Publications by authors named "Le Shu"

24Publications

Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner.

Stem Cell Res Ther 2020 06 25;11(1):248. Epub 2020 Jun 25.

College of Life Science, Zhejiang University, Hangzhou, 310058, Zhejiang Province, People's Republic of China.

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http://dx.doi.org/10.1186/s13287-020-01734-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318764PMC
June 2020

Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice.

Biochim Biophys Acta Mol Basis Dis 2020 01 25;1866(1):165569. Epub 2019 Oct 25.

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, California 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993985PMC
January 2020

Predicting the weld width from high-speed successive images of the weld zone using different machine learning algorithms during laser welding.

Math Biosci Eng 2019 06;16(5):5595-5612

School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

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http://dx.doi.org/10.3934/mbe.2019278DOI Listing
June 2019

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

Diabetes 2019 09 5;68(9):1730-1746. Epub 2019 Jun 5.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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http://dx.doi.org/10.2337/db18-0927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702639PMC
September 2019

Integrative Genomics Analysis Unravels Tissue-Specific Pathways, Networks, and Key Regulators of Blood Pressure Regulation.

Front Cardiovasc Med 2019 12;6:21. Epub 2019 Mar 12.

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fcvm.2019.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423920PMC
March 2019

Multi-omics integration reveals molecular networks and regulators of psoriasis.

BMC Syst Biol 2019 01 14;13(1). Epub 2019 Jan 14.

Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA.

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https://bmcsystbiol.biomedcentral.com/articles/10.1186/s1291
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http://dx.doi.org/10.1186/s12918-018-0671-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332659PMC
January 2019

Prenatal Bisphenol A Exposure in Mice Induces Multitissue Multiomics Disruptions Linking to Cardiometabolic Disorders.

Endocrinology 2019 02;160(2):409-429

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1210/en.2018-00817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349005PMC
February 2019

Signature miRNAs in peripheral blood monocytes of patients with gastric or breast cancers.

Open Biol 2018 10 31;8(10). Epub 2018 Oct 31.

Laboratory for Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology and College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China

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http://rsob.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsob.180051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223219PMC
October 2018

Translating GWAS Findings to Novel Therapeutic Targets for Coronary Artery Disease.

Front Cardiovasc Med 2018 30;5:56. Epub 2018 May 30.

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fcvm.2018.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989327PMC
May 2018

FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 May 25;1863(5):538-548. Epub 2018 Feb 25.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Department of Basic Veterinary Medicine, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei Province, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.02.003DOI Listing
May 2018

Shrimp miR-12 Suppresses White Spot Syndrome Virus Infection by Synchronously Triggering Antiviral Phagocytosis and Apoptosis Pathways.

Authors:
Le Shu Xiaobo Zhang

Front Immunol 2017 31;8:855. Epub 2017 Jul 31.

College of Life Sciences, Laboratory for Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.3389/fimmu.2017.00855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534442PMC
July 2017

Multidimensional Integrative Genomics Approaches to Dissecting Cardiovascular Disease.

Front Cardiovasc Med 2017 27;4. Epub 2017 Feb 27.

Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA; Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA; Molecular, Cellular, and Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA; Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fcvm.2017.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327355PMC
February 2017

Mergeomics: a web server for identifying pathological pathways, networks, and key regulators via multidimensional data integration.

BMC Genomics 2016 09 9;17(1):722. Epub 2016 Sep 9.

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12864-016-3057-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016927PMC
September 2016

Exposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function.

PLoS Genet 2016 07 29;12(7):e1006223. Epub 2016 Jul 29.

Molecular Toxicology Inter-departmental Program, University of California, Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966967PMC
July 2016

The role of shrimp miR-965 in virus infection.

Fish Shellfish Immunol 2016 Jul 29;54:427-34. Epub 2016 Apr 29.

College of Life Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.fsi.2016.04.129DOI Listing
July 2016

Resistin Induces Hypertension and Insulin Resistance in Mice via a TLR4-Dependent Pathway.

Sci Rep 2016 Feb 26;6:22193. Epub 2016 Feb 26.

College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.

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http://dx.doi.org/10.1038/srep22193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768137PMC
February 2016

Translocation of CIDEC in hepatocytes depends on fatty acids.

Genes Cells 2014 Nov 25;19(11):793-802. Epub 2014 Sep 25.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.

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http://dx.doi.org/10.1111/gtc.12180DOI Listing
November 2014

Long-term effect of dietary fibre intake on glycosylated haemoglobin A1c level and glycaemic control status among Chinese patients with type 2 diabetes mellitus.

Public Health Nutr 2014 Aug 24;17(8):1858-64. Epub 2013 Jul 24.

1Department of Epidemiology,School of Public Health,Key Laboratory of Public Health Safety,Ministry of Education,Fudan University,138 Yi Xue Yuan Road,Shanghai 200032, People's Republic ofChina.

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http://dx.doi.org/10.1017/S1368980013002000DOI Listing
August 2014

Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway.

Hepatology 2013 Apr 25;57(4):1384-93. Epub 2013 Jan 25.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.

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http://dx.doi.org/10.1002/hep.26167DOI Listing
April 2013

siRNA, miRNA and HIV: promises and challenges.

Cell Res 2005 Nov-Dec;15(11-12):935-46

National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA.

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http://dx.doi.org/10.1038/sj.cr.7290371DOI Listing
February 2006