Leah S Torrie

Leah S Torrie

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Leah S Torrie

Leah S Torrie

Publications by authors named "Leah S Torrie"

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Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS One 2019 31;14(5):e0217828. Epub 2019 May 31.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544269PMC
January 2020

Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target.

FEBS J 2019 Nov 16;286(22):4509-4524. Epub 2019 Jul 16.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, UK.

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http://dx.doi.org/10.1111/febs.14976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899670PMC
November 2019

Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.01082-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761512PMC
October 2019

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay.

Antimicrob Agents Chemother 2019 09 23;63(9). Epub 2019 Aug 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.00309-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709497PMC
September 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

J Med Chem 2018 09 12;61(18):8374-8389. Epub 2018 Sep 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167002PMC
September 2018

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

ACS Infect Dis 2017 10 2;3(10):718-727. Epub 2017 Oct 2.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395PMC
October 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.

ACS Chem Biol 2015 Jun 27;10(6):1425-34. Epub 2015 Feb 27.

†Division of Molecular Microbiology, ‡Division of Biological Chemistry and Drug Discovery, §MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/cb5008647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477619PMC
June 2015

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.

Biochem J 2014 Apr;459(2):323-32

*Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20131033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969225PMC
April 2014

A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays.

PLoS Biol 2013 25;11(6):e1001593. Epub 2013 Jun 25.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, James Black Centre, Dow Street, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1001593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692445PMC
January 2014

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

PLoS One 2012 25;7(4):e35792. Epub 2012 Apr 25.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340893PMC
September 2012

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

ChemMedChem 2012 Jan 8;7(1):95-106. Epub 2011 Dec 8.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cmdc.201100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320663PMC
January 2012

Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.

ChemMedChem 2011 Dec 13;6(12):2214-24. Epub 2011 Sep 13.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201100344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272345PMC
December 2011

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

J Biol Chem 2009 Dec 14;284(52):36137-45. Epub 2009 Oct 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.045336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794729PMC
December 2009

Resolution of the insect ouabain paradox.

Proc Natl Acad Sci U S A 2004 Sep 3;101(37):13689-93. Epub 2004 Sep 3.

Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, Scotland, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0403087101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518814PMC
September 2004