Lee J Helman

Lee J Helman

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Lee J Helman

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Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.

Oncogenesis 2019 Feb 26;8(3):20. Epub 2019 Feb 26.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41389-019-0129-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391386PMC
February 2019

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

J Clin Oncol 2017 May 28;35(14):1561-1569. Epub 2017 Mar 28.

Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T. Do, Baris Turkbey, Paul S. Meltzer, Eric Polley, Peter L. Choyke, Robert Meehan, Yvonne Horneffer, Ann Lih, Amul Choudhary, Sandra A. Mitchell, Lee J. Helman, James H. Doroshow, and Alice P. Chen, National Cancer Institute, National Institutes of Health, Bethesda; and Rasa Vilimas and Lamin Juwara, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD.

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http://dx.doi.org/10.1200/JCO.2016.71.1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455706PMC
May 2017

Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic.

J Clin Oncol 2017 Feb 28;35(5):523-528. Epub 2016 Dec 28.

Christopher B. Weldon and Arin L. Madenci, Boston Children's Hospital; Christopher B. Weldon, Arin L. Madenci, Katherine A. Janeway, and Suzanne George, Harvard Medical School; Christopher B. Weldon, Katherine A. Janeway, and Suzanne George, Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Arin L. Madenci, Brigham and Women's Hospital, Boston, MA; Sosipatros A. Boikos, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA; Margaret von Mehren, Fox Chase Cancer Center, Philadelphia, PA; Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Joshua D. Schiffman and Jennifer Wright, Huntsman Cancer Institute, Salt Lake City, UT; Jonathan C. Trent, Sylvester Comprehensive Cancer Center, Miami, FL; Karel Pacak and Constantine A. Stratakis, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Lee J. Helman, National Cancer Institute, Bethesda, MD; and Michael P. La Quaglia, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.68.6733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455315PMC
February 2017

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.

Neoplasia 2016 Oct 28;18(11):699-710. Epub 2016 Oct 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Ethos Discovery in Washington DC and Ethos Veterinary Health, Wolburn MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094383PMC
October 2016

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Clin Cancer Res 2016 Aug 15;22(16):4105-18. Epub 2016 Mar 15.

Division of Pediatric Hematology/Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee. Van Andel Research Institute, Grand Rapids, Michigan. Helen De Vos Children's Hospital, Grand Rapids, Michigan. Department of Pediatrics, Michigan State University School of Medicine, East Lansing, Michigan.

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http://clincancerres.aacrjournals.org/content/early/2016/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987166PMC
August 2016

Precision Therapy for Pediatric Cancers.

JAMA Oncol 2016 May;2(5):575-577

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2015.5685DOI Listing
May 2016

Carney triad can be (rarely) associated with germline succinate dehydrogenase defects.

Eur J Hum Genet 2016 Apr 15;24(4):569-73. Epub 2015 Jul 15.

Section on Endocrinology and Genetics (SEGEN), Program on Developmental Endocrinology and Genetics (PDEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1038/ejhg.2015.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929866PMC
April 2016

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma.

Neoplasia 2015 Apr;17(4):358-66

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586150003
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http://dx.doi.org/10.1016/j.neo.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415145PMC
April 2015

New strategies in ewing sarcoma: lost in translation?

Clin Cancer Res 2014 Jun 22;20(12):3050-6. Epub 2014 Apr 22.

Authors' Affiliation: Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058417PMC
June 2014

Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.

Clin Cancer Res 2014 Mar 25;20(5):1190-203. Epub 2013 Nov 25.

Authors' Affiliations: Monroe Carrell Jr. Children's Hospital at Vanderbilt and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee; Molecular Oncology Section, Pediatric Oncology Branch; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and Istituto di Ricerche Farmacologiche "Mario Negri" -IRCCS, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510643PMC
March 2014

Prospects and challenges for the development of new therapies for Ewing sarcoma.

Pharmacol Ther 2013 Feb 18;137(2):216-24. Epub 2012 Oct 18.

Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carrell Junior Children's Hospital, Vanderbilt-Ingram Cancer Center, 2220 Pierce Ave, PRB 397, Nashville, TN 37232-6310, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01637258120022
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http://dx.doi.org/10.1016/j.pharmthera.2012.10.004DOI Listing
February 2013

Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma.

Cancer Res 2012 Nov 20;72(22):5889-99. Epub 2012 Sep 20.

Molecular Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500453PMC
November 2012

Targeting cancer metabolism.

Clin Cancer Res 2012 Oct;18(20):5537-45

Molecular Pharmacology Branch, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475613PMC
October 2012

Gastrointestinal stromal tumor: psychosocial characteristics and considerations.

Support Care Cancer 2012 Jun 17;20(6):1343-9. Epub 2012 Mar 17.

Behavioral Science Core, Psychosocial Support and Research Program, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Pediatric Clinic, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00520-012-1426-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191473PMC
June 2012

Targeting the insulin growth factor receptor 1.

Hematol Oncol Clin North Am 2012 Jun 28;26(3):527-42, vii-viii. Epub 2012 Feb 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985881200005
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http://dx.doi.org/10.1016/j.hoc.2012.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334849PMC
June 2012

Genomic investigation of dedifferentiated liposarcoma suggests a role for therapeutic targeting of the tumor epigenome.

Cancer Discov 2011 Dec;1(7):555-6

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0291DOI Listing
December 2011

Low Dose Histone Deacetylase Inhibitor, Depsipeptide (FR901228), Promotes Adenoviral Transduction in Human Rhabdomyosarcoma Cell Lines.

Sarcoma 2004 ;8(1):25-30

Pediatric Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD 20892-1928 USA.

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http://dx.doi.org/10.1080/13577140410001679220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395599PMC
July 2011

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

J Natl Cancer Inst 2011 Jun 8;103(12):962-78. Epub 2011 Jun 8.

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr-MSC 1104, 10 CRC 1W-3816, Bethesda, MD 20892-1104, USA.

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http://dx.doi.org/10.1093/jnci/djr156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119649PMC
June 2011

Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.

Neoplasia 2011 Feb;13(2):145-53

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033593PMC
http://dx.doi.org/10.1593/neo.101202DOI Listing
February 2011

Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.

Cancer Res 2010 Aug 27;70(16):6497-508. Epub 2010 Jul 27.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Human Genome Research Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922412PMC
August 2010

Targeting IGF-1R in the treatment of sarcomas: past, present and future.

Bull Cancer 2009 Jul-Aug;96(7):E52-60

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1684/bdc.2009.0915DOI Listing
August 2009

The role of IGF-1R in pediatric malignancies.

Oncologist 2009 Jan 6;14(1):83-91. Epub 2009 Jan 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1634/theoncologist.2008-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721475PMC
January 2009

Progress in the curative treatment of childhood hematologic malignancies.

J Natl Cancer Inst 2008 Sep 9;100(18):1271-3. Epub 2008 Sep 9.

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http://dx.doi.org/10.1093/jnci/djn306DOI Listing
September 2008

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.

J Pediatr Hematol Oncol 2008 Aug;30(8):612-7

Pediatric Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/MPH.0b013e318168f072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748653PMC
August 2008

Dilemmas associated with congenital ewing sarcoma family tumors.

J Pediatr Hematol Oncol 2008 Jan;30(1):4-7

Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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https://insights.ovid.com/crossref?an=00043426-200801000-000
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http://dx.doi.org/10.1097/MPH.0b013e31815cf71fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668808PMC
January 2008

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Nat Med 2007 Dec 25;13(12):1504-9. Epub 2007 Nov 25.

Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://www.nature.com/articles/nm1686
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http://dx.doi.org/10.1038/nm1686DOI Listing
December 2007

The biology behind mTOR inhibition in sarcoma.

Oncologist 2007 Aug;12(8):1007-18

Molecular Oncology Section, Pediatric Oncology Branch, Building 10, Room CRC-1W-3816, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1928, USA.

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.12-8-1007DOI Listing
August 2007

Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival.

Cancer Res 2007 Apr;67(7):3431-40

Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Cellular and Gene Therapy, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1344DOI Listing
April 2007

Thromboembolic events in children and young adults with pediatric sarcoma.

J Clin Oncol 2007 Apr;25(12):1519-24

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1200/JCO.2006.06.9930DOI Listing
April 2007

Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway.

Clin Exp Metastasis 2006 22;23(3-4):227-36. Epub 2006 Sep 22.

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1-3816, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10585-006-9033-yDOI Listing
February 2007

Molecular approaches in pediatric oncology.

Annu Rev Med 2006 ;57:83-97

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA.

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http://dx.doi.org/10.1146/annurev.med.57.121304.131247DOI Listing
May 2006

CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling.

Neoplasia 2006 May;8(5):394-401

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://dx.doi.org/10.1593/neo.05820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592447PMC
May 2006

The molecular biology of pulmonary metastasis.

Thorac Surg Clin 2006 May;16(2):115-24

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.thorsurg.2005.12.003DOI Listing
May 2006

CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta.

Cancer Res 2006 Apr;66(7):3869-75

Vaccine Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bldg. 10/Rm. 6B12, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3421DOI Listing
April 2006

Identification and epitope enhancement of a PAX-FKHR fusion protein breakpoint epitope in alveolar rhabdomyosarcoma cells created by a tumorigenic chromosomal translocation inducing CTL capable of lysing human tumors.

Cancer Res 2006 Feb;66(3):1818-23

Vaccine Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 10, Rm. 6B-04, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2549DOI Listing
February 2006

The biology of metastases in pediatric sarcomas.

Cancer J 2005 Jul-Aug;11(4):306-13

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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December 2005

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.

Nat Med 2005 Nov 16;11(11):1238-43. Epub 2005 Oct 16.

Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nm1312DOI Listing
November 2005

Telomere stability genes are not mutated in osteosarcoma cell lines.

Cancer Genet Cytogenet 2005 Jul;160(1):79-81

Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892-4605, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.12.004DOI Listing
July 2005

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma.

Cancer Res 2005 Mar;65(6):2406-11

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1106, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3135DOI Listing
March 2005

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.

Nat Med 2004 Feb 4;10(2):182-6. Epub 2004 Jan 4.

Pediatric Oncology Branch and Tissue Array Project Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nm982DOI Listing
February 2004

Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells.

Oncogene 2003 Nov;22(50):8205-11

Molecular Oncology Section, Pediatric Oncology Branch, NCI, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://dx.doi.org/10.1038/sj.onc.1206878DOI Listing
November 2003

Mechanisms of sarcoma development.

Nat Rev Cancer 2003 Sep;3(9):685-94

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 13N240, MSC 1928, Bethesda, Maryland 20892-1928, USA.

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http://www.nature.com/articles/nrc1168
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http://dx.doi.org/10.1038/nrc1168DOI Listing
September 2003

Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor.

Lab Invest 2003 Sep;83(9):1255-65

Laboratory of Pathology, National Institutes of Health, National Cancer Institute, Bethesda, Maryland, USA.

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September 2003

Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway.

Neoplasia 2002 Sep-Oct;4(5):400-8

Molecular Oncology Section, Pediatric Oncology Branch, NCI, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://dx.doi.org/10.1038/sj.neo.7900242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564119PMC
February 2003

Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels.

J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):440-6

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-2669, USA.

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http://dx.doi.org/10.1097/00043426-200208000-00007DOI Listing
December 2002

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.

Nat Med 2002 Nov 7;8(11):1276-80. Epub 2002 Oct 7.

Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA.

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http://www.nature.com/articles/nm787
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http://dx.doi.org/10.1038/nm787DOI Listing
November 2002

Focus on sarcomas.

Cancer Cell 2002 Sep;2(3):175-8

National Cancer Institute, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2002