Lee Helman

Lee Helman

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Lee Helman

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A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor.

Authors:
John Glod Fernanda I Arnaldez Lori Wiener Melissa Spencer J Keith Killian Paul Meltzer Eva Dombi Claudia Derse-Anthony Joanne Derdak Ramaprasad Srinivasan W Marston Linehan Markku Miettinen Seth M Steinberg Lee Helman Brigitte C Widemann

Clin Cancer Res 2019 Nov 22;25(21):6302-6308. Epub 2019 Aug 22.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825553PMC
November 2019

Insights into pediatric rhabdomyosarcoma research: Challenges and goals.

Authors:
Marielle E Yohe Christine M Heske Elizabeth Stewart Peter C Adamson Nabil Ahmed Cristina R Antonescu Eleanor Chen Natalie Collins Alan Ehrlich Rene L Galindo Berkley E Gryder Heidi Hahn Sharon Hammond Mark E Hatley Douglas S Hawkins Madeline N Hayes Andrea Hayes-Jordan Lee J Helman Simone Hettmer Myron S Ignatius Charles Keller Javed Khan David G Kirsch Corinne M Linardic Philip J Lupo Rossella Rota Jack F Shern Janet Shipley Sivasish Sindiri Stephen J Tapscott Christopher R Vakoc Leonard H Wexler David M Langenau

Pediatr Blood Cancer 2019 Oct 21;66(10):e27869. Epub 2019 Jun 21.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts.

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http://dx.doi.org/10.1002/pbc.27869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707829PMC
October 2019

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.

Authors:
Choh Yeung Anna E Gibson Sameer H Issaq Nobu Oshima Joshua T Baumgart Leah D Edessa Ganesha Rai Daniel J Urban Michelle S Johnson Gloria A Benavides Giuseppe L Squadrito Marielle E Yohe Haiyan Lei Sandy Eldridge John Hamre Tyrone Dowdy Victor Ruiz-Rodado Adrian Lita Arnulfo Mendoza Jack F Shern Mioara Larion Lee J Helman Gordon M Stott Murali C Krishna Matthew D Hall Victor Darley-Usmar Leonard M Neckers Christine M Heske

Cancer Res 2019 Oct 20;79(19):5060-5073. Epub 2019 Aug 20.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774872PMC
October 2019

Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).

Authors:
Brigitte C Widemann Yao Lu Denise Reinke Scott H Okuno Christian F Meyer Gregory M Cote Rashmi Chugh Mohammed M Milhem Angela C Hirbe AeRang Kim Brian Turpin Joseph G Pressey Eva Dombi Nalini Jayaprakash Lee J Helman Ndidi Onwudiwe Karen Cichowski John P Perentesis

Sarcoma 2019 24;2019:7656747. Epub 2019 Jul 24.

Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1155/2019/7656747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681622PMC
July 2019

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.

Authors:
Sameer H Issaq Arnulfo Mendoza Stephen D Fox Lee J Helman

Oncogenesis 2019 Feb 26;8(3):20. Epub 2019 Feb 26.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41389-019-0129-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391386PMC
February 2019

Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.

Authors:
James J Morrow Ian Bayles Alister P W Funnell Tyler E Miller Alina Saiakhova Michael M Lizardo Cynthia F Bartels Maaike Y Kapteijn Stevephen Hung Arnulfo Mendoza Gursimran Dhillon Daniel R Chee Jay T Myers Frederick Allen Marco Gambarotti Alberto Righi Analisa DiFeo Brian P Rubin Alex Y Huang Paul S Meltzer Lee J Helman Piero Picci Henri H Versteeg John A Stamatoyannopoulos Chand Khanna Peter C Scacheri

Nat Med 2018 Apr;24(4):525

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http://dx.doi.org/10.1038/nm0418-525cDOI Listing
April 2018

Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.

Authors:
James J Morrow Ian Bayles Alister P W Funnell Tyler E Miller Alina Saiakhova Michael M Lizardo Cynthia F Bartels Maaike Y Kapteijn Stevephen Hung Arnulfo Mendoza Gursimran Dhillon Daniel R Chee Jay T Myers Frederick Allen Marco Gambarotti Alberto Righi Analisa DiFeo Brian P Rubin Alex Y Huang Paul S Meltzer Lee J Helman Piero Picci Henri H Versteeg John A Stamatoyannopoulos Chand Khanna Peter C Scacheri

Nat Med 2018 02 15;24(2):176-185. Epub 2018 Jan 15.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nm.4475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803371PMC
February 2018

Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma.

Authors:
Christine M Heske Mindy I Davis Joshua T Baumgart Kelli Wilson Michael V Gormally Lu Chen Xiaohu Zhang Michele Ceribelli Damien Y Duveau Rajarshi Guha Marc Ferrer Fernanda I Arnaldez Jiuping Ji Huong-Lan Tran Yiping Zhang Arnulfo Mendoza Lee J Helman Craig J Thomas

Clin Cancer Res 2017 Dec 12;23(23):7301-7311. Epub 2017 Sep 12.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636827PMC
December 2017

A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript.

Authors:
Patrick J Grohar John Glod Cody J Peer Tristan M Sissung Fernanda I Arnaldez Lauren Long William D Figg Patricia Whitcomb Lee J Helman Brigitte C Widemann

Cancer Chemother Pharmacol 2017 Sep 22;80(3):645-652. Epub 2017 Jul 22.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00280-017-3382-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413860PMC
September 2017

SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors.

Authors:
Christine S Higham Seth M Steinberg Eva Dombi Arie Perry Lee J Helman Scott M Schuetze Joseph A Ludwig Arthur Staddon Mohammed M Milhem Daniel Rushing Robin L Jones Michael Livingston Stewart Goldman Christopher Moertel Lars Wagner David Janhofer Christina M Annunziata Denise Reinke Lauren Long David Viskochil Larry Baker Brigitte C Widemann

Sarcoma 2017 12;2017:8685638. Epub 2017 Sep 12.

Pediatric Oncology Branch, NCI, CCR, Bethesda, MD, USA.

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http://dx.doi.org/10.1155/2017/8685638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613633PMC
September 2017

Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma.

Authors:
Jennifer M Kalish Leslie Doros Lee J Helman Raoul C Hennekam Roland P Kuiper Saskia M Maas Eamonn R Maher Kim E Nichols Sharon E Plon Christopher C Porter Surya Rednam Kris Ann P Schultz Lisa J States Gail E Tomlinson Kristin Zelley Todd E Druley

Clin Cancer Res 2017 07;23(13):e115-e122

Division of Pediatric Hematology and Oncology, Washington University, St. Louis, Missouri.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538793PMC
July 2017

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

Authors:
Shivaani Kummar Geraldine O'Sullivan Coyne Khanh T Do Baris Turkbey Paul S Meltzer Eric Polley Peter L Choyke Robert Meehan Rasa Vilimas Yvonne Horneffer Lamin Juwara Ann Lih Amul Choudhary Sandra A Mitchell Lee J Helman James H Doroshow Alice P Chen

J Clin Oncol 2017 May 28;35(14):1561-1569. Epub 2017 Mar 28.

Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T. Do, Baris Turkbey, Paul S. Meltzer, Eric Polley, Peter L. Choyke, Robert Meehan, Yvonne Horneffer, Ann Lih, Amul Choudhary, Sandra A. Mitchell, Lee J. Helman, James H. Doroshow, and Alice P. Chen, National Cancer Institute, National Institutes of Health, Bethesda; and Rasa Vilimas and Lamin Juwara, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD.

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http://dx.doi.org/10.1200/JCO.2016.71.1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455706PMC
May 2017

Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic.

Authors:
Christopher B Weldon Arin L Madenci Sosipatros A Boikos Katherine A Janeway Suzanne George Margaret von Mehren Alberto S Pappo Joshua D Schiffman Jennifer Wright Jonathan C Trent Karel Pacak Constantine A Stratakis Lee J Helman Michael P La Quaglia

J Clin Oncol 2017 Feb 28;35(5):523-528. Epub 2016 Dec 28.

Christopher B. Weldon and Arin L. Madenci, Boston Children's Hospital; Christopher B. Weldon, Arin L. Madenci, Katherine A. Janeway, and Suzanne George, Harvard Medical School; Christopher B. Weldon, Katherine A. Janeway, and Suzanne George, Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Arin L. Madenci, Brigham and Women's Hospital, Boston, MA; Sosipatros A. Boikos, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA; Margaret von Mehren, Fox Chase Cancer Center, Philadelphia, PA; Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Joshua D. Schiffman and Jennifer Wright, Huntsman Cancer Institute, Salt Lake City, UT; Jonathan C. Trent, Sylvester Comprehensive Cancer Center, Miami, FL; Karel Pacak and Constantine A. Stratakis, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Lee J. Helman, National Cancer Institute, Bethesda, MD; and Michael P. La Quaglia, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.68.6733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455315PMC
February 2017

A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.

Authors:
Marco A Ferraz Nogueira Filho Cody J Peer Jeffers Nguyen Amy McCalla Lee Helman William D Figg

J Pharm Biomed Anal 2017 Jan 5;132:223-226. Epub 2016 Oct 5.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085163079
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http://dx.doi.org/10.1016/j.jpba.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357958PMC
January 2017

The Role of PDGFR-β Activation in Acquired Resistance to IGF-1R Blockade in Preclinical Models of Rhabdomyosarcoma.

Authors:
Christine M Heske Choh Yeung Arnulfo Mendoza Joshua T Baumgart Leah D Edessa Xiaolin Wan Lee J Helman

Transl Oncol 2016 Dec 16;9(6):540-547. Epub 2016 Nov 16.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S19365233163011
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http://dx.doi.org/10.1016/j.tranon.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114528PMC
December 2016

STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.

Authors:
Christine M Heske Arnulfo Mendoza Leah D Edessa Joshua T Baumgart Sunmin Lee Jane Trepel David A Proia Len Neckers Lee J Helman

Oncotarget 2016 Oct;7(40):65540-65552

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.11869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323173PMC
October 2016

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.

Authors:
Michael M Lizardo James J Morrow Tyler E Miller Ellen S Hong Ling Ren Arnulfo Mendoza Charles H Halsey Peter C Scacheri Lee J Helman Chand Khanna

Neoplasia 2016 Oct 28;18(11):699-710. Epub 2016 Oct 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Ethos Discovery in Washington DC and Ethos Veterinary Health, Wolburn MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094383PMC
October 2016

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Authors:
Christy L Osgood Nichole Maloney Christopher G Kidd Susan Kitchen-Goosen Laura Segars Meti Gebregiorgis Girma M Woldemichael Min He Savita Sankar Stephen L Lessnick Min Kang Malcolm Smith Lisa Turner Zachary B Madaj Mary E Winn Luz-Elena Núñez Javier González-Sabín Lee J Helman Francisco Morís Patrick J Grohar

Clin Cancer Res 2016 Aug 15;22(16):4105-18. Epub 2016 Mar 15.

Division of Pediatric Hematology/Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee. Van Andel Research Institute, Grand Rapids, Michigan. Helen De Vos Children's Hospital, Grand Rapids, Michigan. Department of Pediatrics, Michigan State University School of Medicine, East Lansing, Michigan.

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http://clincancerres.aacrjournals.org/content/early/2016/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987166PMC
August 2016

Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic.

Authors:
Sosipatros A Boikos Alberto S Pappo J Keith Killian Michael P LaQuaglia Chris B Weldon Suzanne George Jonathan C Trent Margaret von Mehren Jennifer A Wright Josh D Schiffman Margarita Raygada Karel Pacak Paul S Meltzer Markku M Miettinen Constantine Stratakis Katherine A Janeway Lee J Helman

JAMA Oncol 2016 Jul;2(7):922-8

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamaoncol.2016.0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472100PMC
July 2016

Preface: The Status of Pediatric Solid Tumors in 2015.

Authors:
Carol J Thiele Lee J Helman

Crit Rev Oncog 2015 ;20(3-4):v-vi

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685204PMC
http://dx.doi.org/10.1615/critrevoncog.2015013950DOI Listing
June 2016

Response to Early Treatment Evaluated with 18F-FDG PET and PERCIST 1.0 Predicts Survival in Patients with Ewing Sarcoma Family of Tumors Treated with a Monoclonal Antibody to the Insulinlike Growth Factor 1 Receptor.

Authors:
Joo Hyun O Brandon S Luber Jeffrey P Leal Hao Wang Vanessa Bolejack Scott M Schuetze Lawrence H Schwartz Lee J Helman Denise Reinke Laurence H Baker Richard L Wahl

J Nucl Med 2016 May 21;57(5):735-40. Epub 2016 Jan 21.

Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland

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http://jnm.snmjournals.org/content/early/2016/01/20/jnumed.1
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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.115.162412
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http://dx.doi.org/10.2967/jnumed.115.162412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548359PMC
May 2016

Precision Therapy for Pediatric Cancers.

Authors:
Javed Khan Lee J Helman

JAMA Oncol 2016 May;2(5):575-577

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2015.5685DOI Listing
May 2016

Carney triad can be (rarely) associated with germline succinate dehydrogenase defects.

Authors:
Sosipatros A Boikos Paraskevi Xekouki Elena Fumagalli Fabio R Faucz Margarita Raygada Eva Szarek Evan Ball Su Young Kim Markku Miettinen Lee J Helman J Aidan Carney Karel Pacak Constantine A Stratakis

Eur J Hum Genet 2016 Apr 15;24(4):569-73. Epub 2015 Jul 15.

Section on Endocrinology and Genetics (SEGEN), Program on Developmental Endocrinology and Genetics (PDEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1038/ejhg.2015.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929866PMC
April 2016

Risk-Based Therapy for Localized Osteosarcoma.

Authors:
Rajkumar Venkatramani Jeffrey Murray Lee Helman William Meyer M John Hicks Robert Krance Ching Lau Eunji Jo Murali Chintagumpala

Pediatr Blood Cancer 2016 Mar 26;63(3):412-7. Epub 2015 Oct 26.

Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.25808DOI Listing
March 2016

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.

Authors:
Heinrich Kovar James Amatruda Erika Brunet Stefan Burdach Florencia Cidre-Aranaz Enrique de Alava Uta Dirksen Wietske van der Ent Patrick Grohar Thomas G P Grünewald Lee Helman Peter Houghton Kristiina Iljin Eberhard Korsching Marc Ladanyi Elizabeth Lawlor Stephen Lessnick Joseph Ludwig Paul Meltzer Markus Metzler Jaume Mora Richard Moriggl Takuro Nakamura Theodore Papamarkou Branka Radic Sarikas Francoise Rédini Guenther H S Richter Claudia Rossig Keri Schadler Beat W Schäfer Katia Scotlandi Nathan C Sheffield Anang Shelat Ewa Snaar-Jagalska Poul Sorensen Kimberly Stegmaier Elizabeth Stewart Alejandro Sweet-Cordero Karoly Szuhai Oscar M Tirado Franck Tirode Jeffrey Toretsky Kalliopi Tsafou Aykut Üren Andrei Zinovyev Olivier Delattre

Oncotarget 2016 Feb;7(8):8613-24

INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.

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http://dx.doi.org/10.18632/oncotarget.6937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890991PMC
February 2016

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology.

Authors:
Amy K LeBlanc Matthew Breen Peter Choyke Mark Dewhirst Timothy M Fan Daniel L Gustafson Lee J Helman Michael B Kastan Deborah W Knapp Wendy J Levin Cheryl London Nicola Mason Christina Mazcko Patricia N Olson Rodney Page Beverly A Teicher Douglas H Thamm Jeffrey M Trent David M Vail Chand Khanna

Sci Transl Med 2016 Feb;8(324):324ps5

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf0746DOI Listing
February 2016

Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.

Authors:
Patrick J Grohar Suntae Kim Guillermo O Rangel Rivera Nirmalya Sen Sara Haddock Matt L Harlow Nichole K Maloney Jack Zhu Maura O'Neill Tamara L Jones Konrad Huppi Magdalena Grandin Kristen Gehlhaus Carleen A Klumpp-Thomas Eugen Buehler Lee J Helman Scott E Martin Natasha J Caplen

Cell Rep 2016 Jan 14;14(3):598-610. Epub 2016 Jan 14.

Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755295PMC
January 2016

AACR Cancer Progress Report 2015.

Authors:
José Baselga Nina Bhardwaj Lewis C Cantley Ronald DeMatteo Raymond N DuBois Margaret Foti Susan M Gapstur William C Hahn Lee J Helman Roy A Jensen Electra D Paskett Theodore S Lawrence Stuart G Lutzker Eva Szabo

Clin Cancer Res 2015 Oct;21(19 Suppl):S1-128

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001568PMC
October 2015

SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma.

Authors:
Sai-Wen Tang Sven Bilke Liang Cao Junko Murai Fabricio G Sousa Mihoko Yamade Vinodh Rajapakse Sudhir Varma Lee J Helman Javed Khan Paul S Meltzer Yves Pommier

Clin Cancer Res 2015 Sep 16;21(18):4184-93. Epub 2015 Mar 16.

Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, NCI, NIH, Bethesda, Maryland.

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http://clincancerres.aacrjournals.org/content/early/2015/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-2112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573368PMC
September 2015

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.

Authors:
Lisa Mirabello Roelof Koster Branden S Moriarity Logan G Spector Paul S Meltzer Joy Gary Mitchell J Machiela Nathan Pankratz Orestis A Panagiotou David Largaespada Zhaoming Wang Julie M Gastier-Foster Richard Gorlick Chand Khanna Silvia Regina Caminada de Toledo Antonio S Petrilli Ana Patiño-Garcia Luis Sierrasesúmaga Fernando Lecanda Irene L Andrulis Jay S Wunder Nalan Gokgoz Massimo Serra Claudia Hattinger Piero Picci Katia Scotlandi Adrienne M Flanagan Roberto Tirabosco Maria Fernanda Amary Dina Halai Mandy L Ballinger David M Thomas Sean Davis Donald A Barkauskas Neyssa Marina Lee Helman George M Otto Kelsie L Becklin Natalie K Wolf Madison T Weg Margaret Tucker Sholom Wacholder Joseph F Fraumeni Neil E Caporaso Joseph F Boland Belynda D Hicks Aurelie Vogt Laurie Burdett Meredith Yeager Robert N Hoover Stephen J Chanock Sharon A Savage

Cancer Discov 2015 Sep 17;5(9):920-31. Epub 2015 Jun 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560660PMC
September 2015

Rare Tumors in Children: Progress Through Collaboration.

Authors:
Alberto S Pappo Wayne L Furman Kris A Schultz Andrea Ferrari Lee Helman Mark D Krailo

J Clin Oncol 2015 Sep 24;33(27):3047-54. Epub 2015 Aug 24.

Alberto S. Pappo and Wayne L. Furman, St Jude Children's Research Hospital, Memphis, TN; Kris A. Schultz, Children's Hospital of Minnesota, Minneapolis, MN; Andrea Ferrari, Instituto Nazionale Tumori, Milano, Italy; Lee Helman, National Cancer Institute Center for Cancer Research, Bethesda, MD; and Mark D. Krailo, Keck School of Medicine, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2014.59.3632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979197PMC
September 2015

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma.

Authors:
Xiaolin Wan Choh Yeung Christine Heske Arnulfo Mendoza Lee J Helman

Neoplasia 2015 Apr;17(4):358-66

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586150003
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http://dx.doi.org/10.1016/j.neo.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415145PMC
April 2015

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

Authors:
Zhaoming Wang Bin Zhu Mingfeng Zhang Hemang Parikh Jinping Jia Charles C Chung Joshua N Sampson Jason W Hoskins Amy Hutchinson Laurie Burdette Abdisamad Ibrahim Christopher Hautman Preethi S Raj Christian C Abnet Andrew A Adjei Anders Ahlbom Demetrius Albanes Naomi E Allen Christine B Ambrosone Melinda Aldrich Pilar Amiano Christopher Amos Ulrika Andersson Gerald Andriole Irene L Andrulis Cecilia Arici Alan A Arslan Melissa A Austin Dalsu Baris Donald A Barkauskas Bryan A Bassig Laura E Beane Freeman Christine D Berg Sonja I Berndt Pier Alberto Bertazzi Richard B Biritwum Amanda Black William Blot Heiner Boeing Paolo Boffetta Kelly Bolton Marie-Christine Boutron-Ruault Paige M Bracci Paul Brennan Louise A Brinton Michelle Brotzman H Bas Bueno-de-Mesquita Julie E Buring Mary Ann Butler Qiuyin Cai Geraldine Cancel-Tassin Federico Canzian Guangwen Cao Neil E Caporaso Alfredo Carrato Tania Carreon Angela Carta Gee-Chen Chang I-Shou Chang Jenny Chang-Claude Xu Che Chien-Jen Chen Chih-Yi Chen Chung-Hsing Chen Constance Chen Kuan-Yu Chen Yuh-Min Chen Anand P Chokkalingam Lisa W Chu Francoise Clavel-Chapelon Graham A Colditz Joanne S Colt David Conti Michael B Cook Victoria K Cortessis E David Crawford Olivier Cussenot Faith G Davis Immaculata De Vivo Xiang Deng Ti Ding Colin P Dinney Anna Luisa Di Stefano W Ryan Diver Eric J Duell Joanne W Elena Jin-Hu Fan Heather Spencer Feigelson Maria Feychting Jonine D Figueroa Adrienne M Flanagan Joseph F Fraumeni Neal D Freedman Brooke L Fridley Charles S Fuchs Manuela Gago-Dominguez Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Reina Garcia-Closas Julie M Gastier-Foster J Michael Gaziano Daniela S Gerhard Carol A Giffen Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Michael Goggins Nalan Gokgoz Alisa M Goldstein Carlos Gonzalez Richard Gorlick Mark H Greene Myron Gross H Barton Grossman Robert Grubb Jian Gu Peng Guan Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Patricia Hartge Claudia Hattinger Richard B Hayes Qincheng He Lee Helman Brian E Henderson Roger Henriksson Judith Hoffman-Bolton Chancellor Hohensee Elizabeth A Holly Yun-Chul Hong Robert N Hoover H Dean Hosgood Chin-Fu Hsiao Ann W Hsing Chao Agnes Hsiung Nan Hu Wei Hu Zhibin Hu Ming-Shyan Huang David J Hunter Peter D Inskip Hidemi Ito Eric J Jacobs Kevin B Jacobs Mazda Jenab Bu-Tian Ji Christoffer Johansen Mattias Johansson Alison Johnson Rudolf Kaaks Ashish M Kamat Aruna Kamineni Margaret Karagas Chand Khanna Kay-Tee Khaw Christopher Kim In-Sam Kim Jin Hee Kim Yeul Hong Kim Young-Chul Kim Young Tae Kim Chang Hyun Kang Yoo Jin Jung Cari M Kitahara Alison P Klein Robert Klein Manolis Kogevinas Woon-Puay Koh Takashi Kohno Laurence N Kolonel Charles Kooperberg Christian P Kratz Vittorio Krogh Hideo Kunitoh Robert C Kurtz Nilgun Kurucu Qing Lan Mark Lathrop Ching C Lau Fernando Lecanda Kyoung-Mu Lee Maxwell P Lee Loic Le Marchand Seth P Lerner Donghui Li Linda M Liao Wei-Yen Lim Dongxin Lin Jie Lin Sara Lindstrom Martha S Linet Jolanta Lissowska Jianjun Liu Börje Ljungberg Josep Lloreta Daru Lu Jing Ma Nuria Malats Satu Mannisto Neyssa Marina Giuseppe Mastrangelo Keitaro Matsuo Katherine A McGlynn Roberta McKean-Cowdin Lorna H McNeill Robert R McWilliams Beatrice S Melin Paul S Meltzer James E Mensah Xiaoping Miao Dominique S Michaud Alison M Mondul Lee E Moore Kenneth Muir Shelley Niwa Sara H Olson Nick Orr Salvatore Panico Jae Yong Park Alpa V Patel Ana Patino-Garcia Sofia Pavanello Petra H M Peeters Beata Peplonska Ulrike Peters Gloria M Petersen Piero Picci Malcolm C Pike Stefano Porru Jennifer Prescott Xia Pu Mark P Purdue You-Lin Qiao Preetha Rajaraman Elio Riboli Harvey A Risch Rebecca J Rodabough Nathaniel Rothman Avima M Ruder Jeong-Seon Ryu Marc Sanson Alan Schned Fredrick R Schumacher Ann G Schwartz Kendra L Schwartz Molly Schwenn Katia Scotlandi Adeline Seow Consol Serra Massimo Serra Howard D Sesso Gianluca Severi Hongbing Shen Min Shen Sanjay Shete Kouya Shiraishi Xiao-Ou Shu Afshan Siddiq Luis Sierrasesumaga Sabina Sierri Alan Dart Loon Sihoe Debra T Silverman Matthias Simon Melissa C Southey Logan Spector Margaret Spitz Meir Stampfer Par Stattin Mariana C Stern Victoria L Stevens Rachael Z Stolzenberg-Solomon Daniel O Stram Sara S Strom Wu-Chou Su Malin Sund Sook Whan Sung Anthony Swerdlow Wen Tan Hideo Tanaka Wei Tang Ze-Zhang Tang Adonina Tardon Evelyn Tay Philip R Taylor Yao Tettey David M Thomas Roberto Tirabosco Anne Tjonneland Geoffrey S Tobias Jorge R Toro Ruth C Travis Dimitrios Trichopoulos Rebecca Troisi Ann Truelove Ying-Huang Tsai Margaret A Tucker Rosario Tumino David Van Den Berg Stephen K Van Den Eeden Roel Vermeulen Paolo Vineis Kala Visvanathan Ulla Vogel Chaoyu Wang Chengfeng Wang Junwen Wang Sophia S Wang Elisabete Weiderpass Stephanie J Weinstein Nicolas Wentzensen William Wheeler Emily White John K Wiencke Alicja Wolk Brian M Wolpin Maria Pik Wong Margaret Wrensch Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Yong-Bing Xiang Jun Xu Hannah P Yang Pan-Chyr Yang Yasushi Yatabe Yuanqing Ye Edward D Yeboah Zhihua Yin Chen Ying Chong-Jen Yu Kai Yu Jian-Min Yuan Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Lisa Mirabello Sharon A Savage Peter Kraft Stephen J Chanock Meredith Yeager Maria Terese Landi Jianxin Shi Nilanjan Chatterjee Laufey T Amundadottir

Hum Mol Genet 2014 Dec 15;23(24):6616-33. Epub 2014 Jul 15.

Division of Cancer Epidemiology and Genetics,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240198PMC
December 2014

Recurrent epimutation of SDHC in gastrointestinal stromal tumors.

Authors:
J Keith Killian Markku Miettinen Robert L Walker Yonghong Wang Yuelin Jack Zhu Joshua J Waterfall Natalia Noyes Parvathy Retnakumar Zhiming Yang William I Smith M Scott Killian C Christopher Lau Marbin Pineda Jennifer Walling Holly Stevenson Carly Smith Zengfeng Wang Jerzy Lasota Su Young Kim Sosipatros A Boikos Lee J Helman Paul S Meltzer

Sci Transl Med 2014 Dec;6(268):268ra177

Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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December 2014

Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application.

Authors:
Jeffrey Roth Cody J Peer Brigitte Widemann Diane E Cole Rachel Ershler Lee Helman David Schrump William D Figg

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Nov 6;970:95-101. Epub 2014 Sep 6.

Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2014.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188709PMC
November 2014

Rhabdomyosarcoma: current challenges and their implications for developing therapies.

Authors:
Simone Hettmer Zhizhong Li Andrew N Billin Frederic G Barr D D W Cornelison Alan R Ehrlich Denis C Guttridge Andrea Hayes-Jordan Lee J Helman Peter J Houghton Javed Khan David M Langenau Corinne M Linardic Ranadip Pal Terence A Partridge Grace K Pavlath Rossella Rota Beat W Schäfer Janet Shipley Bruce Stillman Leonard H Wexler Amy J Wagers Charles Keller

Cold Spring Harb Perspect Med 2014 Nov 3;4(11):a025650. Epub 2014 Nov 3.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208704PMC
November 2014

A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: results of a Sarcoma Alliance for Research Through Collaboration study.

Authors:
Alberto S Pappo Gilles Vassal John J Crowley Vanessa Bolejack Pancras C W Hogendoorn Rashmi Chugh Marc Ladanyi Joseph F Grippo Georgina Dall Arthur P Staddon Sant P Chawla Robert G Maki Dejka M Araujo Birgit Geoerger Kristen Ganjoo Neyssa Marina Jean-Yves Blay Scott M Schuetze Warren A Chow Lee J Helman

Cancer 2014 Aug 2;120(16):2448-56. Epub 2014 May 2.

Solid Tumor Division, St. Jude Children's Research Hospital, Memphis, Tennessee.

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August 2014

Toward a drug development path that targets metastatic progression in osteosarcoma.

Authors:
Chand Khanna Timothy M Fan Richard Gorlick Lee J Helman Eugenie S Kleinerman Peter C Adamson Peter J Houghton William D Tap Danny R Welch Patricia S Steeg Glenn Merlino Poul H B Sorensen Paul Meltzer David G Kirsch Katherine A Janeway Brenda Weigel Lor Randall Stephen J Withrow Melissa Paoloni Rosandra Kaplan Beverly A Teicher Nita L Seibel Malcolm Smith Aykut Uren Shreyaskumar R Patel Jeffrey Trent Sharon A Savage Lisa Mirabello Denise Reinke Donald A Barkaukas Mark Krailo Mark Bernstein

Clin Cancer Res 2014 Aug 6;20(16):4200-9. Epub 2014 May 6.

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134738PMC
August 2014

Thyroid hormone inactivation in gastrointestinal stromal tumors.

Authors:
Sosipatros A Boikos Lee J Helman Constantine A Stratakis

N Engl J Med 2014 07;371(1):85-6

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http://dx.doi.org/10.1056/NEJMc1405198DOI Listing
July 2014

New strategies in ewing sarcoma: lost in translation?

Authors:
Fernanda I Arnaldez Lee J Helman

Clin Cancer Res 2014 Jun 22;20(12):3050-6. Epub 2014 Apr 22.

Authors' Affiliation: Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058417PMC
June 2014

Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.

Authors:
Patrick J Grohar Laure E Segars Choh Yeung Yves Pommier Maurizio D'Incalci Arnulfo Mendoza Lee J Helman

Clin Cancer Res 2014 Mar 25;20(5):1190-203. Epub 2013 Nov 25.

Authors' Affiliations: Monroe Carrell Jr. Children's Hospital at Vanderbilt and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee; Molecular Oncology Section, Pediatric Oncology Branch; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and Istituto di Ricerche Farmacologiche "Mario Negri" -IRCCS, Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510643PMC
March 2014

Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].

Authors:
Lorna Kelly Kenneth Bryan Su Young Kim Katherine A Janeway J Keith Killian Hans-Ulrich Schildhaus Markku Miettinen Lee Helman Paul S Meltzer Matt van de Rijn Maria Debiec-Rychter Maureen O'Sullivan

PLoS One 2013 24;8(5):e64102. Epub 2013 May 24.

Histopathology Department, School of Medicine, Trinity College Dublin, Dublin, Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663836PMC
November 2013

Genome-wide association study identifies two susceptibility loci for osteosarcoma.

Authors:
Sharon A Savage Lisa Mirabello Zhaoming Wang Julie M Gastier-Foster Richard Gorlick Chand Khanna Adrienne M Flanagan Roberto Tirabosco Irene L Andrulis Jay S Wunder Nalan Gokgoz Ana Patiño-Garcia Luis Sierrasesúmaga Fernando Lecanda Nilgün Kurucu Inci Ergurhan Ilhan Neriman Sari Massimo Serra Claudia Hattinger Piero Picci Logan G Spector Donald A Barkauskas Neyssa Marina Silvia Regina Caminada de Toledo Antonio S Petrilli Maria Fernanda Amary Dina Halai David M Thomas Chester Douglass Paul S Meltzer Kevin Jacobs Charles C Chung Sonja I Berndt Mark P Purdue Neil E Caporaso Margaret Tucker Nathaniel Rothman Maria Teresa Landi Debra T Silverman Peter Kraft David J Hunter Nuria Malats Manolis Kogevinas Sholom Wacholder Rebecca Troisi Lee Helman Joseph F Fraumeni Meredith Yeager Robert N Hoover Stephen J Chanock

Nat Genet 2013 Jul 2;45(7):799-803. Epub 2013 Jun 2.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA.

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July 2013

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.

Authors:
J Keith Killian Su Young Kim Markku Miettinen Carly Smith Maria Merino Maria Tsokos Martha Quezado William I Smith Mona S Jahromi Paraskevi Xekouki Eva Szarek Robert L Walker Jerzy Lasota Mark Raffeld Brandy Klotzle Zengfeng Wang Laura Jones Yuelin Zhu Yonghong Wang Joshua J Waterfall Maureen J O'Sullivan Marina Bibikova Karel Pacak Constantine Stratakis Katherine A Janeway Joshua D Schiffman Jian-Bing Fan Lee Helman Paul S Meltzer

Cancer Discov 2013 Jun 2;3(6):648-57. Epub 2013 Apr 2.

National Cancer Institute-Center for Cancer Research, Bethesda, MD 20892-4265, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135374PMC
June 2013

Cediranib for metastatic alveolar soft part sarcoma.

Authors:
Shivaani Kummar Deborah Allen Anne Monks Eric C Polley Curtis D Hose S Percy Ivy Ismail B Turkbey Scott Lawrence Robert J Kinders Peter Choyke Richard Simon Seth M Steinberg James H Doroshow Lee Helman

J Clin Oncol 2013 Jun 29;31(18):2296-302. Epub 2013 Apr 29.

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1200/JCO.2012.47.4288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677840PMC
June 2013

Prospects and challenges for the development of new therapies for Ewing sarcoma.

Authors:
Patrick J Grohar Lee J Helman

Pharmacol Ther 2013 Feb 18;137(2):216-24. Epub 2012 Oct 18.

Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carrell Junior Children's Hospital, Vanderbilt-Ingram Cancer Center, 2220 Pierce Ave, PRB 397, Nashville, TN 37232-6310, USA.

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February 2013

Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.

Authors:
Markku Miettinen Jonathan Keith Killian Zeng-Feng Wang Jerzy Lasota Christopher Lau Laura Jones Robert Walker Marbin Pineda Yuelin Jack Zhu Su Y Kim Lee Helman Paul Meltzer

Am J Surg Pathol 2013 Feb;37(2):234-40

Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545041PMC
February 2013

Expression of the receptor for type i insulin-like growth factor (IGF1R) in gastrointestinal stromal tumors: an immunohistochemical study of 1078 cases with diagnostic and therapeutic implications.

Authors:
Jerzy Lasota Zengfeng Wang Su Young Kim Lee Helman Markku Miettinen

Am J Surg Pathol 2013 Jan;37(1):114-9

Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502638PMC
January 2013

Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma.

Authors:
Xiaolin Wan Choh Yeung Su Young Kim Joseph G Dolan Vu N Ngo Sandra Burkett Javed Khan Louis M Staudt Lee J Helman

Cancer Res 2012 Nov 20;72(22):5889-99. Epub 2012 Sep 20.

Molecular Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500453PMC
November 2012

Targeting cancer metabolism.

Authors:
Beverly A Teicher W Marston Linehan Lee J Helman

Clin Cancer Res 2012 Oct;18(20):5537-45

Molecular Pharmacology Branch, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475613PMC
October 2012

Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003.

Authors:
Elizabeth Fox Shreyaskumar Patel J Kyle Wathen Scott Schuetze Sant Chawla David Harmon Denise Reinke Rashmi Chugh Robert S Benjamin Lee J Helman

Oncologist 2012 23;17(3):321. Epub 2012 Feb 23.

The Children's Hospital of Philadelphia, Division of Oncology, 3501 Civic Center Boulevard, CTRB- 4016, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1634/theoncologist.2010-0265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316916PMC
September 2012

The first European interdisciplinary ewing sarcoma research summit.

Authors:
Heinrich Kovar Javier Alonso Pierre Aman Dave N T Aryee Jozef Ban Sue A Burchill Stefan Burdach Enrique De Alava Olivier Delattre Uta Dirksen Argyro Fourtouna Simone Fulda Lee J Helman David Herrero-Martin Pancras C W Hogendoorn Udo Kontny Elizabeth R Lawlor Stephen L Lessnick Antonio Llombart-Bosch Markus Metzler Richard Moriggl Stephan Niedan Jenny Potratz Françoise Redini Günther H S Richter Lucia T Riedmann Claudia Rossig Beat W Schäfer Raphaela Schwentner Katia Scotlandi Poul H Sorensen Martin S Staege Franck Tirode Jeffrey Toretsky Selena Ventura Angelika Eggert Ruth Ladenstein

Front Oncol 2012 29;2:54. Epub 2012 May 29.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung Vienna, Austria.

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http://dx.doi.org/10.3389/fonc.2012.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361960PMC
August 2012

Gastrointestinal stromal tumor: psychosocial characteristics and considerations.

Authors:
Lori Wiener Haven Battles Sima Zadeh Carly J Smith Lee J Helman Su Young Kim

Support Care Cancer 2012 Jun 17;20(6):1343-9. Epub 2012 Mar 17.

Behavioral Science Core, Psychosocial Support and Research Program, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Pediatric Clinic, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00520-012-1426-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191473PMC
June 2012

Targeting the insulin growth factor receptor 1.

Authors:
Fernanda I Arnaldez Lee J Helman

Hematol Oncol Clin North Am 2012 Jun 28;26(3):527-42, vii-viii. Epub 2012 Feb 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334849PMC
June 2012

R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.

Authors:
Alberto S Pappo Shreyaskumar R Patel John Crowley Denise K Reinke Klaus-Peter Kuenkele Sant P Chawla Guy C Toner Robert G Maki Paul A Meyers Rashmi Chugh Kristen N Ganjoo Scott M Schuetze Heribert Juergens Michael G Leahy Birgit Geoerger Robert S Benjamin Lee J Helman Laurence H Baker

J Clin Oncol 2011 Dec 24;29(34):4541-7. Epub 2011 Oct 24.

St Jude Children’s Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1200/JCO.2010.34.0000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236654PMC
December 2011

Genomic investigation of dedifferentiated liposarcoma suggests a role for therapeutic targeting of the tumor epigenome.

Authors:
Paul S Meltzer Lee J Helman

Cancer Discov 2011 Dec;1(7):555-6

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0291DOI Listing
December 2011

Low Dose Histone Deacetylase Inhibitor, Depsipeptide (FR901228), Promotes Adenoviral Transduction in Human Rhabdomyosarcoma Cell Lines.

Authors:
Fariba Navid Blaine T Mischen Lee J Helman

Sarcoma 2004 ;8(1):25-30

Pediatric Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD 20892-1928 USA.

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http://dx.doi.org/10.1080/13577140410001679220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395599PMC
July 2011

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

Authors:
Patrick J Grohar Girma M Woldemichael Laurie B Griffin Arnulfo Mendoza Qing-Rong Chen Choh Yeung Duane G Currier Sean Davis Chand Khanna Javed Khan James B McMahon Lee J Helman

J Natl Cancer Inst 2011 Jun 8;103(12):962-78. Epub 2011 Jun 8.

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr-MSC 1104, 10 CRC 1W-3816, Bethesda, MD 20892-1104, USA.

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http://dx.doi.org/10.1093/jnci/djr156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119649PMC
June 2011

Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1.

Authors:
Paul F Robbins Richard A Morgan Steven A Feldman James C Yang Richard M Sherry Mark E Dudley John R Wunderlich Azam V Nahvi Lee J Helman Crystal L Mackall Udai S Kammula Marybeth S Hughes Nicholas P Restifo Mark Raffeld Chyi-Chia Richard Lee Catherine L Levy Yong F Li Mona El-Gamil Susan L Schwarz Carolyn Laurencot Steven A Rosenberg

J Clin Oncol 2011 Mar 31;29(7):917-24. Epub 2011 Jan 31.

National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, MD 20892-1201, USA.

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http://dx.doi.org/10.1200/JCO.2010.32.2537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068063PMC
March 2011

Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.

Authors:
Patrick J Grohar Laurie B Griffin Choh Yeung Qing-Rong Chen Yves Pommier Chand Khanna Javed Khan Lee J Helman

Neoplasia 2011 Feb;13(2):145-53

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033593PMC
http://dx.doi.org/10.1593/neo.101202DOI Listing
February 2011

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.

Authors:
Katherine A Janeway Su Young Kim Maya Lodish Vânia Nosé Pierre Rustin José Gaal Patricia L M Dahia Bernadette Liegl Evan R Ball Margarita Raygada Angela H Lai Lorna Kelly Jason L Hornick Maureen O'Sullivan Ronald R de Krijger Winand N M Dinjens George D Demetri Cristina R Antonescu Jonathan A Fletcher Lee Helman Constantine A Stratakis

Proc Natl Acad Sci U S A 2011 Jan 20;108(1):314-8. Epub 2010 Dec 20.

Department of Pediatric Hematology-Oncology, Dana Farber Cancer Institute and Children's Hospital, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017134PMC
January 2011

Strategies to explore new approaches in the investigation and treatment of osteosarcoma.

Authors:
Su Young Kim Lee J Helman

Cancer Treat Res 2009 ;152:517-28

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October 2010

Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.

Authors:
Liang Cao Yunkai Yu Sven Bilke Robert L Walker Linnia H Mayeenuddin David O Azorsa Fan Yang Marbin Pineda Lee J Helman Paul S Meltzer

Cancer Res 2010 Aug 27;70(16):6497-508. Epub 2010 Jul 27.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Human Genome Research Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922412PMC
August 2010

Randomized trial and pharmacokinetic study of pegfilgrastim versus filgrastim after dose-intensive chemotherapy in young adults and children with sarcomas.

Authors:
Elizabeth Fox Brigitte C Widemann Douglas S Hawkins Nalini Jayaprakash Ramzi Dagher Alberta A Aikin Donna Bernstein Lauren Long Crystal Mackall Lee Helman Seth M Steinberg Frank M Balis

Clin Cancer Res 2009 Dec 17;15(23):7361-7. Epub 2009 Nov 17.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-0761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787766PMC
December 2009

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

Authors:
James G Taylor Adam T Cheuk Patricia S Tsang Joon-Yong Chung Young K Song Krupa Desai Yanlin Yu Qing-Rong Chen Kushal Shah Victoria Youngblood Jun Fang Su Young Kim Choh Yeung Lee J Helman Arnulfo Mendoza Vu Ngo Louis M Staudt Jun S Wei Chand Khanna Daniel Catchpoole Stephen J Qualman Stephen M Hewitt Glenn Merlino Stephen J Chanock Javed Khan

J Clin Invest 2009 Nov 5;119(11):3395-407. Epub 2009 Oct 5.

Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland 20892-4605, USA.

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http://dx.doi.org/10.1172/JCI39703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769177PMC
November 2009

Secondary supratentorial primitive neuroectodermal tumor following treatment of childhood osteosarcoma.

Authors:
Courtney D Fitzhugh Barbara Wise Kristin Baird Maria Tsokos Lee Helman Crystal Mackall Sharon A Savage Katherine E Warren

Pediatr Blood Cancer 2009 Sep;53(3):496-8

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://doi.wiley.com/10.1002/pbc.22074
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760453PMC
September 2009

Targeting IGF-1R in the treatment of sarcomas: past, present and future.

Authors:
Su Young Kim Xiaolin Wan Lee J Helman

Bull Cancer 2009 Jul-Aug;96(7):E52-60

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1684/bdc.2009.0915DOI Listing
August 2009

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies.

Authors:
Shivaani Kummar Robert Kinders Martin E Gutierrez Larry Rubinstein Ralph E Parchment Lawrence R Phillips Jiuping Ji Anne Monks Jennifer A Low Alice Chen Anthony J Murgo Jerry Collins Seth M Steinberg Helen Eliopoulos Vincent L Giranda Gary Gordon Lee Helman Robert Wiltrout Joseph E Tomaszewski James H Doroshow

J Clin Oncol 2009 Jun 13;27(16):2705-11. Epub 2009 Apr 13.

Center for Cancer Research and the Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://ascopubs.org/doi/10.1200/JCO.2008.19.7681
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739635PMC
June 2009

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Authors:
Sung-Hyeok Hong Joseph Briggs Rachel Newman Karen Hoffman Arnulfo Mendoza Derek LeRoith Lee Helman Shoshana Yakar Chand Khanna

Int J Cancer 2009 May;124(9):2042-9

Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ijc.24169DOI Listing
May 2009

The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors.

Authors:
Fei Huang Ann Greer Warren Hurlburt Xia Han Rameh Hafezi Gayle M Wittenberg Karen Reeves Jiwen Chen Douglas Robinson Aixin Li Francis Y Lee Marco M Gottardis Edwin Clark Lee Helman Ricardo M Attar Ashok Dongre Joan M Carboni

Cancer Res 2009 Jan;69(1):161-70

Bristol-Myers Squibb Company, Princeton, NJ 08543, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0835DOI Listing
January 2009

The role of IGF-1R in pediatric malignancies.

Authors:
Su Young Kim Jeffrey A Toretsky Daniel Scher Lee J Helman

Oncologist 2009 Jan 6;14(1):83-91. Epub 2009 Jan 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1634/theoncologist.2008-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721475PMC
January 2009

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.

Authors:
Liang Cao Yunkai Yu Isaac Darko Duane Currier Linnia H Mayeenuddin Xiaolin Wan Chand Khanna Lee J Helman

Cancer Res 2008 Oct;68(19):8039-48

Genetics Branch, Center for Cancer Research, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4265, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671680PMC
October 2008

Phase 0 clinical trials: conceptions and misconceptions.

Authors:
Shivaani Kummar Larry Rubinstein Robert Kinders Ralph E Parchment Martin E Gutierrez Anthony J Murgo Jay Ji Barbara Mroczkowski Oxana K Pickeral Mel Simpson Melinda Hollingshead Sherry X Yang Lee Helman Robert Wiltrout Jerry Collins Joseph E Tomaszewski James H Doroshow

Cancer J 2008 May-Jun;14(3):133-7

Center for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/PPO.0b013e318172d6f3DOI Listing
September 2008

Progress in the curative treatment of childhood hematologic malignancies.

Authors:
Alan S Wayne Gregory H Reaman Lee J Helman

J Natl Cancer Inst 2008 Sep 9;100(18):1271-3. Epub 2008 Sep 9.

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http://dx.doi.org/10.1093/jnci/djn306DOI Listing
September 2008

A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas.

Authors:
Crystal L Mackall Eunice H Rhee Elizabeth J Read Hanh M Khuu Susan F Leitman Donna Bernstein Merertu Tesso Lauren M Long David Grindler Margret Merino William Kopp Maria Tsokos Jay A Berzofsky Lee J Helman

Clin Cancer Res 2008 Aug;14(15):4850-8

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1104, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2497450PMC
August 2008

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome.

Authors:
Francis J Mussai Lea C Cunningham Geoffrey Rezvani Constantine A Stratakis James C Reynolds Galina Nesterova Robert M Henshaw Jason E Levine Lee J Helman Diane C Arthur Su Young Kim

J Pediatr Hematol Oncol 2008 Aug;30(8):612-7

Pediatric Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/MPH.0b013e318168f072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748653PMC
August 2008

Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases.

Authors:
Su Young Kim Chih Hung Lee Brieanne V Midura Choh Yeung Arnulfo Mendoza Sung Hyeok Hong Ling Ren Donald Wong Walter Korz Ahmed Merzouk Hassan Salari Hong Zhang Sam T Hwang Chand Khanna Lee J Helman

Clin Exp Metastasis 2008 11;25(3):201-11. Epub 2007 Dec 11.

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://link.springer.com/10.1007/s10585-007-9133-3
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730112PMC
July 2008

Designing phase 0 cancer clinical trials.

Authors:
Anthony J Murgo Shivaani Kummar Larry Rubinstein Martin Gutierrez Jerry Collins Robert Kinders Ralph E Parchment Jiuping Ji Seth M Steinberg Sherry X Yang Melinda Hollingshead Alice Chen Lee Helman Robert Wiltrout Joseph E Tomaszewski James H Doroshow

Clin Cancer Res 2008 Jun;14(12):3675-82

Division of Cancer Treatment and Diagnosis and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-2440, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435428PMC
June 2008

Osteosarcoma: the same old drugs or more?

Authors:
Stefan S Bielack Neyssa Marina Stefano Ferrari Lee J Helman Sigbjørn Smeland Jeremy S Whelan Gregory H Reaman

J Clin Oncol 2008 Jun;26(18):3102-3; author reply 3104-5

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http://dx.doi.org/10.1200/JCO.2008.17.1108DOI Listing
June 2008

Dilemmas associated with congenital ewing sarcoma family tumors.

Authors:
Su Young Kim Maria Tsokos Lee J Helman

J Pediatr Hematol Oncol 2008 Jan;30(1):4-7

Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668808PMC
January 2008

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Authors:
Yien Che Tsai Arnulfo Mendoza Jennifer M Mariano Ming Zhou Zlatka Kostova Bo Chen Timothy Veenstra Stephen M Hewitt Lee J Helman Chand Khanna Allan M Weissman

Nat Med 2007 Dec 25;13(12):1504-9. Epub 2007 Nov 25.

Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://www.nature.com/articles/nm1686
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December 2007

Phase 0 clinical trials in cancer drug development: from FDA guidance to clinical practice.

Authors:
Robert Kinders Ralph E Parchment Jay Ji Shivaani Kummar Anthony J Murgo Martin Gutierrez Jerry Collins Larry Rubinstein Oxana Pickeral Seth M Steinberg Sherry Yang Melinda Hollingshead Alice Chen Lee Helman Robert Wiltrout Mel Simpson Joseph E Tomaszewski James H Doroshow

Mol Interv 2007 Dec;7(6):325-34

Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Support Directorate, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1124/mi.7.6.9DOI Listing
December 2007

The biology behind mTOR inhibition in sarcoma.

Authors:
Xiaolin Wan Lee J Helman

Oncologist 2007 Aug;12(8):1007-18

Molecular Oncology Section, Pediatric Oncology Branch, Building 10, Room CRC-1W-3816, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1928, USA.

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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August 2007

Immune reconstitution prevents metastatic recurrence of murine osteosarcoma.

Authors:
Melinda S Merchant Fraia Melchionda Manoj Sinha Chand Khanna Lee Helman Crystal L Mackall

Cancer Immunol Immunother 2007 Jul 6;56(7):1037-46. Epub 2006 Dec 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00262-006-0257-0DOI Listing
July 2007

Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival.

Authors:
Emanuel F Petricoin Virginia Espina Robyn P Araujo Brieanne Midura Choh Yeung Xiaolin Wan Gabriel S Eichler Donald J Johann Stephen Qualman Maria Tsokos Kartik Krishnan Lee J Helman Lance A Liotta

Cancer Res 2007 Apr;67(7):3431-40

Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Cellular and Gene Therapy, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1344DOI Listing
April 2007

Thromboembolic events in children and young adults with pediatric sarcoma.

Authors:
Ido Paz-Priel Lauren Long Lee J Helman Crystal L Mackall Alan S Wayne

J Clin Oncol 2007 Apr;25(12):1519-24

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1200/JCO.2006.06.9930DOI Listing
April 2007

Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway.

Authors:
Kartik Krishnan Ben Bruce Stephen Hewitt Dafydd Thomas Chand Khanna Lee J Helman

Clin Exp Metastasis 2006 22;23(3-4):227-36. Epub 2006 Sep 22.

Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1-3816, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s10585-006-9033-yDOI Listing
February 2007

Compressing drug development timelines in oncology using phase '0' trials.

Authors:
Shivaani Kummar Robert Kinders Larry Rubinstein Ralph E Parchment Anthony J Murgo Jerry Collins Oxana Pickeral Jennifer Low Seth M Steinberg Martin Gutierrez Sherry Yang Lee Helman Robert Wiltrout Joseph E Tomaszewski James H Doroshow

Nat Rev Cancer 2007 02;7(2):131-9

Center for Cancer Research, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA.

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http://dx.doi.org/10.1038/nrc2066DOI Listing
February 2007

Molecular approaches in pediatric oncology.

Authors:
Chand Khanna Lee J Helman

Annu Rev Med 2006 ;57:83-97

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA.

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http://dx.doi.org/10.1146/annurev.med.57.121304.131247DOI Listing
May 2006

CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling.

Authors:
Xiaolin Wan Na Shen Arnulfo Mendoza Chand Khanna Lee J Helman

Neoplasia 2006 May;8(5):394-401

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1928, USA.

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http://dx.doi.org/10.1593/neo.05820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592447PMC
May 2006

The molecular biology of pulmonary metastasis.

Authors:
Kartik Krishnan Chand Khanna Lee J Helman

Thorac Surg Clin 2006 May;16(2):115-24

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1-3816, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.thorsurg.2005.12.003DOI Listing
May 2006

CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta.

Authors:
Masaki Terabe Chand Khanna Seuli Bose Fraia Melchionda Arnulfo Mendoza Crystal L Mackall Lee J Helman Jay A Berzofsky

Cancer Res 2006 Apr;66(7):3869-75

Vaccine Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bldg. 10/Rm. 6B12, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3421DOI Listing
April 2006

Identification and epitope enhancement of a PAX-FKHR fusion protein breakpoint epitope in alveolar rhabdomyosarcoma cells created by a tumorigenic chromosomal translocation inducing CTL capable of lysing human tumors.

Authors:
Leon T van den Broeke C David Pendleton Crystal Mackall Lee J Helman Jay A Berzofsky

Cancer Res 2006 Feb;66(3):1818-23

Vaccine Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 10, Rm. 6B-04, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2549DOI Listing
February 2006

The biology of metastases in pediatric sarcomas.

Authors:
Kartik Krishnan Chand Khanna Lee J Helman

Cancer J 2005 Jul-Aug;11(4):306-13

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/00130404-200507000-00006DOI Listing
December 2005

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.

Authors:
Hua Zhang Kevin S Chua Martin Guimond Veena Kapoor Margaret V Brown Thomas A Fleisher Lauren M Long Donna Bernstein Brenna J Hill Daniel C Douek Jay A Berzofsky Charles S Carter E J Read Lee J Helman Crystal L Mackall

Nat Med 2005 Nov 16;11(11):1238-43. Epub 2005 Oct 16.

Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nm1312DOI Listing
November 2005

Expression profiles of osteosarcoma that can predict response to chemotherapy.

Authors:
Tsz-Kwong Man Murali Chintagumpala Jaya Visvanathan Jianhe Shen Laszlo Perlaky John Hicks Mark Johnson Nelson Davino Jeffrey Murray Lee Helman William Meyer Timothy Triche Kwong-Kwok Wong Ching C Lau

Cancer Res 2005 Sep;65(18):8142-50

Department of Pediatrics, Texas Children's Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0985DOI Listing
September 2005

Evaluation of the molecular mechanisms involved in the gain of function of a Li-Fraumeni TP53 mutation.

Authors:
Silvia Capponcelli Elena Pedrini Maria Antonietta Cerone Valeria Corti Silvia Fontanesi Massimo Alessio Angela Bachi Silvia Soddu Domenico Ribatti Piero Picci Lee J Helman Giorgio Cantelli-Forti Luca Sangiorgi

Hum Mutat 2005 Aug;26(2):94-103

Genetics Unit, Laboratory of Oncology Research, Rizzoli Orthopedic Institute, Bologna, Italy.

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http://doi.wiley.com/10.1002/humu.20192
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August 2005

Telomere stability genes are not mutated in osteosarcoma cell lines.

Authors:
Sharon A Savage Brian J Stewart Jason S Liao Lee J Helman Stephen J Chanock

Cancer Genet Cytogenet 2005 Jul;160(1):79-81

Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892-4605, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.12.004DOI Listing
July 2005

Adjuvant chemotherapy for the treatment of advanced pediatric nonrhabdomyosarcoma soft tissue sarcoma: the National Cancer Institute experience.

Authors:
Paul C Nathan Maria Tsokos Lauren Long Donna Bernstein Leonard H Wexler Crystal L Mackall Lee J Helman

Pediatr Blood Cancer 2005 May;44(5):449-54

National Cancer Institute, Pediatric Oncology Branch, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/pbc.20262DOI Listing
May 2005

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma.

Authors:
Xiaolin Wan Arnulfo Mendoza Chand Khanna Lee J Helman

Cancer Res 2005 Mar;65(6):2406-11

Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1106, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3135DOI Listing
March 2005