Lee M Ellis

Lee M Ellis

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Comment on "A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare Environment".

Ann Surg 2019 Dec;270(6):e114-e115

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/SLA.0000000000003334DOI Listing
December 2019

Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.

Commun Biol 2019 18;2:386. Epub 2019 Oct 18.

1Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas USA.

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http://dx.doi.org/10.1038/s42003-019-0609-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802217PMC
October 2019

Scientific Integrity and Data Accuracy.

JAMA Oncol 2019 May;5(5):745

Deputy Editor.

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http://dx.doi.org/10.1001/jamaoncol.2019.0656DOI Listing
May 2019

Assessment of Reported Trial Characteristics, Rate of Publication, and Inclusion of Mandatory Biopsies of Research Biopsies in Clinical Trials in Oncology.

JAMA Oncol 2019 03;5(3):402-405

Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2018.4640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439840PMC
March 2019

Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion.

Mol Cancer Res 2019 01 21;17(1):20-29. Epub 2018 Aug 21.

Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318043PMC
January 2019

Ethics and the Underreporting of Research Biopsy Findings in Clinical Trials.

JAMA Oncol 2018 08;4(8):1041-1042

Department of Medical Ethics and Health Policy, University of Pennsylvania Perelman School of Medicine, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia.

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http://dx.doi.org/10.1001/jamaoncol.2018.1002DOI Listing
August 2018

A Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research.

Clin Cancer Res 2018 07 11;24(14):3447-3455. Epub 2018 Apr 11.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050098PMC
July 2018

Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.

PLoS One 2018 2;13(1):e0190070. Epub 2018 Jan 2.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749743PMC
February 2018

It Is Time to Re-Evaluate the Peer Review Process for Preclinical Research.

Bioessays 2018 Jan 11;40(1). Epub 2017 Dec 11.

Department of Surgical Oncology The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/bies.201700185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789767PMC
January 2018

Underreporting of Research Biopsies from Clinical Trials in Oncology.

Clin Cancer Res 2017 Nov 28;23(21):6450-6457. Epub 2017 Jul 28.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668146PMC
November 2017

Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion.

Br J Cancer 2017 Sep 25;117(6):848-855. Epub 2017 Jul 25.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/bjc.2017.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589988PMC
September 2017

Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion.

Mol Oncol 2017 08 6;11(8):1023-1034. Epub 2017 Jun 6.

Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/1878-0261.12071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537915PMC
August 2017

Words matter: Restoring respect and dignity when referring to individuals with cancer.

Cancer 2017 07 9;123(13):2390-2391. Epub 2017 Feb 9.

Gynecologic Cancer Therapeutics, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cncr.30625DOI Listing
July 2017

Preclinical data: Three-point plan for reproducibility.

Nature 2017 03;543(7643):40

University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/543040dDOI Listing
March 2017

Reply to "Improving Microbiology Research: the Problems Are Less Statistical and More Biological".

MBio 2016 10 18;7(5). Epub 2016 Oct 18.

University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1128/mBio.01680-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082904PMC
October 2016

A Framework for Improving the Quality of Research in the Biological Sciences.

MBio 2016 08 30;7(4). Epub 2016 Aug 30.

University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1128/mBio.01256-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999552PMC
August 2016

Antiangiogenic therapy in oncology: current status and future directions.

Lancet 2016 Jul 5;388(10043):518-29. Epub 2016 Feb 5.

Department of Medical Oncology, Churchill Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(15)01088-0DOI Listing
July 2016

Therapy: Colorectal cancer: how to teach an old drug new tricks.

Nat Rev Gastroenterol Hepatol 2016 07 25;13(7):384-5. Epub 2016 May 25.

Department of Surgical Oncology and Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1038/nrgastro.2016.87DOI Listing
July 2016

Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells.

Cancer Res 2016 05 17;76(10):3014-24. Epub 2016 Mar 17.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873444PMC
May 2016

A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.

Stem Cells Transl Med 2016 Mar 7;5(3):331-8. Epub 2016 Jan 7.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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http://dx.doi.org/10.5966/sctm.2015-0168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807666PMC
March 2016

From Protocols to Publications: A Study in Selective Reporting of Outcomes in Randomized Trials in Oncology.

J Clin Oncol 2015 Nov 24;33(31):3583-90. Epub 2015 Aug 24.

Kanwal Pratap Singh Raghav, Sminil Mahajan, James C. Yao, Brian P. Hobbs, Donald A. Berry, Alda Tam, Waun K. Hong, Lee M. Ellis, and Michael J. Overman, The University of Texas MD Anderson Cancer Center, Houston, TX; Rebecca D. Pentz, Emory School of Medicine, Atlanta, GA; and James Abbruzzese, Duke Cancer Institute, Durham, NC.

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http://dx.doi.org/10.1200/JCO.2015.62.4148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979242PMC
November 2015

VEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells.

Mol Cancer Res 2015 Sep 3;13(9):1274-82. Epub 2015 Jun 3.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573265PMC
September 2015

CCR 20th Anniversary Commentary: RAS as a Biomarker for EGFR--Targeted Therapy for Colorectal Cancer-From Concept to Practice.

Clin Cancer Res 2015 Aug;21(16):3578-80

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538994PMC
August 2015

The erosion of research integrity: the need for culture change.

Authors:
Lee M Ellis

Lancet Oncol 2015 Jul;16(7):752-4

Department of Surgical Oncology and Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1402, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00085-6DOI Listing
July 2015

Pragmatic issues in biomarker evaluation for targeted therapies in cancer.

Nat Rev Clin Oncol 2015 Apr 25;12(4):197-212. Epub 2014 Nov 25.

Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, USA.

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http://www.nature.com/articles/nrclinonc.2014.202
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http://dx.doi.org/10.1038/nrclinonc.2014.202DOI Listing
April 2015

TP53 loss creates therapeutic vulnerability in colorectal cancer.

Nature 2015 Apr 22;520(7549):697-701. Epub 2015 Apr 22.

1] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA [2] Center for RNA Interference and Non-coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature14418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417759PMC
April 2015

Losing "Losing the Battle With Cancer".

JAMA Oncol 2015 Apr;1(1):13-4

Fight Colorectal Cancer, Alexandria, Virginia.

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http://dx.doi.org/10.1001/jamaoncol.2014.188DOI Listing
April 2015

Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression.

Clin Cancer Res 2015 Feb 16;21(4):899-906. Epub 2014 Dec 16.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas. The University of Texas Graduate School of Biomedical Sciences, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334736PMC
February 2015

Therapeutic silencing of KRAS using systemically delivered siRNAs.

Mol Cancer Ther 2014 Dec 3;13(12):2876-85. Epub 2014 Oct 3.

Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416486PMC
December 2014

Analysis of LGR4 receptor distribution in human and mouse tissues.

PLoS One 2013 21;8(10):e78144. Epub 2013 Oct 21.

Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078144PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804454PMC
September 2014

American Society of Clinical Oncology perspective: Raising the bar for clinical trials by defining clinically meaningful outcomes.

J Clin Oncol 2014 Apr 17;32(12):1277-80. Epub 2014 Mar 17.

Lee M. Ellis, University of Texas MD Anderson Cancer Center, Houston, TX; David S. Bernstein and Richard L. Schilsky, American Society of Clinical Oncology, Alexandria, VA; Emile E. Voest, University Medical Center Utrecht, Utrecht, the Netherlands; Jordan D. Berlin, Vanderbilt-Ingram Cancer Center, Nashville, TN; Daniel Sargent, Mayo Clinic, Rochester, MN; Patricia Cortazar, US Food and Drug Administration, Silver Spring, MD; Elizabeth Garrett-Mayer, Medical University of South Carolina, Charleston, SC; Roy S. Herbst and Rogerio C. Lilenbaum, Yale Cancer Center, New Haven, CT; Camelia Sima and Mithat Gonen, Memorial Sloan-Kettering Cancer Center, New York, NY; Alan P. Venook, Helen Diller Family Comprehensive Cancer Center at University of California San Francisco, San Francisco, CA; Neal J. Meropol, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH; Lowell E. Schnipper, Beth Israel Deaconess Medical Center, Boston, MA.

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http://jco.ascopubs.org/content/early/2014/03/14/JCO.2013.53
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.53.8009
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http://dx.doi.org/10.1200/JCO.2013.53.8009DOI Listing
April 2014

miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase.

Mol Oncol 2014 Feb 8;8(1):83-92. Epub 2013 Oct 8.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 0173, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124530PMC
February 2014

Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

Clin Cancer Res 2014 Feb 9;20(4):837-46. Epub 2013 Dec 9.

Authors' Affiliations: INSERM U837 Team 4 "Molecular and Cellular Targeting of Cancers"; SIRIC ONCOLille; INSERM U837 Team 5 "Mucins, Epithelial Differentiation, and Carcinogenesis" Jean-Pierre Aubert Research Centre, Université Lille and CHU, Univ Nord de France; Unit of Biostatistics; Department of Digestive Surgery and Transplantation; Department of Medical Oncology, CHU, Univ Nord de France; IBL UMR-8161 CNRS, Université Lille Nord de France, Institut Pasteur, Lille; IRI USR 3078 CNRS, Villeneuve d'Ascq; INSERM U938, Molecular and Clinical Oncology, Hôpital Saint Antoine, Université Pierre et Marie Curie 6, Paris, France; and The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387277PMC
February 2014

ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.

Mol Cancer Ther 2013 Dec 16;12(12):2782-91. Epub 2013 Oct 16.

Corresponding Authors: Zhang Weihua, Department of Biology and Biochemistry, College of Natural Sciences and Mathematics University of Houston, 4800 Calhoun Rd, HSC358, Houston, TX 77204.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302275PMC
December 2013

An audience with : Lee M. Ellis. Interviewd by Man Tsuey Tse.

Authors:
Lee M Ellis

Nat Rev Drug Discov 2013 Aug 19;12(8):572-3. Epub 2013 Jul 19.

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http://dx.doi.org/10.1038/nrd4085DOI Listing
August 2013

Predictive biomarkers for bevacizumab: are we there yet?

Clin Cancer Res 2013 Jun 2;19(11):2824-7. Epub 2013 Apr 2.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3409DOI Listing
June 2013

DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway.

Cell Rep 2013 Jun 20;3(6):2100-12. Epub 2013 Jun 20.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796289PMC
June 2013

Morbidity of staged proctectomy after hepatectomy for colorectal cancer: a matched case-control analysis.

Ann Surg Oncol 2013 Feb 30;20(2):482-90. Epub 2012 Aug 30.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-012-2620-zDOI Listing
February 2013

Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma.

Cancer 2012 Dec 6;118(24):6188-98. Epub 2012 Jun 6.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.27653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465518PMC
December 2012

GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes.

Carcinogenesis 2012 Jul 12;33(7):1327-31. Epub 2012 Apr 12.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/carcin/bgs147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072910PMC
July 2012

Genetic variants within ultraconserved elements and susceptibility to right- and left-sided colorectal adenocarcinoma.

Carcinogenesis 2012 Apr 8;33(4):841-7. Epub 2012 Feb 8.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/carcin/bgs096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324446PMC
April 2012

Drug development: Raise standards for preclinical cancer research.

Nature 2012 Mar 28;483(7391):531-3. Epub 2012 Mar 28.

Hematology and Oncology Research, Amgen, Thousand Oaks, California 91359, USA.

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http://www.nature.com/articles/483531a
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http://dx.doi.org/10.1038/483531aDOI Listing
March 2012

Antiangiogenic therapy--evolving view based on clinical trial results.

Nat Rev Clin Oncol 2012 02 14;9(5):297-303. Epub 2012 Feb 14.

Department of Medical Oncology, Christie Hospital and University of Manchester, Wilmslow Road, Manchester Academic Health Sciences Centre, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/nrclinonc.2012.8DOI Listing
February 2012

Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells.

Cancer Res 2012 Jan 14;72(1):304-14. Epub 2011 Nov 14.

Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601736PMC
January 2012

Targeted therapies: peaking beneath the surface of recent bevacizumab trials.

Nat Rev Clin Oncol 2011 Jun 19;8(6):319-20. Epub 2011 Apr 19.

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http://dx.doi.org/10.1038/nrclinonc.2011.66DOI Listing
June 2011

Is there really a yin and yang to VEGF-targeted therapies?

Lancet Oncol 2010 Sep 13;11(9):809-11. Epub 2010 Jul 13.

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http://dx.doi.org/10.1016/S1470-2045(10)70161-3DOI Listing
September 2010

Finding the tumor copycat. Therapy fails, patients don't.

Nat Med 2010 Sep;16(9):974-5

Department of Cancer Biology, Houston, Texas, USA.

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http://dx.doi.org/10.1038/nm0910-974DOI Listing
September 2010

Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care.

Lancet Oncol 2010 Apr 18;11(4):373-82. Epub 2010 Feb 18.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.

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http://dx.doi.org/10.1016/S1470-2045(09)70341-9DOI Listing
April 2010

Phase II trial of neoadjuvant bevacizumab, capecitabine, and radiotherapy for locally advanced rectal cancer.

Int J Radiat Oncol Biol Phys 2010 Mar 21;76(3):824-30. Epub 2009 May 21.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2009.02.037DOI Listing
March 2010

Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death.

Clin Cancer Res 2009 Dec;15(24):7453-7455

Authors' Affiliations: Angiogenesis Research Laboratory, Department of Restorative Sciences, School of Dentistry; Department of Biomedical Engineering, College of Engineering; Department of Otolaryngology, School of Medicine, University of Michigan, Ann Arbor, Michigan; and Departments of Surgical Oncology and Cancer Biology, Maryland Anderson Cancer Center, University of Texas, Houston, Texas.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-2578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796551PMC
December 2009

Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology.

Clin Cancer Res 2009 Dec;15(24):7471-7478

Authors' Affiliations: Departments of Surgical Oncology and Cancer Biology, University of Texas M.D. Anderson Cancer Center, University of Texas Graduate School of Biomedical Sciences, Houston, Texas and Oncology Discovery, Schering-Plough Research Institute, Schering-Plough Corporation, Kenilworth, New Jersey.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1070DOI Listing
December 2009

Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis.

Clin Cancer Res 2009 Nov 3;15(22):6763-70. Epub 2009 Nov 3.

Departments of Surgical Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1810DOI Listing
November 2009

Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.

Cancer Res 2009 May 21;69(9):3842-9. Epub 2009 Apr 21.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center and Program in Cancer Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030-4009, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709758PMC
May 2009

Targeting tumor angiogenesis.

Semin Oncol 2009 Apr;36(2 Suppl 1):S12-9

Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2009.02.002DOI Listing
April 2009

Cancer: The nuances of therapy.

Nature 2009 Mar;458(7236):290-2

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http://dx.doi.org/10.1038/458290aDOI Listing
March 2009

Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma.

Clin Cancer Res 2008 Dec;14(24):8052-60

Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1520DOI Listing
December 2008

Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases.

J Clin Oncol 2008 Nov 14;26(32):5254-60. Epub 2008 Oct 14.

Department of Surgical Oncology, Cancer Biology, Biostatistics, and Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1200/JCO.2008.17.7857DOI Listing
November 2008

Bevacizumab beyond progression: does this make sense?

J Clin Oncol 2008 Nov 14;26(33):5313-5. Epub 2008 Oct 14.

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http://dx.doi.org/10.1200/JCO.2008.17.4540DOI Listing
November 2008

Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases.

J Clin Oncol 2008 Nov 20;26(33):5344-51. Epub 2008 Oct 20.

Department of Surgical Oncology, Gastrointestinal Medical Oncology, and Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1200/JCO.2008.17.5299DOI Listing
November 2008

Pathways mediating resistance to vascular endothelial growth factor-targeted therapy.

Clin Cancer Res 2008 Oct;14(20):6371-5

Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-5287DOI Listing
October 2008

Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies.

Cancer J 2008 May-Jun;14(3):170-7

Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1097/PPO.0b013e318178d9deDOI Listing
September 2008

VEGF-targeted therapy: mechanisms of anti-tumour activity.

Nat Rev Cancer 2008 Aug 3;8(8):579-91. Epub 2008 Jul 3.

Department of Surgical Oncology, Unit 444, University of Texas M.D. Anderson Cancer Center, PO Box 301402, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1038/nrc2403DOI Listing
August 2008

Endoglin (CD105): a marker of tumor vasculature and potential target for therapy.

Clin Cancer Res 2008 Apr;14(7):1931-7

Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4478DOI Listing
April 2008

Impact of vessel maturation on antiangiogenic therapy in ovarian cancer.

Am J Obstet Gynecol 2008 Apr;198(4):477.e1-9; discussion 477.e9-10

Department of Gynecologic Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ajog.2007.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346589PMC
April 2008

Effect of molecular therapeutics on liver regeneration in a murine model.

J Clin Oncol 2008 Apr;26(11):1836-42

Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, PO Box 301402, Houston, TX 77230-1402, USA.

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http://dx.doi.org/10.1200/JCO.2007.11.6566DOI Listing
April 2008

Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells.

Cancer Metastasis Rev 2007 Dec;26(3-4):433-41

Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77230-1402, USA,

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http://dx.doi.org/10.1007/s10555-007-9070-2DOI Listing
December 2007

Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab.

Clin Cancer Res 2007 Dec;13(24):7432-40

Department of Preclinical Pharmacology, ImClone Systems Incorporated, New York, NY 10014, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1768DOI Listing
December 2007

The development and characterization of a human midgut carcinoid cell line.

Clin Cancer Res 2007 Aug;13(16):4704-12

Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2723DOI Listing
August 2007