Lee Helman

Lee Helman

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Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.

Oncogenesis 2019 Feb 26;8(3):20. Epub 2019 Feb 26.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41389-019-0129-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391386PMC
February 2019

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

J Clin Oncol 2017 May 28;35(14):1561-1569. Epub 2017 Mar 28.

Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T. Do, Baris Turkbey, Paul S. Meltzer, Eric Polley, Peter L. Choyke, Robert Meehan, Yvonne Horneffer, Ann Lih, Amul Choudhary, Sandra A. Mitchell, Lee J. Helman, James H. Doroshow, and Alice P. Chen, National Cancer Institute, National Institutes of Health, Bethesda; and Rasa Vilimas and Lamin Juwara, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD.

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http://dx.doi.org/10.1200/JCO.2016.71.1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455706PMC
May 2017

Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic.

J Clin Oncol 2017 Feb 28;35(5):523-528. Epub 2016 Dec 28.

Christopher B. Weldon and Arin L. Madenci, Boston Children's Hospital; Christopher B. Weldon, Arin L. Madenci, Katherine A. Janeway, and Suzanne George, Harvard Medical School; Christopher B. Weldon, Katherine A. Janeway, and Suzanne George, Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Arin L. Madenci, Brigham and Women's Hospital, Boston, MA; Sosipatros A. Boikos, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA; Margaret von Mehren, Fox Chase Cancer Center, Philadelphia, PA; Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Joshua D. Schiffman and Jennifer Wright, Huntsman Cancer Institute, Salt Lake City, UT; Jonathan C. Trent, Sylvester Comprehensive Cancer Center, Miami, FL; Karel Pacak and Constantine A. Stratakis, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Lee J. Helman, National Cancer Institute, Bethesda, MD; and Michael P. La Quaglia, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.68.6733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455315PMC
February 2017

A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.

J Pharm Biomed Anal 2017 Jan 5;132:223-226. Epub 2016 Oct 5.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085163079
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http://dx.doi.org/10.1016/j.jpba.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357958PMC
January 2017

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.

Neoplasia 2016 Oct 28;18(11):699-710. Epub 2016 Oct 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Ethos Discovery in Washington DC and Ethos Veterinary Health, Wolburn MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094383PMC
October 2016

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Clin Cancer Res 2016 Aug 15;22(16):4105-18. Epub 2016 Mar 15.

Division of Pediatric Hematology/Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee. Van Andel Research Institute, Grand Rapids, Michigan. Helen De Vos Children's Hospital, Grand Rapids, Michigan. Department of Pediatrics, Michigan State University School of Medicine, East Lansing, Michigan.

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http://clincancerres.aacrjournals.org/content/early/2016/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987166PMC
August 2016

Precision Therapy for Pediatric Cancers.

JAMA Oncol 2016 May;2(5):575-577

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2015.5685DOI Listing
May 2016

Carney triad can be (rarely) associated with germline succinate dehydrogenase defects.

Eur J Hum Genet 2016 Apr 15;24(4):569-73. Epub 2015 Jul 15.

Section on Endocrinology and Genetics (SEGEN), Program on Developmental Endocrinology and Genetics (PDEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1038/ejhg.2015.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929866PMC
April 2016

Risk-Based Therapy for Localized Osteosarcoma.

Pediatr Blood Cancer 2016 Mar 26;63(3):412-7. Epub 2015 Oct 26.

Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.25808DOI Listing
March 2016

Rare Tumors in Children: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):3047-54. Epub 2015 Aug 24.

Alberto S. Pappo and Wayne L. Furman, St Jude Children's Research Hospital, Memphis, TN; Kris A. Schultz, Children's Hospital of Minnesota, Minneapolis, MN; Andrea Ferrari, Instituto Nazionale Tumori, Milano, Italy; Lee Helman, National Cancer Institute Center for Cancer Research, Bethesda, MD; and Mark D. Krailo, Keck School of Medicine, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2014.59.3632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979197PMC
September 2015

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma.

Neoplasia 2015 Apr;17(4):358-66

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586150003
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http://dx.doi.org/10.1016/j.neo.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415145PMC
April 2015

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

Authors:
Zhaoming Wang Bin Zhu Mingfeng Zhang Hemang Parikh Jinping Jia Charles C Chung Joshua N Sampson Jason W Hoskins Amy Hutchinson Laurie Burdette Abdisamad Ibrahim Christopher Hautman Preethi S Raj Christian C Abnet Andrew A Adjei Anders Ahlbom Demetrius Albanes Naomi E Allen Christine B Ambrosone Melinda Aldrich Pilar Amiano Christopher Amos Ulrika Andersson Gerald Andriole Irene L Andrulis Cecilia Arici Alan A Arslan Melissa A Austin Dalsu Baris Donald A Barkauskas Bryan A Bassig Laura E Beane Freeman Christine D Berg Sonja I Berndt Pier Alberto Bertazzi Richard B Biritwum Amanda Black William Blot Heiner Boeing Paolo Boffetta Kelly Bolton Marie-Christine Boutron-Ruault Paige M Bracci Paul Brennan Louise A Brinton Michelle Brotzman H Bas Bueno-de-Mesquita Julie E Buring Mary Ann Butler Qiuyin Cai Geraldine Cancel-Tassin Federico Canzian Guangwen Cao Neil E Caporaso Alfredo Carrato Tania Carreon Angela Carta Gee-Chen Chang I-Shou Chang Jenny Chang-Claude Xu Che Chien-Jen Chen Chih-Yi Chen Chung-Hsing Chen Constance Chen Kuan-Yu Chen Yuh-Min Chen Anand P Chokkalingam Lisa W Chu Francoise Clavel-Chapelon Graham A Colditz Joanne S Colt David Conti Michael B Cook Victoria K Cortessis E David Crawford Olivier Cussenot Faith G Davis Immaculata De Vivo Xiang Deng Ti Ding Colin P Dinney Anna Luisa Di Stefano W Ryan Diver Eric J Duell Joanne W Elena Jin-Hu Fan Heather Spencer Feigelson Maria Feychting Jonine D Figueroa Adrienne M Flanagan Joseph F Fraumeni Neal D Freedman Brooke L Fridley Charles S Fuchs Manuela Gago-Dominguez Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Reina Garcia-Closas Julie M Gastier-Foster J Michael Gaziano Daniela S Gerhard Carol A Giffen Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Michael Goggins Nalan Gokgoz Alisa M Goldstein Carlos Gonzalez Richard Gorlick Mark H Greene Myron Gross H Barton Grossman Robert Grubb Jian Gu Peng Guan Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Patricia Hartge Claudia Hattinger Richard B Hayes Qincheng He Lee Helman Brian E Henderson Roger Henriksson Judith Hoffman-Bolton Chancellor Hohensee Elizabeth A Holly Yun-Chul Hong Robert N Hoover H Dean Hosgood Chin-Fu Hsiao Ann W Hsing Chao Agnes Hsiung Nan Hu Wei Hu Zhibin Hu Ming-Shyan Huang David J Hunter Peter D Inskip Hidemi Ito Eric J Jacobs Kevin B Jacobs Mazda Jenab Bu-Tian Ji Christoffer Johansen Mattias Johansson Alison Johnson Rudolf Kaaks Ashish M Kamat Aruna Kamineni Margaret Karagas Chand Khanna Kay-Tee Khaw Christopher Kim In-Sam Kim Jin Hee Kim Yeul Hong Kim Young-Chul Kim Young Tae Kim Chang Hyun Kang Yoo Jin Jung Cari M Kitahara Alison P Klein Robert Klein Manolis Kogevinas Woon-Puay Koh Takashi Kohno Laurence N Kolonel Charles Kooperberg Christian P Kratz Vittorio Krogh Hideo Kunitoh Robert C Kurtz Nilgun Kurucu Qing Lan Mark Lathrop Ching C Lau Fernando Lecanda Kyoung-Mu Lee Maxwell P Lee Loic Le Marchand Seth P Lerner Donghui Li Linda M Liao Wei-Yen Lim Dongxin Lin Jie Lin Sara Lindstrom Martha S Linet Jolanta Lissowska Jianjun Liu Börje Ljungberg Josep Lloreta Daru Lu Jing Ma Nuria Malats Satu Mannisto Neyssa Marina Giuseppe Mastrangelo Keitaro Matsuo Katherine A McGlynn Roberta McKean-Cowdin Lorna H McNeill Robert R McWilliams Beatrice S Melin Paul S Meltzer James E Mensah Xiaoping Miao Dominique S Michaud Alison M Mondul Lee E Moore Kenneth Muir Shelley Niwa Sara H Olson Nick Orr Salvatore Panico Jae Yong Park Alpa V Patel Ana Patino-Garcia Sofia Pavanello Petra H M Peeters Beata Peplonska Ulrike Peters Gloria M Petersen Piero Picci Malcolm C Pike Stefano Porru Jennifer Prescott Xia Pu Mark P Purdue You-Lin Qiao Preetha Rajaraman Elio Riboli Harvey A Risch Rebecca J Rodabough Nathaniel Rothman Avima M Ruder Jeong-Seon Ryu Marc Sanson Alan Schned Fredrick R Schumacher Ann G Schwartz Kendra L Schwartz Molly Schwenn Katia Scotlandi Adeline Seow Consol Serra Massimo Serra Howard D Sesso Gianluca Severi Hongbing Shen Min Shen Sanjay Shete Kouya Shiraishi Xiao-Ou Shu Afshan Siddiq Luis Sierrasesumaga Sabina Sierri Alan Dart Loon Sihoe Debra T Silverman Matthias Simon Melissa C Southey Logan Spector Margaret Spitz Meir Stampfer Par Stattin Mariana C Stern Victoria L Stevens Rachael Z Stolzenberg-Solomon Daniel O Stram Sara S Strom Wu-Chou Su Malin Sund Sook Whan Sung Anthony Swerdlow Wen Tan Hideo Tanaka Wei Tang Ze-Zhang Tang Adonina Tardon Evelyn Tay Philip R Taylor Yao Tettey David M Thomas Roberto Tirabosco Anne Tjonneland Geoffrey S Tobias Jorge R Toro Ruth C Travis Dimitrios Trichopoulos Rebecca Troisi Ann Truelove Ying-Huang Tsai Margaret A Tucker Rosario Tumino David Van Den Berg Stephen K Van Den Eeden Roel Vermeulen Paolo Vineis Kala Visvanathan Ulla Vogel Chaoyu Wang Chengfeng Wang Junwen Wang Sophia S Wang Elisabete Weiderpass Stephanie J Weinstein Nicolas Wentzensen William Wheeler Emily White John K Wiencke Alicja Wolk Brian M Wolpin Maria Pik Wong Margaret Wrensch Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Yong-Bing Xiang Jun Xu Hannah P Yang Pan-Chyr Yang Yasushi Yatabe Yuanqing Ye Edward D Yeboah Zhihua Yin Chen Ying Chong-Jen Yu Kai Yu Jian-Min Yuan Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Lisa Mirabello Sharon A Savage Peter Kraft Stephen J Chanock Meredith Yeager Maria Terese Landi Jianxin Shi Nilanjan Chatterjee Laufey T Amundadottir

Hum Mol Genet 2014 Dec 15;23(24):6616-33. Epub 2014 Jul 15.

Division of Cancer Epidemiology and Genetics,

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http://kooperberg.fhcrc.org/papers/2014wang.pdf
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http://hmg.oxfordjournals.org/content/23/24/6616.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu363
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http://dx.doi.org/10.1093/hmg/ddu363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240198PMC
December 2014

Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Nov 6;970:95-101. Epub 2014 Sep 6.

Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15700232140053
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http://dx.doi.org/10.1016/j.jchromb.2014.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188709PMC
November 2014

New strategies in ewing sarcoma: lost in translation?

Clin Cancer Res 2014 Jun 22;20(12):3050-6. Epub 2014 Apr 22.

Authors' Affiliation: Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058417PMC
June 2014

Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.

Clin Cancer Res 2014 Mar 25;20(5):1190-203. Epub 2013 Nov 25.

Authors' Affiliations: Monroe Carrell Jr. Children's Hospital at Vanderbilt and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee; Molecular Oncology Section, Pediatric Oncology Branch; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and Istituto di Ricerche Farmacologiche "Mario Negri" -IRCCS, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510643PMC
March 2014

Prospects and challenges for the development of new therapies for Ewing sarcoma.

Pharmacol Ther 2013 Feb 18;137(2):216-24. Epub 2012 Oct 18.

Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carrell Junior Children's Hospital, Vanderbilt-Ingram Cancer Center, 2220 Pierce Ave, PRB 397, Nashville, TN 37232-6310, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01637258120022
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http://dx.doi.org/10.1016/j.pharmthera.2012.10.004DOI Listing
February 2013

Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma.

Cancer Res 2012 Nov 20;72(22):5889-99. Epub 2012 Sep 20.

Molecular Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500453PMC
November 2012

Targeting cancer metabolism.

Clin Cancer Res 2012 Oct;18(20):5537-45

Molecular Pharmacology Branch, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475613PMC
October 2012

Gastrointestinal stromal tumor: psychosocial characteristics and considerations.

Support Care Cancer 2012 Jun 17;20(6):1343-9. Epub 2012 Mar 17.

Behavioral Science Core, Psychosocial Support and Research Program, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Pediatric Clinic, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00520-012-1426-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191473PMC
June 2012

Targeting the insulin growth factor receptor 1.

Hematol Oncol Clin North Am 2012 Jun 28;26(3):527-42, vii-viii. Epub 2012 Feb 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985881200005
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http://dx.doi.org/10.1016/j.hoc.2012.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334849PMC
June 2012

Genomic investigation of dedifferentiated liposarcoma suggests a role for therapeutic targeting of the tumor epigenome.

Cancer Discov 2011 Dec;1(7):555-6

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0291DOI Listing
December 2011

Low Dose Histone Deacetylase Inhibitor, Depsipeptide (FR901228), Promotes Adenoviral Transduction in Human Rhabdomyosarcoma Cell Lines.

Sarcoma 2004 ;8(1):25-30

Pediatric Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD 20892-1928 USA.

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http://dx.doi.org/10.1080/13577140410001679220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395599PMC
July 2011

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

J Natl Cancer Inst 2011 Jun 8;103(12):962-78. Epub 2011 Jun 8.

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr-MSC 1104, 10 CRC 1W-3816, Bethesda, MD 20892-1104, USA.

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http://dx.doi.org/10.1093/jnci/djr156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119649PMC
June 2011

Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.

Neoplasia 2011 Feb;13(2):145-53

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033593PMC
http://dx.doi.org/10.1593/neo.101202DOI Listing
February 2011

Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.

Cancer Res 2010 Aug 27;70(16):6497-508. Epub 2010 Jul 27.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Human Genome Research Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922412PMC
August 2010

Secondary supratentorial primitive neuroectodermal tumor following treatment of childhood osteosarcoma.

Pediatr Blood Cancer 2009 Sep;53(3):496-8

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://doi.wiley.com/10.1002/pbc.22074
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http://dx.doi.org/10.1002/pbc.22074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760453PMC
September 2009

Targeting IGF-1R in the treatment of sarcomas: past, present and future.

Bull Cancer 2009 Jul-Aug;96(7):E52-60

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1684/bdc.2009.0915DOI Listing
August 2009

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Int J Cancer 2009 May;124(9):2042-9

Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ijc.24169DOI Listing
May 2009

The role of IGF-1R in pediatric malignancies.

Oncologist 2009 Jan 6;14(1):83-91. Epub 2009 Jan 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1634/theoncologist.2008-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721475PMC
January 2009

Phase 0 clinical trials: conceptions and misconceptions.

Cancer J 2008 May-Jun;14(3):133-7

Center for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/PPO.0b013e318172d6f3DOI Listing
September 2008

Progress in the curative treatment of childhood hematologic malignancies.

J Natl Cancer Inst 2008 Sep 9;100(18):1271-3. Epub 2008 Sep 9.

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http://dx.doi.org/10.1093/jnci/djn306DOI Listing
September 2008

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.

J Pediatr Hematol Oncol 2008 Aug;30(8):612-7

Pediatric Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/MPH.0b013e318168f072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748653PMC
August 2008

Designing phase 0 cancer clinical trials.

Clin Cancer Res 2008 Jun;14(12):3675-82

Division of Cancer Treatment and Diagnosis and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-2440, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435428PMC
June 2008

Dilemmas associated with congenital ewing sarcoma family tumors.

J Pediatr Hematol Oncol 2008 Jan;30(1):4-7

Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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https://insights.ovid.com/crossref?an=00043426-200801000-000
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http://dx.doi.org/10.1097/MPH.0b013e31815cf71fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668808PMC
January 2008

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Nat Med 2007 Dec 25;13(12):1504-9. Epub 2007 Nov 25.

Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://www.nature.com/articles/nm1686
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http://dx.doi.org/10.1038/nm1686DOI Listing
December 2007

Phase 0 clinical trials in cancer drug development: from FDA guidance to clinical practice.

Mol Interv 2007 Dec;7(6):325-34

Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Support Directorate, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1124/mi.7.6.9DOI Listing
December 2007

The biology behind mTOR inhibition in sarcoma.

Oncologist 2007 Aug;12(8):1007-18

Molecular Oncology Section, Pediatric Oncology Branch, Building 10, Room CRC-1W-3816, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1928, USA.

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.12-8-1007DOI Listing
August 2007

Immune reconstitution prevents metastatic recurrence of murine osteosarcoma.

Cancer Immunol Immunother 2007 Jul 6;56(7):1037-46. Epub 2006 Dec 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00262-006-0257-0DOI Listing
July 2007

Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival.

Cancer Res 2007 Apr;67(7):3431-40

Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Cellular and Gene Therapy, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1344DOI Listing
April 2007

Thromboembolic events in children and young adults with pediatric sarcoma.

J Clin Oncol 2007 Apr;25(12):1519-24

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1200/JCO.2006.06.9930DOI Listing
April 2007

Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway.

Clin Exp Metastasis 2006 22;23(3-4):227-36. Epub 2006 Sep 22.

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1-3816, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10585-006-9033-yDOI Listing
February 2007

Molecular approaches in pediatric oncology.

Annu Rev Med 2006 ;57:83-97

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA.

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http://dx.doi.org/10.1146/annurev.med.57.121304.131247DOI Listing
May 2006

CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling.

Neoplasia 2006 May;8(5):394-401

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://dx.doi.org/10.1593/neo.05820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592447PMC
May 2006

The molecular biology of pulmonary metastasis.

Thorac Surg Clin 2006 May;16(2):115-24

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.thorsurg.2005.12.003DOI Listing
May 2006

CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta.

Cancer Res 2006 Apr;66(7):3869-75

Vaccine Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bldg. 10/Rm. 6B12, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3421DOI Listing
April 2006

Identification and epitope enhancement of a PAX-FKHR fusion protein breakpoint epitope in alveolar rhabdomyosarcoma cells created by a tumorigenic chromosomal translocation inducing CTL capable of lysing human tumors.

Cancer Res 2006 Feb;66(3):1818-23

Vaccine Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 10, Rm. 6B-04, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2549DOI Listing
February 2006

The biology of metastases in pediatric sarcomas.

Cancer J 2005 Jul-Aug;11(4):306-13

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/00130404-200507000-00006DOI Listing
December 2005

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.

Nat Med 2005 Nov 16;11(11):1238-43. Epub 2005 Oct 16.

Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nm1312DOI Listing
November 2005

Telomere stability genes are not mutated in osteosarcoma cell lines.

Cancer Genet Cytogenet 2005 Jul;160(1):79-81

Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892-4605, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.12.004DOI Listing
July 2005

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma.

Cancer Res 2005 Mar;65(6):2406-11

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1106, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3135DOI Listing
March 2005