Leander Beekman

Leander Beekman

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Leander Beekman

Leander Beekman

Publications by authors named "Leander Beekman"

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Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores.

Eur Heart J 2019 Oct;40(37):3097-3107

Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehz435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769824PMC
October 2019

Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy.

Int J Cardiol 2018 07;263:54-62

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.03.044DOI Listing
July 2018

The Brugada Syndrome Susceptibility Gene Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.

Circ Res 2017 Aug 21;121(5):537-548. Epub 2017 Jun 21.

From the Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands (C.C.V., S.P., R.T., E.M.L., I.M., L.B., A.A.M.W., R.C., A.O.V., C.A.R., C.R.B.); Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute, Canada (R.T.); Université de Montréal, Canada (R.T.); Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands (B.d.J., R.W., B.J.B., A.O.V.); INSERM, CNRS, Université de Nantes, L'institut du Thorax, Nantes, France (J.B.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia (A.A.M.W.); and Electrophysiology and Heart Modeling Institute LIRYC, Université de Bordeaux, France (R.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31095
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http://dx.doi.org/10.1161/CIRCRESAHA.117.310959DOI Listing
August 2017

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation.

Int J Cardiol 2017 Jun 29;236:187-193. Epub 2017 Jan 29.

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.01.113DOI Listing
June 2017

Sudden Cardiac Arrest and Rare Genetic Variants in the Community.

Circ Cardiovasc Genet 2016 Apr 22;9(2):147-53. Epub 2016 Jan 22.

From the Department of Clinical & Experimental Cardiology, Heart Center, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands (A.M., M.T.B., E.M.L., D.A.v.H., J.B., T.T.K., A.B., L.B., A.A.M.W., C.R.B., H.L.T.); Institut für Humangenetik, Helmholtz Zentrum München, Munich, Germany; Institut für Humangenetik, Technische Universität München, Munich, Germany (P.L.); Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.P.v.d.B.); and Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Kingdom of Saudi Arabia (A.A.M.W.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001263DOI Listing
April 2016

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Circ Cardiovasc Genet 2014 Dec 12;7(6):790-8. Epub 2014 Sep 12.

From the Department of Experimental Cardiology (E.M.L., B.P.S., L.B., M.E.A., C.R.B.), and Department of Clinical Epidemiology, Biostatistics and Bioinformatics (P.D.M., M.W.T.T.), University of Amsterdam, Academic Medical Center, Amsterdam, Netherlands; and Groningen Bioinformatics Centre, University of Groningen, Groningen, Netherlands (D.A.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000537DOI Listing
December 2014

A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence.

J Am Coll Cardiol 2014 Jan 25;63(3):259-66. Epub 2013 Sep 25.

Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.07.091DOI Listing
January 2014

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.

J Mol Cell Cardiol 2011 Mar 18;50(3):380-9. Epub 2010 Sep 18.

Heart Failure Research Center, Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2010.09.009DOI Listing
March 2011

Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort.

Heart Rhythm 2007 Jun 2;4(6):752-5. Epub 2007 Mar 2.

Center for Heart Failure Research, Experimental and Molecular Cardiology Group, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.hrthm.2007.02.021DOI Listing
June 2007

Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome.

Cardiovasc Res 2005 Dec 25;68(3):441-53. Epub 2005 Jul 25.

Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cardiores.2005.06.027DOI Listing
December 2005