Le Zhen

Le Zhen

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Le Zhen

Le Zhen

Publications by authors named "Le Zhen"

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Bio-inspired drug-dominated supramolecular nanocomplex based on low molecular weight heparin for progressive tumor therapy.

Carbohydr Polym 2019 Sep 15;220:30-42. Epub 2019 May 15.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Stability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2019.05.051DOI Listing
September 2019

Iminium Ion and N-Hydroxyimide as the Surrogate Components in DEAD-Promoted Oxidative Ugi Variant.

J Org Chem 2018 11 23;83(21):13121-13131. Epub 2018 Oct 23.

Key Laboratory of Drug Metabolism and Pharmacokinetics , China Pharmaceutical University , 24 Tongjia Xiang , Nanjing 210009 , Jiangsu , China.

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http://dx.doi.org/10.1021/acs.joc.8b01868DOI Listing
November 2018

Simultaneous determination of gemcitabine prodrug, gemcitabine and its major metabolite 2', 2'-difluorodeoxyuridine in rat plasma by UFLC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 May 14;1084:4-13. Epub 2018 Mar 14.

Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.03.025DOI Listing
May 2018

Simultaneous determination of tenofovir alafenamide and its active metabolites tenofovir and tenofovir diphosphate in HBV-infected hepatocyte with a sensitive LC-MS/MS method.

J Pharm Biomed Anal 2017 Nov 30;146:147-153. Epub 2017 Aug 30.

Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173120
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http://dx.doi.org/10.1016/j.jpba.2017.08.028DOI Listing
November 2017

Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation.

J Med Chem 2017 07 10;60(14):6077-6088. Epub 2017 Jul 10.

Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University , 24 Tongjia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00262DOI Listing
July 2017

Direct Intermolecular C-H Functionalization Triggered by 1,5-Hydride Shift: Access to N-Arylprolinamides via Ugi-Type Reaction.

Org Lett 2017 04 14;19(7):1566-1569. Epub 2017 Mar 14.

Key Laboratory of Drug Metabolism and Pharmacokinetics and ‡Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University , 24 Tongjia Xiang, Nanjing 210009, Jiangsu, China.

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http://dx.doi.org/10.1021/acs.orglett.7b00378DOI Listing
April 2017

In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine.

Acta Pharmacol Sin 2017 Mar 2;38(3):351-361. Epub 2017 Jan 2.

Key Lab of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

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http://dx.doi.org/10.1038/aps.2016.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342660PMC
March 2017

Sensitive analysis and simultaneous assessment of pharmacokinetic properties of crocin and crocetin after oral administration in rats.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Feb 15;1044-1045:1-7. Epub 2016 Dec 15.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, PR China.

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http://dx.doi.org/10.1016/j.jchromb.2016.12.003DOI Listing
February 2017

High fat diet aggravates the nephrotoxicity of berberrubine by influencing on its pharmacokinetic profile.

Environ Toxicol Pharmacol 2016 Sep 3;46:319-327. Epub 2016 Aug 3.

Key Lab of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, PR China.

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http://dx.doi.org/10.1016/j.etap.2016.08.003DOI Listing
September 2016

Photoluminescence detection of 2,4,6-trinitrotoluene (TNT) binding on diatom frustule biosilica functionalized with an anti-TNT monoclonal antibody fragment.

Biosens Bioelectron 2016 May 4;79:742-8. Epub 2016 Jan 4.

School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon, 97331 USA. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2016.01.002DOI Listing
May 2016

Orthogonal optimization of prokaryotic expression of a natural snake venom phospholipase A2 inhibitor from Sinonatrix annularis.

Toxicon 2015 Dec 9;108:264-71. Epub 2015 Nov 9.

Department of Biochemistry, College of Basic Medical Science, Nanchang University, Nanchang, 330006, China. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.10.018DOI Listing
December 2015

Dynamic dialysis: an efficient technique for large-volume sample desalting.

Prep Biochem Biotechnol 2015 Aug;45(6):588-95

a Department of Biochemistry, Faculty of Basic Medical Sciences , Nanchang University , Nanchang, Jiangxi Province , Republic of China.

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http://dx.doi.org/10.1080/10826068.2014.940537DOI Listing
August 2015

Ultra-sensitive immunoassay biosensors using hybrid plasmonic-biosilica nanostructured materials.

J Biophotonics 2015 Aug 25;8(8):659-67. Epub 2014 Sep 25.

School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, 97331, USA.

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http://dx.doi.org/10.1002/jbio.201400070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758816PMC
August 2015

Visible-light induced isoindoles formation to trigger intermolecular Diels-Alder reactions in the presence of air.

Org Lett 2015 Jun 14;17(11):2684-7. Epub 2015 May 14.

Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.1021/acs.orglett.5b01078DOI Listing
June 2015

Intramolecular redox reaction for the synthesis of N-aryl pyrroles catalyzed by Lewis acids.

Org Biomol Chem 2014 Dec 29;12(47):9716-9. Epub 2014 Oct 29.

Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and Center of Drug Discovery, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.1039/c4ob02009jDOI Listing
December 2014

Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolecular [1,5]-hydride shift/isomerization reaction.

Beilstein J Org Chem 2014 5;10:2892-6. Epub 2014 Dec 5.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.3762/bjoc.10.306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273273PMC
December 2014

Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists.

Bioorg Med Chem Lett 2011 Jul 24;21(13):3894-7. Epub 2011 May 24.

Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.1016/j.bmcl.2011.05.034DOI Listing
July 2011