Lawrence E Heisler

Lawrence E Heisler

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Lawrence E Heisler

Lawrence E Heisler

Publications by authors named "Lawrence E Heisler"

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32Publications

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The Paf1 Complex Broadly Impacts the Transcriptome of .

Genetics 2019 07 15;212(3):711-728. Epub 2019 May 15.

Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260

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http://dx.doi.org/10.1534/genetics.119.302262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614894PMC
July 2019

The Proteogenomic Landscape of Curable Prostate Cancer.

Cancer Cell 2019 03;35(3):414-427.e6

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Human Genetics, University of California, 12-109 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, CA 90024, USA; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA 90024, USA; Institute for Precision Health, University of California, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511374PMC
March 2019

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.

Cell 2018 05 19;173(4):1003-1013.e15. Epub 2018 Apr 19.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.029DOI Listing
May 2018

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

Nat Commun 2015 Dec 9;6:10001. Epub 2015 Dec 9.

CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncomms10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682041PMC
December 2015

A genome scale overexpression screen to reveal drug activity in human cells.

Genome Med 2014 29;6(4):32. Epub 2014 Apr 29.

Department of Molecular Genetics, University of Toronto, Toronto, M5S 3E1, Canada ; Banting and Best Department of Medical Research, University of Toronto, Toronto, M5S 3E1, Canada ; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada ; Donnelly Sequencing Center, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada ; Department of Pharmaceutical Sciences, University of British Columbia, 6619-2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1186/gm549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062067PMC
June 2014

CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor.

Biochem Biophys Res Commun 2014 Mar 19;445(4):746-56. Epub 2014 Feb 19.

Donnelly Centre, University of Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X140028
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http://dx.doi.org/10.1016/j.bbrc.2014.02.033DOI Listing
March 2014

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

G3 (Bethesda) 2013 Aug 7;3(8):1375-87. Epub 2013 Aug 7.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/g3.113.006437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737177PMC
August 2013

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation.

Mol Cell Biol 2013 Jan 29;33(1):170-82. Epub 2012 Oct 29.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.01233-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536304PMC
January 2013

Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents.

ACS Chem Biol 2012 Nov 5;7(11):1892-901. Epub 2012 Sep 5.

Department of Molecular Genetics and the Donnelly Centre, University of Toronto, Toronto, ON, M5S3E1 Canada.

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http://dx.doi.org/10.1021/cb300320dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500413PMC
November 2012

Multiple means to the same end: the genetic basis of acquired stress resistance in yeast.

PLoS Genet 2011 Nov 10;7(11):e1002353. Epub 2011 Nov 10.

Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213159PMC
November 2011

Competitive genomic screens of barcoded yeast libraries.

J Vis Exp 2011 Aug 11(54). Epub 2011 Aug 11.

Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, Canada.

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http://www.jove.com/details.php?id=2864
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http://dx.doi.org/10.3791/2864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211125PMC
August 2011

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

Nucleic Acids Res 2010 Jul 11;38(13):e142. Epub 2010 May 11.

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1093/nar/gkq368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910071PMC
July 2010

Genotype to phenotype: a complex problem.

Science 2010 Apr;328(5977):469

Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1189015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412269PMC
April 2010

Quantitative phenotyping via deep barcode sequencing.

Genome Res 2009 Oct 21;19(10):1836-42. Epub 2009 Jul 21.

Department of Molecular Genetics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1101/gr.093955.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765281PMC
October 2009

A comparative analysis of DNA barcode microarray feature size.

BMC Genomics 2009 Oct 13;10:471. Epub 2009 Oct 13.

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1186/1471-2164-10-471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765990PMC
October 2009

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.

Nat Methods 2008 Aug 11;5(8):719-25. Epub 2008 Jul 11.

Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

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http://www.nature.com/articles/nmeth.1231
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http://dx.doi.org/10.1038/nmeth.1231DOI Listing
August 2008

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

PLoS Genet 2008 Aug 8;4(8):e1000151. Epub 2008 Aug 8.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483942PMC
August 2008

Genomic DNA functions as a universal external standard in quantitative real-time PCR.

Nucleic Acids Res 2006 Jul 13;34(12):e85. Epub 2006 Jul 13.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1093/nar/gkl400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524913PMC
July 2006