Lee A Witters

Lee A Witters

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Lee A Witters

Lee A Witters

Publications by authors named "Lee A Witters"

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AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.

J Neurochem 2013 Oct 29;127(1):66-77. Epub 2013 Jul 29.

Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Gunma, Japan.

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http://dx.doi.org/10.1111/jnc.12362DOI Listing
October 2013

Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.

Mol Cell Biol 2009 Jul 20;29(13):3455-64. Epub 2009 Apr 20.

Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, 240 E. Huron, McGaw M-300, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/MCB.00054-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698765PMC
July 2009

The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.

Am J Physiol Heart Circ Physiol 2007 Dec 28;293(6):H3456-64. Epub 2007 Sep 28.

Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, 474 Heritage Medical Research Centre, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpheart.00936.2007DOI Listing
December 2007

Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.

Diabetes 2007 Aug 18;56(8):2062-9. Epub 2007 May 18.

Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.2337/db07-0255DOI Listing
August 2007

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.

J Biol Chem 2007 Apr 7;282(14):10341-51. Epub 2007 Feb 7.

Howard Hughes Medical Institute and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M610631200
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http://dx.doi.org/10.1074/jbc.M610631200DOI Listing
April 2007

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.

Am J Physiol Endocrinol Metab 2007 Mar 14;292(3):E802-11. Epub 2006 Nov 14.

Department of Medicine, Dartmouth Medical School, Dartmouth College, Hanover, NH 03755-3833, USA.

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http://dx.doi.org/10.1152/ajpendo.00369.2006DOI Listing
March 2007

Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.

J Biol Chem 2006 Dec 5;281(48):36662-72. Epub 2006 Oct 5.

Department of Medicine and Biochemistry, Dartmouth Medical School, Remsen 322, N. College St., Hanover, NH 03755, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M606676200
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http://dx.doi.org/10.1074/jbc.M606676200DOI Listing
December 2006

Chutes and Ladders: the search for protein kinases that act on AMPK.

Trends Biochem Sci 2006 Jan 13;31(1):13-6. Epub 2005 Dec 13.

Departments of Medicine and Biochemistry, Dartmouth Medical School and the Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096800040500339
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http://dx.doi.org/10.1016/j.tibs.2005.11.009DOI Listing
January 2006

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

J Biol Chem 2005 Aug 24;280(32):29060-6. Epub 2005 Jun 24.

Departments of Medicine and Biochemistry, Dartmouth Medical School and the Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503824200
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http://dx.doi.org/10.1074/jbc.M503824200DOI Listing
August 2005

AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270).

J Biol Chem 2005 Apr 28;280(14):13395-400. Epub 2005 Jan 28.

St. Vincent's Institute, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1074/jbc.M412993200DOI Listing
April 2005

Dual mechanisms regulating AMPK kinase action in the ischemic heart.

Circ Res 2005 Feb 13;96(3):337-45. Epub 2005 Jan 13.

Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA.

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http://dx.doi.org/10.1161/01.RES.0000155723.53868.d2DOI Listing
February 2005

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

Genes Dev 2004 Dec 15;18(23):2893-904. Epub 2004 Nov 15.

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1256804
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http://dx.doi.org/10.1101/gad.1256804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534650PMC
December 2004

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Proc Natl Acad Sci U S A 2004 Mar 25;101(10):3329-35. Epub 2004 Feb 25.

Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.0308061100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC373461PMC
March 2004

C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism.

J Biol Chem 2004 Jan 13;279(5):3817-27. Epub 2003 Nov 13.

Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/jbc.M310991200DOI Listing
January 2004

Effect of exercise intensity on skeletal muscle AMPK signaling in humans.

Diabetes 2003 Sep;52(9):2205-12

St. Vincent's Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.2337/diabetes.52.9.2205DOI Listing
September 2003

Insulin-like growth factor 1 is essential for normal dendritic growth.

J Neurosci Res 2003 Jul;73(1):1-9

Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/jnr.10634DOI Listing
July 2003

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.

Am J Physiol Cell Physiol 2003 May 2;284(5):C1297-308. Epub 2003 Jan 2.

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00227.2002
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http://dx.doi.org/10.1152/ajpcell.00227.2002DOI Listing
May 2003

AMPK beta subunit targets metabolic stress sensing to glycogen.

Curr Biol 2003 May;13(10):867-71

St. Vincent's Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Australia.

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http://dx.doi.org/10.1016/s0960-9822(03)00292-6DOI Listing
May 2003

Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination.

Biochim Biophys Acta 2003 Apr;1631(3):229-38

Laboratoire de Biogenèse Membranaire, UMR-CNRS 5544, Université Victor Segalen Bordeaux 2, Bordeaux, France.

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http://dx.doi.org/10.1016/s1388-1981(03)00041-6DOI Listing
April 2003

Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells.

J Biol Chem 2003 Jan 8;278(2):998-1004. Epub 2002 Nov 8.

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1074/jbc.M210621200DOI Listing
January 2003

Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment.

Am J Physiol Endocrinol Metab 2002 Nov;283(5):E867-79

Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1152/ajpendo.00178.2002DOI Listing
November 2002

Fatty acid synthase expression during peripheral nervous system myelination.

Brain Res Mol Brain Res 2002 May;101(1-2):52-8

Laboratoire de Biogenèse Membranaire, UMR-CNRS 5544, case 92, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.

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http://dx.doi.org/10.1016/s0169-328x(02)00161-4DOI Listing
May 2002

AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.

Biochem Biophys Res Commun 2002 May;293(3):892-8

Departments of Medicine and Biochemistry, Endocrine-Metabolism Division, Dartmouth Medical School, Hanover, NH 03755-3833, USA.

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http://dx.doi.org/10.1016/S0006-291X(02)00312-1DOI Listing
May 2002