Lee S Weinstein

Lee S Weinstein

UNVERIFIED PROFILE

Are you Lee S Weinstein?   Register this Author

Register author
Lee S Weinstein

Lee S Weinstein

Publications by authors named "Lee S Weinstein"

Are you Lee S Weinstein?   Register this Author

90Publications

1463Reads

6Profile Views

Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo.

J Mol Cell Cardiol 2019 Jul 7;132:49-59. Epub 2019 May 7.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2019.05.002DOI Listing
July 2019

High prevalence of chronic kidney disease in patients with multiple endocrine neoplasia type 1 and improved kidney function after parathyroidectomy.

Surgery 2019 01 7;165(1):124-128. Epub 2018 Nov 7.

Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00396060183050
Publisher Site
http://dx.doi.org/10.1016/j.surg.2018.04.064DOI Listing
January 2019

Frequency and consequence of the recurrent p.T372R mutation in sporadic insulinomas.

Endocr Relat Cancer 2018 05 21;25(5):L31-L35. Epub 2018 Feb 21.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
https://erc.bioscientifica.com/view/journals/erc/25/5/ERC-17
Publisher Site
http://dx.doi.org/10.1530/ERC-17-0311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862779PMC
May 2018

Heterotrimeric G Stimulatory Protein α Subunit Is Required for Intestinal Smooth Muscle Contraction in Mice.

Gastroenterology 2017 04 30;152(5):1114-1125.e5. Epub 2016 Dec 30.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2016.12.017DOI Listing
April 2017

Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism.

Ann Surg Oncol 2016 12 27;23(Suppl 5):701-707. Epub 2016 Jul 27.

Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-016-5467-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415766PMC
December 2016

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.

PLoS One 2016 9;11(2):e0147535. Epub 2016 Feb 9.

West China Developmental & Stem Cell Institute, West China Second Hospital, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147535PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747491PMC
July 2016

A patient with MEN1 typical features and MEN2-like features.

Int J Endocr Oncol 2016 May 8;3(2):89-95. Epub 2016 Apr 8.

National Institute of Diabetes & Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/ije-2015-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008851PMC
May 2016

Limited Parathyroidectomy in Multiple Endocrine Neoplasia Type 1-Associated Primary Hyperparathyroidism: A Setup for Failure.

Ann Surg Oncol 2016 Feb 5;23(2):416-23. Epub 2015 Nov 5.

Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-015-4865-9DOI Listing
February 2016

Ablation of the Stimulatory G Protein α-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D.

Endocrinology 2016 Feb 15;157(2):497-507. Epub 2015 Dec 15.

Endocrine Unit (Z.Y., Q.H., C.A., H.J., M.B.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; Department of Endodontics (C.A.), Gülhane Military Medical Academy, 06018 Ankara, Turkey; Faculty of Medicine (I.R., M.T.), Université de Nice Sophia Antipolis, 06107 Nice, France; Metabolic Diseases Branch (M.C., L.S.W.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; Program in Membrane Biology (V.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; Pediatric Nephrology Unit (H.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2015-1639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733111PMC
February 2016

Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.

Endocrinology 2016 Feb 15;157(2):600-10. Epub 2015 Dec 15.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2015-1700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733121PMC
February 2016

Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy.

J Biol Chem 2016 Jan 23;291(4):1631-42. Epub 2015 Nov 23.

From the Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.679753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722446PMC
January 2016

Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.

Proc Natl Acad Sci U S A 2016 Jan 28;113(2):446-51. Epub 2015 Dec 28.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1517142113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720348PMC
January 2016

Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity.

J Genet Genomics 2015 Nov 20;42(11):613-624. Epub 2015 Oct 20.

West China Developmental and Stem Cell Institute, West China Second Hospital, Sichuan University, Chengdu 610041, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China; SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China; Nerdbio Inc., SIP Biobay, Suzhou 215213, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jgg.2015.08.006DOI Listing
November 2015

Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression.

Neurosci Lett 2015 Jun 24;597:97-103. Epub 2015 Apr 24.

West China Developmental and Stem Cell Institute, West China Second Hospital, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Shenzhen Key Laboratory for Molecular Biology of Neural Development, Laboratory of Developmental and Regenerative biology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China; SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China; Nerdbio Inc. SIP Biobay, Jiangsu 215213, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2015.04.034DOI Listing
June 2015

Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

Nat Cell Biol 2015 Jun 11;17(6):793-803. Epub 2015 May 11.

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb3164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449815PMC
June 2015

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.

Nat Med 2014 Sep 24;20(9):1035-42. Epub 2014 Aug 24.

1] Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. [2] Department of Pediatrics, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China. [3] Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334261PMC
September 2014

Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.

Dev Cell 2014 Apr 17;29(2):217-32. Epub 2014 Apr 17.

Department of Radiation Oncology, University of California, Davis, Sacramento, CA 95817, USA; NCI-Designated Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA 95817, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2014.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156313PMC
April 2014

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.

Nat Commun 2014 Apr 30;5:3673. Epub 2014 Apr 30.

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114-2696, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154354PMC
April 2014

Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone resistance owing to heterozygous Gαs disruption.

J Bone Miner Res 2014 Mar;29(3):749-60

Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Pediatric Endocrinology, Marmara University School of Medicine Hospital, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.2070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926912PMC
March 2014

Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.

J Clin Endocrinol Metab 2013 Nov 12;98(11):E1796-801. Epub 2013 Sep 12.

MD, Chief, Clinical Endocrine Section, Diabetes, Endocrinology, and Obesity Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive MSC 1613, Building 10, CRC, Room 6-3940, Bethesda, Maryland 20892-1613.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2013-1594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816268PMC
November 2013

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.

Nat Med 2013 Nov 29;19(11):1505-12. Epub 2013 Sep 29.

1] National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917515PMC
November 2013

Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.

Cell 2013 Sep;154(6):1314-25

Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan; Department of Brain Function, School of Medical Science, University of Fukui, Fukui 910-1193, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2013.08.033DOI Listing
September 2013

The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins.

Am J Physiol Regul Integr Comp Physiol 2013 Aug 22;305(4):R435-42. Epub 2013 May 22.

William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, London, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00037.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073991PMC
August 2013

Utility of intraoperative parathyroid hormone monitoring in patients with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism undergoing initial parathyroidectomy.

World J Surg 2013 Aug;37(8):1966-72

Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC1201 Room 3-3940, Bethesda, MD 20892-1201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00268-013-2054-1DOI Listing
August 2013

Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1.

J Clin Endocrinol Metab 2013 Jan 23;98(1):E109-14. Epub 2012 Oct 23.

Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2012-2781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537107PMC
January 2013

Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.

Endocrinology 2012 Sep 25;153(9):4256-65. Epub 2012 Jun 25.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2012-1113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423628PMC
September 2012

Development and treatment of tertiary hyperparathyroidism in patients with pseudohypoparathyroidism type 1B.

J Clin Endocrinol Metab 2012 Sep 26;97(9):3025-30. Epub 2012 Jun 26.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2012-1655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431579PMC
September 2012

Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.

J Clin Endocrinol Metab 2012 Jun 16;97(6):1834-41. Epub 2012 Apr 16.

Diabetes, Endocrine and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2011-3030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387414PMC
June 2012

Improved fatigue resistance in Gsα-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers.

J Appl Physiol (1985) 2011 Sep 16;111(3):834-43. Epub 2011 Jun 16.

Dept. of Physiology, Wayne State Univ. School of Medicine, Detroit, Michigan 48201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00031.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174792PMC
September 2011

Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.

Endocrinology 2011 Sep 19;152(9):3343-50. Epub 2011 Jul 19.

Metabolic Diseases Branch, Building 10 Room 8C101, National Institute for Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2011-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159780PMC
September 2011

Effects of deficiency of the G protein Gsα on energy and glucose homeostasis.

Eur J Pharmacol 2011 Jun 3;660(1):119-24. Epub 2011 Jan 3.

Signal Transduction Section, National Institute of Diabetes and Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2010.10.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084343PMC
June 2011

Renal failure in mice with Gsalpha deletion in juxtaglomerular cells.

Am J Nephrol 2010 11;32(1):83-94. Epub 2010 Jun 11.

National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Md., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000314635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914394PMC
October 2010

Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation.

J Endocrinol 2010 Sep 11;206(3):261-9. Epub 2010 Jun 11.

Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/JOE-10-0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929693PMC
September 2010

Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.

J Am Soc Nephrol 2010 Jun 15;21(6):986-92. Epub 2010 Apr 15.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 31, Room 2B11, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2009030307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900955PMC
June 2010

GNAS haploinsufficiency leads to subcutaneous tumor formation with collagen and elastin deposition and calcification.

Endocr Res 2009 ;34(1-2):1-9

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07435800902841280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702697PMC
August 2009

Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.

Cell Metab 2009 Jun;9(6):548-55

Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2009.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698878PMC
June 2009

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.

Nature 2009 May 25;459(7243):103-7. Epub 2009 Mar 25.

Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature07859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761017PMC
May 2009

G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.

Am J Physiol Cell Physiol 2009 Apr 21;296(4):C930-40. Epub 2009 Jan 21.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00443.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670650PMC
April 2009

Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling.

J Biol Chem 2008 Nov 24;283(48):33384-93. Epub 2008 Sep 24.

Section of Molecular Cardiology, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M803302200
Publisher Site
http://dx.doi.org/10.1074/jbc.M803302200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586242PMC
November 2008

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.

Proc Natl Acad Sci U S A 2008 Nov 28;105(44):16976-81. Epub 2008 Oct 28.

Endocrine Unit and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0802898105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579363PMC
November 2008

A gastrointestinal stromal tumor in a patient with multiple endocrine neoplasia type 2A and metastatic medullary thyroid cancer to the ovaries.

Endocr Pract 2008 Oct;14(7):898-901

Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586146PMC
http://dx.doi.org/10.4158/EP.14.7.898DOI Listing
October 2008

Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.

Endocrinology 2008 May 17;149(5):2443-50. Epub 2008 Jan 17.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Building 10, Room 8C101, Bethesda, Maryland 20892-1752, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2007-1458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329281PMC
May 2008

Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene.

Cell Tissue Res 2007 Dec 6;330(3):487-501. Epub 2007 Oct 6.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00441-007-0491-6DOI Listing
December 2007

Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes.

Proc Natl Acad Sci U S A 2007 Dec 20;104(49):19601-6. Epub 2007 Nov 20.

Metabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0704796104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148335PMC
December 2007

Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.

Pharmacol Ther 2007 Aug 21;115(2):271-91. Epub 2007 Apr 21.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20854, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2007.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2031856PMC
August 2007

The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.

J Clin Endocrinol Metab 2007 May 13;92(5):1948-51. Epub 2007 Feb 13.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1802, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2006-2563DOI Listing
May 2007

Body mass index differences in pseudohypoparathyroidism type 1a versus pseudopseudohypoparathyroidism may implicate paternal imprinting of Galpha(s) in the development of human obesity.

J Clin Endocrinol Metab 2007 Mar 12;92(3):1073-9. Epub 2006 Dec 12.

Division of Pediatric Endocrinology, Department of Pediatrics, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2006-1497DOI Listing
March 2007

Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha in juxtaglomerular cells.

Am J Physiol Renal Physiol 2007 Jan 5;292(1):F27-37. Epub 2006 Jul 5.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1370, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajprenal.00193.2006
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00193.2006DOI Listing
January 2007

G(s)alpha mutations in fibrous dysplasia and McCune-Albright syndrome.

Authors:
Lee S Weinstein

J Bone Miner Res 2006 Dec;21 Suppl 2:P120-4

Metabolic Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1359/jbmr.06s223DOI Listing
December 2006

Genetic diseases associated with heterotrimeric G proteins.

Trends Pharmacol Sci 2006 May 5;27(5):260-6. Epub 2006 Apr 5.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2006.03.005DOI Listing
May 2006

Fibroblast growth factor-23 is regulated by 1alpha,25-dihydroxyvitamin D.

J Bone Miner Res 2005 Nov 18;20(11):1944-50. Epub 2005 Jul 18.

Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-4320, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1359/JBMR.050718DOI Listing
November 2005

Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone.

J Biol Chem 2005 Jun 28;280(22):21369-75. Epub 2005 Mar 28.

Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M500346200DOI Listing
June 2005

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

Proc Natl Acad Sci U S A 2005 May 9;102(20):7386-91. Epub 2005 May 9.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0408268102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129092PMC
May 2005

Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation.

J Bone Miner Res 2005 Apr 6;20(4):663-71. Epub 2004 Dec 6.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1359/JBMR.041210DOI Listing
April 2005

Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit.

Proc Natl Acad Sci U S A 2005 Apr 5;102(15):5513-8. Epub 2005 Apr 5.

Metabolic Diseases Branch and Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0408262102
Publisher Site
http://dx.doi.org/10.1073/pnas.0408262102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556240PMC
April 2005

Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB.

Hum Mol Genet 2005 Jan 10;14(1):95-102. Epub 2004 Nov 10.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddi009DOI Listing
January 2005

Minireview: GNAS: normal and abnormal functions.

Endocrinology 2004 Dec 26;145(12):5459-64. Epub 2004 Aug 26.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2004-0865DOI Listing
December 2004

Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo.

Proc Natl Acad Sci U S A 2004 Oct 30;101(41):14794-9. Epub 2004 Sep 30.

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0405091101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522030PMC
October 2004

Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance.

Endocrinology 2004 Sep 27;145(9):4094-102. Epub 2004 May 27.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Building 10, Room 8C101, Bethesda, Maryland 20892-1752, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
Publisher Site
http://dx.doi.org/10.1210/en.2004-0038DOI Listing
September 2004

Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma.

J Clin Endocrinol Metab 2004 Aug;89(8):3776-84

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2003-031511DOI Listing
August 2004

Inherited diseases involving g proteins and g protein-coupled receptors.

Annu Rev Med 2004 ;55:27-39

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev.med.55.091902.103843DOI Listing
May 2004

Tissue-specific imprinting of the G protein Gsalpha is associated with tissue-specific differences in histone methylation.

Hum Mol Genet 2004 Apr 19;13(8):819-28. Epub 2004 Feb 19.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddh098DOI Listing
April 2004

Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1.

Surgery 2003 Dec;134(6):858-64; discussion 864-5

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0039-6060(03)00406-9DOI Listing
December 2003

HRPT2, a marker of parathyroid cancer.

N Engl J Med 2003 Oct;349(18):1691-2

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMp038159DOI Listing
October 2003

The stimulatory G protein alpha-subunit Gs alpha is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B.

J Clin Endocrinol Metab 2003 Sep;88(9):4336-41

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2003-030393DOI Listing
September 2003

Persistent primary hyperparathyroidism caused by adenomas identified in pharyngeal or adjacent structures.

World J Surg 2003 Jun 13;27(6):675-9. Epub 2003 May 13.

National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 2B07, Bethesda, Maryland 20892-1502, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00268-003-6812-3DOI Listing
June 2003

Hyperparathyroidism in hereditary syndromes: special expressions and special managements.

J Bone Miner Res 2002 Nov;17 Suppl 2:N37-43

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-1802, USA.

View Article

Download full-text PDF

Source
November 2002

Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit.

Mol Endocrinol 2002 Aug;16(8):1912-9

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2002-0054DOI Listing
August 2002

Analysis of genomic imprinting of Gs alpha gene.

Methods Enzymol 2002 ;344:369-83

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0076-6879(02)44728-3DOI Listing
June 2002

Gs(alpha) mutations and imprinting defects in human disease.

Ann N Y Acad Sci 2002 Jun;968:173-97

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04335.xDOI Listing
June 2002