Leah E Mechanic

Leah E Mechanic

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Leah E Mechanic

Leah E Mechanic

Publications by authors named "Leah E Mechanic"

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Genetic Simulation Resources and the GSR Certification Program.

Bioinformatics 2019 02;35(4):709-710

Division of Cancer Control and Population Sciences, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/bty666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378936PMC
February 2019

Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology.

PLoS Genet 2017 09 28;13(9):e1006945. Epub 2017 Sep 28.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619686PMC
September 2017

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.

J Clin Oncol 2017 Jul 11;35(20):2329-2337. Epub 2017 Apr 11.

Goli Samimi, Charlisse F. Caga-anan, Michael Dean, Leah E. Mechanic, Lori M. Minasian, and Mark E. Sherman, National Cancer Institute; Lawrence C. Brody, National Human Genome Research Institute, Bethesda, MD; Marcus Q. Bernardini, Stephanie Lheureux, Patricia A. Shaw, Princess Margaret Cancer Centre, Toronto, Ontario; Janice S. Kwon, University of British Columbia; British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Ian G. Campbell, Paul A. James, Masataka Takenaka, and David D. Bowtell, Peter MacCallum Cancer Centre; David D. Bowtell, University of Melbourne, Melbourne, Victoria; Georgia Chenevix-Trench, QIMR Berghofer Medical Research Institute, Brisbane, Queensland; Michael Friedlander, The Prince of Wales Hospital; Susan J. Ramus, University of New South Wales; Susan J. Ramus and David D. Bowtell, Garvan Institute of Medical Research, Sydney, New South Wales, Australia; Fergus J. Couch, Mayo Clinic, Rochester, MN; Joanne A. de Hullu and Marline G. Harmsen, Radboud University Medical Center, Nijmegen, the Netherlands; Susan M. Domchek and Ronny Drapkin, University of Pennsylvania, Philadelphia; Phuong L. Mai, Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA; Heather Spencer Feigelson, Kaiser Permanente Institute for Health Research, Denver, CO; Mia M. Gaudet, American Cancer Society, Atlanta, GA; Karen Hurley and Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson, Weill Cornell Medical College, New York, NY; Felicitas Lacbawan, Quest Diagnostics Nichols Institute, San Juan Capistrano; Thomas P. Slavin, City of Hope, Duarte, CA; Evan R. Myers, Duke University Medical Center, Durham, NC; Lisa F. Rezende, FORCE: Facing Our Risk of Cancer Empowered, Tampa; Mark E. Sherman, Mayo Clinic, Jacksonville, FL; and Elizabeth M. Swisher, University of Washington Medical Center, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2016.70.3439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501360PMC
July 2017

Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know?

Genet Epidemiol 2016 07 7;40(5):356-65. Epub 2016 Apr 7.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1002/gepi.21967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911236PMC
July 2016

Leveraging biospecimen resources for discovery or validation of markers for early cancer detection.

J Natl Cancer Inst 2015 Apr 16;107(4). Epub 2015 Feb 16.

: Division of Cancer Control and Population Sciences (SDS, DMC, LEM, VPDR, MJK), Division of Cancer Prevention (SuS, BSK), and Division of Cancer Treatment and Diagnosis (LMM), National Cancer Institute, Bethesda, MD; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (GLA, NU); Department of Medicine, University of North Carolina, Chapel Hill, NC (JAB, DFR); Department of Radiation Oncology, Johns Hopkins Medicine, Baltimore, MD (CDB); Center for Prostate Disease Research, Department of Defense, Rockville, MD (JC); Mount Sinai Hospital, Toronto, Ontario, Canada (EPD); Center for Health Research, Kaiser Permanente, Northwest, Portland, OR (KABG); Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA (SEH); Division of Research, Kaiser Permanente, Oakland, CA (LHK); Group Health Research Institute, Seattle, WA (EBL); American Society of Clinical Oncology, Alexandria, VA (RLS); Genomic Health, Inc., Redwood City, CA (StS); Biostatistics Center, Massachusetts General Hospital, Boston, MA (SJS); Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA (MJK).

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http://dx.doi.org/10.1093/jnci/djv012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342676PMC
April 2015

Genetic data simulators and their applications: an overview.

Genet Epidemiol 2015 Jan 13;39(1):2-10. Epub 2014 Dec 13.

Department of Bioinformatics and Computational Biology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1002/gepi.21876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804465PMC
January 2015

Approaches to integrating germline and tumor genomic data in cancer research.

Carcinogenesis 2014 Oct 12;35(10):2157-63. Epub 2014 Aug 12.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.

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http://dx.doi.org/10.1093/carcin/bgu165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178473PMC
October 2014

The use of biospecimens in population-based research: a review of the National Cancer Institute's Division of Cancer Control and Population Sciences grant portfolio.

Biopreserv Biobank 2014 Aug;12(4):240-5

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health , Rockville, Maryland.

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http://dx.doi.org/10.1089/bio.2014.0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150371PMC
August 2014

Pharmacogenomics in oncology care.

Front Genet 2014 8;5:73. Epub 2014 Apr 8.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute Rockville, MD, USA.

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http://dx.doi.org/10.3389/fgene.2014.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986526PMC
June 2014

NCI think tank concerning the identifiability of biospecimens and "omic" data.

Genet Med 2013 Dec 11;15(12):997-1003. Epub 2013 Apr 11.

Diagnostics Evaluation Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://www.nature.com/articles/gim201340
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http://dx.doi.org/10.1038/gim.2013.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097316PMC
December 2013

Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report.

Genet Epidemiol 2013 Nov 5;37(7):643-57. Epub 2013 Oct 5.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1002/gepi.21756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143122PMC
November 2013

Genetic Simulation Resources: a website for the registration and discovery of genetic data simulators.

Bioinformatics 2013 Apr 23;29(8):1101-2. Epub 2013 Feb 23.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624809PMC
April 2013

A review of NCI's extramural grant portfolio: identifying opportunities for future research in genes and environment in cancer.

Cancer Epidemiol Biomarkers Prev 2013 Apr 5;22(4):501-7. Epub 2013 Mar 5.

Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617050PMC
April 2013

Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer.

Anticancer Res 2012 Sep;32(9):3917-22

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647250PMC
September 2012

SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.

Anticancer Res 2012 Sep;32(9):3923-8

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643307PMC
September 2012

Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.

J Natl Cancer Inst 2011 Jul 17;103(14):1112-22. Epub 2011 Jun 17.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1093/jnci/djr216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139587PMC
July 2011

Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.

Carcinogenesis 2010 Oct 20;31(10):1778-86. Epub 2010 Aug 20.

Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/carcin/bgq156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981456PMC
October 2010

Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Am J Epidemiol 2010 Jun 21;171(12):1270-81. Epub 2010 May 21.

Department of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, DC, USA.

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http://dx.doi.org/10.1093/aje/kwq085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915494PMC
June 2010

Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk.

Cancer Epidemiol Biomarkers Prev 2009 Dec;18(12):3375-83

Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951599PMC
December 2009

Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians.

Cancer Epidemiol Biomarkers Prev 2009 Jan;18(1):215-22

Lombardi Cancer Center, Georgetown University, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790156PMC
January 2009

Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.

BMC Bioinformatics 2008 Mar 6;9:146. Epub 2008 Mar 6.

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2105-9-146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335300PMC
March 2008

Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene.

J Natl Cancer Inst 2007 Sep 11;99(18):1401-9. Epub 2007 Sep 11.

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1093/jnci/djm128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278934PMC
September 2007

Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.

J Natl Cancer Inst 2007 Aug 8;99(16):1257-69. Epub 2007 Aug 8.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1093/jnci/djm083DOI Listing
August 2007

The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.

Carcinogenesis 2007 Apr 27;28(4):828-36. Epub 2006 Oct 27.

Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) Bethesda, MD 20892-4258, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgl198DOI Listing
April 2007

Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors.

Cancer Epidemiol Biomarkers Prev 2007 Feb;16(2):214-22

Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892-4258, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0790DOI Listing
February 2007

Association of MTHFR gene polymorphisms with breast cancer survival.

BMC Cancer 2006 Oct 27;6:257. Epub 2006 Oct 27.

Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2407-6-257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634868PMC
October 2006

MDM2 SNP309 and SNP354 are not associated with lung cancer risk.

Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1559-61

Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0217DOI Listing
August 2006

Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.

Carcinogenesis 2006 Jul 6;27(7):1377-85. Epub 2006 Jan 6.

Laboratory of Human Carcinogenesis, NCI/NIH, 37 Convent Drive MSC 4255, Bldg 37 Rm 3060, Bethesda, MD 20892-4255, USA.

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http://dx.doi.org/10.1093/carcin/bgi330DOI Listing
July 2006

Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.

Int J Cancer 2006 Apr;118(7):1790-7

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ijc.21523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1451415PMC
April 2006

TP53 mutation spectrum in lung cancer is not different in women and men.

Cancer Epidemiol Biomarkers Prev 2005 Apr;14(4):1031-3

Laboratory of Carcinogenesis and Biomarkers, Clinical Breast Care Project Immunology and Research Center, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0640DOI Listing
April 2005

Polymorphisms in XPD and TP53 and mutation in human lung cancer.

Carcinogenesis 2005 Mar 25;26(3):597-604. Epub 2004 Nov 25.

Laboratory of Human Carcinogenesis, NCI Center for Cancer Research, 37 Convent Drive, Bethesda, MD 20892-4255, USA.

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http://dx.doi.org/10.1093/carcin/bgh344DOI Listing
March 2005

Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer.

Clin Cancer Res 2005 Mar;11(6):2106-10

Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute/NIH, 41 Library Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1853DOI Listing
March 2005

Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.

Cancer Res 2004 Oct;64(19):6849-53

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2201DOI Listing
October 2004