0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086241PMC
July 2014

Risperidone metabolic ratio as a biomarker of individual CYP2D6 genotype in schizophrenic patients.

Eur J Clin Pharmacol 2014 Jun 20;70(6):695-9. Epub 2014 Mar 20.

Karolinska Institutet, Department of Clinical Science and Education at Södersjukhuset, Stockholm, Sweden,

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http://link.springer.com/10.1007/s00228-014-1664-3
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http://dx.doi.org/10.1007/s00228-014-1664-3DOI Listing
June 2014

Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.

Drug Metab Dispos 2013 Aug 14;41(8):1488-93. Epub 2013 May 14.

Division of Clinical Pharmacology C1-68, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1124/dmd.113.052316DOI Listing
August 2013

Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans.

J Clin Pharmacol 2012 Oct 21;52(10):1527-34. Epub 2011 Nov 21.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1177/0091270011420261DOI Listing
October 2012

Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance.

Drug Metab Pharmacokinet 2012 20;27(1):55-67. Epub 2011 Dec 20.

Pharmacogenomics Centre PROMISE, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor DE, Malaysia.

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July 2012

Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes.

Eur J Clin Pharmacol 2012 Jul 1;68(7):1033-42. Epub 2012 Feb 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet-Karolinska University Hospital, Huddinge 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-012-1210-0DOI Listing
July 2012

Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation.

Eur J Clin Pharmacol 2012 May 9;68(5):571-7. Epub 2011 Dec 9.

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00228-011-1163-8
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http://dx.doi.org/10.1007/s00228-011-1163-8DOI Listing
May 2012

Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.

Eur J Clin Pharmacol 2011 Jul 19;67(7):715-22. Epub 2011 Jan 19.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00228-010-0984-1
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http://dx.doi.org/10.1007/s00228-010-0984-1DOI Listing
July 2011

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.

Br J Clin Pharmacol 2011 Feb;71(2):183-9

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2010.03773.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040538PMC
February 2011

CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking.

Eur J Clin Pharmacol 2010 Sep 25;66(9):871-7. Epub 2010 May 25.

Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital-Huddinge C1:68, 14186 Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00228-010-0835
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http://link.springer.com/10.1007/s00228-010-0835-0
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http://dx.doi.org/10.1007/s00228-010-0835-0DOI Listing
September 2010

Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.

Eur J Clin Pharmacol 2010 Aug 20;66(8):791-5. Epub 2010 Apr 20.

Department of Laboratory Medicine, Karolinska Institutet, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden.

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http://link.springer.com/10.1007/s00228-010-0820-7
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http://dx.doi.org/10.1007/s00228-010-0820-7DOI Listing
August 2010

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.

Br J Clin Pharmacol 2011 Feb;71(2):183-9

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2010.03773.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040538PMC
February 2011

Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients.

Eur J Clin Pharmacol 2010 May 9;66(5):465-74. Epub 2010 Feb 9.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge-Karolinska Institutet, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-009-0783-8DOI Listing
May 2010

Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease.

Eur J Clin Pharmacol 2010 Mar 26;66(3):269-73. Epub 2009 Nov 26.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-009-0759-8DOI Listing
March 2010

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.

Pharmacogenomics J 2009 Jun 10;9(3):208-17. Epub 2009 Mar 10.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

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http://www.nature.com/articles/tpj20094
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http://dx.doi.org/10.1038/tpj.2009.4DOI Listing
June 2009

MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs.

Eur Neuropsychopharmacol 2009 May 14;19(5):363-70. Epub 2009 Feb 14.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.euroneuro.2009.01.006DOI Listing
May 2009

4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.

Br J Clin Pharmacol 2009 Jan 6;67(1):38-43. Epub 2008 Nov 6.

Division of Clinical Chemistry, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2008.03309.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668082PMC
January 2009

CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction.

Eur J Clin Pharmacol 2008 Dec 22;64(12):1163-73. Epub 2008 Jul 22.

Course of Clinical Pharmacology, Department of Hospital Therapy, St. Petersburg State Medical Academy named after I.I. Mechnikov, Piskarevsky Prospect 47, 195067 St. Petersburg, Russia.

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http://dx.doi.org/10.1007/s00228-008-0525-3DOI Listing
December 2008

Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects.

Eur J Clin Pharmacol 2008 Dec 25;64(12):1175-9. Epub 2008 Jul 25.

Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00228-008-0529-z
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http://dx.doi.org/10.1007/s00228-008-0529-zDOI Listing
December 2008

Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.

Br J Clin Pharmacol 2008 May 12;65(5):708-15. Epub 2008 Feb 12.

Division of Paediatrics, Department of Clinical Sciences, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2007.03078.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432481PMC
May 2008

Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes.

Eur J Clin Pharmacol 2008 Apr 22;64(4):381-5. Epub 2007 Dec 22.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, C1: 68, SE-14186, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-007-0438-6DOI Listing
April 2008

Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI).

Eur J Clin Pharmacol 2008 Mar 29;64(3):275-82. Epub 2007 Nov 29.

Course of Clinical Pharmacology, Department of Hospital Therapy, St. Petersburg I.I. Mechnikov State Medical Academy, Piskarevsky Prospect, 47, 195 067 St Petersburg, Russia.

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http://link.springer.com/10.1007/s00228-007-0404-3
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http://dx.doi.org/10.1007/s00228-007-0404-3DOI Listing
March 2008

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Pharmacogenet Genomics 2008 Mar;18(3):201-8

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e3282f50ee9DOI Listing
March 2008

Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression.

Neuropsychopharmacology 2007 Oct 14;32(10):2143-51. Epub 2007 Feb 14.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge,C-168,SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.npp.1301336DOI Listing
October 2007

Voriconazole and fluconazole increase the exposure to oral diazepam.

Eur J Clin Pharmacol 2007 Oct 4;63(10):941-9. Epub 2007 Aug 4.

Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, 20520, Turku, Finland.

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http://link.springer.com/10.1007/s00228-007-0350-0
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http://dx.doi.org/10.1007/s00228-007-0350-0DOI Listing
October 2007

Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population.

Fundam Clin Pharmacol 2007 Aug;21(4):379-86

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, 3rd floor, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1111/j.1472-8206.2007.00494.xDOI Listing
August 2007

Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans.

Eur J Clin Pharmacol 2007 Jun 17;63(6):537-46. Epub 2007 Mar 17.

Division of Clinical Pharmacology, Karolinska University Hospital-Huddinge, Karolinska Institutet, C1-68, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-007-0288-2DOI Listing
June 2007

CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

Pharmacogenet Genomics 2007 May;17(5):339-47

Biomarker and Clinical Pharmacology Unit, VA Long Beach Medical Center, and School of Medicine, University of California-Irvine, 3844 East 15th Street, Long Beach, Irvine, CA 90804, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32801a3c10DOI Listing
May 2007

Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.

Eur J Clin Pharmacol 2007 Feb 3;63(2):173-9. Epub 2007 Jan 3.

Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology at Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-006-0230-zDOI Listing
February 2007

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.

Pharmacogenet Genomics 2006 Sep;16(9):637-45

Department of Clinical Toxicology, Central Laboratories & Blood Bank, King Fahad Medical City, Riyadh 11525, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1097/01.fpc.0000230411.89973.1bDOI Listing
September 2006

Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.

Pharmacogenet Genomics 2006 Aug;16(8):565-8

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1097/01.fpc.0000215070.52212.0eDOI Listing
August 2006

Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.

Eur J Clin Pharmacol 2006 Jul 17;62(7):539-46. Epub 2006 Jun 17.

Division of Clinical Pharmacology C1:68, Karolinska University Hospital - Huddinge, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-006-0121-3DOI Listing
July 2006

Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines.

Expert Opin Pharmacother 2006 Feb;7(2):119-33

VA Long Beach Healthcare System, Southern California Institute for Research and Education, Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, Long Beach, CA 90822, USA.

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http://dx.doi.org/10.1517/14656566.7.2.119DOI Listing
February 2006

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.

Clin Pharmacol Ther 2006 Jan;79(1):103-13

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm.

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http://dx.doi.org/10.1016/j.clpt.2005.10.002DOI Listing
January 2006

Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles.

Biochem Biophys Res Commun 2005 Dec 13;338(1):299-305. Epub 2005 Sep 13.

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2005.09.020DOI Listing
December 2005

Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects.

Eur J Clin Pharmacol 2005 Apr 2;61(2):113-8. Epub 2005 Apr 2.

Division of Clinical Pharmacology C1:68, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-004-0861-xDOI Listing
April 2005

Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy.

Ther Drug Monit 2004 Dec;26(6):685-7

Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1097/00007691-200412000-00016DOI Listing
December 2004

Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes.

Basic Clin Pharmacol Toxicol 2004 Sep;95(3):112-9

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1742-7843.2004.950302.xDOI Listing
September 2004

Dose of proton pump inhibitors and the CYP2C19 genotype.

Authors:
Leif Bertilsson

Basic Clin Pharmacol Toxicol 2004 Jul;95(1)

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http://dx.doi.org/10.1111/j.1742-7843.2004.pto950101.xDOI Listing
July 2004

Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study.

Eur J Clin Pharmacol 2004 Jan 2;59(11):803-7. Epub 2003 Dec 2.

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, 14186 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-003-0701-4DOI Listing
January 2004

Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.

Br J Clin Pharmacol 2003 Dec;56(6):679-82

Department of Psychiatry and Institute of Occupational, Social and Environmental Medicine University of Mainz, Mainz, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884289PMC
http://dx.doi.org/10.1046/j.1365-2125.2003.01933.xDOI Listing
December 2003

Xanthine oxidase activity is influenced by environmental factors in Ethiopians.

Eur J Clin Pharmacol 2003 Oct 21;59(7):533-6. Epub 2003 Aug 21.

Division of Molecular Toxicology, IMM, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-003-0653-8DOI Listing
October 2003

Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes.

Br J Clin Pharmacol 2003 Oct;56(4):415-21

Division of Clinical Pharmacology at Department of Medicine Laboratory, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884377PMC
http://dx.doi.org/10.1046/j.1365-2125.2003.01874.xDOI Listing
October 2003

Interferon-beta treatment in patients with multiple sclerosis does not alter CYP2C19 or CYP2D6 activity.

Br J Clin Pharmacol 2003 Sep;56(3):337-40

Division of Clinical Pharmacology, Department of Laboratory Medicine, NEUROTEC, Karolinska Institutet at Huddinge University Hospital, S-141 86 Huddinge, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884353PMC
http://dx.doi.org/10.1046/j.0306-5251.2003.01859.xDOI Listing
September 2003

Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.

Mol Pharmacol 2003 Sep;64(3):659-69

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1124/mol.64.3.659DOI Listing
September 2003

Metabolism and elimination of quinine in healthy volunteers.

Eur J Clin Pharmacol 2003 Sep 12;59(5-6):423-7. Epub 2003 Aug 12.

Department of Laboratory Medicine and Technology, C1-68 Huddinge University Hospital, 141 86 Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00228-003-0637
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http://link.springer.com/10.1007/s00228-003-0637-8
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http://dx.doi.org/10.1007/s00228-003-0637-8DOI Listing
September 2003

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

Clin Pharmacol Ther 2003 Jun;73(6):517-28

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0009-9236(03)00050-XDOI Listing
June 2003

Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

Eur J Clin Pharmacol 2003 May 11;59(1):23-8. Epub 2003 Mar 11.

Division of Clinical Pharmacology, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet and Hospital Pharmacy, C1-68 Huddinge University Hospital, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-003-0575-5DOI Listing
May 2003

Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).

Clin Pharmacol Ther 2002 Mar;71(3):141-52

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology at Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1067/mcp.2002.121788DOI Listing
March 2002

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs.

Br J Clin Pharmacol 2002 Feb;53(2):111-22

Department of Medical Laboratory Sciences & Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874287PMC
http://dx.doi.org/10.1046/j.0306-5251.2001.01548.xDOI Listing
February 2002

The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity.

Clin Pharmacol Ther 2002 Jan;71(1):77-88

Division of Clinical Pharmacology, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet at Huddinge University Hospital, Stockholm.

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http://dx.doi.org/10.1067/mcp.2002.120239DOI Listing
January 2002

Electroconvulsive Therapy Effects on Cerebrospinal Fluid Monoamine Metabolites and Platelet Serotonin Uptake In Melancholia.

Convuls Ther 1986 ;2(2):91-98

Department of Psychiatry, Danderyd Hospital, Danderyd, Sweden.

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January 1986