Publications by authors named "Le Cai"

136 Publications

A new cycloheptane derivative from the fungus JT-8.

Nat Prod Res 2021 Sep 9:1-9. Epub 2021 Sep 9.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. China.

A new highly oxygenated cycloheptane derivative crustane (), along with fourteen known compounds (-) were isolated from JT-8. The structure of compound was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound exhibited moderate antibacterial activity against with MIC of 4.0 μg/mL.
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http://dx.doi.org/10.1080/14786419.2021.1949592DOI Listing
September 2021

Research on preparation and in vitro evaluation of the dendrimer-peptide nuclear acid conjugate for amplification pretargeting.

J Labelled Comp Radiopharm 2021 Sep 10;64(11):428-439. Epub 2021 Aug 10.

Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.

Amplification pretargeting has the potential to increase the tracer's accumulation in the tumor. This study aimed to develop a three-step amplification pretargeting strategy in nuclear medicine with a polymer conjugated with multiple copies of peptide nuclear acid (PNA). In this study, the tracer F-labeled complementary PNA ( F-cPNA) was prepared by click-chemistry with high radiochemical purity (>99%) and great stability in vitro. The PAMMA dendrimer generation 4 (G4) was conjugated with multiple copies of PNAs. The average number of PNA groups in the G4-PNA conjugate was determined by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and the accessibility to the F-cPNA was identified by size-exclusion high-performance liquid chromatography (SE-HPLC). There were approximately 11.7 of 64 carboxyl groups modified with PNAs, of which more than 99% were accessible to F-cPNA. F-cPNA was added to a mixture of CC49-cPNA and G4-PNA, and the complex exhibited a single peak on high-performance liquid chromatography (HPLC) as evidence of complete hybridization between F-cPNA and CC49-cPNA/G4-PNA. The LS174T tumor cells were incubated with CC49-cPNA followed by G4-PNA as an amplification platform before F-cPNA was added to hybridize with CC49-cPNA/G4-PNA. Compared with conventional pretargeting without G4-PNA, the radioactivity signal was amplified about four times, which demonstrated that the dendrimer-PNA conjugate plays a crucial role in signal amplification.
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http://dx.doi.org/10.1002/jlcr.3937DOI Listing
September 2021

Socioeconomic differentials in trends in the prevalence of hypertension and pre-hypertension and hypertension awareness, treatment, and control in rural Southwestern China.

BMC Cardiovasc Disord 2021 05 26;21(1):259. Epub 2021 May 26.

School of Public Health, Kunming Medical University, 1168 Yu Hua Street Chun Rong Road, Cheng Gong New City, 650500, Kunming, China.

Background: This study examines the socioeconomic differentials in trends in the prevalence of hypertension and pre-hypertension and hypertension awareness, treatment, and control in rural Southwestern China.

Methods: Two cross-sectional interviews and health examination surveys were administered in rural Yunnan Province, including 6,350 consenting participants in 2009 and 6,359 consenting participants in 2016 (aged ≥ 35 years). Participant demographics, socioeconomic status (SES), and ethnicity, along with information about hypertension awareness, treatment, and control, were collected using similar questionnaires in the two surveys. The participants' blood pressure levels were also measured.

Results: From 2009 to 2016, the prevalence of hypertension substantially increased from 28.4% to 39.5% (P < 0.01), and awareness and control rose from 42.2 and 25.8% to 53.1 (P < 0.01) and 30.6% (P < 0.05), respectively. Although people with a higher education level also had higher awareness and control rates than the lower education level ones, there were no conspicuous differences in the improvement of awareness and control between publics with different education levels over the 7 years studied. Increases were observed in both rates of awareness and control in people with a high level of income (P < 0.01). However, only the awareness rate increased in participants with a low level of income. Furthermore, the prevalence (P < 0.01) and treatment (P < 0.05) of hypertension were higher in the Han people than in ethnic minorities.

Conclusions: Individual SES has clear associations with trends in the prevalence, awareness, and control of hypertension. Future interventions to improve hypertension prevention and control should be tailored to address individual SES.
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http://dx.doi.org/10.1186/s12872-021-02062-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157672PMC
May 2021

Bioactive sesterterpenoids from the fungus Penicillium roqueforti YJ-14.

Phytochemistry 2021 Jul 30;187:112762. Epub 2021 Apr 30.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. Electronic address:

Seven previously undescribed sesterterpenes were characterized from Penicillium roqueforti YJ-14 by solid fermentation. Their structures were initially investigated in detail by spectroscopic analyses and HR-ESI-MS and were further confirmed by X-crystallography. In in vitro bioassays, compounds 1, 5 and 7 showed cytotoxic activity against the MCF-7 breast cancer cell line with IC values of 7.98 ± 0.93, 6.42 ± 0.41 and 7.32 ± 0.18 μM, respectively. Compounds 5 and 7 displayed significant cytotoxicity against the A549 lung cancer cell line (IC values of 4.83 ± 0.22 μM and 4.58 ± 0.85 μM, respectively). In addition, compound 5 showed an obvious inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages with an IC value of 9.53 ± 0.16 μM.
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http://dx.doi.org/10.1016/j.phytochem.2021.112762DOI Listing
July 2021

Four new phenanthrene derivatives from Bulbophyllum retusiusculum.

Fitoterapia 2021 Jul 24;152:104910. Epub 2021 Apr 24.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; College of pharmacy, Dali University, Dali 671000, China. Electronic address:

Three new dihydrophenanthrenes, retusiusine D (1), retusiusine E (2), retusiusine F (3), and a new phenanthrene retusiusine G (4), together with two known dihydrophenanthrenes 4,7-dihydroxy-2,3-methylenedioxy-9,10-dihydrophenanthrene (5) and epemeranthol-A (6) were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1 and 2 exhibited potent cytotoxic activities against SMMC-7721 and weak cytotoxic activities against HL-60. Compound 4 showed moderate cytotoxic activity against SMMC-7721 and MCF-7.
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http://dx.doi.org/10.1016/j.fitote.2021.104910DOI Listing
July 2021

Heteroatom-doped carbon materials with interconnected channels as ultrastable anodes for lithium/sodium ion batteries.

Dalton Trans 2021 Mar 10;50(12):4335-4344. Epub 2021 Mar 10.

Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China.

Carbon materials have been extensively investigated as promising negative electrode materials for lithium/sodium ion batteries. However, most common carbon materials always suffer from limitations in regards to high reversible capacity and long-term cycling stability because of their low theoretical specific capacities and sluggish kinetics. Herein, we report a facile MOF-derived strategy for the synthesis of nitrogen/oxygen co-doped porous carbon polyhedra (NOPCP) with abundant channel-connected cavities with their inner surface decorated with a large number of N and O atoms, which can provide a large number of active sites (defects and edge doping sites) for the sorption of Li/Na. These cavities can also be considered as "ponds" where the electrolyte is stored, which shortens the diffusion distance of ions during the discharge/charge process. When evaluated as an anode material for LIBs, NOPCP-600 delivers a high reversible capacity of 1663 mA h g at 0.1 A g after 120 cycles and superior cycling stability with a capacity of 667 mA h g after 1000 cycles at 2 A g. For SIBs, NOPCP-600 delivers a high reversible capacity of 313 mA h g at 0.1 A g after 100 cycles and an excellent long-term cycling stability of 228 mA h g at 1 A g after 2000 cycles.
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http://dx.doi.org/10.1039/d1dt00243kDOI Listing
March 2021

Wireless and battery-free technologies for neuroengineering.

Nat Biomed Eng 2021 Mar 8. Epub 2021 Mar 8.

Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

Tethered and battery-powered devices that interface with neural tissues can restrict natural motions and prevent social interactions in animal models, thereby limiting the utility of these devices in behavioural neuroscience research. In this Review Article, we discuss recent progress in the development of miniaturized and ultralightweight devices as neuroengineering platforms that are wireless, battery-free and fully implantable, with capabilities that match or exceed those of wired or battery-powered alternatives. Such classes of advanced neural interfaces with optical, electrical or fluidic functionality can also combine recording and stimulation modalities for closed-loop applications in basic studies or in the practical treatment of abnormal physiological processes.
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http://dx.doi.org/10.1038/s41551-021-00683-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423863PMC
March 2021

Bifunctional Fluorinated Separator Enabling Polysulfide Trapping and Li Deposition for Lithium-Sulfur Batteries.

ACS Appl Mater Interfaces 2021 Mar 4;13(10):11920-11929. Epub 2021 Mar 4.

School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Lithium-sulfur batteries (LSBs) are deemed as one of the most promising next generation energy storage system substitutes for conventional lithium ion batteries due to their high energy density, low cost, and environmental friendliness. The practical application of LSBs has long been blocked by the serious lithium polysulfide (LiPS) shuttle effect and notorious Li dendrite growth, inducing fast capacity decay and limited cycling lifespan. Herein, fluorinated carbon prepared via a safe and scalable strategy has rationally been coated on a separator affording bifunctional fluorinated Celgard (F-Celgard) for LSB construction. The F-Celgard shows superior Li flux modulation and LiPS trapping capability, which has been verified by the density function theory calculations. The Li symmetric cells demonstrate long and stable Li plating/stripping with much smaller polarization voltage and dendrite-free Li deposition. In addition, LSBs show superior rate performances with higher discharge capacities and long-time stable cycling over 1000 cycles at 1 C with a low decay rate of ∼0.038% per cycle. With a high sulfur loading (∼5.2 mg cm), a high initial areal capacity of ∼4.2 mAh cm can be obtained with a superior capacity retention of ∼91.8% at 0.2 C. This work demonstrates a facile, cost-effective, and scalable strategy toward highly stable LSBs for practical usage.
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http://dx.doi.org/10.1021/acsami.0c22190DOI Listing
March 2021

Fabrication Strategies of Twisted Bilayer Graphenes and Their Unique Properties.

Authors:
Le Cai Gui Yu

Adv Mater 2021 Apr 22;33(13):e2004974. Epub 2021 Feb 22.

Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Twisted bilayer graphene (tBLG) exhibits a host of innovative physical phenomena owing to the formation of moiré superlattice. Especially, the discovery of superconducting behavior has generated new interest in graphene. The growing studies of tBLG mainly focus on its physical properties, while the fabrication of high-quality tBLG is a prerequisite for achieving the desired properties due to the great dependence on the twist angle and the interfacial contact. Here, the cutting-edge preparation strategies and challenges of tBLG fabrication are reviewed. The advantages and disadvantages of chemical vapor deposition, epitaxial growth on silicon carbide, stacking monolayer graphene, and folding monolayer graphene methods for the fabrication of tBLG are analyzed in detail, providing a reference for further development of preparation methods. Moreover, the characterization methods of twist angle for the tBLG are presented. Then, the unique physicochemical properties and corresponding applications of tBLG, containing correlated insulating and superconducting states, ferromagnetic state, soliton, enhanced optical absorption, tunable bandgap, and lithium intercalation and diffusion, are described. Finally, the opportunities and challenges for fabricating high-quality and large-area tBLG are discussed, unique physical properties are displayed, and new applications inferred from its angle-dependent features are explored, thereby impelling the commercialization of tBLG from laboratory to market.
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http://dx.doi.org/10.1002/adma.202004974DOI Listing
April 2021

Soft, Wireless and subdermally implantable recording and neuromodulation tools.

J Neural Eng 2021 Feb 19. Epub 2021 Feb 19.

Biomedical Engineering, University of Arizona, 1230 N Cherry Ave., Tucson, Arizona, 85719, UNITED STATES.

Progress in understanding neuronal interaction and circuit behavior of the central and peripheral nervous system strongly relies on the advancement of tools that record and stimulate with high fidelity and specificity. Currently, devices used in exploratory research predominantly utilize cables or tethers to provide pathways for power supply, data communication, stimulus delivery and recording, which constrains the scope and use of such devices. In particular, the tethered connection, mechanical mismatch to surrounding soft tissues and bones frustrate the interface leading to irritation and limitation of motion of the subject, which in the case of fundamental and preclinical studies, impacts naturalistic behaviors of animals and precludes the use in experiments involving social interaction and ethologically relevant three-dimensional environments, limiting the use of current tools to mostly rodents and exclude species such as birds and fish. This review explores the current state-of-the-art in wireless, subdermally implantable tools that quantitively expand capabilities in analysis and perturbation of the central and peripheral nervous system by removing tethers and externalized features of implantable neuromodulation and recording tools. Specifically, the review explores power harvesting strategies, wireless communication schemes, and soft materials and mechanics that enable the creation of such devices and discuss their capabilities in the context of freely-behaving subjects. Highlights of this class of devices includes wireless battery-free and fully implantable operation with capabilities in cell specific recording, multimodal neural stimulation and electrical, optogenetic and pharmacological neuromodulation capabilities. We conclude with discussion on translation of such technologies which promises routes towards broad dissemination.
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http://dx.doi.org/10.1088/1741-2552/abe805DOI Listing
February 2021

Wireless and battery-free platforms for collection of biosignals.

Biosens Bioelectron 2021 Apr 23;178:113007. Epub 2021 Jan 23.

Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Department of Electrical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Bio5 Institute, University of Arizona, Tucson, AZ, 85721, USA; Neuroscience GIDP, University of Arizona, Tucson, AZ, 85721, USA. Electronic address:

Recent progress in biosensors have quantitively expanded current capabilities in exploratory research tools, diagnostics and therapeutics. This rapid pace in sensor development has been accentuated by vast improvements in data analysis methods in the form of machine learning and artificial intelligence that, together, promise fantastic opportunities in chronic sensing of biosignals to enable preventative screening, automated diagnosis, and tools for personalized treatment strategies. At the same time, the importance of widely accessible personal monitoring has become evident by recent events such as the COVID-19 pandemic. Progress in fully integrated and chronic sensing solutions is therefore increasingly important. Chronic operation, however, is not truly possible with tethered approaches or bulky, battery-powered systems that require frequent user interaction. A solution for this integration challenge is offered by wireless and battery-free platforms that enable continuous collection of biosignals. This review summarizes current approaches to realize such device architectures and discusses their building blocks. Specifically, power supplies, wireless communication methods and compatible sensing modalities in the context of most prevalent implementations in target organ systems. Additionally, we highlight examples of current embodiments that quantitively expand sensing capabilities because of their use of wireless and battery-free architectures.
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http://dx.doi.org/10.1016/j.bios.2021.113007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112193PMC
April 2021

Socioeconomic and lifestyle determinants of the prevalence of hypertension among elderly individuals in rural southwest China: a structural equation modelling approach.

BMC Cardiovasc Disord 2021 02 2;21(1):64. Epub 2021 Feb 2.

School of Public Health, Kunming Medical University, 1168 Yu Hua Street, Chun Rong Road, Cheng Gong New City, Kunming, 650500, China.

Background: This study examines the association between socioeconomic and lifestyle factors and the prevalence of hypertension among elderly individuals in rural Southwest China.

Methods: A cross-sectional survey of 4833 consenting adults aged ≥ 60 years in rural regions of Yunnan Province, China, was conducted in 2017. Data on individual socioeconomic status, sleep quality, physical activity level, and family history of hypertension were collected with a standardized questionnaire. Blood pressure, fasting blood glucose, height, weight, and waist circumference were also measured. An individual socioeconomic position (SEP) index was constructed using principal component analysis. Structural equation modelling (SEM) was applied to analyse the association between socioeconomic and lifestyle factors and the prevalence of hypertension.

Results: The overall prevalence of hypertension was 50.6% in the study population. Body fat distribution, including measures of obesity and central obesity, had the greatest total effect on hypertension (0.21), followed by family history of hypertension (0.14), biological sex (0.08), sleep quality (- 0.07), SEP (- 0.06), physical inactivity (0.06), and diabetes (0.06). Body fat distribution, SEP, and family history of hypertension had both direct and indirect effects on hypertension, whereas physical inactivity, diabetes, and sleep quality were directly associated with the prevalence of hypertension. Biological sex was indirectly associated with the prevalence of hypertension.

Conclusions: SEP, body fat distribution, physical inactivity, diabetes, and sleep quality critically influence the prevalence of hypertension. Future interventions to prevent and control hypertension should give increased attention to individuals with low SEP and should focus on controlling diabetes and obesity, increasing physical activity levels, and improving quality of sleep among older adults aged ≥ 60 years in rural Southwest China.
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http://dx.doi.org/10.1186/s12872-021-01885-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851929PMC
February 2021

Biotransformation of 1,8-Dihydroxyanthraquinone into Peniphenone under the Fermentation of .

ACS Omega 2020 Dec 16;5(51):33380-33386. Epub 2020 Dec 16.

School of Life Sciences, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.

The present study verified that 1,8-dihydroxyanthraquinone (), a common component in some industrial raw materials and dyes, could be converted into peniphenone (), which possesses immunosuppressive activity and other medicinal potential, by fermentation. The yield of peniphenone () after 7 days of fermentation was 11.05 ± 2.19%. To reveal the transformation mechanism, two secondary metabolites, emodin () and monodictyphenone (), were isolated from the fermentation broth of , implying that polyketide metabolic pathways from emodin () to monodictyphenone () might exist in . 1,8-Dihydroxyanthraquinone () was suspected to be converted into peniphenone () via the same pathway since emodin () and 1,8-dihydroxyanthraquinone () share very similar skeletons. The P450 enzyme and Baeyer-Villiger oxidase in were confirmed to catalyze this biotransformation on the basis of ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis. This novel investigation could shed light on the mechanism and therefore development of peniphenone production from 1,8-dihydroxyanthraquinone by microbial fermentation.
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http://dx.doi.org/10.1021/acsomega.0c05216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774269PMC
December 2020

A new cytotoxic indole alkaloid from the fungus TY12.

Nat Prod Res 2020 Oct 4:1-7. Epub 2020 Oct 4.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, P.R. China.

A new dimeric monoterpene indole alkaloid polonidine A (), along with five known compounds, cyclopenol (), verrucosidin (), fructigenine A (), 3-O-methylviridicatin () and aurantiomides C (), were isolated from TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound exhibited moderate cytotoxic activities and moderate antibacterial activity against with MIC of 4.0 μg/mL.
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http://dx.doi.org/10.1080/14786419.2020.1828406DOI Listing
October 2020

Resilience mediates the association between school bullying victimization and self-harm in Chinese adolescents.

J Affect Disord 2020 12 11;277:115-120. Epub 2020 Aug 11.

Department of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, Yunnan 650500, China. Electronic address:

Objective: The association between school bullying and self-harm (SH) in adolescents has been extensively discussed. Nevertheless, little is known about the mechanism of this relationship, particularly the role of resilience. Our research aimed to explore and evaluate the potential moderation and mediation of resilience in the association between school bullying victimization and SH in a large sample of Chinese adolescents.

Method: We conducted a population-based cross-sectional survey of 3146 adolescents in southwest China. The data were collected by a self-administered questionnaire. Multivariate Logistic regression which incorporated the product term of bullying victimization and resilience was used to estimate the moderation of resilience. Mediation of resilience in bullying victimization and SH were evaluated by path model.

Results: The prevalence of bullying involvement and SH were 13.13% (95% CI:9.31%-18.00%) and 47.0% (95% CI: 36.3%-58.0%), respectively. School bullying victimization was positively associated with SH. Resilience was a prominent mediator which accounted for 27.7% of the total association. Among all five dimensions of resilience, emotion regulation (30.90%), interpersonal assistance (24.78%), and family support (22.16%) showed the strongest mediation. Nevertheless, the moderation of resilience in this association was not statistically significant.

Conclusions: The findings of the present study suggest that resilience strengthening measures, particularly those aimed at improving emotion regulation ability and building social support could be effective in reducing school bullying victimization related SH behaviors among Chinese teenagers.
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http://dx.doi.org/10.1016/j.jad.2020.07.136DOI Listing
December 2020

A new tremulane sesquiterpene from by solid-state fermentation.

Nat Prod Res 2020 Aug 13:1-6. Epub 2020 Aug 13.

School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.

A new tremulane sesquiterpene, lactedine (), along with seven known tremulane sesquiterpenes (-) and one known triterpene () were isolated from the fungus . Their structures were established on the basis of extensive spectroscopic data and DP4+ probability analyses.
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http://dx.doi.org/10.1080/14786419.2020.1806272DOI Listing
August 2020

A meta-analysis of the therapeutic effect of gefitinib combined with chemotherapy and chemotherapy alone in treating non-small cell lung cancer.

Medicine (Baltimore) 2020 Jul;99(31):e21490

Department of Pharmacy, Medical Supplies Center, Chinese PLA General Hospital, Beijing, China.

Background: Whether the combination of gefitinib and chemotherapy is beneficial for advanced non-small cell lung cancer (NSCLC) remains controversial. This study aimed to summarize the currently available evidence and compare the efficacy and safety of gefitinib combined with chemotherapy versus chemotherapy alone for treating advanced NSCLC.

Methods: Literature on comparing the effects of gefitinib combined with chemotherapy and chemotherapy alone in treating NSCLC was retrieved from the PubMed, EMBASE and Cochrane Database. The primary outcome measures included progression-free survival (PFS) and overall survival (OS). Revman 5.3 was used for data processing.

Results: Seven randomized controlled trials were included, involving a total of 1418 patients. There appeared a significant improvement in PFS (hazard ratio (HR) = 0.60 [95% CI 0.43, 0.82], P = .001) after treatment with gefitinib combined with chemotherapy when compared with chemotherapy alone. The subgroup analysis showed a significant advantage of sequential administration (HR = 0.67 [95% CI 0.57, 0.79], P < .00001). There was no significant improvement in OS (HR = 0.92 [95% CI 0.71, 1.20], P = .54), and no significant improvement in overall response rate (ORR) (HR = 0.98 [95% CI 0.67, 1.44], P = .93). The risks of rash and diarrhea (odds ratios) were higher in gefitinib combined with chemotherapy group when compared with chemotherapy alone, and there were significant differences on grade 3/4 rash and thrombocytopenia between 2 groups.

Conclusion: Gefitinib combined with chemotherapy is superior to chemotherapy alone in PFS, sequential administration prolongs the patients' PFS, however, a survival advantage is not shown in OS or ORR. Gefitinib combined with chemotherapy aggravates rash, diarrhea and thrombocytopenia.
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http://dx.doi.org/10.1097/MD.0000000000021490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402902PMC
July 2020

Psychometric evaluation of the Chinese version of the Person-Centred Care Assessment Tool.

BMJ Open 2020 07 13;10(7):e031580. Epub 2020 Jul 13.

Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden

Objective: This study aims to test a Chinese cross-cultural adaptation of the English version of the Person-Centred Care Assessment Tool (P-CAT) and evaluate its psychometric properties.

Design: P-CAT was translated/back-translated using established procedures before the psychometric evaluation of the Chinese version was made.

Setting: Two hospitals covering urban and suburban areas of Kunming in the Yunnan province of China.

Participants: 152 female hospital staff completed the survey.

Main Outcome Measures: Construct validity and reliability, including internal consistency and test-retest reliability, were assessed among a sample of hospital staff.

Results: The factor analysis resulted in a two-component solution that consisted of two subscales. The corrected item-total correlations for all of the items ranged from 0.14 to 0.44, with six items not meeting the cut-off level for item-total correlation (>0.3). The Chinese P-CAT demonstrated strong reliability, with a Cronbach's alpha of 0.91-0.94 for the scales and a test-retest reliability coefficient of 0.88 for the overall scale scores. The intraclass correlation was 0.92 (95% CI 0.90 to 0.95).

Conclusion: P-CAT appears to be a promising measure for evaluating staff perceptions of person-centredness in Chinese hospital environments. The results show that P-CAT can be a useful tool for improving the quality of healthcare in terms of person-centred care in the Chinese context.
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http://dx.doi.org/10.1136/bmjopen-2019-031580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359066PMC
July 2020

Association of socioeconomic factors and prevalence of hypertension with sleep disorder among the elderly in rural southwest China.

Sleep Med 2020 07 21;71:106-110. Epub 2020 Mar 21.

School of Public Health, Kunming Medical University, 1168 Yu Hua Street Chun Rong Road, Cheng Gong New City, Kunming 650500, China. Electronic address:

Objectives: This study examines the distribution of sleep disorder prevalence across socioeconomic status (SES) and investigates the relationship between sleep disorders and hypertension among southwest China's rural older adult population.

Methods: A cross-sectional survey was conducted in rural Yunnan Province, China from 2017 to 2018, consisting of 4833 consenting participants aged ≥60 years. Each participant completed a structured interview and had their blood pressure measured. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Multivariate logistic regression was used to model variations in prevalence of sleep disorders and hypertension.

Results: In the study population, the prevalence rates of sleep disorders and hypertension were 46.5% and 50.3%, respectively. Women had higher prevalence of both chronic illnesses (53.4% vs. 38.7%, 53.1% vs. 47.6%, P < 0.01). After adjusting for age, sex, and residential status, older adults of minority ethnicity had a higher prevalence of sleep disorders than the Han ethnic majority (P < 0.01). Attainment of higher levels of education and lower annual household income were also associated with a greater risk of sleep disorders (P < 0.01). Further, logistic regression analysis indicated that older adults with sleep disorders had a greater risk of being hypertensive (P < 0.01).

Conclusions: Sleep disorders are highly prevalent in rural southwest China. Future interventions to improve sleep quality would benefit from tailoring to address individual SES. Improving sleep quality profoundly reduces prevalence of hypertension.
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http://dx.doi.org/10.1016/j.sleep.2020.03.006DOI Listing
July 2020

Socioeconomic variations in chronic obstructive pulmonary disease prevalence, diagnosis, and treatment in rural Southwest China.

BMC Public Health 2020 Apr 19;20(1):536. Epub 2020 Apr 19.

School of Public Health, Kunming Medical University, 1168 Yu Hua Street Chun Rong Road, Cheng Gong New City, Kunming, 650500, China.

Background: Chronic obstructive pulmonary disease (COPD) is a major and growing cause of morbidity and mortality throughout the world. However, there remains a limited understanding of the association between individual socioeconomic status (SES) and COPD diagnosis and treatment worldwide, including in China. This study investigates socioeconomic variations in prevalence, diagnosis, and treatment of COPD in rural China.

Methods: The present study employed a cross-sectional survey design. The study population was composed of Han majority as well as Na Xi and Bai ethnic minority individuals 35 years of age and older living in Yunnan Province from 2017 to 2019. In total, 7534 individuals consented to participate in the study and complete a structured interview as well as a post-bronchodilator spirometry test. Multivariate logistic regression was used to analyze the association between individual socioeconomic status variables and the prevalence, diagnosis, and treatment of COPD.

Results: The age-standardized prevalence of COPD in the present study was 14.3%. Prevalence differed by gender: prevalence for men was 17.1%, versus 11.4% for women (P = 0.0001). Overall, levels of diagnosis and treatment of COPD for participants with COPD were 24.2 and 23.1%, respectively. Multivariate logistic regression indicated that higher educational levels and good access to medical services was associated with an overall lower risk of COPD (P = 0.032 vs. P = 0.018) as well as a higher probability of COPD diagnosis among those with COPD (P = 0.0001 vs. P = 0.002). Participants with COPD with higher educational levels (P = 0.0001) and higher annual household incomes (P = 0.0001) as well as good access to medical services (P = 0.016) were more likely to receive COPD medications and treatment than their counterparts. While Na Xi and Bai participants had a higher probability of having COPD (P = 0.0001), they had a lower probability of having received a diagnosis or treatment for COPD than Han participants (P = 0.0001 vs. P = 0.0012).

Conclusions: Future interventions to further control COPD and improve diagnosis and treatment should focus on ethnic minority communities, and those with low education levels, low annual household incomes, and poor access to medical services.
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http://dx.doi.org/10.1186/s12889-020-08687-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169015PMC
April 2020

Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics.

Proc Natl Acad Sci U S A 2020 02 23;117(6):2835-2845. Epub 2020 Jan 23.

Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721;

Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research.
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http://dx.doi.org/10.1073/pnas.1920073117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022161PMC
February 2020

Human Papillomavirus (HPV) Vaccine Uptake and the Willingness to Receive the HPV Vaccination among Female College Students in China: A Multicenter Study.

Vaccines (Basel) 2020 Jan 16;8(1). Epub 2020 Jan 16.

Department of Epidemiology, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315200, China.

Background: This study aimed to determine human papillomavirus (HPV) vaccine uptake and willingness to receive HPV vaccination among female college students, in China, and its associated factors.

Methods: An online cross-sectional survey of female college students across the eastern, central, and western regions of China was undertaken between April and September 2019. Partial least squares structural equation modeling (PLS-SEM) was used to examine factors associated with the HPV vaccine uptake and willingness to receive the HPV vaccine.

Results: Among the total 4220 students who participated in this study, 11.0% reported having been vaccinated against HPV. There are direct effects of indicators of higher socioeconomic status, older age (β = 0.084 and p = 0.006), and geographical region (residing in Eastern China, β = 0.033, and p = 0.024) on HPV vaccine uptake. Higher knowledge (β = 0.062 and p < 0.000) and perceived susceptibility (β = 0.043 and p = 0.002) were also predictors of HPV vaccine uptake. Of those who had not received the HPV vaccine, 53.5% expressed a willingness to do so. Likewise, social economic status indicators were associated with the willingness to receive the HPV vaccine. Total knowledge score (β = 0.138 and < 0.001), both perceived susceptibility (β = 0.092 and < 0.001) and perceived benefit (β = 0.088 and < 0.001), and sexual experience (β = 0.041 and = 0.007) had a positive and significant direct effect on the willingness to receive the HPV vaccine, while perceived barriers (β = -0.071 and < 0.001) had a negative effect on the willingness to receive the HPV vaccine.

Conclusions: Geographical region and socioeconomic disparities in the HPV vaccination uptake rate and willingness to receive the HPV vaccine provide valuable information for public health planning that aims to improve vaccination rates in underserved areas in China. The influence of knowledge and perceptions of HPV vaccination suggests the importance of communication for HPV immunization.
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http://dx.doi.org/10.3390/vaccines8010031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157221PMC
January 2020

Ethnic disparities in prevalence and patterns of smoking and nicotine dependence in rural southwest China: a cross-sectional study.

BMJ Open 2019 09 20;9(9):e028770. Epub 2019 Sep 20.

School of Public Health, Kunming Medical University in Kunming, Kunming, China

Objectives: This study examines ethnic disparities in prevalence and patterns of smoking and nicotine dependence in rural southwest China.

Design: This was a cross-sectional design.

Setting: This study was conducted in rural Yunnan Province of China.

Participants: 7027 consenting individuals aged ≥35 years among Han majority and four ethnic minority groups (Na Xi, Li Shu, Dai and Jing Po) participated in this study. Information about participants' demographic characteristics as well as smoking habits and an assessment of nicotine dependence with the Fagerstrom Test for Nicotine Dependence (FTND) was obtained using a standard questionnaire.

Results: Males had significantly higher prevalence of current smoking than females (64.8% and 44.4%, p<0.01). Among current smokers, the prevalence of nicotine dependence was significantly higher in males compared with females (19.9% and 7.1%, p<0.01). Jing Po men and women had the highest prevalence of current smokers (72.2% vs 23.1%, p<0.01), whereas the highest prevalence of nicotine dependence was found in male Dai current smokers and female Li Shu current smokers (44.8% vs 32.5%, p<0.01). Filtered cigarettes were the most popular form of tobacco used across all five ethnic groups. Over 75% of tobacco users initiated smoking and regularly smoked during adolescence, and those of minority ethnicity smoked regularly at a younger age than those of Han descent (p<0.05). Individuals in all five ethnic groups with higher levels of education had a lower probability of current smoking status (p<0.05), whereas a negative association of level of education with nicotine dependence was only observed in current smokers in the Han majority and Dai ethnic minority groups. Among Han majority current smokers, higher annual household income was associated with a higher risk of nicotine dependence (p<0.05).

Conclusion: Future interventions to control tobacco use should be tailored to address ethnicity and socioeconomic factors.
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http://dx.doi.org/10.1136/bmjopen-2018-028770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756462PMC
September 2019

Short-Term Trends in Economic Burden and Catastrophic Costs of Type 2 Diabetes Mellitus in Rural Southwest China.

J Diabetes Res 2019 1;2019:9626413. Epub 2019 Aug 1.

School of Public Health, Kunming Medical University, 1168 Yu Hua Street Chun Rong Road, Cheng Gong New City, Kunming 650500, China.

Objectives: This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China.

Materials And Methods: Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Province. A prevalence-based cost-of-illness method was used to estimate the cost of diabetes. Information about the participants' demographic characteristics and economic consequences of diabetes was obtained using a standard questionnaire. Fasting blood sugar levels were recorded for each study participant.

Results: During the study period, the overall prevalence of diabetes increased from 7.7% to 9.5% ( < 0.01) and the economic cost of diabetes increased 1.52-fold. The largest increases were observed in hospital costs (1.77-fold increase), while unit medication costs fell by 18.6%. Both in 2009 and in 2016, males had higher overall direct and indirect costs of diabetes than females ( < 0.05). Direct costs represented the largest component of economic cost of diabetes while hospital costs were the main drivers of direct medical expenditures, accounting for 66.2% of the total direct costs in 2009 and 75.9% in 2016. The incidence of household catastrophic health payment and household impoverishment due to diabetes was 24.0% and 17.9% in 2009 and 23.6% and 17.6% in 2016, respectively. These rates did not differ between the two survey years ( > 0.05).

Conclusions: The prevalence and economic burden of diabetes increased substantially from 2009 to 2016 in rural southwest China. The findings underscore an urgent need for the government to invest more financial resources in the prevention of diabetes and improvement of access to affordable medication in rural southwest China.
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http://dx.doi.org/10.1155/2019/9626413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701269PMC
January 2020

Ethnic disparities in prevalence and clustering of cardiovascular disease risk factors in rural Southwest China.

BMC Cardiovasc Disord 2019 08 19;19(1):200. Epub 2019 Aug 19.

Cheng Gong New City, School of Public Health, Kunming Medical University, 1168 Yu Hua Street Chun Rong Road, Kunming, 650500, China.

Background: This study examines how prevalence and clustering of cardiovascular disease (CVD) risk factors differ by ethnicity and socioeconomic status (SES) among rural southwest Chinese adults.

Methods: A cross-sectional survey of 7027 adults aged ≥35 years of Han and four ethnic minority group descent (Na Xi, Li Shu, Dai, and Jing Po) was used to derive prevalence of tobacco smoking and exposure to secondhand smoke (SHS) as well as alcohol consumption and physical activity data. Anthropometric measurements were also taken, including height, weight, and waist and hip circumference, as well as blood pressure (BP) and fasting blood glucose (FBG) measurements.

Results: Current smoking and drinking status were the top two CVD risk factors in the study population. Dai ethnic minority participants had the highest prevalence of hypertension, obesity, and central obesity, whereas Jing Po ethnic minority participants had the highest prevalence of current smoking status, SHS exposure, and current drinking status (P < 0.01). Han participants had the highest prevalence of diabetes and physical inactivity (P < 0.01). 11.1% of all participants did not have any of the studied CVD risk factors, while 68.6% of Han, 60.2% of Na Xi, 50.7% of Li Shu, 82.2% of Dai, and 73.0% of Jing Po participants had clustering of two or more CVD risk factors. Prevalence of CVD risk factor clusters increased with age (P < 0.01). Males and individuals with lower education levels and lower annual household income were more likely to have CVD risk factors than their counterparts (P < 0.01).

Conclusion: Clustering of CVD risk factors is common in rural southwest China. Ethnicity and individual SES significantly impact prevalence of CVD risk factors and their clustering.
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http://dx.doi.org/10.1186/s12872-019-1185-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701110PMC
August 2019

Socioeconomic disparities in prevalence and behaviors of smoking in rural Southwest China.

BMC Public Health 2019 Aug 14;19(1):1117. Epub 2019 Aug 14.

School of Public Health, Kunming Medical University, 1168 Yu Hua Street Chun Rong Road, Cheng Gong New City, Kunming, 650500, China.

Background: This study examines how prevalence and behaviors of smoking differ by socioeconomic status among rural southwest Chinese adults.

Methods: A cross-sectional survey was conducted including 7743 adults aged ≥35 years in rural regions of Yunnan Province, China from 2016 to 2018. Information on individual socioeconomic status (SES), ethnicity, and self-reported smoking behaviors was collected utilizing a standardized questionnaire. The individual socioeconomic position (SEP) index was constructed using principal component analysis. Multivariate logistic regression models were used to analyze the association between individual SES variables and the prevalence and behaviors of smoking.

Results: In the study population, the overall prevalence rate of current smokers was 33.5%. Males had a markedly higher prevalence of current smokers than females (62.6% vs. 4.8%, P < 0.01). Of these smokers, 74.5% began smoking during adolescence, 88.8% had never attempted to quit smoking, and 81.1% reported smoking in public places. Ethnic minority participants and those with low levels of education and/or low SEP were more likely to use tobacco as well as more likely to start smoking, and regularly smoke, during adolescence (P < 0.01). Participants with poor access to medical services had a higher prevalence of current smoking than their counterparts (P < 0.01). Among current smokers, Han ethnicity, good access to medical services, and high SEP were positively associated with the probability of having attempted to quit smoking at least once, while a high level of education and high SEP were negatively associated with the probability of smoking in public places.

Conclusions: Disparities in prevalence and behaviors of smoking exist across a diversity of indicators of individual SES in rural southwest China. Future tobacco cessation interventions should focus on men, ethnic minorities, and those with low education levels, poor access to medical services, and low SEP.
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http://dx.doi.org/10.1186/s12889-019-7455-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694669PMC
August 2019

Primary Nucleation-Dominated Chemical Vapor Deposition Growth for Uniform Graphene Monolayers on Dielectric Substrate.

J Am Chem Soc 2019 Jul 5;141(28):11004-11008. Epub 2019 Jul 5.

Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , People's Republic of China.

Direct chemical vapor deposition growth of high quality graphene on dielectric substrates holds great promise for practical applications in electronics and optoelectronics. However, graphene growth on dielectrics always suffers from the issues of inhomogeneity and/or poor quality. Here, we first reveal that a novel precursor-modification strategy can successfully suppress the secondary nucleation of graphene to evolve ultrauniform graphene monolayer film on dielectric substrates. A mechanistic study indicates that the hydroxylation of silica substrate weakens the binding between graphene edges and substrate, thus realizing the primary nucleation-dominated growth. Field-effect transistors based on the graphene films show exceptional electrical performance with the charge carrier mobility up to 3800 cm V s in air, which is much higher than those reported results of graphene films grown on dielectrics.
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http://dx.doi.org/10.1021/jacs.9b05705DOI Listing
July 2019

(-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from .

Nat Prod Res 2021 Mar 10;35(5):763-769. Epub 2019 May 10.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Kunming, 650091, PR China.

A new dibenzopyrrocoline alkaloid, (-)-grandifloramine (), together with five known ones, actinodaphnine (), -methyllaurotetanine (), boldine (), lindcarpine (), and (+)-norboldine (), were isolated from W. W. Sm. et J. F. Jeff. The structure of was identified by HRESIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound and exhibited the moderate inhibitory activity against acetylcholinesterase and showed moderate butyrylcholinesterase inhibitory activity. This is the first report of the chemical constituents of .
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http://dx.doi.org/10.1080/14786419.2019.1608542DOI Listing
March 2021

Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum.

Fitoterapia 2019 Jun 23;135:1-4. Epub 2019 Mar 23.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address:

Two novel 8,15-seco C-diterpenoid alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C-diterpenoid alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC values of 72.63 ± 0.39 μM and 52.98 ± 0.50 μM, respectively.
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http://dx.doi.org/10.1016/j.fitote.2019.03.021DOI Listing
June 2019
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