Lefkos T Middleton

Lefkos T Middleton

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Lefkos T Middleton

Lefkos T Middleton

Publications by authors named "Lefkos T Middleton"

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Cortisol, Amyloid-β, and Reserve Predicts Alzheimer's Disease Progression for Cognitively Normal Older Adults.

J Alzheimers Dis 2019 ;70(2):553-562

Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology and Medicine, London, UK.

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http://dx.doi.org/10.3233/JAD-181030DOI Listing
January 2019

α-Synuclein: Multiple System Atrophy Prions.

Cold Spring Harb Perspect Med 2018 07 2;8(7). Epub 2018 Jul 2.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a024588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561534PMC
July 2018

MSA prions exhibit remarkable stability and resistance to inactivation.

Acta Neuropathol 2018 01 28;135(1):49-63. Epub 2017 Aug 28.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1007/s00401-017-1762-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756500PMC
January 2018

Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses.

Alzheimers Dement 2017 Apr 4;13(4):406-418. Epub 2016 Sep 4.

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.07.152DOI Listing
April 2017

Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group.

BMC Med 2016 Nov 3;14(1):162. Epub 2016 Nov 3.

Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology and Medicine, Charing Cross Hospital, St Dunstan's Road, W6 8RP, London, UK.

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http://dx.doi.org/10.1186/s12916-016-0719-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093932PMC
November 2016

α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.

Ann Neurol 2016 Jun 5;79(6):991-9. Epub 2016 May 5.

Centre for Applied Neurogenetics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://doi.wiley.com/10.1002/ana.24664
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http://dx.doi.org/10.1002/ana.24664DOI Listing
June 2016

Why has therapy development for dementia failed in the last two decades?

Alzheimers Dement 2016 Jan 19;12(1):60-4. Epub 2015 Dec 19.

Neuroepidemiology and Ageing Research, School of Public Health, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.12.003DOI Listing
January 2016

Propagation of prions causing synucleinopathies in cultured cells.

Proc Natl Acad Sci U S A 2015 Sep 18;112(35):E4949-58. Epub 2015 Aug 18.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143; Department of Neurology, University of California, San Francisco, CA 94143; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143

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http://dx.doi.org/10.1073/pnas.1513426112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568231PMC
September 2015

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Proc Natl Acad Sci U S A 2015 Sep 31;112(38):E5308-17. Epub 2015 Aug 31.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143; Department of Neurology, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1514475112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586853PMC
September 2015

A novel GBA2 gene missense mutation in spastic ataxia.

Ann Hum Genet 2014 Jan 20;78(1):13-22. Epub 2013 Nov 20.

The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

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http://dx.doi.org/10.1111/ahg.12045DOI Listing
January 2014

A novel GBA2 gene missense mutation in spastic ataxia.

Ann Hum Genet 2014 Jan 20;78(1):13-22. Epub 2013 Nov 20.

The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

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http://dx.doi.org/10.1111/ahg.12045DOI Listing
January 2014

Pharmacogenetics in drug development.

Philos Trans R Soc Lond B Biol Sci 2005 Aug;360(1460):1579-88

Translational Medicine & Genetics, GlaxoSmithKline, Greenford Road, Greenford, Middlesex UB6 0HE, UK.

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http://dx.doi.org/10.1098/rstb.2005.1688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569527PMC
August 2005

A novel NF-L mutation Pro22Ser is associated with CMT2 in a large Slovenian family.

Neurogenetics 2002 Oct;4(2):93-6

The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

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October 2002