Publications by authors named "Leah C Biggs"

14Publications

Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle.

Cell Metab 2020 Oct 8;32(4):629-642.e8. Epub 2020 Sep 8.

Max Planck Institute for Biology of Ageing, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address:

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October 2020

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.

Cell 2020 05 16;181(4):800-817.e22. Epub 2020 Apr 16.

Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland; Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany. Electronic address:

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May 2020

Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation.

Sci Rep 2020 03 18;10(1):4963. Epub 2020 Mar 18.

Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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March 2020

Interferon regulatory factor 6 is required for proper wound healing in vivo.

Dev Dyn 2020 04 2;249(4):509-522. Epub 2019 Dec 2.

Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa.

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April 2020

Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function.

J Invest Dermatol 2020 02 18;140(2):284-290. Epub 2019 Jul 18.

Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Max Planck Institute for Biology of Ageing, Cologne, Germany; Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), University of Cologne, Cologne, Germany. Electronic address:

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February 2020

Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche.

Stem Cells 2019 09 10;37(9):1238-1248. Epub 2019 Jun 10.

Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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September 2019

Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.

Stem Cells 2016 07 4;34(7):1896-908. Epub 2016 Apr 4.

Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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July 2016

Palatogenesis and cutaneous repair: A two-headed coin.

Dev Dyn 2015 Mar 25;244(3):289-310. Epub 2014 Nov 25.

Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, Iowa.

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March 2015

Interferon regulatory factor 6 regulates keratinocyte migration.

J Cell Sci 2014 Jul 28;127(Pt 13):2840-8. Epub 2014 Apr 28.

Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA

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July 2014

Early inductive events in ectodermal appendage morphogenesis.

Semin Cell Dev Biol 2014 Jan-Feb;25-26:11-21. Epub 2014 Jan 30.

Developmental Biology Program, Institute of Biotechnology, P.O. Box 56, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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January 2015

Transforming growth factor Beta 3 is required for excisional wound repair in vivo.

PLoS One 2012 26;7(10):e48040. Epub 2012 Oct 26.

Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America.

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April 2013

Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation.

J Invest Dermatol 2012 Jan 15;132(1):50-8. Epub 2011 Sep 15.

Interdisciplinary Graduate Program in Genetics and Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA.

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January 2012