Lea M Starita

Lea M Starita

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Lea M Starita

Lea M Starita

Publications by authors named "Lea M Starita"

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MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect.

Genome Biol 2019 11 4;20(1):223. Epub 2019 Nov 4.

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://dx.doi.org/10.1186/s13059-019-1845-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827219PMC
November 2019

A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function.

Am J Hum Genet 2018 10 12;103(4):498-508. Epub 2018 Sep 12.

Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183024
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http://dx.doi.org/10.1016/j.ajhg.2018.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174279PMC
October 2018

Variant Interpretation: Functional Assays to the Rescue.

Am J Hum Genet 2017 Sep;101(3):315-325

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590843PMC
September 2017

Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks.

Hum Mutat 2015 Dec 22;36(12):1205-14. Epub 2015 Sep 22.

Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1002/humu.22902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005381PMC
December 2015

Deep Mutational Scanning: Library Construction, Functional Selection, and High-Throughput Sequencing.

Cold Spring Harb Protoc 2015 Aug 3;2015(8):777-80. Epub 2015 Aug 3.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195; Department of Medicine, University of Washington, Seattle, Washington 98195; Howard Hughes Medical Institute, Seattle, Washington 98195.

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http://dx.doi.org/10.1101/pdb.prot085225DOI Listing
August 2015

Deep Mutational Scanning: Calculating Enrichment Scores for Protein Variants from DNA Sequencing Output Files.

Cold Spring Harb Protoc 2015 Aug 3;2015(8):781-3. Epub 2015 Aug 3.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195; Department of Medicine, University of Washington, Seattle, Washington 98195; Howard Hughes Medical Institute, Seattle, Washington 98195.

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http://dx.doi.org/10.1101/pdb.prot085233DOI Listing
August 2015

Deep Mutational Scanning: A Highly Parallel Method to Measure the Effects of Mutation on Protein Function.

Cold Spring Harb Protoc 2015 Aug 3;2015(8):711-4. Epub 2015 Aug 3.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195; Department of Medicine, University of Washington, Seattle, Washington 98195; Howard Hughes Medical Institute, Seattle, Washington 98195.

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http://dx.doi.org/10.1101/pdb.top077503DOI Listing
August 2015

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.

Genetics 2015 Jun 30;200(2):413-22. Epub 2015 Mar 30.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195 Department of Medicine, University of Washington, Seattle, Washington 98195 Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195

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http://dx.doi.org/10.1534/genetics.115.175802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492368PMC
June 2015

Massively parallel single-amino-acid mutagenesis.

Nat Methods 2015 Mar 5;12(3):203-6, 4 p following 206. Epub 2015 Jan 5.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nmeth.3223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344410PMC
March 2015

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

Proc Natl Acad Sci U S A 2013 Apr 18;110(14):E1263-72. Epub 2013 Mar 18.

Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.1303309110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619334PMC
April 2013

Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Proteomics 2012 Jan 20;12(2):236-40. Epub 2011 Dec 20.

Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1002/pmic.201100166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337332PMC
January 2012

Unique classes of mutations in the Saccharomyces cerevisiae G-protein translation elongation factor 1A suppress the requirement for guanine nucleotide exchange.

Genetics 2006 Oct 1;174(2):651-63. Epub 2006 Sep 1.

Department of Molecular Genetics, Microbiology and Immunology UMDNJ Robert Wood Johnson Medical School, New Jersey 08854, USA.

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http://dx.doi.org/10.1534/genetics.106.059899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602096PMC
October 2006

Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function.

Cancer Res 2006 Apr;66(8):4100-7

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4430DOI Listing
April 2006

Substrates of the BRCA1-dependent ubiquitin ligase.

Cancer Biol Ther 2006 Feb 4;5(2):137-41. Epub 2006 Feb 4.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cbt.5.2.2479DOI Listing
February 2006

BRCA1 DNA-binding activity is stimulated by BARD1.

Cancer Res 2006 Feb;66(4):2012-8

Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3296DOI Listing
February 2006

Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.

Mol Cell Biol 2005 Oct;25(19):8656-68

Department of Pathology, Brigham and Women's Hospital, NRB 630, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.25.19.8656-8668.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265743PMC
October 2005

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

J Biol Chem 2005 Jul 10;280(26):24498-505. Epub 2005 May 10.

Program in Biology and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M414020200DOI Listing
July 2005

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

Mol Cell Biol 2004 Oct;24(19):8457-66

Brigham and Women's Hospital, Department of Pathology, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.24.19.8457-8466.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516733PMC
October 2004

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair.

Curr Opin Cell Biol 2003 Jun;15(3):345-50

Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0955-0674(03)00042-5DOI Listing
June 2003

Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells.

Oncogene 2003 Feb;22(7):983-91

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.onc.1206195DOI Listing
February 2003