Lawrence Kazak

Lawrence Kazak

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Lawrence Kazak

Lawrence Kazak

Publications by authors named "Lawrence Kazak"

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mTOR as a central regulator of lifespan and aging.

F1000Res 2019 2;8. Epub 2019 Jul 2.

Département de Biochimie et Médecine Moléculaire, Université de Montréal, CP 6128, Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.12688/f1000research.17196.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156PMC
July 2019

New Advances in Adaptive Thermogenesis: UCP1 and Beyond.

Cell Metab 2019 01 29;29(1):27-37. Epub 2018 Nov 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.11.002DOI Listing
January 2019

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication.

Nucleic Acids Res 2018 11;46(20):10771-10781

Department of Clinical Movement Neurosciences, Institute of Neurology, Royal Free Campus, University College London, London NW3 2PF, UK.

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http://dx.doi.org/10.1093/nar/gky852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237803PMC
November 2018

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Cell Metab 2018 10 2;28(4):631-643.e3. Epub 2018 Aug 2.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183044
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http://dx.doi.org/10.1016/j.cmet.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170693PMC
October 2018

Bioenergetic Analyses in Adipose Tissue.

Authors:
Lawrence Kazak

Methods Mol Biol 2017 ;1566:125-134

Dana-Faber Cancer Institute, Harvard Medical School, Cancer Biology CLS 111146, 3 Blackfan Circle, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-6820-6_12DOI Listing
February 2018

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.

J Biol Chem 2017 10 24;292(41):16810-16816. Epub 2017 Aug 24.

From the Dana-Farber Cancer Institute, Harvard Medical School and

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http://dx.doi.org/10.1074/jbc.R117.789628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641863PMC
October 2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Cell Metab 2017 Oct 24;26(4):660-671.e3. Epub 2017 Aug 24.

Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629120PMC
October 2017

Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.

Mitochondrion 2017 Jan 11;32:31-35. Epub 2016 Nov 11.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2016.11.001DOI Listing
January 2017

Analysis of Replicating Mitochondrial DNA by In Organello Labeling and Two-Dimensional Agarose Gel Electrophoresis.

Methods Mol Biol 2016 ;1351:95-113

MRC-Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1007/978-1-4939-3040-1_8DOI Listing
September 2016

A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

Cell 2015 Oct 22;163(3):643-55. Epub 2015 Oct 22.

Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656041PMC
October 2015

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

Nature 2014 Sep 13;513(7516):100-4. Epub 2014 Jul 13.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature13528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224962PMC
September 2014

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Cell 2014 Jul;158(1):69-83

Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116691PMC
July 2014

Fat cells directly sense temperature to activate thermogenesis.

Proc Natl Acad Sci U S A 2013 Jul 1;110(30):12480-5. Epub 2013 Jul 1.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1310261110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725077PMC
July 2013

Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts.

Nucleic Acids Res 2013 Jun 16;41(11):5837-50. Epub 2013 Apr 16.

MRC-Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/nar/gkt196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675460PMC
June 2013

Alternative translation initiation augments the human mitochondrial proteome.

Nucleic Acids Res 2013 Feb 28;41(4):2354-69. Epub 2012 Dec 28.

MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/nar/gks1347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575844PMC
February 2013

Minimizing the damage: repair pathways keep mitochondrial DNA intact.

Nat Rev Mol Cell Biol 2012 Oct 20;13(10):659-71. Epub 2012 Sep 20.

MRC-Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, UK.

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http://dx.doi.org/10.1038/nrm3439DOI Listing
October 2012

Effects of endurance training on apoptotic susceptibility in striated muscle.

J Appl Physiol (1985) 2011 Jun 7;110(6):1638-45. Epub 2011 Apr 7.

School of Kinesiology and Health Science, York Univ., Toronto, Ontario M3J 1P3, Canada.

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http://dx.doi.org/10.1152/japplphysiol.00020.2011DOI Listing
June 2011