Lawrence L Rudel

Lawrence L Rudel

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Lawrence L Rudel

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Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells.

Sci Rep 2017 06 23;7(1):4163. Epub 2017 Jun 23.

Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, 108-8641, Japan.

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http://dx.doi.org/10.1038/s41598-017-04177-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482845PMC
June 2017

Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss.

Lipids 2016 Feb 4;51(2):151-7. Epub 2016 Jan 4.

Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s11745-015-4116-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221701PMC
February 2016

PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.

J Pharmacol Exp Ther 2015 Nov 17;355(2):159-67. Epub 2015 Aug 17.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas (A.M.L., J-C.C., K.S.P., S.D.T.); Graduate School of Pharmaceutical Science, Kitasato University, Tokyo, Japan (T.O., H.T.); and Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina (T.O., L.L.R.)

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22720
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http://dx.doi.org/10.1124/jpet.115.227207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613965PMC
November 2015

New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.

J Pharmacol Exp Ther 2015 Nov 3;355(2):299-307. Epub 2015 Sep 3.

Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan (T.O., M.O., T.N., D.M., H.T.); Department of Medicine, Jichi Medical University, Tochigi, Japan (T.O., H.Y., S.I.); and Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina (T.O., M.A.D., L.L.R.)

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22734
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http://dx.doi.org/10.1124/jpet.115.227348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613958PMC
November 2015

Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.

Arterioscler Thromb Vasc Biol 2015 Sep 30;35(9):1920-7. Epub 2015 Jul 30.

From the Department of Pathology, Section on Lipid Sciences (J.T.M., K.L.K., M.D.W., J.K.S., L.L.R.), and Department of Radiology, Center for Biomolecular Imaging (J.D.O., K.M.L.), Wake Forest University Health Sciences, Winston-Salem, NC.

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http://dx.doi.org/10.1161/ATVBAHA.115.305747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552612PMC
September 2015

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

PLoS One 2014 5;9(6):e98953. Epub 2014 Jun 5.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America; Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047063PMC
July 2015

High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans.

Atherosclerosis 2015 Feb 9;238(2):231-8. Epub 2014 Dec 9.

Department of Biochemistry Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346138PMC
February 2015

Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs.

J Lipid Res 2014 Nov 16;55(11):2261-75. Epub 2014 Jul 16.

Departments of Cell Biology and Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11203 Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209.

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http://dx.doi.org/10.1194/jlr.M047951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617129PMC
November 2014

Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.

Circ Res 2014 Oct 19;115(10):826-33. Epub 2014 Sep 19.

From the Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC (J.Z., J.K.S., S.M.M., K.L.K., M.A.D., M.D.W., L.L.R.); and Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, OH (S.M.M., J.M.B.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.30437
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http://dx.doi.org/10.1161/CIRCRESAHA.115.304378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209196PMC
October 2014

Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice.

PLoS One 2014 3;9(1):e84418. Epub 2014 Jan 3.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America ; Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880293PMC
September 2014

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.

Arterioscler Thromb Vasc Biol 2014 Sep 17;34(9):1917-23. Epub 2014 Jul 17.

From the Children's Hospital Oakland Research Institute, CA (M.W.M., F.B., D.N., E.T., K.S., R.M.K.); Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany (J.S., H.R.); Sage Bionetworks, Seattle, WA (L.M.M.); Section on Lipid Sciences, Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC (L.L.R., R.E.T.); and Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany (C.S., H.R.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141484PMC
September 2014

LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.

J Lipid Res 2013 Sep 26;54(9):2495-503. Epub 2013 Jun 26.

Department of Pathology, Section of Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M039644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735946PMC
September 2013

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.

Bioorg Med Chem Lett 2013 Jul 8;23(13):3798-801. Epub 2013 May 8.

Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo 108-8641, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2013.04.075DOI Listing
July 2013

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.

Bioorg Med Chem Lett 2013 May 6;23(9):2659-62. Epub 2013 Mar 6.

Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo 108 8641, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2013.02.088DOI Listing
May 2013

Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.

Am J Pathol 2013 Apr 1;182(4):1131-8. Epub 2013 Feb 1.

Section on Lipid Sciences, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130002
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http://dx.doi.org/10.1016/j.ajpath.2012.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620394PMC
April 2013

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.

Bioorg Med Chem Lett 2013 Mar 9;23(5):1285-7. Epub 2013 Jan 9.

Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2012.12.099DOI Listing
March 2013

ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity.

Arterioscler Thromb Vasc Biol 2013 Jan 8;33(1):4-12. Epub 2012 Nov 8.

Marc and Ruti Bell Vascular Biology and Disease Research Program of the Leon H. Charney Division of Cardiology and the Department of Medicine (Cardiology), New York University School of Medicine, Smilow 7, 522 First Ave, New York, NY 10029, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.252056
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http://dx.doi.org/10.1161/ATVBAHA.112.252056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617493PMC
January 2013

Fatty acids in cardiovascular health and disease: a comprehensive update.

J Clin Lipidol 2012 May-Jun;6(3):216-34. Epub 2012 Apr 13.

Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.jacl.2012.04.077DOI Listing
September 2012

25(OH)D3 and cardiovascular risk factors in female nonhuman primates.

J Womens Health (Larchmt) 2012 Sep 9;21(9):959-65. Epub 2012 Aug 9.

Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1089/jwh.2011.3416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482874PMC
September 2012

Letter to the editor.

Authors:
Lawrence L Rudel

J Clin Lipidol 2011 Nov-Dec;5(6):500. Epub 2011 Jun 30.

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https://linkinghub.elsevier.com/retrieve/pii/S19332874110061
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http://dx.doi.org/10.1016/j.jacl.2011.06.008DOI Listing
March 2012

Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.

Arterioscler Thromb Vasc Biol 2011 May 10;31(5):1108-15. Epub 2011 Mar 10.

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

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http://dx.doi.org/10.1161/ATVBAHA.111.223552DOI Listing
May 2011

Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake.

PLoS One 2011 Apr 29;6(4):e19420. Epub 2011 Apr 29.

Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084847PMC
April 2011

Dietary monounsaturated fatty acids appear not to provide cardioprotection.

Curr Atheroscler Rep 2010 Nov;12(6):391-6

Department of Translational Pharmacology, Consorzio Mario Negri Sud, via Nazionale 8/A, 66030, S. Maria Imbaro, CH, Italy.

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http://dx.doi.org/10.1007/s11883-010-0133-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995267PMC
November 2010

Dietary n-3 LCPUFA from fish oil but not alpha-linolenic acid-derived LCPUFA confers atheroprotection in mice.

J Lipid Res 2010 Jul 11;51(7):1897-905. Epub 2010 Feb 11.

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M005058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882748PMC
July 2010

Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery.

Curr Opin Lipidol 2010 Jun;21(3):192-7

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.

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http://dx.doi.org/10.1097/MOL.0b013e32833854acDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099527PMC
June 2010

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome.

Curr Opin Lipidol 2009 Oct;20(5):379-85

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.

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http://dx.doi.org/10.1097/MOL.0b013e32832fa5c4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099529PMC
October 2009

Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys.

Arterioscler Thromb Vasc Biol 2009 Oct;29(10):1471-7

Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.191825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763273PMC
October 2009

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.

J Lipid Res 2009 May 13;50(5):915-23. Epub 2009 Jan 13.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M800631-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666178PMC
May 2009

LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat.

J Lipid Res 2009 Apr 22;50 Suppl:S434-9. Epub 2008 Nov 22.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem NC 27157, USA.

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http://dx.doi.org/10.1194/jlr.R800076-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674687PMC
April 2009

Concerns regarding lipoprotein particle measurement by ion mobility analysis.

Clin Chem 2008 Dec;54(12):2086-7; author reply 2088-9

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http://dx.doi.org/10.1373/clinchem.2008.113795DOI Listing
December 2008

Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species.

J Antibiot (Tokyo) 2008 Sep;61(9):568-72

School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

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http://www.nature.com/articles/ja200876
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http://dx.doi.org/10.1038/ja.2008.76DOI Listing
September 2008

Identification of putative active site residues of ACAT enzymes.

J Lipid Res 2008 Aug 13;49(8):1770-81. Epub 2008 May 13.

Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040, USA.

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http://www.jlr.org/content/49/8/1770.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M800131-JLR200
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http://dx.doi.org/10.1194/jlr.M800131-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444009PMC
August 2008

Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition.

J Biol Chem 2008 Jul 22;283(29):19967-80. Epub 2008 May 22.

Department of Anatomy and Cell Biology and Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M800398200
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http://dx.doi.org/10.1074/jbc.M800398200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459284PMC
July 2008

In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids.

J Biol Chem 2008 Jun 30;283(26):18441-9. Epub 2008 Apr 30.

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1074/jbc.M802107200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440608PMC
June 2008

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

J Biol Chem 2008 Apr 14;283(16):10522-34. Epub 2008 Feb 14.

Department of Pathology, Biochemistry, and Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.

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http://dx.doi.org/10.1074/jbc.M707659200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447638PMC
April 2008

Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.

J Biol Chem 2008 Apr 19;283(16):10453-60. Epub 2008 Feb 19.

Department of Biochemistry, Section on Lipid Science, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157-1040, USA.

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http://dx.doi.org/10.1074/jbc.M709460200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447654PMC
April 2008

Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients.

J Lipid Res 2008 Feb 15;49(2):464-72. Epub 2007 Nov 15.

Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, 200025 Shanghai, China.

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http://dx.doi.org/10.1194/jlr.M700295-JLR200DOI Listing
February 2008

Mechanisms by which botanical lipids affect inflammatory disorders.

Am J Clin Nutr 2008 Feb;87(2):498S-503S

Center for Botanical Lipids, Wake Forest University, Winston Salem, NC, USA.

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http://dx.doi.org/10.1093/ajcn/87.2.498SDOI Listing
February 2008

Monounsaturated fatty acids and atherosclerosis: opposing views from epidemiology and experimental animal models.

Curr Atheroscler Rep 2007 Dec;9(6):494-500

Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA.

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December 2007

Diet effects on atherosclerosis in mice.

Curr Drug Targets 2007 Nov;8(11):1150-60

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.2174/138945007782403847DOI Listing
November 2007

CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells.

J Lipid Res 2007 Oct 30;48(10):2295-305. Epub 2007 Jul 30.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M700279-JLR200
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http://dx.doi.org/10.1194/jlr.M700279-JLR200DOI Listing
October 2007

Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice.

J Clin Invest 2007 Oct;117(10):2983-92

Department of Internal Medicine and Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI30485
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http://dx.doi.org/10.1172/JCI30485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978419PMC
October 2007

NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells.

Biochem J 2007 Sep;406(2):273-83

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1040, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/BJ20070168
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http://dx.doi.org/10.1042/BJ20070168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948962PMC
September 2007

ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins.

J Lipid Res 2007 Jul 16;48(7):1618-27. Epub 2007 Apr 16.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M700109-JLR200
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http://dx.doi.org/10.1194/jlr.M700109-JLR200DOI Listing
July 2007

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.

J Clin Invest 2007 Jul;117(7):1968-78

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.

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http://dx.doi.org/10.1172/JCI30060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888567PMC
July 2007

Characterization and heritability of obesity and associated risk factors in vervet monkeys.

Obesity (Silver Spring) 2007 Jul;15(7):1666-74

Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1038/oby.2007.199DOI Listing
July 2007

Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys.

Obesity (Silver Spring) 2007 Jul;15(7):1675-84

Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1038/oby.2007.200DOI Listing
July 2007

Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.

Arterioscler Thromb Vasc Biol 2007 Jun 12;27(6):1396-402. Epub 2007 Apr 12.

Wake Forest University School of Medicine, Department of Pathology/Lipid Sciences, Medical Center Blvd, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.142802DOI Listing
June 2007

Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.

J Lipid Res 2007 May 4;48(5):1122-31. Epub 2007 Feb 4.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1194/jlr.M600526-JLR200DOI Listing
May 2007

Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes.

J Antibiot (Tokyo) 2007 Jan;60(1):43-51

Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

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http://dx.doi.org/10.1038/ja.2007.6DOI Listing
January 2007

Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers.

J Org Chem 2006 Sep;71(20):7643-9

Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.

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http://pubs.acs.org/doi/abs/10.1021/jo0611667
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http://dx.doi.org/10.1021/jo0611667DOI Listing
September 2006

Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.

Arterioscler Thromb Vasc Biol 2006 Aug 4;26(8):1814-20. Epub 2006 May 4.

Department of Pathology, Section on Lipid Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1161/01.ATV.0000225289.30767.06DOI Listing
August 2006

ACAT inhibition and the progression of coronary atherosclerosis.

N Engl J Med 2006 Jun;354(24):2616-7; author reply 2616-7

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http://dx.doi.org/10.1056/NEJMc061094DOI Listing
June 2006

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake.

J Biol Chem 2006 Mar 30;281(10):6616-24. Epub 2005 Dec 30.

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M511123200
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http://dx.doi.org/10.1074/jbc.M511123200DOI Listing
March 2006

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

J Lipid Res 2005 Nov 8;46(11):2423-31. Epub 2005 Sep 8.

Department of Pathology, Section on Lipid Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M500232-JLR200DOI Listing
November 2005

Redistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading.

J Lipid Res 2005 Oct 16;46(10):2114-21. Epub 2005 Jul 16.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298-0050, USA.

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http://dx.doi.org/10.1194/jlr.M500207-JLR200DOI Listing
October 2005

A role for the pregnane X receptor in high-density lipoprotein metabolism.

Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2016-7

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http://dx.doi.org/10.1161/01.ATV.0000186042.94668.2bDOI Listing
October 2005

Control of ACAT2 liver expression by HNF1.

J Lipid Res 2005 Sep 16;46(9):1868-76. Epub 2005 Jun 16.

Metabolism Unit, Center for Metabolism and Endocrinology, NOVUM, Karolinska Institutet at Karolinska University Hospital in Huddinge, S-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.M400450-JLR200DOI Listing
September 2005

ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.

J Lipid Res 2005 Jun 1;46(6):1205-12. Epub 2005 Apr 1.

Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M500018-JLR200DOI Listing
June 2005

ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia.

Arterioscler Thromb Vasc Biol 2005 Jun 14;25(6):1112-8. Epub 2005 Apr 14.

Lipid Sciences Research Program, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000166548.65
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June 2005

Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys.

J Lipid Res 2005 May 16;46(5):1009-16. Epub 2005 Feb 16.

Department of Pathology/Comparative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.

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May 2005

Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin.

Clin Cancer Res 2004 Dec;10(24):8275-83

Department of Pathology, Wake Forest University, School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1357DOI Listing
December 2004

Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.

Circ Res 2004 Nov 14;95(10):998-1004. Epub 2004 Oct 14.

Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1161/01.RES.0000147558.15554.67DOI Listing
November 2004

ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.

Circulation 2004 Oct 27;110(14):2017-23. Epub 2004 Sep 27.

Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, Novum, Karolinska Institute at Huddinge University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1161/01.CIR.0000143163.76212.0BDOI Listing
October 2004

Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness.

J Lipid Res 2004 Feb 16;45(2):378-86. Epub 2003 Nov 16.

Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.D300037-JLR200DOI Listing
February 2004

Associations of low density lipoprotein particle composition with atherogenicity.

Curr Opin Lipidol 2004 Feb;15(1):19-24

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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February 2004

Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression.

J Lipid Res 2003 Dec 1;44(12):2331-8. Epub 2003 Sep 1.

Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1194/jlr.M300224-JLR200DOI Listing
December 2003

Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.

J Biol Chem 2003 Nov 15;278(48):47594-601. Epub 2003 Sep 15.

Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M308235200DOI Listing
November 2003

Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase.

J Lipid Res 2003 Oct 1;44(10):1833-40. Epub 2003 Jul 1.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298-0050, USA.

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http://dx.doi.org/10.1194/jlr.M300162-JLR200DOI Listing
October 2003

Effects of LDL enriched with different dietary fatty acids on cholesteryl ester accumulation and turnover in THP-1 macrophages.

J Lipid Res 2003 Apr 16;44(4):770-9. Epub 2003 Jan 16.

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1194/jlr.M200431-JLR200DOI Listing
April 2003

Is there a need for cholesteryl ester transfer protein inhibition?

Arterioscler Thromb Vasc Biol 2003 Mar;23(3):374-5

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http://dx.doi.org/10.1161/01.ATV.0000060447.25136.1CDOI Listing
March 2003

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.

Proc Natl Acad Sci U S A 2003 Feb 21;100(3):1262-7. Epub 2003 Jan 21.

Gladstone Institute of Cardiovascular Disease, P. O. Box 419100, San Francisco, CA 94141-9100, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0336398100
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http://dx.doi.org/10.1073/pnas.0336398100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298761PMC
February 2003

Dietary monounsaturated versus polyunsaturated fatty acids: which is really better for protection from coronary heart disease?

Curr Opin Lipidol 2003 Feb;14(1):41-6

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1097/01.mol.0000052854.26236.29DOI Listing
February 2003

Alpha-tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits.

J Lipid Res 2002 Nov;43(11):1927-38

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.m200261-jlr200DOI Listing
November 2002

Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not.

J Biol Chem 2002 Aug 21;277(35):31401-6. Epub 2002 Jun 21.

Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M204106200DOI Listing
August 2002

Preclinical and clinical pharmacology of a new class of lipid management agents.

Authors:
Lawrence L Rudel

Am J Manag Care 2002 Feb;8(2 Suppl):S33-5; discussion S45-7

Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

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February 2002