Leena Peltonen

Leena Peltonen

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Leena Peltonen

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Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering.

Biotechnol J 2019 Apr 23;14(4):e1800413. Epub 2018 Nov 23.

Drug Research Program, Division of Pharmaceutical Chemistry and , University of Helsinki, Viikinkaari 5 E (PO Box 56), 00014 Helsinki, Finland.

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http://dx.doi.org/10.1002/biot.201800413DOI Listing
April 2019

Submission of Rifaximin to Different Techniques: Characterization, Solubility Study, and Microbiological Evaluation.

AAPS PharmSciTech 2019 Feb 25;20(3):125. Epub 2019 Feb 25.

Department of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil.

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http://dx.doi.org/10.1208/s12249-019-1329-8DOI Listing
February 2019

Understanding Dissolution and Crystallization with Imaging: A Surface Point of View.

Mol Pharm 2018 11 9;15(11):5361-5373. Epub 2018 Oct 9.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy , University of Helsinki , Viikinkaari 5 E , 00014 Helsinki , Finland.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00840
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221374PMC
November 2018

High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions.

Biomacromolecules 2018 10 12;19(10):3983-3993. Epub 2018 Sep 12.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy , University of Helsinki , FI-00014 , Finland.

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http://dx.doi.org/10.1021/acs.biomac.8b00931DOI Listing
October 2018

Design Space and QbD Approach for Production of Drug Nanocrystals by Wet Media Milling Techniques.

Authors:
Leena Peltonen

Pharmaceutics 2018 Jul 25;10(3). Epub 2018 Jul 25.

Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

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http://dx.doi.org/10.3390/pharmaceutics10030104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161287PMC
July 2018

Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry.

Authors:
Leena Peltonen

Adv Drug Deliv Rev 2018 06 18;131:101-115. Epub 2018 Jun 18.

Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, P.O. Box 56, FI-00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2018.06.009DOI Listing
June 2018

Drug nanocrystals - Versatile option for formulation of poorly soluble materials.

Int J Pharm 2018 Feb 17;537(1-2):73-83. Epub 2017 Dec 17.

Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, 00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.12.005DOI Listing
February 2018

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Authors:
Robert A Scott Laura J Scott Reedik Mägi Letizia Marullo Kyle J Gaulton Marika Kaakinen Natalia Pervjakova Tune H Pers Andrew D Johnson John D Eicher Anne U Jackson Teresa Ferreira Yeji Lee Clement Ma Valgerdur Steinthorsdottir Gudmar Thorleifsson Lu Qi Natalie R Van Zuydam Anubha Mahajan Han Chen Peter Almgren Ben F Voight Harald Grallert Martina Müller-Nurasyid Janina S Ried Nigel W Rayner Neil Robertson Lennart C Karssen Elisabeth M van Leeuwen Sara M Willems Christian Fuchsberger Phoenix Kwan Tanya M Teslovich Pritam Chanda Man Li Yingchang Lu Christian Dina Dorothee Thuillier Loic Yengo Longda Jiang Thomas Sparso Hans A Kestler Himanshu Chheda Lewin Eisele Stefan Gustafsson Mattias Frånberg Rona J Strawbridge Rafn Benediktsson Astradur B Hreidarsson Augustine Kong Gunnar Sigurðsson Nicola D Kerrison Jian'an Luan Liming Liang Thomas Meitinger Michael Roden Barbara Thorand Tõnu Esko Evelin Mihailov Caroline Fox Ching-Ti Liu Denis Rybin Bo Isomaa Valeriya Lyssenko Tiinamaija Tuomi David J Couper James S Pankow Niels Grarup Christian T Have Marit E Jørgensen Torben Jørgensen Allan Linneberg Marilyn C Cornelis Rob M van Dam David J Hunter Peter Kraft Qi Sun Sarah Edkins Katharine R Owen John R B Perry Andrew R Wood Eleftheria Zeggini Juan Tajes-Fernandes Goncalo R Abecasis Lori L Bonnycastle Peter S Chines Heather M Stringham Heikki A Koistinen Leena Kinnunen Bengt Sennblad Thomas W Mühleisen Markus M Nöthen Sonali Pechlivanis Damiano Baldassarre Karl Gertow Steve E Humphries Elena Tremoli Norman Klopp Julia Meyer Gerald Steinbach Roman Wennauer Johan G Eriksson Satu Mӓnnistö Leena Peltonen Emmi Tikkanen Guillaume Charpentier Elodie Eury Stéphane Lobbens Bruna Gigante Karin Leander Olga McLeod Erwin P Bottinger Omri Gottesman Douglas Ruderfer Matthias Blüher Peter Kovacs Anke Tonjes Nisa M Maruthur Chiara Scapoli Raimund Erbel Karl-Heinz Jöckel Susanne Moebus Ulf de Faire Anders Hamsten Michael Stumvoll Panagiotis Deloukas Peter J Donnelly Timothy M Frayling Andrew T Hattersley Samuli Ripatti Veikko Salomaa Nancy L Pedersen Bernhard O Boehm Richard N Bergman Francis S Collins Karen L Mohlke Jaakko Tuomilehto Torben Hansen Oluf Pedersen Inês Barroso Lars Lannfelt Erik Ingelsson Lars Lind Cecilia M Lindgren Stephane Cauchi Philippe Froguel Ruth J F Loos Beverley Balkau Heiner Boeing Paul W Franks Aurelio Barricarte Gurrea Domenico Palli Yvonne T van der Schouw David Altshuler Leif C Groop Claudia Langenberg Nicholas J Wareham Eric Sijbrands Cornelia M van Duijn Jose C Florez James B Meigs Eric Boerwinkle Christian Gieger Konstantin Strauch Andres Metspalu Andrew D Morris Colin N A Palmer Frank B Hu Unnur Thorsteinsdottir Kari Stefansson Josée Dupuis Andrew P Morris Michael Boehnke Mark I McCarthy Inga Prokopenko

Diabetes 2017 11 31;66(11):2888-2902. Epub 2017 May 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db16-1253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652602PMC
November 2017

Multimodal Nonlinear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations.

Anal Chem 2017 11 18;89(21):11460-11467. Epub 2017 Oct 18.

Division of Pharmaceutical Chemistry and Technology, University of Helsinki , Viikinkaari 5E, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1021/acs.analchem.7b02639DOI Listing
November 2017

Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes.

AAPS PharmSciTech 2017 Jul 7;18(5):1554-1563. Epub 2016 Sep 7.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Viikinkaari 5E, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1208/s12249-016-0622-zDOI Listing
July 2017

Elucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) Microscopy.

Pharm Res 2017 05 13;34(5):957-970. Epub 2016 Oct 13.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s11095-016-2046-6DOI Listing
May 2017

Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy.

Int J Pharm 2017 May 12;523(1):270-280. Epub 2017 Mar 12.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ijpharm.2017.03.015DOI Listing
May 2017

Development and in-vitro characterization of sorbitan monolaurate and poloxamer 184 based niosomes for oral delivery of diacerein.

Eur J Pharm Sci 2016 Dec 4;95:88-95. Epub 2016 Sep 4.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, P.O. Box 56, 00014, University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.09.002DOI Listing
December 2016

Editorial, Special Issue BBBB.

Eur J Pharm Sci 2016 Dec;95

University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.10.022DOI Listing
December 2016

Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin.

Data Brief 2016 Sep 23;8:741-9. Epub 2016 Jun 23.

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Molecular Medicine, Biomedicum, National Public Health Institute, PO Box 104, FIN 00300 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.dib.2016.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950137PMC
September 2016

The effect of surfactants on the dissolution behavior of amorphous formulations.

Eur J Pharm Biopharm 2016 Jun 5;103:13-22. Epub 2016 Mar 5.

Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ejpb.2016.03.007DOI Listing
June 2016

Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability.

Pharmaceutics 2016 May 20;8(2). Epub 2016 May 20.

Division of Pharmaceutical Chemistry and Technology, P.O. Box 56 (Viikinkaari 5 E), University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.3390/pharmaceutics8020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932479PMC
May 2016

A Pooled Genome-Wide Association Study of Asperger Syndrome.

PLoS One 2015 15;10(7):e0131202. Epub 2015 Jul 15.

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131202PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503355PMC
April 2016

Differential scanning calorimetry predicts the critical quality attributes of amorphous glibenclamide.

Eur J Pharm Sci 2015 Dec 19;80:74-81. Epub 2015 Aug 19.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S09280987150036
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http://dx.doi.org/10.1016/j.ejps.2015.08.006DOI Listing
December 2015

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Authors:
Kyle J Gaulton Teresa Ferreira Yeji Lee Anne Raimondo Reedik Mägi Michael E Reschen Anubha Mahajan Adam Locke N William Rayner Neil Robertson Robert A Scott Inga Prokopenko Laura J Scott Todd Green Thomas Sparso Dorothee Thuillier Loic Yengo Harald Grallert Simone Wahl Mattias Frånberg Rona J Strawbridge Hans Kestler Himanshu Chheda Lewin Eisele Stefan Gustafsson Valgerdur Steinthorsdottir Gudmar Thorleifsson Lu Qi Lennart C Karssen Elisabeth M van Leeuwen Sara M Willems Man Li Han Chen Christian Fuchsberger Phoenix Kwan Clement Ma Michael Linderman Yingchang Lu Soren K Thomsen Jana K Rundle Nicola L Beer Martijn van de Bunt Anil Chalisey Hyun Min Kang Benjamin F Voight Gonçalo R Abecasis Peter Almgren Damiano Baldassarre Beverley Balkau Rafn Benediktsson Matthias Blüher Heiner Boeing Lori L Bonnycastle Erwin P Bottinger Noël P Burtt Jason Carey Guillaume Charpentier Peter S Chines Marilyn C Cornelis David J Couper Andrew T Crenshaw Rob M van Dam Alex S F Doney Mozhgan Dorkhan Sarah Edkins Johan G Eriksson Tonu Esko Elodie Eury João Fadista Jason Flannick Pierre Fontanillas Caroline Fox Paul W Franks Karl Gertow Christian Gieger Bruna Gigante Omri Gottesman George B Grant Niels Grarup Christopher J Groves Maija Hassinen Christian T Have Christian Herder Oddgeir L Holmen Astradur B Hreidarsson Steve E Humphries David J Hunter Anne U Jackson Anna Jonsson Marit E Jørgensen Torben Jørgensen Wen-Hong L Kao Nicola D Kerrison Leena Kinnunen Norman Klopp Augustine Kong Peter Kovacs Peter Kraft Jasmina Kravic Cordelia Langford Karin Leander Liming Liang Peter Lichtner Cecilia M Lindgren Eero Lindholm Allan Linneberg Ching-Ti Liu Stéphane Lobbens Jian'an Luan Valeriya Lyssenko Satu Männistö Olga McLeod Julia Meyer Evelin Mihailov Ghazala Mirza Thomas W Mühleisen Martina Müller-Nurasyid Carmen Navarro Markus M Nöthen Nikolay N Oskolkov Katharine R Owen Domenico Palli Sonali Pechlivanis Leena Peltonen John R B Perry Carl G P Platou Michael Roden Douglas Ruderfer Denis Rybin Yvonne T van der Schouw Bengt Sennblad Gunnar Sigurðsson Alena Stančáková Gerald Steinbach Petter Storm Konstantin Strauch Heather M Stringham Qi Sun Barbara Thorand Emmi Tikkanen Anke Tonjes Joseph Trakalo Elena Tremoli Tiinamaija Tuomi Roman Wennauer Steven Wiltshire Andrew R Wood Eleftheria Zeggini Ian Dunham Ewan Birney Lorenzo Pasquali Jorge Ferrer Ruth J F Loos Josée Dupuis Jose C Florez Eric Boerwinkle James S Pankow Cornelia van Duijn Eric Sijbrands James B Meigs Frank B Hu Unnur Thorsteinsdottir Kari Stefansson Timo A Lakka Rainer Rauramaa Michael Stumvoll Nancy L Pedersen Lars Lind Sirkka M Keinanen-Kiukaanniemi Eeva Korpi-Hyövälti Timo E Saaristo Juha Saltevo Johanna Kuusisto Markku Laakso Andres Metspalu Raimund Erbel Karl-Heinz Jöcke Susanne Moebus Samuli Ripatti Veikko Salomaa Erik Ingelsson Bernhard O Boehm Richard N Bergman Francis S Collins Karen L Mohlke Heikki Koistinen Jaakko Tuomilehto Kristian Hveem Inger Njølstad Panagiotis Deloukas Peter J Donnelly Timothy M Frayling Andrew T Hattersley Ulf de Faire Anders Hamsten Thomas Illig Annette Peters Stephane Cauchi Rob Sladek Philippe Froguel Torben Hansen Oluf Pedersen Andrew D Morris Collin N A Palmer Sekar Kathiresan Olle Melander Peter M Nilsson Leif C Groop Inês Barroso Claudia Langenberg Nicholas J Wareham Christopher A O'Callaghan Anna L Gloyn David Altshuler Michael Boehnke Tanya M Teslovich Mark I McCarthy Andrew P Morris

Nat Genet 2015 Dec 9;47(12):1415-25. Epub 2015 Nov 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666734PMC
December 2015

Understanding Critical Quality Attributes for Nanocrystals from Preparation to Delivery.

Molecules 2015 Dec 12;20(12):22286-300. Epub 2015 Dec 12.

Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P. O. Box 56, Viikinkaari 5 E, 00014, Finland.

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http://dx.doi.org/10.3390/molecules201219851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332140PMC
December 2015

Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions.

Eur J Pharm Biopharm 2015 Oct 5;96:338-48. Epub 2015 Sep 5.

Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2015.09.003DOI Listing
October 2015

Solid formulations by a nanocrystal approach: critical process parameters regarding scale-ability of nanocrystals for tableting applications.

Int J Pharm 2015 May 5;485(1-2):77-86. Epub 2015 Mar 5.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ijpharm.2015.03.009DOI Listing
May 2015

Interaction studies between indomethacin nanocrystals and PEO/PPO copolymer stabilizers.

Pharm Res 2015 Feb 22;32(2):628-39. Epub 2014 Aug 22.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s11095-014-1491-3DOI Listing
February 2015

Mesoporous materials and nanocrystals for enhancing the dissolution behavior of poorly water-soluble drugs.

Curr Pharm Biotechnol 2013 ;14(10):926-38

Division of Pharmaceutical Technology, Faculty of Pharmacy, FI-00014 University of Helsinki, Finland.

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September 2014

Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo.

Int J Pharm 2014 Jun 26;467(1-2):34-41. Epub 2014 Mar 26.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ijpharm.2014.03.048DOI Listing
June 2014

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.

Biol Psychiatry 2014 Mar 17;75(5):386-97. Epub 2013 Jul 17.

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http://dx.doi.org/10.1016/j.biopsych.2013.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923972PMC
March 2014

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Authors:
Anubha Mahajan Min Jin Go Weihua Zhang Jennifer E Below Kyle J Gaulton Teresa Ferreira Momoko Horikoshi Andrew D Johnson Maggie C Y Ng Inga Prokopenko Danish Saleheen Xu Wang Eleftheria Zeggini Goncalo R Abecasis Linda S Adair Peter Almgren Mustafa Atalay Tin Aung Damiano Baldassarre Beverley Balkau Yuqian Bao Anthony H Barnett Ines Barroso Abdul Basit Latonya F Been John Beilby Graeme I Bell Rafn Benediktsson Richard N Bergman Bernhard O Boehm Eric Boerwinkle Lori L Bonnycastle Noël Burtt Qiuyin Cai Harry Campbell Jason Carey Stephane Cauchi Mark Caulfield Juliana C N Chan Li-Ching Chang Tien-Jyun Chang Yi-Cheng Chang Guillaume Charpentier Chien-Hsiun Chen Han Chen Yuan-Tsong Chen Kee-Seng Chia Manickam Chidambaram Peter S Chines Nam H Cho Young Min Cho Lee-Ming Chuang Francis S Collins Marylin C Cornelis David J Couper Andrew T Crenshaw Rob M van Dam John Danesh Debashish Das Ulf de Faire George Dedoussis Panos Deloukas Antigone S Dimas Christian Dina Alex S Doney Peter J Donnelly Mozhgan Dorkhan Cornelia van Duijn Josée Dupuis Sarah Edkins Paul Elliott Valur Emilsson Raimund Erbel Johan G Eriksson Jorge Escobedo Tonu Esko Elodie Eury Jose C Florez Pierre Fontanillas Nita G Forouhi Tom Forsen Caroline Fox Ross M Fraser Timothy M Frayling Philippe Froguel Philippe Frossard Yutang Gao Karl Gertow Christian Gieger Bruna Gigante Harald Grallert George B Grant Leif C Grrop Chrisropher J Groves Elin Grundberg Candace Guiducci Anders Hamsten Bok-Ghee Han Kazuo Hara Neelam Hassanali Andrew T Hattersley Caroline Hayward Asa K Hedman Christian Herder Albert Hofman Oddgeir L Holmen Kees Hovingh Astradur B Hreidarsson Cheng Hu Frank B Hu Jennie Hui Steve E Humphries Sarah E Hunt David J Hunter Kristian Hveem Zafar I Hydrie Hiroshi Ikegami Thomas Illig Erik Ingelsson Muhammed Islam Bo Isomaa Anne U Jackson Tazeen Jafar Alan James Weiping Jia Karl-Heinz Jöckel Anna Jonsson Jeremy B M Jowett Takashi Kadowaki Hyun Min Kang Stavroula Kanoni Wen Hong L Kao Sekar Kathiresan Norihiro Kato Prasad Katulanda Kirkka M Keinanen-Kiukaanniemi Ann M Kelly Hassan Khan Kay-Tee Khaw Chiea-Chuen Khor Hyung-Lae Kim Sangsoo Kim Young Jin Kim Leena Kinnunen Norman Klopp Augustine Kong Eeva Korpi-Hyövälti Sudhir Kowlessur Peter Kraft Jasmina Kravic Malene M Kristensen S Krithika Ashish Kumar Jesus Kumate Johanna Kuusisto Soo Heon Kwak Markku Laakso Vasiliki Lagou Timo A Lakka Claudia Langenberg Cordelia Langford Robert Lawrence Karin Leander Jen-Mai Lee Nanette R Lee Man Li Xinzhong Li Yun Li Junbin Liang Samuel Liju Wei-Yen Lim Lars Lind Cecilia M Lindgren Eero Lindholm Ching-Ti Liu Jian Jun Liu Stéphane Lobbens Jirong Long Ruth J F Loos Wei Lu Jian'an Luan Valeriya Lyssenko Ronald C W Ma Shiro Maeda Reedik Mägi Satu Männisto David R Matthews James B Meigs Olle Melander Andres Metspalu Julia Meyer Ghazala Mirza Evelin Mihailov Susanne Moebus Viswanathan Mohan Karen L Mohlke Andrew D Morris Thomas W Mühleisen Martina Müller-Nurasyid Bill Musk Jiro Nakamura Eitaro Nakashima Pau Navarro Peng-Keat Ng Alexandra C Nica Peter M Nilsson Inger Njølstad Markus M Nöthen Keizo Ohnaka Twee Hee Ong Katharine R Owen Colin N A Palmer James S Pankow Kyong Soo Park Melissa Parkin Sonali Pechlivanis Nancy L Pedersen Leena Peltonen John R B Perry Annette Peters Janini M Pinidiyapathirage Carl G Platou Simon Potter Jackie F Price Lu Qi Venkatesan Radha Loukianos Rallidis Asif Rasheed Wolfgang Rathman Rainer Rauramaa Soumya Raychaudhuri N William Rayner Simon D Rees Emil Rehnberg Samuli Ripatti Neil Robertson Michael Roden Elizabeth J Rossin Igor Rudan Denis Rybin Timo E Saaristo Veikko Salomaa Juha Saltevo Maria Samuel Dharambir K Sanghera Jouko Saramies James Scott Laura J Scott Robert A Scott Ayellet V Segrè Joban Sehmi Bengt Sennblad Nabi Shah Sonia Shah A Samad Shera Xiao Ou Shu Alan R Shuldiner Gunnar Sigurđsson Eric Sijbrands Angela Silveira Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Wing Yee So Alena Stančáková Kari Stefansson Gerald Steinbach Valgerdur Steinthorsdottir Kathleen Stirrups Rona J Strawbridge Heather M Stringham Qi Sun Chen Suo Ann-Christine Syvänen Ryoichi Takayanagi Fumihiko Takeuchi Wan Ting Tay Tanya M Teslovich Barbara Thorand Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Joseph Trakalo Elena Tremoli Mieke D Trip Fuu Jen Tsai Tiinamaija Tuomi Jaakko Tuomilehto Andre G Uitterlinden Adan Valladares-Salgado Sailaja Vedantam Fabrizio Veglia Benjamin F Voight Congrong Wang Nicholas J Wareham Roman Wennauer Ananda R Wickremasinghe Tom Wilsgaard James F Wilson Steven Wiltshire Wendy Winckler Tien Yin Wong Andrew R Wood Jer-Yuarn Wu Ying Wu Ken Yamamoto Toshimasa Yamauchi Mingyu Yang Loic Yengo Mitsuhiro Yokota Robin Young Delilah Zabaneh Fan Zhang Rong Zhang Wei Zheng Paul Z Zimmet David Altshuler Donald W Bowden Yoon Shin Cho Nancy J Cox Miguel Cruz Craig L Hanis Jaspal Kooner Jong-Young Lee Mark Seielstad Yik Ying Teo Michael Boehnke Esteban J Parra Jonh C Chambers E Shyong Tai Mark I McCarthy Andrew P Morris

Nat Genet 2014 Mar 9;46(3):234-44. Epub 2014 Feb 9.

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http://dx.doi.org/10.1038/ng.2897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969612PMC
March 2014

Unravelling the relationship between degree of disorder and the dissolution behavior of milled glibenclamide.

Mol Pharm 2014 Jan 17;11(1):234-42. Epub 2013 Dec 17.

School of Pharmacy, University of Otago , Dunedin, New Zealand.

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http://dx.doi.org/10.1021/mp4004145DOI Listing
January 2014

Indomethacin: new polymorphs of an old drug.

Mol Pharm 2013 Dec 30;10(12):4472-80. Epub 2013 Oct 30.

School of Pharmacy, University of Otago , Dunedin 9016, New Zealand.

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http://dx.doi.org/10.1021/mp400299aDOI Listing
December 2013

Evaluation of drug interactions with nanofibrillar cellulose.

Eur J Pharm Biopharm 2013 Nov 15;85(3 Pt B):1238-44. Epub 2013 Jun 15.

Faculty of Pharmacy, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2013.05.015DOI Listing
November 2013

Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods.

Eur J Pharm Sci 2013 Nov 30;50(3-4):511-9. Epub 2013 Aug 30.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2013.08.030DOI Listing
November 2013

Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels.

Eur J Pharm Sci 2013 Sep 14;50(1):69-77. Epub 2013 Mar 14.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, PO Box 56, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ejps.2013.02.023DOI Listing
September 2013

Dissolution studies of poorly soluble drug nanosuspensions in non-sink conditions.

AAPS PharmSciTech 2013 Jun 25;14(2):748-56. Epub 2013 Apr 25.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1208/s12249-013-9960-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666001PMC
June 2013

Early environment and neurobehavioral development predict adult temperament clusters.

PLoS One 2012 18;7(7):e38065. Epub 2012 Jul 18.

University of California Los Angeles Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399831PMC
March 2013

Coated particle assemblies for the concomitant pulmonary administration of budesonide and salbutamol sulphate.

Int J Pharm 2013 Jan 28;441(1-2):248-54. Epub 2012 Nov 28.

Department of Applied Physics, Aalto University School of Science, P.O. Box 15100, 00076 Aalto, Finland.

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January 2013

Toxicological profile of therapeutic nanodelivery systems.

Curr Drug Metab 2012 Oct;13(8):1068-86

Division of Pharmaceutical Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014 University of Helsinki, Finland.

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October 2012

Nanofibrillar cellulose films for controlled drug delivery.

Eur J Pharm Biopharm 2012 Oct 30;82(2):308-15. Epub 2012 Jun 30.

Division of Pharmaceutical Technology, University of Helsinki, Helsinki, Finland.

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October 2012

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.

Authors:
Zhan Su Laura J Gay Amy Strange Claire Palles Gavin Band David C Whiteman Francesco Lescai Cordelia Langford Manoj Nanji Sarah Edkins Anouk van der Winkel David Levine Peter Sasieni Céline Bellenguez Kimberley Howarth Colin Freeman Nigel Trudgill Art T Tucker Matti Pirinen Maikel P Peppelenbosch Luc J W van der Laan Ernst J Kuipers Joost P H Drenth Wilbert H Peters John V Reynolds Dermot P Kelleher Ross McManus Heike Grabsch Hans Prenen Raf Bisschops Kausila Krishnadath Peter D Siersema Jantine W P M van Baal Mark Middleton Russell Petty Richard Gillies Nicola Burch Pradeep Bhandari Stuart Paterson Cathryn Edwards Ian Penman Kishor Vaidya Yeng Ang Iain Murray Praful Patel Weimin Ye Paul Mullins Anna H Wu Nigel C Bird Helen Dallal Nicholas J Shaheen Liam J Murray Konrad Koss Leslie Bernstein Yvonne Romero Laura J Hardie Rui Zhang Helen Winter Douglas A Corley Simon Panter Harvey A Risch Brian J Reid Ian Sargeant Marilie D Gammon Howard Smart Anjan Dhar Hugh McMurtry Haythem Ali Geoffrey Liu Alan G Casson Wong-Ho Chow Matt Rutter Ashref Tawil Danielle Morris Chuka Nwokolo Peter Isaacs Colin Rodgers Krish Ragunath Chris MacDonald Chris Haigh David Monk Gareth Davies Saj Wajed David Johnston Michael Gibbons Sue Cullen Nicholas Church Ruth Langley Michael Griffin Derek Alderson Panos Deloukas Sarah E Hunt Emma Gray Serge Dronov Simon C Potter Avazeh Tashakkori-Ghanbaria Mark Anderson Claire Brooks Jenefer M Blackwell Elvira Bramon Matthew A Brown Juan P Casas Aiden Corvin Audrey Duncanson Hugh S Markus Christopher G Mathew Colin N A Palmer Robert Plomin Anna Rautanen Stephen J Sawcer Richard C Trembath Ananth C Viswanathan Nicholas Wood Gosia Trynka Cisca Wijmenga Jean-Baptiste Cazier Paul Atherfold Anna M Nicholson Nichola L Gellatly Deborah Glancy Sheldon C Cooper David Cunningham Tore Lind Julie Hapeshi David Ferry Barrie Rathbone Julia Brown Sharon Love Stephen Attwood Stuart MacGregor Peter Watson Scott Sanders Weronica Ek Rebecca F Harrison Paul Moayyedi John de Caestecker Hugh Barr Elia Stupka Thomas L Vaughan Leena Peltonen Chris C A Spencer Ian Tomlinson Peter Donnelly Janusz A Z Jankowski

Nat Genet 2012 Oct 9;44(10):1131-6. Epub 2012 Sep 9.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459818PMC
October 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Authors:
Zari Dastani Marie-France Hivert Nicholas Timpson John R B Perry Xin Yuan Robert A Scott Peter Henneman Iris M Heid Jorge R Kizer Leo-Pekka Lyytikäinen Christian Fuchsberger Toshiko Tanaka Andrew P Morris Kerrin Small Aaron Isaacs Marian Beekman Stefan Coassin Kurt Lohman Lu Qi Stavroula Kanoni James S Pankow Hae-Won Uh Ying Wu Aurelian Bidulescu Laura J Rasmussen-Torvik Celia M T Greenwood Martin Ladouceur Jonna Grimsby Alisa K Manning Ching-Ti Liu Jaspal Kooner Vincent E Mooser Peter Vollenweider Karen A Kapur John Chambers Nicholas J Wareham Claudia Langenberg Rune Frants Ko Willems-Vandijk Ben A Oostra Sara M Willems Claudia Lamina Thomas W Winkler Bruce M Psaty Russell P Tracy Jennifer Brody Ida Chen Jorma Viikari Mika Kähönen Peter P Pramstaller David M Evans Beate St Pourcain Naveed Sattar Andrew R Wood Stefania Bandinelli Olga D Carlson Josephine M Egan Stefan Böhringer Diana van Heemst Lyudmyla Kedenko Kati Kristiansson Marja-Liisa Nuotio Britt-Marie Loo Tamara Harris Melissa Garcia Alka Kanaya Margot Haun Norman Klopp H-Erich Wichmann Panos Deloukas Efi Katsareli David J Couper Bruce B Duncan Margreet Kloppenburg Linda S Adair Judith B Borja James G Wilson Solomon Musani Xiuqing Guo Toby Johnson Robert Semple Tanya M Teslovich Matthew A Allison Susan Redline Sarah G Buxbaum Karen L Mohlke Ingrid Meulenbelt Christie M Ballantyne George V Dedoussis Frank B Hu Yongmei Liu Bernhard Paulweber Timothy D Spector P Eline Slagboom Luigi Ferrucci Antti Jula Markus Perola Olli Raitakari Jose C Florez Veikko Salomaa Johan G Eriksson Timothy M Frayling Andrew A Hicks Terho Lehtimäki George Davey Smith David S Siscovick Florian Kronenberg Cornelia van Duijn Ruth J F Loos Dawn M Waterworth James B Meigs Josee Dupuis J Brent Richards Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Oliver M Hofmann Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Andrew D Morris Colin N A Palmer Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Oluf Pedersen Inês Barroso Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Paul Elliott Denis Rybin Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Taina Lajunen Alex Doney Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Caroline Hayward Simon C Heath Serge Hercberg David R Hillman Aroon D Hingorani Jennie Hui Joe Hung Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Robert Mahley Massimo Mangino María Teresa Martínez-Larrad Jarred B McAteer Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Sutapa Mukherjee Silvia Naitza Matthew J Neville Marco Orrù Ruth Pakyz Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Udo Seedorf Stephen J Sharp Beverley Shields Gunnar Sigurðsson Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper Manuel Serrano-Ríos Lars Lind Lyle J Palmer Frank B Hu Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter Brenda W J H Penninx Dorret I Boomsma Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Leena Peltonen Vincent Mooser Robert Sladek Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Daniel I Chasman Christopher T Johansen Sigrid W Fouchier Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Mary F Feitosa Marju Orho-Melander Olle Melander Xiaohui Li Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Andreas Ziegler Weihua Zhang Robert Y L Zee John B Whitfield John R Thompson Ida Surakka Tim D Spector Johannes H Smit Juha Sinisalo James Scott Juha Saharinen Chiara Sabatti Lynda M Rose Robert Roberts Mark Rieder Alex N Parker Guillaume Pare Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Gavin Lucas Robert Luben Marja-Liisa Lokki Guillaume Lettre Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Inke R König Kay-Tee Khaw Lee M Kaplan Åsa Johansson A Cecile J W Janssens Wilmar Igl G Kees Hovingh Christian Hengstenberg Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Leif C Groop Elena Gonzalez Nelson B Freimer Jeanette Erdmann Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Ulf de Faire Gabriel Crawford Yii-der I Chen Mark J Caulfield S Matthijs Boekholdt Themistocles L Assimes Thomas Quertermous Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Herman A Taylor Stacey B Gabriel Hilma Holm Vilmundur Gudnason Ronald M Krauss Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt David P Strachan Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Sekar Kathiresan

PLoS Genet 2012 29;8(3):e1002607. Epub 2012 Mar 29.

Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.

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September 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Authors:
Andrew P Morris Benjamin F Voight Tanya M Teslovich Teresa Ferreira Ayellet V Segrè Valgerdur Steinthorsdottir Rona J Strawbridge Hassan Khan Harald Grallert Anubha Mahajan Inga Prokopenko Hyun Min Kang Christian Dina Tonu Esko Ross M Fraser Stavroula Kanoni Ashish Kumar Vasiliki Lagou Claudia Langenberg Jian'an Luan Cecilia M Lindgren Martina Müller-Nurasyid Sonali Pechlivanis N William Rayner Laura J Scott Steven Wiltshire Loic Yengo Leena Kinnunen Elizabeth J Rossin Soumya Raychaudhuri Andrew D Johnson Antigone S Dimas Ruth J F Loos Sailaja Vedantam Han Chen Jose C Florez Caroline Fox Ching-Ti Liu Denis Rybin David J Couper Wen Hong L Kao Man Li Marilyn C Cornelis Peter Kraft Qi Sun Rob M van Dam Heather M Stringham Peter S Chines Krista Fischer Pierre Fontanillas Oddgeir L Holmen Sarah E Hunt Anne U Jackson Augustine Kong Robert Lawrence Julia Meyer John R B Perry Carl G P Platou Simon Potter Emil Rehnberg Neil Robertson Suthesh Sivapalaratnam Alena Stančáková Kathleen Stirrups Gudmar Thorleifsson Emmi Tikkanen Andrew R Wood Peter Almgren Mustafa Atalay Rafn Benediktsson Lori L Bonnycastle Noël Burtt Jason Carey Guillaume Charpentier Andrew T Crenshaw Alex S F Doney Mozhgan Dorkhan Sarah Edkins Valur Emilsson Elodie Eury Tom Forsen Karl Gertow Bruna Gigante George B Grant Christopher J Groves Candace Guiducci Christian Herder Astradur B Hreidarsson Jennie Hui Alan James Anna Jonsson Wolfgang Rathmann Norman Klopp Jasmina Kravic Kaarel Krjutškov Cordelia Langford Karin Leander Eero Lindholm Stéphane Lobbens Satu Männistö Ghazala Mirza Thomas W Mühleisen Bill Musk Melissa Parkin Loukianos Rallidis Jouko Saramies Bengt Sennblad Sonia Shah Gunnar Sigurðsson Angela Silveira Gerald Steinbach Barbara Thorand Joseph Trakalo Fabrizio Veglia Roman Wennauer Wendy Winckler Delilah Zabaneh Harry Campbell Cornelia van Duijn Andre G Uitterlinden Albert Hofman Eric Sijbrands Goncalo R Abecasis Katharine R Owen Eleftheria Zeggini Mieke D Trip Nita G Forouhi Ann-Christine Syvänen Johan G Eriksson Leena Peltonen Markus M Nöthen Beverley Balkau Colin N A Palmer Valeriya Lyssenko Tiinamaija Tuomi Bo Isomaa David J Hunter Lu Qi Alan R Shuldiner Michael Roden Ines Barroso Tom Wilsgaard John Beilby Kees Hovingh Jackie F Price James F Wilson Rainer Rauramaa Timo A Lakka Lars Lind George Dedoussis Inger Njølstad Nancy L Pedersen Kay-Tee Khaw Nicholas J Wareham Sirkka M Keinanen-Kiukaanniemi Timo E Saaristo Eeva Korpi-Hyövälti Juha Saltevo Markku Laakso Johanna Kuusisto Andres Metspalu Francis S Collins Karen L Mohlke Richard N Bergman Jaakko Tuomilehto Bernhard O Boehm Christian Gieger Kristian Hveem Stephane Cauchi Philippe Froguel Damiano Baldassarre Elena Tremoli Steve E Humphries Danish Saleheen John Danesh Erik Ingelsson Samuli Ripatti Veikko Salomaa Raimund Erbel Karl-Heinz Jöckel Susanne Moebus Annette Peters Thomas Illig Ulf de Faire Anders Hamsten Andrew D Morris Peter J Donnelly Timothy M Frayling Andrew T Hattersley Eric Boerwinkle Olle Melander Sekar Kathiresan Peter M Nilsson Panos Deloukas Unnur Thorsteinsdottir Leif C Groop Kari Stefansson Frank Hu James S Pankow Josée Dupuis James B Meigs David Altshuler Michael Boehnke Mark I McCarthy

Nat Genet 2012 Sep 12;44(9):981-90. Epub 2012 Aug 12.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442244PMC
September 2012

Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort.

Psychiatr Genet 2012 Aug;22(4):197-201

Public Health Genomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland.

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August 2012

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Authors:
Benjamin F Voight Gina M Peloso Marju Orho-Melander Ruth Frikke-Schmidt Maja Barbalic Majken K Jensen George Hindy Hilma Hólm Eric L Ding Toby Johnson Heribert Schunkert Nilesh J Samani Robert Clarke Jemma C Hopewell John F Thompson Mingyao Li Gudmar Thorleifsson Christopher Newton-Cheh Kiran Musunuru James P Pirruccello Danish Saleheen Li Chen Alexandre F R Stewart Arne Schillert Unnur Thorsteinsdottir Gudmundur Thorgeirsson Sonia Anand James C Engert Thomas Morgan John Spertus Monika Stoll Klaus Berger Nicola Martinelli Domenico Girelli Pascal P McKeown Christopher C Patterson Stephen E Epstein Joseph Devaney Mary-Susan Burnett Vincent Mooser Samuli Ripatti Ida Surakka Markku S Nieminen Juha Sinisalo Marja-Liisa Lokki Markus Perola Aki Havulinna Ulf de Faire Bruna Gigante Erik Ingelsson Tanja Zeller Philipp Wild Paul I W de Bakker Olaf H Klungel Anke-Hilse Maitland-van der Zee Bas J M Peters Anthonius de Boer Diederick E Grobbee Pieter W Kamphuisen Vera H M Deneer Clara C Elbers N Charlotte Onland-Moret Marten H Hofker Cisca Wijmenga W M Monique Verschuren Jolanda M A Boer Yvonne T van der Schouw Asif Rasheed Philippe Frossard Serkalem Demissie Cristen Willer Ron Do Jose M Ordovas Gonçalo R Abecasis Michael Boehnke Karen L Mohlke Mark J Daly Candace Guiducci Noël P Burtt Aarti Surti Elena Gonzalez Shaun Purcell Stacey Gabriel Jaume Marrugat John Peden Jeanette Erdmann Patrick Diemert Christina Willenborg Inke R König Marcus Fischer Christian Hengstenberg Andreas Ziegler Ian Buysschaert Diether Lambrechts Frans Van de Werf Keith A Fox Nour Eddine El Mokhtari Diana Rubin Jürgen Schrezenmeir Stefan Schreiber Arne Schäfer John Danesh Stefan Blankenberg Robert Roberts Ruth McPherson Hugh Watkins Alistair S Hall Kim Overvad Eric Rimm Eric Boerwinkle Anne Tybjaerg-Hansen L Adrienne Cupples Muredach P Reilly Olle Melander Pier M Mannucci Diego Ardissino David Siscovick Roberto Elosua Kari Stefansson Christopher J O'Donnell Veikko Salomaa Daniel J Rader Leena Peltonen Stephen M Schwartz David Altshuler Sekar Kathiresan

Lancet 2012 Aug 17;380(9841):572-80. Epub 2012 May 17.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419820PMC
August 2012

Spray-dried nanofibrillar cellulose microparticles for sustained drug release.

Int J Pharm 2012 Jul 24;430(1-2):47-55. Epub 2012 Mar 24.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, PO Box 56 (Viikinkaari 5E), FI-00014 Helsinki, Finland.

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July 2012

A genome-wide association search for type 2 diabetes genes in African Americans.

Authors:
Nicholette D Palmer Caitrin W McDonough Pamela J Hicks Bong H Roh Maria R Wing S Sandy An Jessica M Hester Jessica N Cooke Meredith A Bostrom Megan E Rudock Matthew E Talbert Joshua P Lewis Assiamira Ferrara Lingyi Lu Julie T Ziegler Michele M Sale Jasmin Divers Daniel Shriner Adebowale Adeyemo Charles N Rotimi Maggie C Y Ng Carl D Langefeld Barry I Freedman Donald W Bowden Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Andrew P Morris Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Claudia Langenberg Oliver M Hofmann Josée Dupuis Lu Qi Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis David J Couper Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Norman Klopp Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne John R B Perry Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Karen L Mohlke Andrew D Morris Colin N A Palmer Peter P Pramstaller Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Nicholas J Wareham Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Frank B Hu James B Meigs James S Pankow Oluf Pedersen H-Erich Wichmann Inês Barroso Jose C Florez Timothy M Frayling Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Toby Johnson Paul Elliott Denis Rybin Peter Henneman Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Josephine M Egan Taina Lajunen Alex Doney Stavroula Kanoni Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Rune Frants Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Caroline Hayward Simon C Heath Serge Hercberg Andrew A Hicks David R Hillman Aroon D Hingorani Jennie Hui Joe Hung Antti Jula Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Robert Mahley Massimo Mangino Alisa K Manning María Teresa Martínez-Larrad Jarred B McAteer Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Sutapa Mukherjee Silvia Naitza Matthew J Neville Ben A Oostra Marco Orrù Ruth Pakyz Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Markus Perola Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Bruce M Psaty Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Udo Seedorf Stephen J Sharp Beverley Shields Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Toshiko Tanaka Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Ruth J F Loos Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Veikko Salomaa George Davey Smith Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper George V Dedoussis Manuel Serrano-Ríos Lars Lind Lyle J Palmer Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter David S Siscovick Brenda W J H Penninx Dorret I Boomsma Panos Deloukas Timothy D Spector Luigi Ferrucci Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Dawn M Waterworth Peter Vollenweider Leena Peltonen Vincent Mooser Robert Sladek

PLoS One 2012 4;7(1):e29202. Epub 2012 Jan 4.

Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251563PMC
May 2012

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Authors:
Alisa K Manning Marie-France Hivert Robert A Scott Jonna L Grimsby Nabila Bouatia-Naji Han Chen Denis Rybin Ching-Ti Liu Lawrence F Bielak Inga Prokopenko Najaf Amin Daniel Barnes Gemma Cadby Jouke-Jan Hottenga Erik Ingelsson Anne U Jackson Toby Johnson Stavroula Kanoni Claes Ladenvall Vasiliki Lagou Jari Lahti Cecile Lecoeur Yongmei Liu Maria Teresa Martinez-Larrad May E Montasser Pau Navarro John R B Perry Laura J Rasmussen-Torvik Perttu Salo Naveed Sattar Dmitry Shungin Rona J Strawbridge Toshiko Tanaka Cornelia M van Duijn Ping An Mariza de Andrade Jeanette S Andrews Thor Aspelund Mustafa Atalay Yurii Aulchenko Beverley Balkau Stefania Bandinelli Jacques S Beckmann John P Beilby Claire Bellis Richard N Bergman John Blangero Mladen Boban Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Ingrid B Borecki Yvonne Böttcher Claude Bouchard Eric Brunner Danijela Budimir Harry Campbell Olga Carlson Peter S Chines Robert Clarke Francis S Collins Arturo Corbatón-Anchuelo David Couper Ulf de Faire George V Dedoussis Panos Deloukas Maria Dimitriou Josephine M Egan Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Elodie Eury Luigi Ferrucci Ian Ford Nita G Forouhi Caroline S Fox Maria Grazia Franzosi Paul W Franks Timothy M Frayling Philippe Froguel Pilar Galan Eco de Geus Bruna Gigante Nicole L Glazer Anuj Goel Leif Groop Vilmundur Gudnason Göran Hallmans Anders Hamsten Ola Hansson Tamara B Harris Caroline Hayward Simon Heath Serge Hercberg Andrew A Hicks Aroon Hingorani Albert Hofman Jennie Hui Joseph Hung Marjo-Riitta Jarvelin Min A Jhun Paul C D Johnson J Wouter Jukema Antti Jula W H Kao Jaakko Kaprio Sharon L R Kardia Sirkka Keinanen-Kiukaanniemi Mika Kivimaki Ivana Kolcic Peter Kovacs Meena Kumari Johanna Kuusisto Kirsten Ohm Kyvik Markku Laakso Timo Lakka Lars Lannfelt G Mark Lathrop Lenore J Launer Karin Leander Guo Li Lars Lind Jaana Lindstrom Stéphane Lobbens Ruth J F Loos Jian'an Luan Valeriya Lyssenko Reedik Mägi Patrik K E Magnusson Michael Marmot Pierre Meneton Karen L Mohlke Vincent Mooser Mario A Morken Iva Miljkovic Narisu Narisu Jeff O'Connell Ken K Ong Ben A Oostra Lyle J Palmer Aarno Palotie James S Pankow John F Peden Nancy L Pedersen Marina Pehlic Leena Peltonen Brenda Penninx Marijana Pericic Markus Perola Louis Perusse Patricia A Peyser Ozren Polasek Peter P Pramstaller Michael A Province Katri Räikkönen Rainer Rauramaa Emil Rehnberg Ken Rice Jerome I Rotter Igor Rudan Aimo Ruokonen Timo Saaristo Maria Sabater-Lleal Veikko Salomaa David B Savage Richa Saxena Peter Schwarz Udo Seedorf Bengt Sennblad Manuel Serrano-Rios Alan R Shuldiner Eric J G Sijbrands David S Siscovick Johannes H Smit Kerrin S Small Nicholas L Smith Albert Vernon Smith Alena Stančáková Kathleen Stirrups Michael Stumvoll Yan V Sun Amy J Swift Anke Tönjes Jaakko Tuomilehto Stella Trompet Andre G Uitterlinden Matti Uusitupa Max Vikström Veronique Vitart Marie-Claude Vohl Benjamin F Voight Peter Vollenweider Gerard Waeber Dawn M Waterworth Hugh Watkins Eleanor Wheeler Elisabeth Widen Sarah H Wild Sara M Willems Gonneke Willemsen James F Wilson Jacqueline C M Witteman Alan F Wright Hanieh Yaghootkar Diana Zelenika Tatijana Zemunik Lina Zgaga Nicholas J Wareham Mark I McCarthy Ines Barroso Richard M Watanabe Jose C Florez Josée Dupuis James B Meigs Claudia Langenberg

Nat Genet 2012 May 13;44(6):659-69. Epub 2012 May 13.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613127PMC
May 2012

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.

Nat Genet 2012 Feb 5;44(3):328-33. Epub 2012 Feb 5.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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http://www.nature.com/articles/ng.1081
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http://dx.doi.org/10.1038/ng.1081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303115PMC
February 2012

Tablet preformulations of indomethacin-loaded mesoporous silicon microparticles.

Int J Pharm 2012 Jan 28;422(1-2):125-31. Epub 2011 Oct 28.

Division of Pharmaceutical Technology, Faculty of Pharmacy, FI-00014, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ijpharm.2011.10.040DOI Listing
January 2012

Association of known loci with lipid levels among children and prediction of dyslipidemia in adults.

Circ Cardiovasc Genet 2011 Dec 7;4(6):673-80. Epub 2011 Oct 7.

Institute for Molecular Medicine, Finland FIMM, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCGENETICS.111.960369DOI Listing
December 2011

Spray-dried cellulose nanofibers as novel tablet excipient.

AAPS PharmSciTech 2011 Dec 18;12(4):1366-73. Epub 2011 Oct 18.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland.

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http://dx.doi.org/10.1208/s12249-011-9705-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225511PMC
December 2011

Intact nanoparticulate indomethacin in fast-dissolving carrier particles by combined wet milling and aerosol flow reactor methods.

Pharm Res 2011 Oct 4;28(10):2403-11. Epub 2011 May 4.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

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http://link.springer.com/10.1007/s11095-011-0456-z
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http://dx.doi.org/10.1007/s11095-011-0456-zDOI Listing
October 2011

Common variants at VRK2 and TCF4 conferring risk of schizophrenia.

Hum Mol Genet 2011 Oct 26;20(20):4076-81. Epub 2011 Jul 26.

deCODE Genetics, IS-101 Reykjavik, Iceland.

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http://dx.doi.org/10.1093/hmg/ddr325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298077PMC
October 2011

A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.

PLoS Genet 2011 Oct 20;7(10):e1002333. Epub 2011 Oct 20.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pgen.1002333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197672PMC
October 2011

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.

Nat Genet 2011 Sep 11;43(10):940-7. Epub 2011 Sep 11.

Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/ng.920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257519PMC
September 2011

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:
Georg B Ehret Patricia B Munroe Kenneth M Rice Murielle Bochud Andrew D Johnson Daniel I Chasman Albert V Smith Martin D Tobin Germaine C Verwoert Shih-Jen Hwang Vasyl Pihur Peter Vollenweider Paul F O'Reilly Najaf Amin Jennifer L Bragg-Gresham Alexander Teumer Nicole L Glazer Lenore Launer Jing Hua Zhao Yurii Aulchenko Simon Heath Siim Sõber Afshin Parsa Jian'an Luan Pankaj Arora Abbas Dehghan Feng Zhang Gavin Lucas Andrew A Hicks Anne U Jackson John F Peden Toshiko Tanaka Sarah H Wild Igor Rudan Wilmar Igl Yuri Milaneschi Alex N Parker Cristiano Fava John C Chambers Ervin R Fox Meena Kumari Min Jin Go Pim van der Harst Wen Hong Linda Kao Marketa Sjögren D G Vinay Myriam Alexander Yasuharu Tabara Sue Shaw-Hawkins Peter H Whincup Yongmei Liu Gang Shi Johanna Kuusisto Bamidele Tayo Mark Seielstad Xueling Sim Khanh-Dung Hoang Nguyen Terho Lehtimäki Giuseppe Matullo Ying Wu Tom R Gaunt N Charlotte Onland-Moret Matthew N Cooper Carl G P Platou Elin Org Rebecca Hardy Santosh Dahgam Jutta Palmen Veronique Vitart Peter S Braund Tatiana Kuznetsova Cuno S P M Uiterwaal Adebowale Adeyemo Walter Palmas Harry Campbell Barbara Ludwig Maciej Tomaszewski Ioanna Tzoulaki Nicholette D Palmer Thor Aspelund Melissa Garcia Yen-Pei C Chang Jeffrey R O'Connell Nanette I Steinle Diederick E Grobbee Dan E Arking Sharon L Kardia Alanna C Morrison Dena Hernandez Samer Najjar Wendy L McArdle David Hadley Morris J Brown John M Connell Aroon D Hingorani Ian N M Day Debbie A Lawlor John P Beilby Robert W Lawrence Robert Clarke Jemma C Hopewell Halit Ongen Albert W Dreisbach Yali Li J Hunter Young Joshua C Bis Mika Kähönen Jorma Viikari Linda S Adair Nanette R Lee Ming-Huei Chen Matthias Olden Cristian Pattaro Judith A Hoffman Bolton Anna Köttgen Sven Bergmann Vincent Mooser Nish Chaturvedi Timothy M Frayling Muhammad Islam Tazeen H Jafar Jeanette Erdmann Smita R Kulkarni Stefan R Bornstein Jürgen Grässler Leif Groop Benjamin F Voight Johannes Kettunen Philip Howard Andrew Taylor Simonetta Guarrera Fulvio Ricceri Valur Emilsson Andrew Plump Inês Barroso Kay-Tee Khaw Alan B Weder Steven C Hunt Yan V Sun Richard N Bergman Francis S Collins Lori L Bonnycastle Laura J Scott Heather M Stringham Leena Peltonen Markus Perola Erkki Vartiainen Stefan-Martin Brand Jan A Staessen Thomas J Wang Paul R Burton Maria Soler Artigas Yanbin Dong Harold Snieder Xiaoling Wang Haidong Zhu Kurt K Lohman Megan E Rudock Susan R Heckbert Nicholas L Smith Kerri L Wiggins Ayo Doumatey Daniel Shriner Gudrun Veldre Margus Viigimaa Sanjay Kinra Dorairaj Prabhakaran Vikal Tripathy Carl D Langefeld Annika Rosengren Dag S Thelle Anna Maria Corsi Andrew Singleton Terrence Forrester Gina Hilton Colin A McKenzie Tunde Salako Naoharu Iwai Yoshikuni Kita Toshio Ogihara Takayoshi Ohkubo Tomonori Okamura Hirotsugu Ueshima Satoshi Umemura Susana Eyheramendy Thomas Meitinger H-Erich Wichmann Yoon Shin Cho Hyung-Lae Kim Jong-Young Lee James Scott Joban S Sehmi Weihua Zhang Bo Hedblad Peter Nilsson George Davey Smith Andrew Wong Narisu Narisu Alena Stančáková Leslie J Raffel Jie Yao Sekar Kathiresan Christopher J O'Donnell Stephen M Schwartz M Arfan Ikram W T Longstreth Thomas H Mosley Sudha Seshadri Nick R G Shrine Louise V Wain Mario A Morken Amy J Swift Jaana Laitinen Inga Prokopenko Paavo Zitting Jackie A Cooper Steve E Humphries John Danesh Asif Rasheed Anuj Goel Anders Hamsten Hugh Watkins Stephan J L Bakker Wiek H van Gilst Charles S Janipalli K Radha Mani Chittaranjan S Yajnik Albert Hofman Francesco U S Mattace-Raso Ben A Oostra Ayse Demirkan Aaron Isaacs Fernando Rivadeneira Edward G Lakatta Marco Orru Angelo Scuteri Mika Ala-Korpela Antti J Kangas Leo-Pekka Lyytikäinen Pasi Soininen Taru Tukiainen Peter Würtz Rick Twee-Hee Ong Marcus Dörr Heyo K Kroemer Uwe Völker Henry Völzke Pilar Galan Serge Hercberg Mark Lathrop Diana Zelenika Panos Deloukas Massimo Mangino Tim D Spector Guangju Zhai James F Meschia Michael A Nalls Pankaj Sharma Janos Terzic M V Kranthi Kumar Matthew Denniff Ewa Zukowska-Szczechowska Lynne E Wagenknecht F Gerald R Fowkes Fadi J Charchar Peter E H Schwarz Caroline Hayward Xiuqing Guo Charles Rotimi Michiel L Bots Eva Brand Nilesh J Samani Ozren Polasek Philippa J Talmud Fredrik Nyberg Diana Kuh Maris Laan Kristian Hveem Lyle J Palmer Yvonne T van der Schouw Juan P Casas Karen L Mohlke Paolo Vineis Olli Raitakari Santhi K Ganesh Tien Y Wong E Shyong Tai Richard S Cooper Markku Laakso Dabeeru C Rao Tamara B Harris Richard W Morris Anna F Dominiczak Mika Kivimaki Michael G Marmot Tetsuro Miki Danish Saleheen Giriraj R Chandak Josef Coresh Gerjan Navis Veikko Salomaa Bok-Ghee Han Xiaofeng Zhu Jaspal S Kooner Olle Melander Paul M Ridker Stefania Bandinelli Ulf B Gyllensten Alan F Wright James F Wilson Luigi Ferrucci Martin Farrall Jaakko Tuomilehto Peter P Pramstaller Roberto Elosua Nicole Soranzo Eric J G Sijbrands David Altshuler Ruth J F Loos Alan R Shuldiner Christian Gieger Pierre Meneton Andre G Uitterlinden Nicholas J Wareham Vilmundur Gudnason Jerome I Rotter Rainer Rettig Manuela Uda David P Strachan Jacqueline C M Witteman Anna-Liisa Hartikainen Jacques S Beckmann Eric Boerwinkle Ramachandran S Vasan Michael Boehnke Martin G Larson Marjo-Riitta Järvelin Bruce M Psaty Gonçalo R Abecasis Aravinda Chakravarti Paul Elliott Cornelia M van Duijn Christopher Newton-Cheh Daniel Levy Mark J Caulfield Toby Johnson

Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs.

Eur J Pharm Biopharm 2011 Aug 15;78(3):531-8. Epub 2011 Feb 15.

Division of Pharmaceutical Technology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ejpb.2011.02.007DOI Listing
August 2011

Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy.

Heart Rhythm 2011 Aug 10;8(8):1214-21. Epub 2011 Mar 10.

Research Program for Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.hrthm.2011.03.015DOI Listing
August 2011

Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods.

J Pharm Sci 2011 Aug 24;100(8):3294-3306. Epub 2011 Apr 24.

Division of Pharmaceutical Technology, Faculty of Pharmacy, FIN-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/jps.22577DOI Listing
August 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
Stephen Sawcer Garrett Hellenthal Matti Pirinen Chris C A Spencer Nikolaos A Patsopoulos Loukas Moutsianas Alexander Dilthey Zhan Su Colin Freeman Sarah E Hunt Sarah Edkins Emma Gray David R Booth Simon C Potter An Goris Gavin Band Annette Bang Oturai Amy Strange Janna Saarela Céline Bellenguez Bertrand Fontaine Matthew Gillman Bernhard Hemmer Rhian Gwilliam Frauke Zipp Alagurevathi Jayakumar Roland Martin Stephen Leslie Stanley Hawkins Eleni Giannoulatou Sandra D'alfonso Hannah Blackburn Filippo Martinelli Boneschi Jennifer Liddle Hanne F Harbo Marc L Perez Anne Spurkland Matthew J Waller Marcin P Mycko Michelle Ricketts Manuel Comabella Naomi Hammond Ingrid Kockum Owen T McCann Maria Ban Pamela Whittaker Anu Kemppinen Paul Weston Clive Hawkins Sara Widaa John Zajicek Serge Dronov Neil Robertson Suzannah J Bumpstead Lisa F Barcellos Rathi Ravindrarajah Roby Abraham Lars Alfredsson Kristin Ardlie Cristin Aubin Amie Baker Katharine Baker Sergio E Baranzini Laura Bergamaschi Roberto Bergamaschi Allan Bernstein Achim Berthele Mike Boggild Jonathan P Bradfield David Brassat Simon A Broadley Dorothea Buck Helmut Butzkueven Ruggero Capra William M Carroll Paola Cavalla Elisabeth G Celius Sabine Cepok Rosetta Chiavacci Françoise Clerget-Darpoux Katleen Clysters Giancarlo Comi Mark Cossburn Isabelle Cournu-Rebeix Mathew B Cox Wendy Cozen Bruce A C Cree Anne H Cross Daniele Cusi Mark J Daly Emma Davis Paul I W de Bakker Marc Debouverie Marie Beatrice D'hooghe Katherine Dixon Rita Dobosi Bénédicte Dubois David Ellinghaus Irina Elovaara Federica Esposito Claire Fontenille Simon Foote Andre Franke Daniela Galimberti Angelo Ghezzi Joseph Glessner Refujia Gomez Olivier Gout Colin Graham Struan F A Grant Franca Rosa Guerini Hakon Hakonarson Per Hall Anders Hamsten Hans-Peter Hartung Rob N Heard Simon Heath Jeremy Hobart Muna Hoshi Carmen Infante-Duarte Gillian Ingram Wendy Ingram Talat Islam Maja Jagodic Michael Kabesch Allan G Kermode Trevor J Kilpatrick Cecilia Kim Norman Klopp Keijo Koivisto Malin Larsson Mark Lathrop Jeannette S Lechner-Scott Maurizio A Leone Virpi Leppä Ulrika Liljedahl Izaura Lima Bomfim Robin R Lincoln Jenny Link Jianjun Liu Aslaug R Lorentzen Sara Lupoli Fabio Macciardi Thomas Mack Mark Marriott Vittorio Martinelli Deborah Mason Jacob L McCauley Frank Mentch Inger-Lise Mero Tania Mihalova Xavier Montalban John Mottershead Kjell-Morten Myhr Paola Naldi William Ollier Alison Page Aarno Palotie Jean Pelletier Laura Piccio Trevor Pickersgill Fredrik Piehl Susan Pobywajlo Hong L Quach Patricia P Ramsay Mauri Reunanen Richard Reynolds John D Rioux Mariaemma Rodegher Sabine Roesner Justin P Rubio Ina-Maria Rückert Marco Salvetti Erika Salvi Adam Santaniello Catherine A Schaefer Stefan Schreiber Christian Schulze Rodney J Scott Finn Sellebjerg Krzysztof W Selmaj David Sexton Ling Shen Brigid Simms-Acuna Sheila Skidmore Patrick M A Sleiman Cathrine Smestad Per Soelberg Sørensen Helle Bach Søndergaard Jim Stankovich Richard C Strange Anna-Maija Sulonen Emilie Sundqvist Ann-Christine Syvänen Francesca Taddeo Bruce Taylor Jenefer M Blackwell Pentti Tienari Elvira Bramon Ayman Tourbah Matthew A Brown Ewa Tronczynska Juan P Casas Niall Tubridy Aiden Corvin Jane Vickery Janusz Jankowski Pablo Villoslada Hugh S Markus Kai Wang Christopher G Mathew James Wason Colin N A Palmer H-Erich Wichmann Robert Plomin Ernest Willoughby Anna Rautanen Juliane Winkelmann Michael Wittig Richard C Trembath Jacqueline Yaouanq Ananth C Viswanathan Haitao Zhang Nicholas W Wood Rebecca Zuvich Panos Deloukas Cordelia Langford Audrey Duncanson Jorge R Oksenberg Margaret A Pericak-Vance Jonathan L Haines Tomas Olsson Jan Hillert Adrian J Ivinson Philip L De Jager Leena Peltonen Graeme J Stewart David A Hafler Stephen L Hauser Gil McVean Peter Donnelly Alastair Compston

Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/nature10251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort.

BMJ Open 2011 Aug 27;1(1):e000087. Epub 2011 Aug 27.

Public Health Genomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1136/bmjopen-2011-000087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191433PMC
August 2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Nat Genet 2011 Jul 10;43(8):761-7. Epub 2011 Jul 10.

Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/ng.873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640413PMC
July 2011

Nanosuspensions of poorly soluble drugs: preparation and development by wet milling.

Int J Pharm 2011 Jun 31;411(1-2):215-22. Epub 2011 Mar 31.

Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, PO Box 56, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ijpharm.2011.03.050DOI Listing
June 2011

Impact of temperament on depression and anxiety symptoms and depressive disorder in a population-based birth cohort.

J Affect Disord 2011 Jun;131(1-3):393-7

Public Health Genomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jad.2010.12.008DOI Listing
June 2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:
Tuomas O Kilpeläinen M Carola Zillikens Alena Stančákova Francis M Finucane Janina S Ried Claudia Langenberg Weihua Zhang Jacques S Beckmann Jian'an Luan Liesbeth Vandenput Unnur Styrkarsdottir Yanhua Zhou Albert Vernon Smith Jing-Hua Zhao Najaf Amin Sailaja Vedantam So-Youn Shin Talin Haritunians Mao Fu Mary F Feitosa Meena Kumari Bjarni V Halldorsson Emmi Tikkanen Massimo Mangino Caroline Hayward Ci Song Alice M Arnold Yurii S Aulchenko Ben A Oostra Harry Campbell L Adrienne Cupples Kathryn E Davis Angela Döring Gudny Eiriksdottir Karol Estrada José Manuel Fernández-Real Melissa Garcia Christian Gieger Nicole L Glazer Candace Guiducci Albert Hofman Steve E Humphries Bo Isomaa Leonie C Jacobs Antti Jula David Karasik Magnus K Karlsson Kay-Tee Khaw Lauren J Kim Mika Kivimäki Norman Klopp Brigitte Kühnel Johanna Kuusisto Yongmei Liu Osten Ljunggren Mattias Lorentzon Robert N Luben Barbara McKnight Dan Mellström Braxton D Mitchell Vincent Mooser José Maria Moreno Satu Männistö Jeffery R O'Connell Laura Pascoe Leena Peltonen Belén Peral Markus Perola Bruce M Psaty Veikko Salomaa David B Savage Robert K Semple Tatjana Skaric-Juric Gunnar Sigurdsson Kijoung S Song Timothy D Spector Ann-Christine Syvänen Philippa J Talmud Gudmar Thorleifsson Unnur Thorsteinsdottir André G Uitterlinden Cornelia M van Duijn Antonio Vidal-Puig Sarah H Wild Alan F Wright Deborah J Clegg Eric Schadt James F Wilson Igor Rudan Samuli Ripatti Ingrid B Borecki Alan R Shuldiner Erik Ingelsson John-Olov Jansson Robert C Kaplan Vilmundur Gudnason Tamara B Harris Leif Groop Douglas P Kiel Fernando Rivadeneira Mark Walker Inês Barroso Peter Vollenweider Gérard Waeber John C Chambers Jaspal S Kooner Nicole Soranzo Joel N Hirschhorn Kari Stefansson H-Erich Wichmann Claes Ohlsson Stephen O'Rahilly Nicholas J Wareham Elizabeth K Speliotes Caroline S Fox Markku Laakso Ruth J F Loos

Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.

Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262230PMC
June 2011

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.

Authors:
Gunter Schumann Lachlan J Coin Anbarasu Lourdusamy Pimphen Charoen Karen H Berger David Stacey Sylvane Desrivières Fazil A Aliev Anokhi A Khan Najaf Amin Yurii S Aulchenko Georgy Bakalkin Stephan J Bakker Beverley Balkau Joline W Beulens Ainhoa Bilbao Rudolf A de Boer Delphine Beury Michiel L Bots Elemi J Breetvelt Stéphane Cauchi Christine Cavalcanti-Proença John C Chambers Toni-Kim Clarke Norbert Dahmen Eco J de Geus Danielle Dick Francesca Ducci Alanna Easton Howard J Edenberg Tõnu Esko Tõnu Esk Alberto Fernández-Medarde Tatiana Foroud Nelson B Freimer Jean-Antoine Girault Diederick E Grobbee Simonetta Guarrera Daniel F Gudbjartsson Anna-Liisa Hartikainen Andrew C Heath Victor Hesselbrock Albert Hofman Jouke-Jan Hottenga Matti K Isohanni Jaakko Kaprio Kay-Tee Khaw Brigitte Kuehnel Jaana Laitinen Stéphane Lobbens Jian'an Luan Massimo Mangino Matthieu Maroteaux Giuseppe Matullo Mark I McCarthy Christian Mueller Gerjan Navis Mattijs E Numans Alejandro Núñez Dale R Nyholt Charlotte N Onland-Moret Ben A Oostra Paul F O'Reilly Miklos Palkovits Brenda W Penninx Silvia Polidoro Anneli Pouta Inga Prokopenko Fulvio Ricceri Eugenio Santos Johannes H Smit Nicole Soranzo Kijoung Song Ulla Sovio Michael Stumvoll Ida Surakk Thorgeir E Thorgeirsson Unnur Thorsteinsdottir Claire Troakes Thorarinn Tyrfingsson Anke Tönjes Cuno S Uiterwaal Andre G Uitterlinden Pim van der Harst Yvonne T van der Schouw Oliver Staehlin Nicole Vogelzangs Peter Vollenweider Gerard Waeber Nicholas J Wareham Dawn M Waterworth John B Whitfield Erich H Wichmann Gonneke Willemsen Jacqueline C Witteman Xin Yuan Guangju Zhai Jing H Zhao Weihua Zhang Nicholas G Martin Andres Metspalu Angela Doering James Scott Tim D Spector Ruth J Loos Dorret I Boomsma Vincent Mooser Leena Peltonen Kari Stefansson Cornelia M van Duijn Paolo Vineis Wolfgang H Sommer Jaspal S Kooner Rainer Spanagel Ulrike A Heberlein Marjo-Riitta Jarvelin Paul Elliott

Proc Natl Acad Sci U S A 2011 Apr 6;108(17):7119-24. Epub 2011 Apr 6.

Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London SE5 8AF, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1017288108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084048PMC
April 2011

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

Authors:
Abbas Dehghan Josée Dupuis Maja Barbalic Joshua C Bis Gudny Eiriksdottir Chen Lu Niina Pellikka Henri Wallaschofski Johannes Kettunen Peter Henneman Jens Baumert David P Strachan Christian Fuchsberger Veronique Vitart James F Wilson Guillaume Paré Silvia Naitza Megan E Rudock Ida Surakka Eco J C de Geus Behrooz Z Alizadeh Jack Guralnik Alan Shuldiner Toshiko Tanaka Robert Y L Zee Renate B Schnabel Vijay Nambi Maryam Kavousi Samuli Ripatti Matthias Nauck Nicholas L Smith Albert V Smith Jouko Sundvall Paul Scheet Yongmei Liu Aimo Ruokonen Lynda M Rose Martin G Larson Ron C Hoogeveen Nelson B Freimer Alexander Teumer Russell P Tracy Lenore J Launer Julie E Buring Jennifer F Yamamoto Aaron R Folsom Eric J G Sijbrands James Pankow Paul Elliott John F Keaney Wei Sun Antti-Pekka Sarin João D Fontes Sunita Badola Brad C Astor Albert Hofman Anneli Pouta Karl Werdan Karin H Greiser Oliver Kuss Henriette E Meyer zu Schwabedissen Joachim Thiery Yalda Jamshidi Ilja M Nolte Nicole Soranzo Timothy D Spector Henry Völzke Alexander N Parker Thor Aspelund David Bates Lauren Young Kim Tsui David S Siscovick Xiuqing Guo Jerome I Rotter Manuela Uda David Schlessinger Igor Rudan Andrew A Hicks Brenda W Penninx Barbara Thorand Christian Gieger Joe Coresh Gonneke Willemsen Tamara B Harris Andre G Uitterlinden Marjo-Riitta Järvelin Kenneth Rice Dörte Radke Veikko Salomaa Ko Willems van Dijk Eric Boerwinkle Ramachandran S Vasan Luigi Ferrucci Quince D Gibson Stefania Bandinelli Harold Snieder Dorret I Boomsma Xiangjun Xiao Harry Campbell Caroline Hayward Peter P Pramstaller Cornelia M van Duijn Leena Peltonen Bruce M Psaty Vilmundur Gudnason Paul M Ridker Georg Homuth Wolfgang Koenig Christie M Ballantyne Jacqueline C M Witteman Emelia J Benjamin Markus Perola Daniel I Chasman

Circulation 2011 Feb 7;123(7):731-8. Epub 2011 Feb 7.

Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam, Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.948570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147232PMC
February 2011

Aerosol-processed polymeric drug nanoparticles for sustained and triggered drug release.

J Control Release 2010 Nov;148(1):e52-3

Department of Applied Physics, Aalto University, PO Box 15100, FI-00076 Aalto, Finland.

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http://dx.doi.org/10.1016/j.jconrel.2010.07.057DOI Listing
November 2010