Dr. Lei Xi, MD - Virginia Commonwealth University - Associate Professor of Medicine

Dr. Lei Xi

MD

Virginia Commonwealth University

Associate Professor of Medicine

Richmond, Virginia | United States

Main Specialties: Biology, Cardiovascular Disease, Endocrinology Diabetes & Metabolism, Pharmacology, Sports Medicine

Additional Specialties: Cardiovascular Research

ORCID logohttps://orcid.org/0000-0002-7569-3329

Dr. Lei Xi, MD - Virginia Commonwealth University - Associate Professor of Medicine

Dr. Lei Xi

MD

Introduction

Primary Affiliation: Virginia Commonwealth University - Richmond, Virginia , United States

Specialties:

Additional Specialties:

Research Interests:

Experience

Jul 2011
Virginia Commonwealth University School of Medicine
Associate Professor
Internal Medicine - Cardiology
Jul 2000 - Jun 2005
Virginia Commonwealth University School of Medicine
Instructor
Internal Medicine - Cardiology
Jul 1996 - Jun 2000
Virginia Commonwealth University School of Medicine
Postdoctoral Associate
Internal Medicine - Cardiology
Jul 1996 - Jun 2000
Virginia Commonwealth University School of Medicine
Postdoctoral Associate
Internal Medicine - Cardiology
Aug 1990 - Dec 1992
University of Wisconsin–Madison
Research Associate
Preventive Medicine
Mar 1988 - Jun 1990
University of Geneva
Research Assistant
Physiology
Aug 1983 - Oct 1987
State Commission of Physical Culture and Sports
Team Physician
Medicine

Publications

84Publications

556Reads

1340Profile Views

1PubMed Central Citations

Beet Juice as Nutraceutical Remedy for Alleviating Pulmonary Arterial Hypertension: Searching for Optimal Treatment Timing and Nitrate Dose.

Authors:
Lei Xi

Am J Hypertens 2019 Jan;32(2):135-138

Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://dx.doi.org/10.1093/ajh/hpy181DOI Listing
January 2019
2 Reads
2.852 Impact Factor

Circulating biomarkers for cardiovascular diseases: the beats never stop.

Acta Pharmacol Sin 2018 07;39(7):1065-1067

Heart & Vascular Institute, Johns Hopkins University, Baltimore, 21205, MD, USA.

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http://dx.doi.org/10.1038/aps.2018.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289340PMC
July 2018
5 Reads
1 Citation
2.500 Impact Factor

Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes.

J Diabetes Res 2016 21;2016:1527852. Epub 2016 Jun 21.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1155/2016/1527852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932165PMC
May 2017
5 Reads

PDE5 Inhibitor Tadalafil and Hydroxychloroquine Cotreatment Provides Synergistic Protection against Type 2 Diabetes and Myocardial Infarction in Mice.

J Pharmacol Exp Ther 2017 04 25;361(1):29-38. Epub 2017 Jan 25.

Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University. Richmond, Virginia

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http://dx.doi.org/10.1124/jpet.116.239087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363764PMC
April 2017
9 Reads
3.972 Impact Factor

Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs.

Oxid Med Cell Longev 2016 17;2016:8139861. Epub 2016 Oct 17.

Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298-0204, USA; School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China.

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http://dx.doi.org/10.1155/2016/8139861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086499PMC
March 2017
9 Reads

Intermittent hypoxia training as non-pharmacologic therapy for cardiovascular diseases: Practical analysis on methods and equipment.

Exp Biol Med (Maywood) 2016 Sep 12;241(15):1708-23. Epub 2016 Jul 12.

Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298-0204, USA Department of Sports Medicine, Chengdu Sport University, Chengdu 610041, China

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http://dx.doi.org/10.1177/1535370216657614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999622PMC
September 2016
10 Reads

Visnagin-a new protectant against doxorubicin cardiotoxicity? Inhibition of mitochondrial malate dehydrogenase 2 (MDH2) and beyond.

Authors:
Lei Xi

Ann Transl Med 2016 Feb;4(4):65

Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298-0204, USA.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.10.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779788PMC
February 2016
4 Reads

Postconditioning of ischemic heart by intermittent ventricular pacing at the beginning of reperfusion: novel mechanisms and potential utilities in interventional cardiology settings.

Authors:
Feiyan Yang Lei Xi

Am J Physiol Heart Circ Physiol 2016 Jan 13;310(1):H1-3. Epub 2015 Nov 13.

Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia; and

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http://dx.doi.org/10.1152/ajpheart.00835.2015DOI Listing
January 2016
6 Reads
3.840 Impact Factor

Intermittent hypoxia in childhood: the harmful consequences versus potential benefits of therapeutic uses.

Front Pediatr 2015 19;3:44. Epub 2015 May 19.

Department of Internal Medicine, Virginia Commonwealth University , Richmond, VA , USA.

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http://dx.doi.org/10.3389/fped.2015.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436817PMC
June 2015
6 Reads

Inosine and hypoxanthine as novel biomarkers for cardiac ischemia: from bench to point-of-care.

Exp Biol Med (Maywood) 2015 Jun 8;240(6):821-31. Epub 2015 May 8.

Division of Cardiology, Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, Richmond VA 23298, USA

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http://dx.doi.org/10.1177/1535370215584931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935215PMC
June 2015
7 Reads

Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S.

Exp Biol Med (Maywood) 2015 May 30;240(5):669-81. Epub 2014 Oct 30.

Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA

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http://dx.doi.org/10.1177/1535370214558024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935262PMC
May 2015
21 Reads

Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance.

Mol Cell Biochem 2015 Apr 1;402(1-2):41-9. Epub 2015 Jan 1.

Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Box 980204, 1101 East Marshall Street, Room 7-020D, Richmond, VA, 23298-0204, USA.

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http://dx.doi.org/10.1007/s11010-014-2312-zDOI Listing
April 2015
8 Reads
2.393 Impact Factor

PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer.

Pharmacol Ther 2015 Mar 31;147:12-21. Epub 2014 Oct 31.

Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494657PMC
March 2015
22 Reads
9.723 Impact Factor

Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice.

PLoS One 2014 22;9(1):e86977. Epub 2014 Jan 22.

VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086977PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899366PMC
September 2014
10 Reads
3.234 Impact Factor

Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.

Am J Physiol Heart Circ Physiol 2014 Jun 11;306(11):H1558-68. Epub 2014 Apr 11.

Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia

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http://www.physiology.org/doi/10.1152/ajpheart.00865.2013
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00865.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042195PMC
June 2014
10 Reads
3.840 Impact Factor

Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

J Biol Chem 2014 Feb 26;289(7):4145-60. Epub 2013 Dec 26.

From the Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia 23298.

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http://dx.doi.org/10.1074/jbc.M113.521062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924280PMC
February 2014
11 Reads
4.573 Impact Factor

Intermittent Hypoxia and Atherosclerosis

Intermittent Hypoxia and Human Diseases

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2012
1 Read

Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.

Exp Clin Cardiol 2011 ;16(4):e30-5

Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University Pauley Heart Center, Richmond, Virginia, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206106PMC
August 2012
7 Reads
0.760 Impact Factor

Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.

Nitric Oxide 2012 May 5;26(4):274-84. Epub 2012 Apr 5.

VCU Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298-0204, United States.

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http://dx.doi.org/10.1016/j.niox.2012.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360792PMC
May 2012
13 Reads
3.521 Impact Factor

Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase δ and Echs1.

J Cell Mol Med 2012 Apr;16(4):950-8

Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23298-0204, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01376.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204159PMC
April 2012
7 Reads

Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.

Basic Res Cardiol 2012 Mar 7;107(2):249. Epub 2012 Feb 7.

Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University Medical Center, 1101 East Marshall Street, Room 7-020D, Box 980204, Richmond, VA 23298-0204, USA.

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http://link.springer.com/10.1007/s00395-012-0249-5
Publisher Site
http://dx.doi.org/10.1007/s00395-012-0249-5DOI Listing
March 2012
9 Reads
5.414 Impact Factor

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

J Cell Mol Med 2011 Nov;15(11):2512-24

VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298–0204, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01257.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110615PMC
November 2011
5 Reads

A rapid and simple chemiluminescence method for screening levels of inosine and hypoxanthine in non-traumatic chest pain patients.

Luminescence 2011 Jan-Feb;26(1):65-75. Epub 2009 Dec 16.

Department of Internal Medicine, Divisions of Nephrology, Clinical Pharmacology and Hypertension, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1002/bio.1187DOI Listing
June 2011
8 Reads
1.520 Impact Factor

Dietary nitrate supplementation protects against Doxorubicin-induced cardiomyopathy by improving mitochondrial function.

J Am Coll Cardiol 2011 May;57(21):2181-9

VCU Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia 23298-0204, USA.

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http://dx.doi.org/10.1016/j.jacc.2011.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127335PMC
May 2011
8 Reads
16.503 Impact Factor

A simple and sensitive HPLC fluorescence method for determination of tadalafil in mouse plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2010 Oct 3;878(28):2891-5. Epub 2010 Aug 3.

Department of Internal Medicine, Division of Nephrology, Clinical Pharmacology and Hypertension, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.jchromb.2010.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950224PMC
October 2010
6 Reads
2.730 Impact Factor

Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.

J Pharmacol Exp Ther 2010 Sep 11;334(3):1023-30. Epub 2010 Jun 11.

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.

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http://dx.doi.org/10.1124/jpet.110.170191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939673PMC
September 2010
7 Reads
3.972 Impact Factor

Hypoxia inducible factor 1 (HIF-1) and cardioprotection.

Acta Pharmacol Sin 2010 Sep 16;31(9):1085-94. Epub 2010 Aug 16.

John P Hussman Institute for Human Genomics, University of Miami, FL, USA.

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http://dx.doi.org/10.1038/aps.2010.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002308PMC
September 2010
8 Reads
2.500 Impact Factor

ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

Am J Physiol Heart Circ Physiol 2009 May 13;296(5):H1236-43. Epub 2009 Mar 13.

Division of Cardiology, Department of Internal Medicine, Box 980281, Virginia Commonwealth Univ. Medical Center, 1101 East Marshall St., Rm. 7-040, Richmond, VA 23298-0281, USA.

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http://dx.doi.org/10.1152/ajpheart.00100.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685342PMC
May 2009
11 Reads
3.840 Impact Factor

Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts.

Acta Pharmacol Sin 2009 Jan 8;30(1):1-24. Epub 2008 Dec 8.

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298-0204, USA.

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http://dx.doi.org/10.1038/aps.2008.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006539PMC
January 2009
3 Reads
2.500 Impact Factor

Commentaries on viewpoint: effect of altitude on leptin, does it go up or down?

J Appl Physiol (1985) 2008 Nov;105(5):1687-8

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November 2008
6 Reads

Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta.

J Biol Chem 2008 Oct 21;283(43):29572-85. Epub 2008 Aug 21.

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1074/jbc.M801547200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570896PMC
October 2008
7 Reads
4.573 Impact Factor

Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.

Circulation 2008 Sep;118(14 Suppl):S32-7

Division of Cardiology, Box 980204, Virginia Commonwealth University, 1101 East Marshall Street, Room 7-042, Richmond, VA 23298-0204, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.752865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057199PMC
September 2008
9 Reads
14.430 Impact Factor

Essential role of mitochondrial Ca2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection.

J Mol Cell Cardiol 2008 Jan 16;44(1):105-13. Epub 2007 Oct 16.

Division of Cardiology, Department of Internal Medicine, Box 980204, Virginia Commonwealth University, 1101 East Mashall Street, Room 7-046, Richmond, VA 23298-0204, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2007.10.006DOI Listing
January 2008
7 Reads
4.660 Impact Factor

Effects of salicylic acid on post-ischaemic ventricular function and purine efflux in isolated mouse hearts.

Biomarkers 2007 Nov-Dec;12(6):623-34

Department of Pharmaceutics, VCU Medical Center, Virginia Commonwealth University, Richmond, VA 23298-0533, USA.

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http://dx.doi.org/10.1080/13547500701605786 DOI Listing
December 2007
32 Reads
2.522 Impact Factor

Hypercholesterolemia enhances tolerance to lethal systemic hypoxia in middle-aged mice: possible role of VEGF downregulation in brain.

Mol Cell Biochem 2006 Oct 23;291(1-2):205-11. Epub 2006 May 23.

Division of Cardiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1007/s11010-006-9194-7DOI Listing
October 2006
5 Reads
2.393 Impact Factor

Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes.

J Mol Cell Cardiol 2006 Aug;41(2):256-64

Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University Medical Center, Richmond, 23298, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2006.04.014DOI Listing
August 2006
8 Reads
4.660 Impact Factor

Genetic deletion of fas receptors or Fas ligands does not reduce infarct size after acute global ischemia-reperfusion in isolated mouse heart.

Cell Biochem Biophys 2006 ;44(1):111-7

Department of Physiology, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1385/CBB:44:1:111DOI Listing
April 2006
7 Reads
1.680 Impact Factor

Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications.

Vascul Pharmacol 2005 Apr-May;42(5-6):219-32. Epub 2005 Mar 29.

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, P.O. Box 980281, 1101 East Mashall Street, Room 7-046, Richmond, VA 23298-0281, USA.

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http://dx.doi.org/10.1016/j.vph.2005.02.010DOI Listing
November 2005
8 Reads
4.620 Impact Factor

Silencing heat shock factor 1 by small interfering RNA abrogates heat shock-induced cardioprotection against ischemia-reperfusion injury in mice.

J Mol Cell Cardiol 2005 Oct;39(4):681-9

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0281, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2005.06.005DOI Listing
October 2005
11 Reads
4.660 Impact Factor

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

J Biol Chem 2005 Apr 24;280(13):12944-55. Epub 2005 Jan 24.

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0281, USA.

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http://dx.doi.org/10.1074/jbc.M404706200DOI Listing
April 2005
10 Reads
4.573 Impact Factor

Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.

Am J Physiol Heart Circ Physiol 2004 Dec 29;287(6):H2369-75. Epub 2004 Jul 29.

Division of Cardiology, Box 980281, Virginia Commonwealth Univ., Richmond, VA 23298-0281, USA.

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http://dx.doi.org/10.1152/ajpheart.00422.2004DOI Listing
December 2004
8 Reads
3.840 Impact Factor

Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice.

Am J Physiol Heart Circ Physiol 2004 Nov 24;287(5):H2070-7. Epub 2004 Jun 24.

Division of Cardiology, Box 980281, Virginia Commonwealth Univ., Richmond, VA 23298-0281, USA.

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http://dx.doi.org/10.1152/ajpheart.00431.2004DOI Listing
November 2004
45 Reads
3.840 Impact Factor

Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy.

J Mol Cell Cardiol 2004 Feb;36(2):165-73

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Medical Center, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2003.11.001DOI Listing
February 2004
6 Reads
4.660 Impact Factor

Sildenafil-induced cardioprotection in rabbits.

Cardiovasc Res 2003 Dec;60(3):700-1; author reply 702-3

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December 2003
13 Reads
5.940 Impact Factor

Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

Circ Res 2003 Apr 13;92(6):595-7. Epub 2003 Mar 13.

Division of Cardiology, Box 980281, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1161/01.RES.0000066853.09821.98DOI Listing
April 2003
7 Reads
11.020 Impact Factor

Exercise does not protect the female heart: an unconvincing conclusion?

Authors:
Lei Xi

Circ Res 2002 Aug;91(3):e2

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August 2002
4 Reads
11.020 Impact Factor

Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia.

Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H5-12

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298-0281, USA.

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http://dx.doi.org/10.1152/ajpheart.00920.2001DOI Listing
July 2002
8 Reads
3.840 Impact Factor

Whole body hyperthermia and preconditioning of the heart: basic concepts, complexity, and potential mechanisms.

Int J Hyperthermia 2001 Sep-Oct;17(5):439-55

Department of Internal Medicine, Virginia Commonwealth University, Richmond 23298, USA.

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February 2002
3 Reads
2.645 Impact Factor

Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart.

Am J Physiol Heart Circ Physiol 2001 Aug;281(2):H523-32

Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1152/ajpheart.2001.281.2.H523DOI Listing
August 2001
3 Reads
3.840 Impact Factor

Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction.

Authors:
L Xi R C Kukreja

Toxicology 2000 Nov;155(1-3):37-44

Division of Cardiology, Medical College of Virginia, Virginia Commonwealh University, Richmond, VA 23298, USA.

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November 2000
4 Reads
3.621 Impact Factor

Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.

Circulation 2000 Aug;102(8):902-7

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

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August 2000
4 Reads
14.430 Impact Factor

Glycolipid RC-552 induces delayed preconditioning-like effect via iNOS-dependent pathway in mice.

Am J Physiol 1999 12;277(6):H2418-24

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1152/ajpheart.1999.277.6.H2418DOI Listing
December 1999
3 Reads

Nitric oxide-dependent mechanism of anti-ischemic myocardial protection induced by monophosphoryl lipid A.

Authors:
L Xi

Zhongguo Yao Li Xue Bao 1999 Oct;20(10):865-71

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA.

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October 1999
3 Reads

Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice.

Life Sci 1999 ;65(9):935-45

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

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September 1999
2 Reads
2.702 Impact Factor

Myocardial preconditioning: basic concepts and potential mechanisms.

Mol Cell Biochem 1999 Jun;196(1-2):3-12

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

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June 1999
3 Reads
2.393 Impact Factor

Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice.

Circulation 1999 Apr;99(16):2157-63

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA.

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April 1999
3 Reads
14.430 Impact Factor

Whole body heat shock fails to protect mouse heart against ischemia/reperfusion injury: role of 72 kDa heat shock protein and antioxidant enzymes.

J Mol Cell Cardiol 1998 Nov;30(11):2213-27

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

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http://dx.doi.org/10.1006/jmcc.1998.0781DOI Listing
November 1998
3 Reads
4.660 Impact Factor

Ischemic preconditioning in isolated perfused mouse heart: reduction in infarct size without improvement of post-ischemic ventricular function.

Mol Cell Biochem 1998 Sep;186(1-2):69-77

Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298, USA.

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September 1998
3 Reads
2.393 Impact Factor

Neural-mechanical coupling of breathing in REM sleep.

J Appl Physiol (1985) 1997 Dec;83(6):1923-32

The John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin 53705-2368, USA.

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http://dx.doi.org/10.1152/jappl.1997.83.6.1923DOI Listing
December 1997
4 Reads

The role of pulmonary CO2 flow in the control of the phase I ventilatory response to exercise in humans.

Eur J Appl Physiol Occup Physiol 1995 ;71(4):287-94

Department of Physiology, CMU, Université de Genéve, Switzerland.

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February 1996
3 Reads

Effects of REM sleep on the ventilatory response to airway occlusion in the dog.

Sleep 1994 Dec;17(8):674-87

John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin-Madison 53705.

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December 1994
4 Reads
4.591 Impact Factor

A volume-dependent apneic threshold during NREM sleep in the dog.

J Appl Physiol (1985) 1994 Jun;76(6):2315-25

John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin-Madison 53705.

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http://dx.doi.org/10.1152/jappl.1994.76.6.2315DOI Listing
June 1994
9 Reads

Ventilatory response at the onset of exercise: an update of the neurohumoral theory.

Adv Exp Med Biol 1993 ;337:327-32

Dept. of Physiology, Univ. of Geneva, Milano, I.

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March 1994
4 Reads

Apnoea following normocapnic mechanical ventilation in awake mammals: a demonstration of control system inertia.

J Physiol 1993 Dec;472:749-68

John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison 53705.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160511PMC
December 1993
5 Reads
5.040 Impact Factor

Effects of rapid-eye-movement sleep on the apneic threshold in dogs.

J Appl Physiol (1985) 1993 Sep;75(3):1129-39

John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison 53705.

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http://dx.doi.org/10.1152/jappl.1993.75.3.1129DOI Listing
September 1993
5 Reads

Ventilatory response to exercise after heart and lung denervation in humans.

Respir Physiol 1993 Jun;92(3):289-304

Section of Physiology, ITBA of CNR, Milan, Italy.

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June 1993
4 Reads

Effects of memory from vagal feedback on short-term potentiation of ventilation in conscious dogs.

J Physiol 1993 Mar;462:547-61

John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison 53705-2368.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175314PMC
March 1993
3 Reads
5.040 Impact Factor

Effects of acute hypoxia on ventilatory response at the onset of submaximal exercise.

Jpn J Physiol 1990 ;40(3):417-22

Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan.

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February 1991
7 Reads

Top co-authors

Rakesh C Kukreja
Rakesh C Kukreja

Pauley Heart Center

34
Anindita Das
Anindita Das

Pauley Heart Center

15
Fadi Salloum
Fadi Salloum

Pauley Heart Center

7
Chang Yin
Chang Yin

Acupuncture and Meridian Science Research Center

7
Fadi N Salloum
Fadi N Salloum

Pauley Heart Center

7
Saisudha Koka
Saisudha Koka

University of Tübingen

6
Xiaoyin Wang
Xiaoyin Wang

Xinxiang Medical University

5
David Durrant
David Durrant

Massey Cancer Center

4
Edward J Lesnefsky
Edward J Lesnefsky

Pauley Heart Center

3