Publications by authors named "Lei Wang"

10,440 Publications

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A Rare Case of Cysticercosis Involving the Whole Spinal Canal.

Acta Parasitol 2021 Dec 1. Epub 2021 Dec 1.

Emergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Cysticercosis is the commonest parasitic disease to affect the central nervous system (CNS). However, cysticercosis affecting the spine is extremely rare. We reported a rare case of cysticercosis involving the whole spinal canal in China.

Case Presentation: A rare case of cysticercosis involving the entire spinal cord, in a 52-year-old Chinese man, was detected in 2021. Epidemiological investigation, clinical and etiological examination was performed.

Conclusion: Since spinal cysticercosis is a rare but potentially life-threatening disease, clinicians should always consider the differential diagnosis of space-occupying lesions.
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http://dx.doi.org/10.1007/s11686-021-00486-1DOI Listing
December 2021

Remotely Controlling Drug Release by Light-Responsive Cholesteric Liquid Crystal Microcapsules Triggered by Molecular Motors.

ACS Appl Mater Interfaces 2021 Dec 1. Epub 2021 Dec 1.

School of Materials Science and Engineering, Peking University, Beijing 100871, P. R. China.

Stimuli-responsive smart nanocarriers are an emerging class of materials applicable in fields including drug delivery and tissue engineering. Instead of constructing responsive polymer shells to control the release and delivery of drugs, in this work, we put forward a novel strategy to endow the internal drugs with light responsivity. The microcapsule consisted of molecular motor (MM)-doped cholesteric liquid crystals (CLCs) and drugs. The drug in gelatin-gum arabic microcapsules can protect the carried drugs for a long time with a low release speed totally resulting from drug diffusion. Under UV light, the MM isomerizes and the chirality changes, inducing the alteration of the superstructure of the CLCs. In this process, the cooperative molecular disturbance accelerates the diffusion of the drugs from the microcapsule core to the outside. As a result, thanks to the cooperative effect of liquid crystalline mesogens, molecular-scale geometric changes of motors could be amplified to the microscale disturbance of the self-organized superstructure of the CLCs, resulting in the acceleration of the drug release. This method is hoped to provide opportunities in the design and fabrication of novel functional drug delivery systems.
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http://dx.doi.org/10.1021/acsami.1c16367DOI Listing
December 2021

MRC4BioER: Joint extraction of biomedical entities and relations in the machine reading comprehension framework.

J Biomed Inform 2021 Nov 27:103956. Epub 2021 Nov 27.

School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China.

Extracting entities and their relations from unstructured literature to form structured triplets is essential for biomedical knowledge extraction. Because sentences in biomedical datasets usually have many special overlapping triplets, it is difficult to use previous work to extract these triplets effectively. In this work, we propose a novel tagging strategy to achieve joint extraction in the machine reading comprehension framework. On the one hand, our method uses Query in the machine reading comprehension framework to introduce the information of the specific relation. On the other hand, our method introduces a tagging strategy for overlapping triplets in the biomedical domain. We use CHEMPROT and DDIExtraction2013 datasets to evaluate our method. The experimental results demonstrate that our proposed method can enhance the model's ability to deal with overlapping triplets, improving extraction performance.
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http://dx.doi.org/10.1016/j.jbi.2021.103956DOI Listing
November 2021

miRNA-338-3p inhibits glioma cell proliferation and progression by targeting MYT1L.

Brain Res Bull 2021 Nov 27. Epub 2021 Nov 27.

Department of Neurosurgery, Hunan Cancer Hospital and The Affliated Cancer Hospital of Xiangya School of Medicine, Central South University, No.283 Tongzipo road, Yuelu district, Changsha 410006, Hunan, China. Electronic address:

Glioma is a common and aggressive primary malignant brain tumor. MicroRNAs (miRNAs) play key roles in the post-transcriptional regulation of gene expression. Currently, miRNAs are considered to be useful biomarkers for the diagnosis and prognosis of glioma. Previously, we screened three differentially expressed miRNAs from Gene Expression Omnibus (GEO) database which included miRNA -338-3p. miRNA-338-3p is involved in tumor development in different cancers. However, in glioma, its function and its underlying mechanism remain unclear. We found that overexpression of miRNA -338-3p suppressed cell proliferation, migration, invasion, and promoted apoptosis of glioma in vitro. Myelin transcription factor 1-like (MYT1L) was found to be a direct target of miRNA-383-3p in glioma cells as the expression of MYT1L was inhibited by overexpressing miRNA-338-3p. Additionally, silencing MYT1L produced similar effects as overexpressing miRNA-338-3p in glioma cells. Overexpression of MYT1L also completely attenuated the inhibitory effect induced by miRNA-338-3p overexpression. These results suggest that the miRNA-338-3p/ MYT1L axis plays a critical role in the progression of glioma. Our study delineates one of the complex molecular mechanisms that drive the growth of glioma and may be useful in finding novel prognostic predictors and treatment targets in glioma. AVAILABILITY OF DATA AND MATERIALS: All data generated or analysed during this study are included in this published article.
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http://dx.doi.org/10.1016/j.brainresbull.2021.11.016DOI Listing
November 2021

A biocompatible dual-AIEgen system without spectral overlap for quantitation of microbial viability and monitoring of biofilm formation.

Mater Horiz 2021 Jun 23;8(6):1816-1824. Epub 2021 Apr 23.

Department of Chemistry, Department of Chemical and Biological Engineering, Hong Kong Branch of Chinese Nation-al Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Advanced Study and Division of Life Science The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

The lack of rapid and reliable microbial detection and sensing platforms and insufficient understanding of microbial behavior may delay precautions that could be made, which is a great threat to human life and increases the heavy financial burden on society. In this contribution, a dual-aggregation-induced emission luminogen (AIEgen) system is successfully developed for microbial imaging and metabolic status sensing. This system consists of two AIEgens (DCQA and TPE-2BA) that bear positively charged groups or boronic acid groups, providing universal microbial staining ability and specific affinity for dead microbes, respectively. Based on the distinctive fluorescence response produced by the diverse interaction of AIEgens with live or dead microbes, this dual-AIEgen system can detect all the microbes and identify their viabilities. Furthermore, the morphology and metabolic status of a sessile biofilm can also be imaged and monitored. The system exhibits rapid labelling properties that suitable for various microbes, and good biocompatibilities.
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http://dx.doi.org/10.1039/d1mh00149cDOI Listing
June 2021

Stabilization of lead and cadmium in soil by sulfur-iron functionalized biochar: Performance, mechanisms and microbial community evolution.

J Hazard Mater 2021 Nov 25:127876. Epub 2021 Nov 25.

School of Resources and Environment, Northeast Agricultural University, Harbin 150030, China; Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, 4888 Shengbei Rd, Changchun 130102, China. Electronic address:

Sulfur-iron functionalized biochar (BC-Fe-S) was designed by simultaneously supporting FeO nanoparticles and grafting sulfur-containing functional groups onto biochar to stabilize Pb and Cd in soil. The BC-Fe-S exhibited excellent stabilization performance for Pb and Cd with fast kinetic equilibrium within 5 days associating with pseudo-second-order model. The bioavailable-Pb and -Cd contents decreased by 59.22% and 70.28% with 3% BC-Fe-S treatment after 20 days of remediation. Speciation transformation analysis revealed that the increase of stabilization time and BC-Fe-S dosage with appropriate soil moisture and pH promoted toxicities decrease of Pb and Cd with transformation of labile fractions to more steady fractions. The labile fractions of Pb and Cd decreased by 12.22% and 16.21% with 3% BC-Fe-S treatment, and transformed to the residual speciation. Meanwhile, wetting-drying and freezing-thawing aging did not markedly alter the bioavailability of Pb and Cd, proving that the BC-Fe-S holds promise for stabilization of Pb and Cd in varying environmental conditions. 16S rRNA sequencing analysis demonstrated that the BC-Fe-S significantly improved diversity and composition of microbial community, especially increasing the relative abundance of heavy metal-resistant bacteria. Overall, these results suggested BC-Fe-S as a high-performance and environmental-friendly amendment with stability to remediate heavy metals polluted soil.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127876DOI Listing
November 2021

Seasonal and spatial variations in nutrients under the influence of natural and anthropogenic factors in coastal waters of the northern Yellow Sea, China.

Mar Pollut Bull 2021 Nov 26:113171. Epub 2021 Nov 26.

Muping Coastal Environmental Research Station, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong 264003, P.R. China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, Shandong 266071, PR China; Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong 264003, PR China. Electronic address:

Analysis of the common and most influential natural and anthropogenic activities on the spatiotemporal variation in nutrients at a multiannual scale is important. Eleven cruises from 2015 to 2017 were carried out to better elucidate the seasonal and spatial variations in nutrients, as well as the impact factors on dissolved inorganic nitrogen (DIN), phosphorus (DIP) and silicate (DSi). Both nutrient concentrations and forms showed similar and significant seasonal variations over the 3 years, and were closely related to the biomass and species of phytoplankton. Terrestrial inputs had significant effects on the spatial distribution of nutrients throughout the year, especially in the surface water, which showed DIN > DIP>DSi. In summer, shellfish aquaculture and hypoxia jointly affected the spatial distribution of nutrients. The bottom water nutrient concentrations in the aquaculture area were 1.1-2.3 times higher than those outside of the aquaculture area. Seasonal hypoxia can increase the release of DSi and NH from the sediment to the water. In summary, anthropogenic activities and physical conditions jointly influenced the nutrient distributions.
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http://dx.doi.org/10.1016/j.marpolbul.2021.113171DOI Listing
November 2021

Gut microbiota changes in patients with spondyloarthritis: A systematic review.

Semin Arthritis Rheum 2021 Nov 15. Epub 2021 Nov 15.

Department of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Objective: Gut microbiota has been proposed as a pivotal role in the progression of Spondyloarthritis (SpA), however diverse results remain to be synthesized. We performed a systematic review to collect evidence on the characteristic of the gut microbiota in patients with SpA, as compared to controls.

Methods: We systematically searched MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials databases, through June 1, 2021 for studies that compared gut microbiota of cases with SpA versus healthy controls.

Results: Of 3756 records identified, 28 studies from 23 articles were included in the analysis. Results of β-diversity showed SpA patients hold a significantly different microbial composition compared with controls. Several taxa-level differences of gut microbiota between SpA (and its subtypes) cases and controls were identified. Fourteen studies including only patients with ankylosing spondylitis (AS) reported increased amounts of Actinobacteria, Dialister, Streptococcus, and Clostridium bolteae, and decreased amounts of Bacteroidales and Parasutterella in AS cases versus controls in ≥ 3 studies. Dialister invisus was increased in axial-SpA cases versus controls in 3 studies. Bacteroides fragilis was increased in enthesitis-related arthritis (ERA) cases versus controls in 2 studies. For all SpA studies, Proteobacteria, Enterobacteriaceae, and Bacteroidaceae were increased, whereas Bacteroidetes, Bacteroidales, and Akkermansia were decreased in cases versus controls in ≥ 3 studies. Over 40% of the studies showed comparable data of both sex and age between cases and controls.

Conclusion: The microbial characteristics of SpA summarized in the systematic review laid the groundwork for evidence-based microbial treatment. The microbial variance among subtypes of SpA remains to be explored. Further studies are needed to elucidate how the altered microbiota participate in the pathogenesis of SpA.
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http://dx.doi.org/10.1016/j.semarthrit.2021.11.002DOI Listing
November 2021

Oral Chinese Patent Medicine Combined With Oxaliplatin-Based Chemotherapy Regimen for the Treatment of Colorectal Cancer: A Network Meta-Analysis.

Integr Cancer Ther 2021 Jan-Dec;20:15347354211058169

China Academy of Chinese Medical Sciences, Beijing, China.

Objective: To access the comparative effectiveness and safety of different oral Chinese patent medicine (OCPM) versus oxaliplatin-based chemotherapy regimen (C) alone for colorectal cancer (CRC) through network meta-analysis (NMA).

Methods: Several electronic databases were searched for randomized controlled trials (RCTs) concentrated on the use of OCPM to treat CRC with C from the inception of the databases to January 10, 2021. We performed frequentist NMA and indirect comparison to compare study outcomes from the included RCTs. The risk of bias of each study was assessed using the Cochrane risk of bias tool. Confidence in evidence was assessed using Confidence in Network Meta-Analysis (CINeMA).

Results: A total of 31 RCTs with 1985 participants comparing 10 OCPM, namely, Antike (ATK), Shenyi (SY), Huachansu (HCS), Boerning (BEN), Xiaoaiping (XAP), Jinlong (JL), Compound matrine (CC), Pingxiao (PX), Xihuang pill (XHW), Kangaiping (KAP) were identified. The methodological quality of included RCTs was not very high. The results of the NMA showed that the comparisons were all indirect. Among diverse OCPM, ATK + C had the highest objective response rate (ORR) with a -score of .63 with risk ratio (RR) of 1.37 (95% CI 1.12-1.66); with a RR of 1.96 (1.26-3.05), SY + C had the highest performance status with a -score of .73; KAP + C had the lowest nausea and vomiting with a -score of .91 and with a RR of 0.29 (0.10-0.79); and JL + C had lowest leukopenia with a -score of .95 with a RR of 0.47 (0.31-0.72). The results of pairwise comparison suggested no difference in outcomes among 10 kinds of OCPM + C. The comparison-adjusted funnel plots suggested that there might not be small-study effects for outcomes. According to the CINeMa approach, the confidence rating of this NMA ranged from "very low" to "low" for various comparisons.

Conclusion: Based on the NMA, ATK + C, SY + C, KAP + C and JL + C were associated with more preferable and options for CRC patients when referring to ORR, performance status, nausea and vomiting, and leukopenia, respectively. However, owing to the limitations of this research, the above conclusions require further verification by more high-quality RCTs.

Prospero Registration: CRD42020160658.
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http://dx.doi.org/10.1177/15347354211058169DOI Listing
November 2021

Role of the macula densa sodium glucose cotransporter type 1-nitric oxide synthase 1-tubuloglomerular feedback pathway in diabetic hyperfiltration.

Kidney Int 2021 Nov 26. Epub 2021 Nov 26.

Department of Molecular Pharmacology & Physiology, College of Medicine, University of South Florida, Tampa, FL.

An increase of glomerular filtration rate (GFR) is a common observation in early diabetes and is considered a key risk factor for subsequent kidney injury. However, the mechanisms underlying diabetic hyperfiltration have not been fully clarified. Here, we tested the hypothesis that macula densa neuronal nitric oxide synthase (NOS1) is upregulated via sodium glucose cotransporter type 1 (SGLT1) in diabetes, which then inhibits tubuloglomerular feedback (TGF) promoting glomerular hyperfiltration. Therefore, we examined changes in cortical NOS1 expression and phosphorylation, nitric oxide production in the macula densa, TGF response, and GFR during the early stage of insulin-deficient (Akita) diabetes in wild-type and macula densa-specific NOS1 knockout mice. A set of sophisticated techniques including microperfusion of juxtaglomerular apparatus in vitro, micropuncture of kidney tubules in vivo, and clearance kinetics of plasma fluorescent-sinistrin were employed. Complementary studies tested the role of SGLT1 in SGLT1 knockout mice and explored NOS1 expression and phosphorylation in kidney biopsies of cadaveric donors. Diabetic mice had upregulated macula densa NOS1, inhibited TGF and elevated GFR. Macula densa-selective NOS1 knockout attenuated the diabetes-induced TGF inhibition and GFR elevation. Additionally, deletion of SGLT1 prevented the upregulation of macula densa NOS1 and attenuated inhibition of TGF in diabetic mice. Furthermore, the expression and phosphorylation levels of NOS1 were increased in cadaveric kidneys of diabetics and positively correlated with blood glucose as well as estimated GFR in the donors. Thus, our findings demonstrate that the macula densa SGLT1-NOS1-TGF pathway plays a crucial role in the control of GFR in diabetes.
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http://dx.doi.org/10.1016/j.kint.2021.10.037DOI Listing
November 2021

H19- and hsa-miR-338-3p-mediated NRP1 expression is an independent predictor of poor prognosis in glioblastoma.

PLoS One 2021 29;16(11):e0260103. Epub 2021 Nov 29.

Medical Section, Xuzhou Children's Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, P.R. China.

Glioblastoma multiforme (GBM) is the most common and also the most invasive brain cancer. GBM progression is rapid and its prognosis is poor. Therefore, finding molecular targets in GBM is a critical goal that could also play important roles in clinical diagnostics and treatments to improve patient prognosis. We jointly analyzed the GSE103227, GSE103229, and TCGA databases for differentially expressed RNA species, obtaining 52 long non-coding RNAs (lncRNAs), 31 microRNAs (miRNAs), and 186 mRNAs, which were used to build a competing endogenous RNA network. Kaplan-Meier and receiver operating characteristic (ROC) analyses revealed five survival-related lncRNAs: H19, LINC01574, LINC01614, RNF144A-AS1, and OSMR-AS1. With multiple optimization mRNAs, we found the H19-hsa-miR-338-3P-NRP1 regulatory pathway. Additionally, we noted high NRP1 expression in GBM patients, and Kaplan-Meier and ROC analyses showed that NRP1 expression was associated with GBM prognosis. Cox analysis indicated that NRP1 is an independent prognostic factor in GBM patients. In conclusion, H19 and hsa-miR-338-3P regulate NRP1 expression, and this pathway plays an important role in GBM.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260103PLOS
November 2021

ZnS anchored on porous N, S-codoped carbon as superior oxygen reduction reaction electrocatalysts for Al-air batteries.

J Colloid Interface Sci 2021 Nov 18. Epub 2021 Nov 18.

College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address:

The development of non-precious based oxygen reduction reaction (ORR) catalysts with outstanding catalytic performance is desirable but still a grand challenge for practical Al-air battery. Herein, we report a vulcanization-assisted pyrolysis strategy for creating zeolitic imidazolate framework-derived catalysts with a N, S co-doped carbon support and highly exposed ZnS and Zn-N sites. The trithiocyanuric acid (TCA) is found not only to introduce S into the carbon derived from ZIF-8 and ZnS to adjust the electronic structure of carbon matrix during the pyrolysis, but also result in a shrinkage of carbon framework with a hierarchical porous structure. Such an architecture boosts abundant active sites exposed and accelerates remote mass transportation. As a result, the optimized 3.5ZnS/NSC-NaCl-900 delivers an impressive enhanced performance toward ORR in alkaline medium with a high half-wave potential of 0.905 V (vs. reversible hydrogen electrode), which is superior to most of non-precious metal-based catalysts. Density functional theory calculations unveil that the ZnS in 3.5ZnS/NSC-NaCl-900 can effectively lower the Gibbs energy barrier of crucial steps and therefore promotes the reaction kinetics. Furthermore, 3.5ZnS/NSC-NaCl-900 also displays greater power density and specific capacity than Pt/C in Al-air batteries.
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http://dx.doi.org/10.1016/j.jcis.2021.11.083DOI Listing
November 2021

Sunlight-Activated Orange Persistent Luminescence from Bi-Doped SrBaZnGaO for Warm-Color Optical Applications.

Inorg Chem 2021 Nov 28. Epub 2021 Nov 28.

College of Physics and Optoelectronics, Taiyuan University of Technology, Taiyuan 030024, P.R. China.

A warm persistent luminescence (PersL) material SrBaZnGaO:Bi was prepared using the conventional high-temperature solid-phase reaction method. We first investigated the PersL properties of SrBaZnGaO:Bi in detail via PersL spectra, PersL excitation spectrum, PersL decay curves, and thermoluminescence (TL) spectra. The highlight of this study is that in addition to the 254 nm light source, the low-energy light source of 365 nm and sunlight can effectively excite electrons and charge traps, resulting in preferable orange PersL performance. The PersL decay time of the representative sample can last for 960 s after excitation by a 365 nm light source and 900 s after excitation by simulated sunlight. Meanwhile, the PersL color can be regulated by changing the excitation wavelength. In order to explain the infrequent PersL phenomena after different light source excitations, we recorded a series of TL spectra as a function of different light sources, different charging times, and different decay times to reveal the distribution of traps in the material and the influence of trap distribution on trapping and detrapping processes. This novel sunlight-activated orange PersL material is expected to promote the development of sunlight-activated PersL materials and expand potential applications in solar energy utilization and anticounterfeit marking.
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http://dx.doi.org/10.1021/acs.inorgchem.1c03024DOI Listing
November 2021

3D hemisphere-based convolutional neural network for whole-brain MRI segmentation.

Comput Med Imaging Graph 2021 Oct 30;95:102000. Epub 2021 Oct 30.

School of Engineering Science, Simon Fraser University, Canada. Electronic address:

Whole-brain segmentation is a crucial pre-processing step for many neuroimaging analyses pipelines. Accurate and efficient whole-brain segmentations are important for many neuroimage analysis tasks to provide clinically relevant information. Several recently proposed convolutional neural networks (CNN) perform whole brain segmentation using individual 2D slices or 3D patches as inputs due to graphical processing unit (GPU) memory limitations, and use sliding windows to perform whole brain segmentation during inference. However, these approaches lack global and spatial information about the entire brain and lead to compromised efficiency during both training and testing. We introduce a 3D hemisphere-based CNN for automatic whole-brain segmentation of T1-weighted magnetic resonance images of adult brains. First, we trained a localization network to predict bounding boxes for both hemispheres. Then, we trained a segmentation network to segment one hemisphere, and segment the opposing hemisphere by reflecting it across the mid-sagittal plane. Our network shows high performance both in terms of segmentation efficiency and accuracy (0.84 overall Dice similarity and 6.1 mm overall Hausdorff distance) in segmenting 102 brain structures. On multiple independent test datasets, our method demonstrated a competitive performance in the subcortical segmentation task and a high consistency in volumetric measurements of intra-session scans.
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http://dx.doi.org/10.1016/j.compmedimag.2021.102000DOI Listing
October 2021

Impacts of chitosan nanoemulsions with thymol or thyme essential oil on volatile compounds and microbial diversity of refrigerated pork meat.

Meat Sci 2021 Nov 9;185:108706. Epub 2021 Nov 9.

College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an, Shaanxi 710119, China.

This study aimed to investigate the effects of antibacterial substances embedded in nanoemulsions on the volatile compounds and the bacterial community composition of refrigerated pork stored at 4 °C for 12 days, and to evaluate the relationship between volatile components and bacterial diversity of refrigerated pork. As compared to the control (CK) group, the treatment groups (thyme essential oil chitosan nanoemulsions (TEO-CS), thymol chitosan nanoemulsions (T-CS) and chitosan nanoemulsions (CS)) showed lower TVB-N values, pH values, TBARs values and better protective against color degradation. The E-nose and GC-MS evaluation indicated that compounds causing unpleasant odors could be inhibited in the T-CS and TEO-CS groups. In addition, high-throughput sequencing showed that Pseudomonas (18.3%), Lactococcus (27.0%) and Acinetobacter (38.8%) were predominant genera of refrigerated pork in the early storage period. At day 12, Pseudomonas (84.3%) increased rapidly in the CK group and became the main microbiota. By contrast, both coatings changed the microbial composition, reduced the proportion of spoilage organisms and retained bacterial diversity. Therefore, chitosan nanoemulsions with antibacterial substance could be considered as an effective supplementary and method to improve the preservation effect of fresh pork, which provides a solution to against conventional packaging and extend the shelf-life of meat.
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http://dx.doi.org/10.1016/j.meatsci.2021.108706DOI Listing
November 2021

Effect of Fe(III)-modified montmorillonite on arsenic oxidation and anthracene transformation in soil.

Sci Total Environ 2021 Nov 25:151939. Epub 2021 Nov 25.

Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:

Studies have shown that Fe(III)-modified montmorillonite can oxidize arsenite (As(III)) and also degrade anthracene. However, the application of Fe(III)-modified montmorillonite to remediate soil contaminated by arsenic and/or polycyclic aromatic hydrocarbons (PAHs) has not been reported. In this study, we first investigated the transformation of arsenic and anthracene on the surface of Fe(III)-modified montmorillonite, and then added Fe(III)-modified montmorillonite to spiked soil to examine its effect on arsenic oxidation and anthracene transformation. The experiments included treatments with As(III) and anthracene added separately or combined (both at a rate of 100 mg/kg). Compared with Na-modified montmorillonite, Fe(III)-modified montmorillonite significantly promoted As(III) oxidation and anthracene transformation on its surface. After 15 days of incubation, the proportion of As(V) (As(V)/[As(III) + As(V)]) on Na-modified montmorillonite was approximately 60%, and the transformation extent of anthracene was <30%; on Fe(III)-modified montmorillonite, on the other hand, the proportion of As(V) was approximately 90%, and almost all anthracene was transformed. Adding 5% Fe(III)-modified montmorillonite to spiked soil also significantly enhanced As(III) oxidation and anthracene transformation. After 15 days, in the soil with added Fe(III)-modified montmorillonite, the proportion of As(V) was approximately 40%, the transformation extent of anthracene was >60%, and approximately half of the initial added anthracene was transformed to anthraquinone. By contrast, in the soil without added Fe(III)-modified montmorillonite, the proportion of As(V) was only approximately 20%, the transformation extent of anthracene was <25%, and anthraquinone was not detected. The transformation of As(III) and anthracene did not have considerable influence on each other, as the proportion of As(V) or the transformation extent of anthracene was almost equal after 15 days regardless of whether As(III) and anthracene were added together or separately. The results showed that Fe(III)-modified montmorillonite has the potential to remediate soil contaminated by arsenic and PAHs.
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http://dx.doi.org/10.1016/j.scitotenv.2021.151939DOI Listing
November 2021

Optimizing organic amendment applications to enhance carbon sequestration and economic benefits in an infertile sandy soil.

J Environ Manage 2021 Nov 24:114129. Epub 2021 Nov 24.

Scientific Observation and Experimental Station of Arable Land Conservation of Jiangsu Province, Ministry of Agriculture and Rural Affairs, Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.

A thorough understanding of the agricultural, ecological, and economic benefits of organic amendment (OA) application in infertile soils is crucial for facilitating agricultural sustainability. We conducted a three-year field study to evaluate the effects of OA application on soil organic carbon (SOC) sequestration, crop yields, and the net ecosystem economic benefit (NEEB) in a typical infertile sandy soil (with an initial SOC content of 2.56 g kg) of the ancient Yellow River alluvial plain. In addition to the control (CK; non-OA application), two types of OAs, namely, manure-based organic fertilizer (M) and spent mushroom residue (MR), were each applied at 12, 24, and 36 Mg ha yr. Two scenarios of OA application practices, namely, conventional manual OA application (AMA) and mechanical OA application (AME), were considered in the economic evaluation. An increase of 1 g kg SOC content could improve the crop yield by 2.25 Mg ha yr. Compared with the CK, the application of OAs enhanced the SOC content and SOC stock by 14.6%-39.8% and 8.5%-28.2%, respectively. However, the SOC sequestration efficiency of the OAs tended to decrease under high rates of OA application. MR was observed to have greater potential than M in sequestering SOC and promoting soil aggregates. OA-induced SOC sequestration could neutralize 36.6%-97.8% of greenhouse gas emissions, which resulted in a reduction in the global warming potential and its cost by 0.62-2.68 Mg CO-eq ha yr and 15.46-65.78 CNY ha yr, respectively. Nevertheless, in terms of the NEEB, the benefits of OA application on crop yield and SOC sequestration were largely offset by the increased material and labor costs. Compared with AMA, AME could save 10%-27% of agricultural costs. The AME of MR at a rate of 24 Mg ha yr achieved the highest NEEB. The results of this study suggest that a strategy involving the appropriate OA, optimal application rate, and cheapest incorporation cost for a specific individual soil should be adopted to achieve a sustainable solution for promoting crop productivity, enhancing SOC sequestration, and ensuring farmer income in infertile farming regions.
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http://dx.doi.org/10.1016/j.jenvman.2021.114129DOI Listing
November 2021

Facial Balamuthia mandrillaris infection with neurological involvement in an immunocompetent child.

Lancet Infect Dis 2021 Nov 24. Epub 2021 Nov 24.

Department of Dermatology, Xinhua Hospital, and Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

Cutaneous infection by Balamuthia mandrillaris is a rare condition that is sometimes complicated by life-threatening CNS involvement. It often evades timely diagnosis due to its rarity and non-specific clinical manifestations. Patients can be either immunocompetent or immunocompromised. It is probably transmitted via inhalation or inoculation through broken skin, and then spreads to the brain and other organs through haematogenous spread. It is important for clinicians to be aware of this disease because rapid diagnosis and subsequent therapy has, in some cases, been associated with survival. In this Grand Round, we report the case of a 7-year-old boy who presented with large, chronic plaques on his face. Several biopsies showed non-specific granulomatous inflammation. The patient deteriorated rapidly and died within 1 month of displaying abnormal symptoms in the CNS. Immunohistochemical staining of skin tissue identified B mandrillaris as the infectious agent. The diagnosis was confirmed with PCR, which detected B mandrillaris DNA in formalin-fixed skin tissue sections. B mandrillaris infection should be considered in the differential diagnosis of patients with chronic granulomatous lesions. We also reviewed the epidemiology, B mandrillaris in nature and in the laboratory, clinical manifestations, histopathology, diagnosis, and treatment of infection.
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http://dx.doi.org/10.1016/S1473-3099(21)00334-0DOI Listing
November 2021

Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7.

J Nanobiotechnology 2021 Nov 27;19(1):396. Epub 2021 Nov 27.

Department of Pharmacology, School of Pharmaceutical, Guangzhou University of Chinese Medicine, 232, Waihuan East Road, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou, 510000, China.

Background: A recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However, little is known regarding the causes of CMD during NAFLD. In this study, we aimed to explore the role of hepatic small extracellular vesicles (sEVs) in regulating the endothelial dysfunction of coronary microvessels during NAFLD.

Results: We established two murine NAFLD models by feeding mice a methionine-choline-deficient (MCD) diet for 4 weeks or a high-fat diet (HFD) for 16 weeks. We found that the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent endothelial hyperpermeability occurred in coronary microvessels during both MCD diet and HFD-induced NAFLD. The in vivo and in vitro experiments proved that novel-microRNA(miR)-7-abundant hepatic sEVs were responsible for NLRP3 inflammasome-dependent endothelial barrier dysfunction. Mechanistically, novel-miR-7 directly targeted lysosomal associated membrane protein 1 (LAMP1) and promotes lysosomal membrane permeability (LMP), which in turn induced Cathepsin B-dependent NLRP3 inflammasome activation and microvascular endothelial hyperpermeability. Conversely, a specific novel-miR-7 inhibitor markedly improved endothelial barrier integrity. Finally, we proved that steatotic hepatocyte was a significant source of novel-miR-7-contained hepatic sEVs, and steatotic hepatocyte-derived sEVs were able to promote NLRP3 inflammasome-dependent microvascular endothelial hyperpermeability through novel-miR-7.

Conclusions: Hepatic sEVs contribute to endothelial hyperpermeability in coronary microvessels by delivering novel-miR-7 and targeting the LAMP1/Cathepsin B/NLRP3 inflammasome axis during NAFLD. Our study brings new insights into the liver-to-microvessel cross-talk and may provide a new diagnostic biomarker and treatment target for microvascular complications of NAFLD.
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http://dx.doi.org/10.1186/s12951-021-01137-3DOI Listing
November 2021

Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust.

J Hazard Mater 2021 Nov 20:127847. Epub 2021 Nov 20.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, China. Electronic address:

Retinoic acid receptors (RARs) control reproduction and development in vertebrates, but little attention has been paid to anthropogenic chemicals exhibiting RAR agoniztic/antagonistic activity. Here we applied a His-RARα pull-down assay combined with high-resolution mass spectrometry to identify chemicals with RARα activity in house dust. After screening, a total of 540 peaks were retained as potential RARα ligands. The mass spectra of 14 chemicals matched with those in the database, of which triphenyl phosphate, galaxolidone, di(2-ethylhexyl) phthalate (DEHP), tris(2-ethylhexyl) phosphate (TEHP), and tris(2-butoxyethyl) phosphate were confirmed by their standards. While one chemical in the sample matched with monophenyl phosphate in the MS/MS database, its retention time was much higher than that of monophenyl phosphate standard, suggesting that it may be an in-source fragment. Its parent ion was finally identified to be m/z 399.2663 using a similarity analysis among chromatographic peaks of hundreds of ions at the same retention time in MS spectrum, and bis(2-ethylhexyl) phenyl phosphate (BEHPP) was identified. BEHPP, DEHP, and TEHP were for the first time identified to be RARα antagonists with IC values of 6556, 6600, and 2538 nM, respectively. This study improved structural annotation and filled the knowledge gap regarding widespread environmental contaminants with RAR antagonistic activity.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127847DOI Listing
November 2021

Peroxymonosulfate Activation by BiWO/BiOCl Heterojunction Nanocomposites under Visible Light for Bisphenol A Degradation.

Nanomaterials (Basel) 2021 Nov 20;11(11). Epub 2021 Nov 20.

State Key Laboratory of Coal Mine Disaster Dynamics and Control, College of Environment and Ecology, Chongqing University, Chongqing 400044, China.

The combination of peroxymonosulfate (PMS) activation and photocatalysis has proven to be effective for organic contaminants treatment. However, the construction of an efficient catalytic material is an important challenge. Herein, novel BiWO/BiOCl heterojunction nanocomposites were successfully designed and fabricated using a facile and effective strategy for bisphenol A (BPA) photodegradation with PMS activation. The well-designed heterojunction with improvement of the contact area and interface microstructure was obtained through in situ growth of the BiWO on the surface of BiOCl. The BiWO/BiOCl nanocomposites exhibit excellent catalytic performance in PMS activation for BPA degradation under visible light irradiation. A possible photocatalytic reaction mechanism was systematically revealed. The excellent catalytic performance is mainly attributed to the strong interaction between BiWO and BiOCl, resulting in an enhanced photoabsorption and a more efficient interfacial charge separation and transfer. This paper provides a novel strategy to design efficient catalytic materials for organic contaminants remediation with PMS activation.
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http://dx.doi.org/10.3390/nano11113130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621688PMC
November 2021

Artificial Neurons Based on Ag/VC/W Threshold Switching Memristors.

Nanomaterials (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

College of Electronic and Optical Engineering & College of Microelectronics, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Artificial synapses and neurons are two critical, fundamental bricks for constructing hardware neural networks. Owing to its high-density integration, outstanding nonlinearity, and modulated plasticity, memristors have attracted emerging attention on emulating biological synapses and neurons. However, fabricating a low-power and robust memristor-based artificial neuron without extra electrical components is still a challenge for brain-inspired systems. In this work, we demonstrate a single two-dimensional (2D) MXene(VC)-based threshold switching (TS) memristor to emulate a leaky integrate-and-fire (LIF) neuron without auxiliary circuits, originating from the Ag diffusion-based filamentary mechanism. Moreover, our VC-based artificial neurons faithfully achieve multiple neural functions including leaky integration, threshold-driven fire, self-relaxation, and linear strength-modulated spike frequency characteristics. This work demonstrates that three-atom-type MXene (e.g., VC) memristors may provide an efficient method to construct the hardware neuromorphic computing systems.
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http://dx.doi.org/10.3390/nano11112860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623555PMC
October 2021

Transgenerational Effects of Maternal Water Condition on the Growth, C:N Stoichiometry and Seed Characteristics of the Desert Annual .

Plants (Basel) 2021 Nov 2;10(11). Epub 2021 Nov 2.

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, 818 South Beijing Road, Urumqi 830011, China.

Water conditions directly affect plant growth and thus modify reproduction allocation. However, little is known about the transgenerational effects of water conditions on xerophytes. The desert annual produces three types of seeds (A: dormant, ebracteate black seeds; B: dormant, bracteolate black seeds; C: non-dormant, bracteolate brown seeds) on a single plant. The aim of this study was to investigate the effects of low/high water treatment (thereafter progeny water treatment) on aboveground biomass, C:N stoichiometry, and offspring seed characteristics of grown from brown seeds whose mother plants were under low/high water treatment (thereafter maternal water treatment). Progeny water only affected shoot dry weight and seed allocation of type A. Under low progeny water treatment, plants from parents with low maternal water treatment had the lowest biomass. Maternal water did not significantly influence the C and N content, however high maternal water increased the C:N ratio. Maternal water treatment did not significantly affect seed number. However, plants under low maternal and progeny water treatments had the lowest weight for type B seeds. When progeny plants were under low water treatment, seed allocation of type A, type B, and total seed allocation of plants under high maternal water were significantly lower than those of plants under low maternal water. These results indicate that water conditions during the maternal generation can dramatically contribute to progeny seed variation, but the transgenerational effects depend on the water conditions of progeny plants.
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http://dx.doi.org/10.3390/plants10112362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620486PMC
November 2021

Genome-Wide Analysis of the Homeobox Gene Family and Identification of Drought-Responsive Members in .

Plants (Basel) 2021 Oct 25;10(11). Epub 2021 Oct 25.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.

(HB) genes play critical roles in the regulation of plant morphogenesis, growth and development. Here, we identified a total of 156 genes from the genome. According to the topologies and taxonomy of the phylogenetic tree constructed by HB members, all PtrHB proteins were divided into six subgroups, namely HD-ZIP, ZF-HD, HB-PHD, TALE, WOX and HB-OTHERS. Multiple alignments of conserved homeodomains (HDs) revealed the conserved loci of each subgroup, while gene structure analysis showed similar exon-intron gene structures, and motif analysis indicated the similarity of motif number and pattern in the same subgroup. Promoter analysis indicated that the promoters of genes contain a series of -acting regulatory elements involved in responding to various abiotic stresses, indicating that s had potential functions in these processes. Collinearity analysis revealed that there are 96 pairs of 127 genes mainly distributing on Chromosomes 1, 2, and 5. We analyzed the spatio-temporal expression patterns of genes, and the virus-induced gene silencing (VIGS) of gene resulted in the compromised tolerance of poplar seedlings to mannitol treatment. The bioinformatics on family and preliminary exploration of drought-responsive genes can provide support for further study of the family in woody plants, especially in drought-related biological processes. It also provides a direction for developing new varieties of poplar with drought resistance. Overall, our results provided significant information for further functional analysis of genes in poplar and demonstrated that is a dominant gene regulating tolerance to water stress treatment in poplar seedlings.
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http://dx.doi.org/10.3390/plants10112284DOI Listing
October 2021

In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, .

Molecules 2021 Nov 16;26(22). Epub 2021 Nov 16.

Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea.

Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed , showed strong antioxidant and anti-inflammatory activities in in vitro and in vivo models. To further explore the potential of (-)-loliode in cosmetics, in the present study, we investigated the photoprotective effect of (-)-loliode in vitro in skin cells and in vivo in zebrafish. The results indicated that (-)-loliode significantly reduced intracellular reactive oxygen species (ROS) level, improved cell viability, and suppressed apoptosis of UVB-irradiated human keratinocytes. In addition, (-)-loliode remarkably attenuated oxidative damage, improved collagen synthesis, and inhibited matrix metalloproteinases expression in UVB-irradiated human dermal fibroblasts. Furthermore, the in vivo test demonstrated that (-)-loliode effectively and dose-dependently suppressed UVB-induced zebrafish damage displayed in decreasing the levels of ROS, nitric oxide, lipid peroxidation, and cell death in UVB-irradiated zebrafish. These results indicate that (-)-loliode possesses strong photoprotective activities and suggest (-)-loliode may an ideal ingredient in the pharmaceutical and cosmeceutical industries.
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http://dx.doi.org/10.3390/molecules26226898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620499PMC
November 2021

Sensitivity and Specificity of CD19.CAR-T Cell Detection by Flow Cytometry and PCR.

Cells 2021 Nov 17;10(11). Epub 2021 Nov 17.

Department of Internal Medicine V-Hematology, Oncology & Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Chimeric-antigen-receptor-T (CAR-T) cells are currently revolutionizing the field of cancer immunotherapy. Therefore, there is an urgent need for CAR-T cell monitoring by clinicians to assess cell expansion and persistence in patients. CAR-T cell manufacturers and researchers need to evaluate transduction efficiency and vector copy number for quality control. Here, CAR expression was analyzed in peripheral blood samples from patients and healthy donors by flow cytometry with four commercially available detection reagents and on the gene level by quantitative polymerase chain reaction (qPCR). Flow cytometric analysis of CAR expression showed higher mean CAR expression values for CD19 CAR detection reagent and the F(ab')2 antibody than Protein L and CD19 Protein. In addition, the CD19 CAR detection reagent showed a significantly lower median background staining of 0.02% (range 0.007-0.06%) when compared to the F(ab')2 antibody, CD19 protein and Protein L with 0.80% (range 0.47-1.58%), 0.65% (range 0.25-1.35%) and 0.73% (range 0.44-1.23%). Furthermore, flow cytometry-based CAR-T cell frequencies by CD19 CAR detection reagent showed a good correlation with qPCR results. In conclusion, quality control of CAR-T cell products can be performed by FACS and qPCR. For the monitoring of CAR-T cell frequencies by FACS in patients, CAR detection reagents with a low background staining are preferable.
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http://dx.doi.org/10.3390/cells10113208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621201PMC
November 2021

Experimental Studies on the Impact of the Projected Ocean Acidification on Fish Survival, Health, Growth, and Meat Quality; Black Sea Bream (), Physiological and Histological Studies.

Animals (Basel) 2021 Oct 31;11(11). Epub 2021 Oct 31.

Ocean Academy, Zhejiang University, Zhoushan 316100, China.

Acidification (OA), a global threat to the world's oceans, is projected to significantly grow if CO continues to be emitted into the atmosphere at high levels. This will result in a slight decrease in pH. Since the latter is a logarithmic scale of acidity, the higher acidic seawater is expected to have a tremendous impact on marine living resources in the long-term. An 8-week laboratory experiment was designed to assess the impact of the projected pH in 2100 and beyond on fish survival, health, growth, and fish meat quality. Two projected scenarios were simulated with the control treatment, in triplicates. The control treatment had a pH of 8.10, corresponding to a pCO of 321.37 ± 11.48 µatm. The two projected scenarios, named Predict_A and Predict_B, had pH values of 7.80-pCO = 749.12 ± 27.03 and 7.40-pCO = 321.37 ± 11.48 µatm, respectively. The experiment was preceded by 2 weeks of acclimation. After the acclimation, 20 juvenile black sea breams () of 2.72 ± 0.01 g were used per tank. This species has been selected mainly due to its very high resistance to diseases and environmental changes, assuming that a weaker fish resistance will also be susceptibly affected. In all tanks, the fish were fed with the same commercial diet. The seawater's physicochemical parameters were measured daily. Fish samples were subjected to physiological, histological, and biochemical analyses. Fish growth, feeding efficiency, protein efficiency ratio, and crude protein content were significantly decreased with a lower pH. Scanning electron microscopy revealed multiple atrophies of microvilli throughout the small intestine's brush border in samples from Predict_A and Predict_B. This significantly reduced nutrient absorption, resulting in significantly lower feed efficiency, lower fish growth, and lower meat quality. As a result of an elevated pCO in seawater, the fish eat more than normal but grow less than normal. Liver observation showed blood congestion, hemorrhage, necrosis, vacuolation of hepatocytes, and an increased number of Kupffer cells, which characterize liver damage. Transmission electron microscopy revealed an elongated and angular shape of the mitochondrion in the liver cell, with an abundance of peroxisomes, symptomatic of metabolic acidosis.
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http://dx.doi.org/10.3390/ani11113119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614255PMC
October 2021

A Nanohook-Equipped Bionanocatalyst for Localized Near-Infrared-Enhanced Catalytic Bacterial Disinfection.

Angew Chem Int Ed Engl 2021 Nov 26. Epub 2021 Nov 26.

Freie Universität Berlin Fachbereich Biologie Chemie Pharmazie: Freie Universitat Berlin Fachbereich Biologie Chemie Pharmazie, Takustr. 3, Institute of Chemistry and Biochemistry, 14195, Berlin, GERMANY.

Novel bionanocatalysts have opened a new era in fighting multidrug-resistant (MDR) bacteria. They can kill bacteria by elevating the level of reactive oxygen species (ROS) in the presence of chemicals like H2O2. However, ROSs' ultrashort diffusion distance limit their bactericidal activity. We present a nanohook-equipped bionanocatalyst ([email protected]) with bacterial binding ability that shows robust ROS-generating capacity under physiological H2O2 levels. The [email protected]'s pH-dependent performance confines its effects to the biofilm microenvironment, leaving healthy tissue unaffected. Furthermore, it can generate heat upon NIR laser irradiation, enhancing its catalytic performance while achieving heat ablation against bacteria. With the [email protected]'s synergistic effects, bacterial populations fall by >99.99%. More surprisingly, mature biofilm shows no recurrence after treatment with the [email protected], demonstrating its tremendous potential for treating MDR bacterial related infections.
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http://dx.doi.org/10.1002/anie.202113833DOI Listing
November 2021

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.

Nature 2021 Nov 25. Epub 2021 Nov 25.

Tokyo Metropolitan Institute of Public Health, Tokyo, 1690073, Japan.

During the current SARS-CoV-2 pandemic, a variety of mutations have accumulated in the viral genome, and currently, four variants of concern (VOCs) are considered potentially hazardous to human society. The recently emerged B.1.617.2/Delta VOC is closely associated with the COVID-19 surge that occurred in India in the spring of 2021. However, its virological properties remain unclear. Here, we show that the B.1.617.2/Delta variant is highly fusogenic and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters. The P681R mutation in the spike protein, which is highly conserved in this lineage, facilitates spike protein cleavage and enhances viral fusogenicity. Moreover, we demonstrate that the P681R-bearing virus exhibits higher pathogenicity than its parental virus. Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity.
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http://dx.doi.org/10.1038/s41586-021-04266-9DOI Listing
November 2021

Characteristics and Risk Assessments of Mercury Pollution Levels at Domestic Garbage Collection Points Distributed within the Main Urban Areas of Changchun City.

Toxics 2021 Nov 16;9(11). Epub 2021 Nov 16.

School of Environment, Northeast Normal University, Changchun 130117, China.

The mercury that is released from the centralized treatment of municipal solid waste is an important source of atmospheric mercury. We chose the main urban area of Changchun as a representative area. Environmental factors such as total mercury content, temperature, wind speed, and other factors were measured in samples from the trash cans of two types of collection points (trash cans and garbage stations), the topsoil under the selected trash cans, and the ambient air above the selected trash cans. The potential ecological risks of mercury pollution were evaluated. The results showed that the mercury content levels of all sample types in the refuse transfer station were higher than the garbage cans and there were no significant differences observed between soil surface mercury and garbage cans. The mercury content levels in the atmosphere and the surface soil at the garbage collection points were found to increase along the cascade relationship of the garbage collection. However, there were no correlations observed between the atmospheric mercury content levels and the surface soil mercury content levels with the attachments and the sum of the former two. There were no correlations observed between surface soil and the attachments, or among the attachments, surface soil, and the atmospheric mercury content levels. The mercury content levels in the attachments, surface soil, and atmosphere of the garbage collection points in the study area were negatively correlated with the loop lines. Meanwhile, the potential ecological risk indexes of the garbage cans and garbage stations were found to be high. The chronic non-carcinogenic risks of mercury to children and adults were determined to be very low. The risks of mercury to children were higher when compared with adults. The highest non-carcinogenic risks of mercury pollution were determined to be within the central area of Changchun.
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http://dx.doi.org/10.3390/toxics9110309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620532PMC
November 2021
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