Publications by authors named "Lei Dai"

344 Publications

Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model.

Sci Rep 2022 Aug 10;12(1):13639. Epub 2022 Aug 10.

Department of Hepatopancreatobiliary Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, 1111 Jiangnan Road, Ningbo, 315040, Zhejiang, China.

Matrix metalloproteinase 1 (MMP1) encodes endopeptidases associated with degradation of multiple components of the extracellular matrix. This function has increasingly been considered to play a major proteolysis role in tumor invasion and metastasis. However, the relationship between MMP1 gene expression, tumor-immune microenvironment and prognosis in hepatocellular carcinoma patients remains mostly unclear. This study focused on a comprehensive analysis of MMP1 in hepatocellular carcinoma, specifically the prognosis and tumor-immune microenvironment. MMP1 expression was analyzed using TCGA database and clinical samples. MMP1 associated mechanisms, pathways, mutations and prognosis in hepatocellular carcinoma were evaluated. We also analyzed the tumor-immune microenvironment and corresponding treatments. Our research demonstrated that MMP1 expression was upregulated in patients with hepatocellular carcinoma and correlated with poor survival. A prognostic model was established and its performance evaluated. We also found and report various correlations between MMP1 and immune-related cells/genes, as well the potential therapeutic agents. These findings indicate that MMP1 can potentially be a promising prognostic biomarker and indicator of the tumor-immune microenvironment status in hepatocellular carcinoma.
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http://dx.doi.org/10.1038/s41598-022-17954-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365786PMC
August 2022

Mechanisms of microRNA action in rectal cancer radiotherapy.

Chin Med J (Engl) 2022 Aug 8. Epub 2022 Aug 8.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.

Abstract: Preoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.
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http://dx.doi.org/10.1097/CM9.0000000000002139DOI Listing
August 2022

Image Compression Using Stochastic-AFD Based Multi-signal Sparse Representation.

IEEE Trans Image Process 2022 Aug 3;PP. Epub 2022 Aug 3.

Adaptive Fourier decomposition (AFD) is a newly developed signal processing tool that can adaptively decompose any single signal using a Szegö kernel dictionary. To process multiple signals, a novel stochastic-AFD (SAFD) theory was recently proposed. The innovation of this study is twofold. First, a SAFD-based general multi-signal sparse representation learning algorithm is designed and implemented for the first time in the literature, which can be used in many signal and image processing areas. Second, a novel SAFD based image compression framework is proposed. The algorithm design and implementation of the SAFD theory and image compression methods are presented in detail. The proposed compression methods are compared with 13 other state-of-the-art compression methods, including JPEG, JPEG2000, BPG, and other popular deep learning-based methods. The experimental results show that our methods achieve the best balanced performance. The proposed methods are based on single image adaptive sparse representation learning, and they require no pre-training. In addition, the decompression quality or compression efficiency can be easily adjusted by a single parameter, that is, the decomposition level. Our method is supported by a solid mathematical foundation, which has the potential to become a new core technology in image compression.
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http://dx.doi.org/10.1109/TIP.2022.3194696DOI Listing
August 2022

Identification of Endoplasmic Reticulum Stress-Related Subtypes, Infiltration Analysis of Tumor Microenvironment, and Construction of a Prognostic Model in Colorectal Cancer.

Cancers (Basel) 2022 Jul 8;14(14). Epub 2022 Jul 8.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

Recently, endoplasmic reticulum (ER) stress has been shown to influence tumor progression and immune cell function in the tumor microenvironment (TME). However, the underlying role of ER stress-related gene patterns in colorectal cancer (CRC) development remains unclear. We analyzed the ER stress-related gene patterns in 884 patients with CRC from the Gene Expression Omnibus database and evaluated the cell-infiltrating patterns in the TME. Two ER stress-related patterns were identified in patients with CRC that had distinct cell-infiltrating patterns in the TME and clinical characteristics. A risk score and nomogram based on 14 screened prognosis-correlated genes was built and validated to predict patient survival. Patients with a higher risk score were shown to have an unfavorable prognosis, and the risk score was associated with cell infiltration and drug sensitivity. Furthermore, spatial transcriptomics data were utilized to explore ER stress-related gene patterns in CRC tissues, and it was shown that ER stress phenotype involves in the formation of the immunosuppressive TME. This study demonstrated that ER stress-related gene patterns play a role in influencing the TME and predicting prognosis. These analyses of ER stress in the TME of CRC might deepen our understanding of CRC progression and immune escape and provide novel insights into therapeutic strategies.
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http://dx.doi.org/10.3390/cancers14143326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322646PMC
July 2022

Hotspots and frontiers in pulmonary arterial hypertension research: a bibliometric and visualization analysis from 2011 to 2020.

Bioengineered 2022 06;13(6):14667-14680

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pulmonary arterial hypertension (PAH) is a group of devastating and progressive disorders, resulting in relentless increases in pulmonary vascular resistance. The number of studies related to PAH has been increasing in recent years. Our study aims to illustrate trends in PAH research over the past decade using bibliometric analysis. Science Citation Index-Expanded was adopted to search studies concerning PAH between 2011 and 2020. The bibliographic information was converted and analyzed automatically using a bibliometric package in R software and citespace. The annual quantity of publications on PAH showed an overall increase last decade. The United States was the most prolific country with 2,479 publications, and it was also the country that cooperated most with other countries. Hôpital Bicêtre made important research achievements on PAH and was a leader in study cooperation. Marc Humbert led the PAH field by publishing 150 articles in the past decade. During the past decade, there was a close transnational relation among countries or regions, institutions and authors. Further, was the most cited journal, followed by the and the , with 3,895, 3,406, and 3,170 citations, respectively. The global research status and trend of PAH are deeply understood for the first time using bibliometric and visual methods, and the results of our study bring us a valuable reference for clinical researchers.
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http://dx.doi.org/10.1080/21655979.2022.2100064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342150PMC
June 2022

Noninvasive photoacoustic computed tomography/ultrasound imaging to identify high-risk atherosclerotic plaques.

Eur J Nucl Med Mol Imaging 2022 Jul 23. Epub 2022 Jul 23.

Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Purpose: Noninvasive detection of high-risk plaques is still challenging. In this study, we aimed to noninvasively assess αvβ3-integrin expression using a customed photoacoustic (PA) computed tomography (PACT)/ultrasound (US) system in atherosclerotic lesions of varying degrees of severity and to explore its potential value for detecting high-risk plaques.

Methods: We constructed αvβ3-integrin-targeted ultrasmall gold nanorods (AuNRs) with cyclo Arg-Gly-Asp (cRGD) and tested their properties. Employing C57BL/6 J (wild-type, WT) mice and apolipoprotein E gene knockout (ApoE) mice fed either a chow diet or a high-fat/high-cholesterol diet (HFHCD), we established varying degrees of lesion severity. In vivo PACT/US imaging was performed to assess αvβ3-integrin expression in the 4 groups by cRGD-AuNRs. Further histopathologic examination was conducted to evaluate the plaque vulnerability indicators.

Results: The data showed that cRGD-AuNRs exhibited excellent photothermal conversion capacity, stability, targeting ability, and biocompatibility. The immunohistochemical results indicated that αvβ3-integrin was upregulated with increasing aggravation of the lesions. In vivo PACT/US imaging showed good consistency with αvβ3-integrin expression. Notably, ApoE mice fed a HFHCD showed an abrupt PA intensity increase compared with the other groups. The histopathologic examination verified that the atherosclerotic plaques of ApoE mice fed the HFHCD developed unstable phenotypes. Correlation analysis showed that PA intensity was mainly related to inflammation and angiogenesis among all of the indicators.

Conclusion: Our data indicated that αvβ3-integrin is an effective indicator of plaque instability, and noninvasive PACT/US molecular imaging assessment of αvβ3-integrin holds promise in detecting high-risk plaques.
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http://dx.doi.org/10.1007/s00259-022-05911-9DOI Listing
July 2022

Highly ordered asymmetric cellulose-based honeycomb membrane for moisture-electricity generation and humidity sensing.

Carbohydr Polym 2022 Oct 3;294:119809. Epub 2022 Jul 3.

College of Bioresources Chemical and Materials Engineering, Shaanxi Province Key Laboratory of papermaking Technology and Specialty paper Development, Shaanxi University of Science & Technology, Xi'an 710021, China. Electronic address:

Moisture-trigged electricity generator (MEG) that can convert ubiquitous moisture into electricity are highly desirable for developing renewable energy supply and ameliorating the crisis in energy. Constructing an asymmetric ordered, namely gradient ordered porous membrane has great potential in MEG. Herein, a series of cellulose acetate (CA)-based membranes with ordered asymmetric honeycomb membranes were fabricated by Breath Figure method, along with silver nanowires (AgNWs) coating. The asymmetric gradient honeycomb pores were achieved by graft modification of lauroyl chloride and adjustment of relative humidity, which not only endowed the MEG with sensitive sensing signals transport under tension and humidity fluctuations but also enhanced voltages generation speed under flowing moisture. The current study provides a facile and scalable strategy for constructing asymmetric gradient ordered porous materials and creates more possibilities for MEG self-powered flexible wearable electronic devices.
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http://dx.doi.org/10.1016/j.carbpol.2022.119809DOI Listing
October 2022

ANGPTL4 Regulates Psoriasis Modulating Hyperproliferation and Inflammation of Keratinocytes.

Front Pharmacol 2022 4;13:850967. Epub 2022 Jul 4.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

: Psoriasis is characterized by keratinocyte proliferation and massive inflammatory leukocytes infiltration, affecting 0.14%-1.99% of the world's population. Our aim was to identify novel potential therapeutic strategies for psoriasis. : Weighted gene co-expression network analysis (WGCNA) was performed to identify gene modules that were closely related to psoriasis based on the GSE30999 dataset, which contained expression data from 85 patients with moderate-to-severe psoriasis. Then, angiopoietin-like 4 (ANGPTL4), one of the most related hub genes, was selected for and functional assays. In our experiments, imiquimod (IMQ)-induced psoriasiform dermatitis in mice and human keratinocytes (HaCaT) cells were used to study the potential roles and mechanisms of ANGPTL4 in psoriasis. : WGCNA analysis revealed the turquoise module was most correlated with psoriasis, and ANGPTL4 is one of the most related hub genes that significantly upregulated in psoriasis lesions compared with non-lesional skin. Consistent with the bioinformatic analysis, the expression of ANGPTL4 was significantly upregulated in IMQ-induced psoriasiform skin of mice. Exogenous recombinant ANGPLT4 protein treatment could promote the proliferation and induce the expression of inflammatory cytokines in HaCaTs, whereas silencing of ANGPTL4 effectively inhibited these effects. Then we demonstrated that recombinant ANGPTL4 protein exacerbated psoriasiform inflammation and epidermal hyperproliferation . Mechanismly, extracellular signal-regulated kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) pathways were involved in ANGPTL4-mediated regulation of proliferation and inflammation. : We found ANGPTL4 was significantly increased in IMQ-induced psoriasiform skin of mice. ANGPTL4 could promote keratinocyte proliferation and inflammatory response ERK1/2 and STAT3 dependent signaling pathways in psoriasis.
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http://dx.doi.org/10.3389/fphar.2022.850967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289168PMC
July 2022

Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.

Clin Epigenetics 2022 07 20;14(1):92. Epub 2022 Jul 20.

Department of Gastrointestinal Surgery, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

Background: SLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal cancer (CRC) and functions as a tumor suppressor. However, the mechanisms underlying the inactivation of SLC5A7 in CRC remain to be elucidated.

Results: In the present study, two broad-spectrum demethylation agents (azacitidine and decitabine) employed to treat CRC cells significantly upregulated SLC5A7 expression. Further results based on the CRC cohort and TCGA database indicated that SLC5A7 promoter methylation inversely correlated with SLC5A7 expression, and the status of SLC5A7 promotor methylation showed a promising prognostic value for patients with CRC. Next, the dCas9-multiGCN4/scFv-TET1CD-based precision demethylation system was constructed, which could significantly and specifically promote SLC5A7 expression in CRC cells through sgRNA targeting the SLC5A7 promoter. Both in vitro and in vivo experiments demonstrated that targeted demethylation of SLC5A7 by dCas9-multiGCN4/scFv-TET1CD-sgSLC5A7 inhibited tumor growth by stabilizing p53 and regulating downstream targets.

Conclusions: Collectively, DNA promoter methylation caused inactivation of SLC5A7 in CRC, and targeted demethylation of SLC5A7 might be a therapeutic target for CRC and other cancers.
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http://dx.doi.org/10.1186/s13148-022-01308-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301853PMC
July 2022

A Review on 3D Zinc Anodes for Zinc Ion Batteries.

Small Methods 2022 Jul 19:e2200597. Epub 2022 Jul 19.

Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen, Fujian, 361005, China.

Zinc ion batteries (ZIBs) have been gradually developed in recent years due to their abundant resources, low cost, and environmental friendliness. Therefore, ZIBs have received a great deal of attention from researchers, which are considered as the next generation of portable energy storage systems. However, poor overall performance of ZIBs restricts their development, which is attributed to zinc dendrites and a series of side reactions. Constructing 3D zinc anodes has proven to be an effective way to significantly improve their electrochemical performance. In this review, the challenges of zinc anodes in ZIBs, including zinc dendrites, hydrogen evolution and corrosion, as well as passivation, are comprehensively summarized and the energy storage mechanisms of the zinc anodes and 3D zinc anodes are discussed. 3D zinc anodes with different structures including fiberous, porous, ridge-like structures, plated zinc anodes on different substrates and other 3D zinc anodes, are subsequently discussed in detail. Finally, emerging opportunities and perspectives on the material design of 3D zinc anodes are highlighted and challenges that need to be solved in future practical applications are discussed, hopefully illuminating the way forward for the development of ZIBs.
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http://dx.doi.org/10.1002/smtd.202200597DOI Listing
July 2022

Pancreatic adenocarcinoma associated immune-gene signature as a novo risk factor for clinical prognosis prediction in hepatocellular carcinoma.

Sci Rep 2022 Jul 13;12(1):11944. Epub 2022 Jul 13.

Department of Hepatopancreatobiliary Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, 1111 Jiangnan Road, Ningbo, 315040, Zhejiang, China.

Pancreatic adenocarcinoma (PAAD) has high mortality and a very poor prognosis. Both surgery and chemotherapy have a suboptimal therapeutic effect, and this caused a need to find new approaches such as immunotherapy. Therefore, it is essential to develop a new model to predict patient prognosis and facilitate early intervention. Our study screened out and validated the target molecules based on the TCGA-PAAD dataset. We established the risk signature using univariate and multivariate Cox regression analysis and used GSE62452 and GSE28735 to verify the accuracy and reliability of the model. Expanded application of PAAD-immune-related genes signature (-IRGS) on other datasets was conducted, and the corresponding nomograms were constructed. We also analyzed the correlation between immune-related cells/genes and potential treatments. Our research demonstrated that a high riskscore of PAAD-IRGS in patients with PAAD was correlated with poor overall survival, disease-specific survival and progression free interval. The same results were observed in patients with LIHC. The models constructed were confirmed to be accurate and reliable. We found various correlations between PAAD-IRGS and immune-related cells/genes, and the potential therapeutic agents. These findings indicate that PAAD-IRGS may be a promising indicator for prognosis and of the tumor-immune microenvironment status in PAAD.
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http://dx.doi.org/10.1038/s41598-022-16155-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279485PMC
July 2022

Profiling of d-alanine production by the microbial isolates of rat gut microbiota.

FASEB J 2022 Aug;36(8):e22446

Department of Chemistry, Carl R. Woese Institute for Genomic Biology, and the Beckman Institute, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

d-alanine (d-Ala) and several other d-amino acids (d-AAs) act as hormones and neuromodulators in nervous and endocrine systems. Unlike the endogenously synthesized d-serine in animals, d-Ala may be from exogenous sources, e.g., diet and intestinal microorganisms. However, it is unclear if the capability to produce d-Ala and other d-AAs varies among different microbial strains in the gut. We isolated individual microorganisms of rat gut microbiota and profiled their d-AA production in vitro, focusing on d-Ala. Serial dilutions of intestinal contents from adult male rats were plated on agar to obtain clonal cultures. Using MALDI-TOF MS for rapid strain typing, we identified 38 unique isolates, grouped into 11 species based on 16S rRNA gene sequences. We then used two-tier screening to profile bacterial d-AA production, combining a d-amino acid oxidase-based enzymatic assay for rapid assessment of non-acidic d-AA amount and chiral LC-MS/MS to quantify individual d-AAs, revealing 19 out of the 38 isolated strains as d-AA producers. LC-MS/MS analysis of the eight top d-AA producers showed high levels of d-Ala in all strains tested, with substantial inter- and intra-species variations. Though results from the enzymatic assay and LC-MS/MS analysis aligned well, LC-MS/MS further revealed the existence of d-glutamate and d-aspartate, which are poor substrates for this enzymatic assay. We observed large inter- and intra-species variation of d-AA production profiles from rat gut microbiome species, demonstrating the importance of chemical profiling of gut microbiota in addition to sequencing, furthering the idea that microbial metabolites modulate host physiology.
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http://dx.doi.org/10.1096/fj.202101595RDOI Listing
August 2022

Serum miRNA-204-5p as a potential non-invasive biomarker for the diagnosis of endometrial cancer with sentinel lymph node mapping.

Oncol Lett 2022 Aug 7;24(2):248. Epub 2022 Jun 7.

Department of Obstetrics and Gynecology, Shanghai General Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China.

The lymph node status is one of the most critical prognostic factors used in determining adjuvant treatment in endometrial cancer (EC). Lymphadenectomy is associated significant surgical and postoperative risks. The use of sentinel lymph node mapping (SLNM) has emerged as an alternative method to complete lymphadenectomy in EC. However, there remains controversy surrounding the use of SLNM in high-risk disease and its false-negative rate (3%). The authors previously identified miR-204-5p as a tumor-suppressor miRNA associated with lymph node metastasis in EC tissues. The present study demonstrated that serum miR-204-5p in patients with EC has the potential for use as an early diagnostic biomarker combined with SLNM to assess the lymph node status prior to surgery. The present study also aimed to identify the optimal cut-off value of serum miR-204-5p. The relative expression levels of miR-204-5p were detected using reverse transcription-quantitative PCR in the serum of 52 patients with EC (total SLNM). A total of 20 patients diagnosed with ovarian cysts, 20 patients diagnosed with myoma, and 20 participants diagnosed with endometrial polyps or endometrial hyperplasia were included as the control group. miR-204-5p expression was also detected in lymph node tissues using hybridization. The results revealed that serum miR-204-5p expression was downregulated in patients with EC compared with its expression in patients with benign ovarian cysts, myoma and endometrial hyperplasia/polyps (P<0.01). In accordance with the final pathological evaluation, patients with EC with a positive SLN status had a significantly lower level of miR-204-5p compared with those with a negative SLN status (P<0.01). The area under the ROC curve of miR-204-5p was 0.923, 95% CI (0.847-1.000), and the diagnostic value had a sensitivity of 87.2% and specificity of 80.0%, with an optimal cut-off value of 0.253. On the whole, it was demonstrated that a lower miR-204-5p expression is associated with lymph node metastasis in these SLN(+) EC tissues, indicating that the downregulation of serum miR-204-5p in patients with EC has potential for use as an early diagnostic biomarker combined with SLNM. In addition, with a cut-off value of 0.253, it appeared optimal for the prediction of lymph node metastasis in EC.
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http://dx.doi.org/10.3892/ol.2022.13368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214711PMC
August 2022

Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis Oxidative Stress and PI3K/Akt Signaling Pathway.

Front Pharmacol 2022 8;13:896523. Epub 2022 Jun 8.

Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, China.

Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction (CQCQD), a Chinese herbal formula, has long been used for the clinical management of AP but its therapeutic actions and the underlying mechanisms have not been fully elucidated. This study has investigated the pharmacological mechanisms of CQCQD in a novel mouse model of obesity-related alcohol-induced AP (OA-AP). The mouse OA-AP model was induced by a high-fat diet for 12 weeks and subsequently two intraperitoneal injections of ethanol, CQCQD was administered 2 h after the first injection of ethanol. The severity of OA-AP was assessed and correlated with changes in transcriptomic profiles and network pharmacology in the pancreatic and adipose tissues, and further docking analysis modeled the interactions between compounds of CQCQD and their key targets. The results showed that CQCQD significantly reduced pancreatic necrosis, alleviated systemic inflammation, and decreased the parameters associated with multi-organ dysfunction. Transcriptomics and network pharmacology analysis, as well as further experimental validation, have shown that CQCQD induced Nrf2/HO-1 antioxidant protein response and decreased Akt phosphorylation in the pancreatic and adipose tissues. , CQCQD protected freshly isolated pancreatic acinar cells from HO-elicited oxidative stress and necrotic cell death. The docking results of AKT1 and the active compounds related to AKT1 in CQCQD showed high binding affinity. In conclusion, CQCQD ameliorates the severity of OA-AP by activating of the antioxidant protein response and down-regulating of the PI3K/Akt signaling pathway in the pancreas and visceral adipose tissue.
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http://dx.doi.org/10.3389/fphar.2022.896523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213732PMC
June 2022

In Situ Construction of a Liquid Film Interface with Fast Ion Transport for Solid Sodium-Ion Batteries.

Nano Lett 2022 Jul 21;22(13):5214-5220. Epub 2022 Jun 21.

School of Chemical Engineering, North China University of Science and Technology, Tangshan 063009, China.

Solid sodium-ion batteries (SSIBs) are considered as one of the promising energy storage systems because of their high safety and high energy density. However, the sodium metal anode presents poor wettability with a solid electrolyte, resulting in high interface impedance and dendrite growth, which severely limits their application in practice. Herein, a novel liquid film (Na-BP) interface is constructed between sodium and solid electrolyte (NaHfSiPO) with an excellent kinetic mass transfer ability and good fluidity, which could guarantee a close contact and fast charge transfer at interface. The symmetric cells with the designed interface show a high-rate and long-cycle performance and could cycle stably more than 1000 and 700 h at 0.2 and 0.5 mA cm, respectively. The critical current density of the cells can reach 3.6 mA cm at room temperature, which is the highest value in similar works.
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http://dx.doi.org/10.1021/acs.nanolett.2c00983DOI Listing
July 2022

Recent advances in the preparation, characterization, and food application of starch-based hydrogels.

Carbohydr Polym 2022 Sep 16;291:119624. Epub 2022 May 16.

College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province 266109, China. Electronic address:

Although synthetic polymer hydrogels have excellent mechanical properties, they are not easily degraded, are toxic, and easily cause environmental pollution. Therefore, starch-based hydrogels have attracted great interest due to their biodegradability, biocompatibility, and non-toxicity. First of all, this review describes in detail the preparation of starch-based hydrogels by physical retrogradation method and chemical crosslinking methods, as well as the intrinsic and extrinsic factors that affect the performance of the hydrogels. Moreover, the commonly used methods to characterize starch-based hydrogels and the properties of responsive (thermo-, pH-, and enzyme-responsive) starch-based hydrogels have also attracted wide attention from researchers. In addition, the applications of starch-based hydrogels in starch noodles, treatment of sewage from the food industry, and food bioactive ingredient carriers are discussed. Furthermore, prospects and future directions of starch-based hydrogels are discussed. We believe that this review provides a valuable reference for the efficient preparation and application of starch-based hydrogels.
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http://dx.doi.org/10.1016/j.carbpol.2022.119624DOI Listing
September 2022

Analysis of Two-Piano Teaching Assistant Training Based on Neural Network Model Sound Sequence Recognition.

Authors:
Lei Dai

Comput Intell Neurosci 2022 2;2022:5768291. Epub 2022 Jun 2.

Department of Art, Hefei Preschool Education College, Hefei, Anhui 230013, China.

In today's society, with the gradual improve5ment of material living standards, people are also more in pursuit of their own spiritual enjoyment. The study of piano has gradually become a way for people to enrich their spiritual life, and more and more people attach importance to it. In the field of piano teaching, the two-piano method is a unique form of playing the piano. In order to solve the problem that the recognition accuracy of the sequence of two pianos is seriously reduced in the environment of noise and reverberation, this paper proposes an auxiliary training analysis system based on the neural network model. Firstly, in order to learn the nonlinear relationship between the sound order and the target task label from the massive data, a multitask preprocessing method combining speech enhancement and detection is used to supervise the deep neural network training. Then, convolutional neural network is used to construct the end-to-end recognition system, and the initial recognition results are checked and corrected by the phonological sequence model. Finally, the sequence recognition is carried out under the condition of noise, and the articulation is improved by speech enhancement front-end module, and then the sequence recognition model is used for recognition. Compared with traditional training methods, it is proved that our method is effective in improving the training efficiency and performance quality of players. At the same time, this method breaks through the limitation of traditional training method of double piano, creates a more scientific training means, and realizes the practice and application of artificial intelligence technology in the teaching of double piano.
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http://dx.doi.org/10.1155/2022/5768291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184186PMC
June 2022

Robust and adhesive lignin hybrid hydrogel as an ultrasensitive sensor.

Int J Biol Macromol 2022 Jul 30;213:226-233. Epub 2022 May 30.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China. Electronic address:

The fabrication of hydrogel for sensing purposes remains to be a challenge since the hydrogel needs to have both good mechanical strength and adhesiveness. This work reports a robust and adhesive hydrogel mainly constructed with [email protected], polyacrylamide (PAM) and sodium alginate (SA). The silver nanoparticles (AgNPs) were in-situ generated via the reaction between lignin and silver ammonia ([Ag(NH)]). The resultant lignin hybrid hydrogel exhibited a stress, strain and tearing energy up to 0.055 MPa, 1000% and 250 J·m, respectively. Furthermore, the hydrogel adhered to different materials with an adhesion energy of higher than 230 J·m. This hydrogel was demonstrated to be an ideal sensing material since it could detect both large-scale motions and tiny physiological signals including breathing and pulse. The hydrogel also exhibited good antibacterial performance and biocompatibility. This work provides a good example to design a lignin-based high-performance hydrogel material for sensing purposes.
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http://dx.doi.org/10.1016/j.ijbiomac.2022.05.168DOI Listing
July 2022

Properties of curcumin-loaded zein-tea saponin nanoparticles prepared by antisolvent co-precipitation and precipitation.

Food Chem 2022 Oct 16;391:133224. Epub 2022 May 16.

College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, People's Republic of China; Qingdao Special Food Research Institute, Qingdao 266109, People's Republic of China. Electronic address:

The properties of nutraceutical-loaded biopolymer nanoparticles fabricated by antisolvent co-precipitation (ASCP) and precipitation (ASP) were compared. Curcumin-loaded zein-tea saponin nanoparticles were fabricated using both methods and then their structural and physicochemical properties were characterized. The diameter of the nanoparticles prepared by ASCP were smaller (120-130 nm) than those prepared by ASP (140-160 nm). The encapsulation efficiency of the ASCP-nanoparticles (80.0%) was higher than the ASP-ones (71.0%) at a zein-to-curcumin mass ratio of 3:1, which was also higher than previous studies. The storage and light stability of curcumin was higher in zein-saponin nanoparticles than in zein nanoparticles. All nanoparticles had good water dispersibility after freeze-drying and rehydration. This study shows that nanoparticles produced by antisolvent co-precipitation have superior properties to those produced by antisolvent precipitation. The co-precipitation method leads to a higher encapsulation efficiency, smaller particle size, and greater storage stability, which may be advantageous for some applications.
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http://dx.doi.org/10.1016/j.foodchem.2022.133224DOI Listing
October 2022

Efficient preparation of cellulose nanocrystals with a high yield through simultaneous acidolysis with a heat-moisture treatment.

Food Chem 2022 Oct 21;391:133285. Epub 2022 May 21.

College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, Shandong Province, PR China; Qingdao Special Food Research Institute, Qingdao 266109, PR China; College of Science, Health, Engineering and Education, Murdoch University, Murdoch 6150, Western Australia, Australia. Electronic address:

This study developed a novel method for the facile and efficient preparation of the cellulose nanocrystals (CNCs) by using a simultaneous collaborative process combining sulfuric acid hydrolysis and heat-moisture treatment. In this work, we significantly reduced acid dosage compared to conventional acid solution hydrolysis methods to prepare CNCs. The weight of diluted sulfuric acid is no more than 25% on dry basis weight of microcrystalline cellulose. In a relatively short time (2 h), the yield could reach 93.68%, which is higher than the existing methods. The obtained CNCs displayed a normal rod-like shape (100 nm) and unusual spherical shape (10 nm) and showed high relative crystallinity ranged from 70.92% to 81.13%. The combination of acidolysis and heat-moisture treatment may be an economical and effective method for large-scale production of CNCs and provides a new method for preparing short CNCs, which can be used in membrane strengthening and food packages.
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http://dx.doi.org/10.1016/j.foodchem.2022.133285DOI Listing
October 2022

The Association Between the Frequency of Annual Health Checks Participation and the Control of Cardiovascular Risk Factors.

Front Cardiovasc Med 2022 10;9:860503. Epub 2022 May 10.

Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: General health checks can help in controlling cardiovascular risk factors. However, few studies have investigated whether regular participation in annual health checks could further improve the control of cardiovascular risk factors compared with intermittent participation. Therefore, our study aimed to explore the association between the frequency of annual health check participation and the control of cardiovascular risk factors.

Methods: Residents aged ≥ 65 years or having chronic diseases (hypertension or diabetes) from 37 communities of Guangzhou, Guangdong, who participated in the Basic Public Health Service project between January 2015 and December 2019, were enrolled and divided into 3 groups ("Sometimes," "Usually," and "Always") according to their frequencies of annual health check participation. Multivariable linear regression models were performed to assess the association between the frequency of annual health check participation and the control of cardiovascular risk factors. A subgroup analysis stratified by gender was also conducted.

Results: In total, 9,102 participants were finally included. Significant differences were identified between groups in systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, and serum creatinine. After fully adjusting for confounding factors, residents who always participated in the annual health check tended to have lower SBP (β = -4.36, 95% : -5.46; -3.26, < 0.001), fasting glucose (β = -0.27, 95% : -0.38; -0.15, < 0.001), and total cholesterol (β = -0.19, 95% CI: -0.26; -0.13, < 0.001), compared with those who attended sometimes. Furthermore, gender did not alter these associations.

Conclusion: A higher frequency of annual health check participation was associated with lower SBP, fasting glucose, and total cholesterol.
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http://dx.doi.org/10.3389/fcvm.2022.860503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127134PMC
May 2022

A specific upregulated long noncoding RNA in colorectal cancer promotes cancer progression.

JCI Insight 2022 Aug 8;7(15). Epub 2022 Aug 8.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.

Long noncoding RNA (lncRNA) plays a crucial role in the pathogenesis of various diseases, including colorectal cancer (CRC). The gene mutations of adenomatous polyposis coli (APC) were found in most patients with CRC. They function as important inducers of tumorigenesis. Based on our microarray results, we identified a specific upregulated lncRNA in CRC (SURC). Further analysis showed that high SURC expression correlated with poorer disease-free survival and overall survival in patients with CRC. Furthermore, we found that mutated APC genes can promote the transcription of SURC by reducing the degradation of β-catenin protein in CRC. Functional assays revealed that knockdown of SURC impaired CRC cell proliferation, colony formation, cell cycle, and tumor growth. Additionally, SURC promotes CCND2 expression by inhibiting the expression of miR-185-5p in CRC cells. In conclusion, we demonstrate that SURC is a specific upregulated lncRNA in CRC and the SURC/miR-185-5p/CCND2 axis may be targetable for CRC diagnosis and therapy.
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http://dx.doi.org/10.1172/jci.insight.158855DOI Listing
August 2022

Ecological dynamics of the gut microbiome in response to dietary fiber.

ISME J 2022 Aug 21;16(8):2040-2055. Epub 2022 May 21.

CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Dietary fibers are generally thought to benefit intestinal health. Their impacts on the composition and metabolic function of the gut microbiome, however, vary greatly across individuals. Previous research showed that each individual's response to fibers depends on their baseline gut microbiome, but the ecology driving microbiota remodeling during fiber intake remained unclear. Here, we studied the long-term dynamics of the gut microbiome and short-chain fatty acids (SCFAs) in isogenic mice with distinct microbiota baselines fed with the fermentable fiber inulin and resistant starch compared to the non-fermentable fiber cellulose. We found that inulin produced a generally rapid response followed by gradual stabilization to new equilibria, and those dynamics were baseline-dependent. We parameterized an ecology model from the time-series data, which revealed a group of bacteria whose growth significantly increased in response to inulin and whose baseline abundance and interspecies competition explained the baseline dependence of microbiome density and community composition dynamics. Fecal levels of SCFAs, such as propionate, were associated with the abundance of inulin responders, yet inter-individual variation of gut microbiome impeded the prediction of SCFAs by machine learning models. We showed that our methods and major findings were generalizable to dietary resistant starch. Finally, we analyzed time-series data of synthetic and natural human gut microbiome in response to dietary fiber and validated the inferred interspecies interactions in vitro. This study emphasizes the importance of ecological modeling to understand microbiome responses to dietary changes and the need for personalized interventions.
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http://dx.doi.org/10.1038/s41396-022-01253-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296629PMC
August 2022

3D Printing Mini-Capsule Device for Islet Delivery to Treat Type 1 Diabetes.

ACS Appl Mater Interfaces 2022 May 11. Epub 2022 May 11.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Transplantation of encapsulated islets has been shown to hold a promising potential treatment for type 1 diabetes (T1D). However, there are several obstacles to overcome, such as immune rejection by the host of the grafts, sustainability of islet function, and retrievability or replacement of the encapsulated system, hinder their clinical applications. In this study, mini-capsule devices containing islets were fabricated by using digital light processing (DLP) 3D printing. To ensure a high survival rate and low immunogenicity of the fabricated islets, 20s was selected as the most suitable printing condition. Meanwhile, the mini-capsule devices with a groove structure were fabricated to prevent islet cells leakage. Subcutaneous transplantations of encapsulated islets in immunocompetent C57BL/6 mice indicated significant improvement in the symptoms of streptozotocin-induced hyperglycemia without any immunosuppression treatment for at least 15 weeks. In vivo intraperitoneal glucose tolerance tests (IPGTT) performed at different time points demonstrated therapeutically relevant glycemic ameliorate of the device. The implants retrieved after 15 weeks still contained viable and adequate numbers of islet cells. The results of this study indicate that the proposed mini-capsule device can deliver sufficient islet cell mass, prevent islet cells leakage, and maintain long-term cell survival while allowing easy retrieval. Furthermore, the proposed encapsulated islets may help with T1D cellular treatment by overcoming the obstacles of islet transplantation.
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http://dx.doi.org/10.1021/acsami.2c02487DOI Listing
May 2022

MicroRNA-203a-3p may prevent the development of thyroid papillary carcinoma via repressing MAP3K1 and activating autophagy.

J Clin Lab Anal 2022 Jun 6;36(6):e24470. Epub 2022 May 6.

Department of Otolaryngology, College of Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Background: Papillary thyroid carcinoma (PTC) grows slowly but has a great risk of metastasis. MicroRNAs are well known as vital tumor-related gene regulators. In PTC, the role of miR-203a-3p and the underlying mechanisms remain not completely understood.

Methods: We conducted CCK8 assay, wound healing assay, transwell experiment and flow cytometry analyses to investigate the function of miRNA-203a-3p. The interaction of miRNA-203a-3p with its gene MAP3K1 was characterized by quantitative real-time polymerase chain reaction, western blotting and luciferase assay.

Results: We found that the levels of miRNA-203a-3p were statistically decreased in PTC tissues. When mimics were delivered to TPC-1 and KTC-1 cells to upregulate miR-203a-3p, it was observed that cell proliferation, metastatic abilities and cell cycle process were prevented but cell apoptosis was enhanced. Furthermore, we proved the interaction between MAP3K1 and miR-203a-3p. Intriguingly, similar to miR-203a-3p mimics, siMAP3K1 showed a tumor-suppressive effect, and this effect could be reversed when miR-203a-3p was simultaneously inhibited. Finally, selected autophagy-linked proteins such as LC3 Beclin-1 were detected and found to be increased when miR-203a-3p was upregulated or MAP3K1 was inhibited.

Conclusion: Overall, miR-203a-3p inhibits the oncogenic characteristics of TPC-1 and KTC-1 cells via suppressing MAP3K1 and activating autophagy. Our findings might enrich the understanding and the therapeutic strategies of PTC.
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http://dx.doi.org/10.1002/jcla.24470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169216PMC
June 2022

Enhanced photocatalytic hydrogen evolution and ammonia sensitivity of double-heterojunction g-CN/TiO/CuO.

RSC Adv 2022 Apr 4;12(21):13381-13392. Epub 2022 May 4.

School of Agricultural Engineering and Food Science, Shandong Research Center of Engineering & Technology for Clean Energy, Shandong University of Technology Zibo 255000 China

The performance of semiconductor photocatalysts has been limited by rapid electron-hole recombination. One strategy to overcome this problem is to construct a heterojunction structure to improve the survival rate of electrons. In this context, a novel g-CN/TiO/CuO double-heterojunction photocatalyst was developed and characterized. Its photocatalytic activity for hydrogen production from water-methanol photocatalytic reforming was explored. Methanol is always used to eliminate semiconductor holes. The g-CN/TiO/CuO double-heterojunction photocatalyst with a narrow bandgap of ∼1.38 eV presented excellent photocatalytic activity for hydrogen evolution (97.48 μmol (g h)) under visible light irradiation. Compared with g-CN/TiO and CuO/TiO, the photocatalytic activity of g-CN/TiO/CuO for hydrogen production was increased approximately 7.6 times and 1.8 times, respectively. Below 240 °C, the sensitivity of g-CN/TiO/CuO to ammonia was approximately 90% and 46% higher than that of g-CN/TiO and CuO/TiO, respectively. The enhancement of the photocatalytic activity and gas sensing properties of the g-CN/TiO/CuO composite resulted from the close interface contact established by the double heterostructure. The trajectory of electrons in the double heterojunction conformed to the S-scheme. UV-vis, PL, and transient photocurrent characterization showed that the double heterostructure effectively inhibited the recombination of e/h pairs and enhanced the migration of photogenerated electrons.
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http://dx.doi.org/10.1039/d2ra01918cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066703PMC
April 2022

Elevated islet prohormone ratios as indicators of insulin dependency in auto-islet transplant recipients.

Am J Transplant 2022 08 21;22(8):1992-2005. Epub 2022 May 21.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

Pancreatic islet transplantation has therapeutic potential in type 1 diabetes and is also an established therapy in chronic pancreatitis. However, the long-term transplant outcomes are modest. Identifying indicators of graft function will aid the preservation of transplanted islets and glycemic control. We analyzed beta cell prohormone peptide levels in a retrospective cohort of total pancreatectomy autologous islet transplant patients (n = 28). Proinsulin-to-C-peptide (PI/C) and proIAPP-to-total IAPP (proIAPP/IAPP) ratios measured at 3 months post-transplant were significantly higher in patients who remained insulin dependent at 1 year follow-up. In an immuno-deficient mouse model of human islet transplantation, recipient mice that later became hyperglycemic displayed significantly higher PI/C ratios than mice that remained normoglycemic. Histological analysis of islet grafts showed reduced proportional insulin- and proinsulin-positive area, but elevated glucagon-positive area in grafts that experienced greater secretory demand. Increased prohormone convertase 1/3 was detected in glucagon-positive cells, and glucagon-like peptide 1 (GLP-1) area was elevated in grafts from mice that displayed hyperglycemia or elevated plasma PI/C ratios, demonstrating intra-islet incretin production in metabolically challenged human islet grafts. These data indicate that in failing grafts, alpha cell prohormone processing is likely altered, and incomplete beta cell prohormone processing may be an early indicator of insulin dependency.
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http://dx.doi.org/10.1111/ajt.17076DOI Listing
August 2022

ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1.

J Biol Chem 2022 06 28;298(6):101989. Epub 2022 Apr 28.

Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, PR China. Electronic address:

Diabetic cardiomyopathy (DCM) is a major complication of diabetes, but its underlying mechanisms still remain unclear. The multifunctional protein Y-box binding protein-1 (YB-1) plays an important role in cardiac pathogenesis by regulating cardiac apoptosis, cardiac fibrosis, and pathological remodeling, whereas its role in chronic DCM requires further investigation. Here, we report that the phosphorylation of YB-1 at serine102 (S102) was markedly elevated in streptozotocin-induced diabetic mouse hearts and in high glucose-treated cardiomyocytes, whereas total YB-1 protein levels were significantly reduced. Coimmunoprecipitation experiments showed that YB-1 interacts with the deubiquitinase otubain-1, but hyperglycemia-induced phosphorylation of YB-1 at S102 diminished this homeostatic interaction, resulting in ubiquitination and degradation of YB-1. Mechanistically, the high glucose-induced phosphorylation of YB-1 at S102 is dependent on the upstream extracellular signal-regulated kinase (ERK)/Ras/mitogen-activated protein kinase (p90 ribosomal S6 kinase [RSK]) signaling pathway. Accordingly, pharmacological inhibition of the ERK pathway using the upstream kinase inhibitor U0126 ameliorated features of DCM compared with vehicle-treated diabetic mice. We demonstrate that ERK inhibition with U0126 also suppressed the phosphorylation of the downstream RSK and YB-1 (S102), which stabilized the interaction between YB-1 and otubain-1 and thereby preserved YB-1 protein expression in diabetic hearts. Taken together, we propose that targeting the ERK/RSK/YB-1 pathway could be a potential therapeutic approach for treating DCM.
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http://dx.doi.org/10.1016/j.jbc.2022.101989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163515PMC
June 2022

Designing a Novel Electrolyte Na Hf Si P O F for All-Solid-State Na-O Batteries.

Small Methods 2022 Jul 1;6(7):e2200345. Epub 2022 May 1.

School of Chemical Engineering, North China University of Science and Technology, Tangshan, 063009, P. R. China.

Sodium-air battery has great development potential due to its high energy density and high safety. However, most previous works are based on liquid electrolyte or polymer electrolyte, which will inevitably result in safety hazards such as electrolyte leakage and sodium dendrite growth. Herein, an all-solid-state Na-O battery based on a well-designed NASICON-type electrolyte Na Hf Si P O F , which has high ionic conductivity (2.39 × 10 S cm ) and excellent chemical stability, is developed. Collaborating with the reasonable humidity of the atmosphere, the battery shows good cycle stability. This research demonstrates that NASICON-type electrolyte Na Hf Si P O F has good application potential for all-solid-state Na-O batteries and lays a solid foundation on the material preparation and optimization for developing high-energy sodium-air batteries.
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http://dx.doi.org/10.1002/smtd.202200345DOI Listing
July 2022

Alcohol predisposes obese mice to acute pancreatitis via adipose triglyceride lipase-dependent visceral adipocyte lipolysis.

Gut 2022 Apr 22. Epub 2022 Apr 22.

Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, People's Republic of China

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http://dx.doi.org/10.1136/gutjnl-2022-326958DOI Listing
April 2022
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