Lawrence Corey

Lawrence Corey

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Lawrence Corey

Lawrence Corey

Publications by authors named "Lawrence Corey"

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100Publications

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A Fixed Spatial Structure of CD8 T Cells in Tissue during Chronic HSV-2 Infection.

J Immunol 2018 Sep 25;201(5):1522-1535. Epub 2018 Jul 25.

Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

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September 2018

Weighing the Evidence of Efficacy of Oral PrEP for HIV Prevention in Women in Southern Africa.

AIDS Res Hum Retroviruses 2018 Aug 19;34(8):645-656. Epub 2018 Jun 19.

10 Perinatal HIV Research Unit, University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital , Johannesburg, South Africa .

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August 2018

Adoptive Immunotherapy of Viral Infections: Should Infectious Disease Embrace Cellular Immunotherapy?

J Infect Dis 2017 Nov;216(8):926-928

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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November 2017

Prospective cohort study showing persistent HSV-2 shedding in women with genital herpes 2 years after acquisition.

Sex Transm Infect 2017 Nov 25. Epub 2017 Nov 25.

Department of Medicine, University of Washington, Seattle, Washington, USA.

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November 2017

Broadly neutralizing antibodies to prevent HIV-1.

Science 2017 10;358(6359):46-47

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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October 2017

Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa.

PLoS One 2016 10;11(6):e0155124. Epub 2016 Jun 10.

Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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July 2017

Valganciclovir for the Suppression of Epstein-Barr Virus Replication.

J Infect Dis 2017 07;216(2):198-202

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.

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July 2017

Preventing acquisition of HIV is the only path to an AIDS-free generation.

Proc Natl Acad Sci U S A 2017 04 30;114(15):3798-3800. Epub 2017 Mar 30.

South African Medical Research Council, Cape Town 7500, South Africa.

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April 2017

Herpes Simplex Virus Type 1 Shedding in Tears and Nasal and Oral Mucosa of Healthy Adults.

Sex Transm Dis 2016 12;43(12):756-760

From the *Department of Medicine, University of Washington, Seattle, WA; †The Aboriginal and Torres Strait Islander Health Program, Kirby Institute, Sydney, Australia; ‡Department of Laboratory Medicine, §Department of Biostatistics, University of Washington; ¶Infectious Disease Division, Fred Hutchinson Cancer Research Center; and ∥Department of Epidemiology, University of Washington, Seattle, WA.

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December 2016

No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.

J Infect Dis 2016 07 7;214(2):258-64. Epub 2016 Apr 7.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center Department of Laboratory Medicine Department of Medicine, University of Washington, Seattle.

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July 2016

In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation.

J Infect Dis 2016 07 25;214(1):23-31. Epub 2016 Apr 25.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center Department of Laboratory Medicine Department of Medicine.

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July 2016

Approaches to preventative and therapeutic HIV vaccines.

Curr Opin Virol 2016 04 15;17:104-109. Epub 2016 Mar 15.

HIV Vaccine Clinical Trials Network, Fred Hutchinson Cancer Research Centre, Seattle, USA; Department of Medicine, University of Washington, Seattle, USA; Department of Laboratory Medicine, University of Washington, Seattle, USA.

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April 2016

Genital Herpes Simplex Virus Type 2 Shedding Among Adults With and Without HIV Infection in Uganda.

J Infect Dis 2016 Feb 20;213(3):439-47. Epub 2015 Oct 20.

Department of Medicine Department of Laboratory Medicine Department of Epidemiology Division of Vaccine and Infectious Disease.

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February 2016

Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding.

Clin Microbiol Rev 2016 Jan;29(1):149-61

Department of Medicine, University of Washington, Seattle, Washington, USA Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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January 2016

Are Clade Specific HIV Vaccines a Necessity? An Analysis Based on Mathematical Models.

EBioMedicine 2015 Dec 5;2(12):2062-9. Epub 2015 Nov 5.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 1100 Fairview Ave. N., PO Box 19024, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 1100 Fairview Ave. N., PO Box 19024, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA, 1959 NE Pacific St, Box 357155, Seattle, WA 98195, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, 1959 NE Pacific St, Box 357155, Seattle, WA 98195, USA.

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December 2015

Immune correlates of vaccine protection against HIV-1 acquisition.

Sci Transl Med 2015 Oct;7(310):310rv7

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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October 2015

Image analysis for accurately counting CD4+ and CD8+ T cells in human tissue.

J Virol Methods 2015 Sep 12;222:117-21. Epub 2015 Jun 12.

Department of Laboratory Medicine, RR-512 Health Sciences Building, University of Washington, Box 356420, 1959 NE Pacific Street, Seattle, WA 98195, USA; Vaccine and Infectious Disease Division, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue N, PO Box 19024, Seattle, WA 98109, USA.

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September 2015

Reduced Mortality of Cytomegalovirus Pneumonia After Hematopoietic Cell Transplantation Due to Antiviral Therapy and Changes in Transplantation Practices.

Clin Infect Dis 2015 Jul 16;61(1):31-9. Epub 2015 Mar 16.

Division of Vaccine and Infectious Disease Division of Clinical Research Department of Medicine, University of Washington, Seattle.

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July 2015

Plasma and cerebrospinal fluid herpes simplex virus levels at diagnosis and outcome of neonatal infection.

J Pediatr 2015 Apr 6;166(4):827-33. Epub 2014 Dec 6.

Department of Medicine, University of Washington, Seattle, WA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Epidemiology, University of Washington, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle, WA.

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April 2015

Reevaluating HIV vaccine clinical trials policy for infants.

J Infect Dis 2015 Feb 27;211(4):501-3. Epub 2014 Aug 27.

HIV Vaccine Trials Network, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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February 2015

Use of placebos in Phase 1 preventive HIV vaccine clinical trials.

Vaccine 2015 Feb 23;33(6):749-52. Epub 2014 Oct 23.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA.

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February 2015

Frequent genital HSV-2 shedding among women during labor in Soweto, South Africa.

Infect Dis Obstet Gynecol 2014 20;2014:258291. Epub 2014 May 20.

Department of Medicine, University of Washington, Seattle, WA, USA ; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA ; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA ; Department of Epidemiology, University of Washington, Seattle, WA, USA.

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September 2014

Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy.

J Clin Virol 2014 Jun 13;60(2):127-32. Epub 2014 Mar 13.

Department of Medicine, University of Washington, USA; Department of Laboratory Medicine, University of Washington, USA; Department of Epidemiology, University of Washington, USA; Department of Global Health, University of Washington, USA; Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Clinical Research Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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June 2014

Nuclear factor kappa B is required for the production of infectious human herpesvirus 8 virions.

Front Microbiol 2014 4;5:129. Epub 2014 Apr 4.

Molecular and Cellular Biology Program, University of Washington School of Medicine Seattle, WA, USA ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center Seattle, WA, USA ; Departments of Medicine, University of Washington School of Medicine Seattle, WA, USA ; Departments of Laboratory Medicine, University of Washington School of Medicine Seattle, WA, USA.

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May 2014

Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Next Generation Herpes Simplex Virus Vaccines".

Vaccine 2014 Mar 28;32(14):1561-2. Epub 2014 Jan 28.

Division of Microbiology and Infectious Diseases, NIAID, Bethesda, MD, United States. Electronic address:

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March 2014

One shot forward for HIV prevention.

Nat Med 2014 Mar;20(3):241-2

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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March 2014

HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.

PLoS Pathog 2013 20;9(6):e1003404. Epub 2013 Jun 20.

Statistical Center for HIV Research and Prevention, Vaccine and Infectious Disease Division and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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January 2014

Helicase-primase inhibitor pritelivir for HSV-2 infection.

N Engl J Med 2014 Jan;370(3):201-10

From the University of Washington and Fred Hutchinson Cancer Research Center, Seattle (A.W., L.C., A.M., C.J., M.-L.H., S. Selke); AiCuris, Wuppertal, Germany (B.T., S. Stoelben, H.-P.S., H.R.-S., A.B.); Westover Heights Clinic, Portland, OR (T.W.); University of Texas, Houston (S.T.); University of Utah, Salt Lake City (J.K.); Indiana University School of Medicine, Indianapolis (K.F.); and Cetero Research, Miami (L.G.).

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January 2014

Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus 2-directed antiviral agents.

Antimicrob Agents Chemother 2013 Dec 9;57(12):5820-9. Epub 2013 Sep 9.

Department of Medicine, University of Washington, Seattle, Washington, USA.

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December 2013

HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection.

Proc Natl Acad Sci U S A 2013 Aug 22;110(33):13492-7. Epub 2013 Jul 22.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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August 2013

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection.

Nature 2013 May 8;497(7450):494-7. Epub 2013 May 8.

Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA.

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May 2013

Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract.

Elife 2013 Apr 16;2:e00288. Epub 2013 Apr 16.

Vaccine and Infectious Diseases Division , Fred Hutchinson Cancer Research Center , Seattle , United States ; Department of Medicine , University of Washington , Seattle , United States.

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April 2013

The need and challenges for development of an Epstein-Barr virus vaccine.

Vaccine 2013 Apr;31 Suppl 2:B194-6

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA.

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April 2013

Rapid host immune response and viral dynamics in herpes simplex virus-2 infection.

Nat Med 2013 Mar;19(3):280-90

Department of Medicine, University of Washington, Seattle, Washington, USA.

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March 2013

Human immunodeficiency virus vaccine trials.

Cold Spring Harb Perspect Med 2012 Dec 1;2(12):a007351. Epub 2012 Dec 1.

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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December 2012

HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation.

Biol Blood Marrow Transplant 2012 Nov 26;18(11):1700-8. Epub 2012 May 26.

Department of Pediatrics, University of Washington, Seattle, Washington 98115, USA.

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November 2012

Efficacy of a viral load-based, risk-adapted, preemptive treatment strategy for prevention of cytomegalovirus disease after hematopoietic cell transplantation.

Biol Blood Marrow Transplant 2012 Nov 7;18(11):1687-99. Epub 2012 Jun 7.

Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division & Clinical Research Division, Seattle, Washington 98109-1024, USA.

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November 2012

An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection.

J Virol 2012 Oct 18;86(19):10587-96. Epub 2012 Jul 18.

Department of Medicine, University of Washington, Seattle, Washington, USA.

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October 2012

Changes in the soluble mucosal immune environment during genital herpes outbreaks.

J Acquir Immune Defic Syndr 2012 Oct;61(2):194-202

Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.

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October 2012

Efficiency and risk factors for CMV transmission in seronegative hematopoietic stem cell recipients.

Biol Blood Marrow Transplant 2012 Sep 3;18(9):1391-1400. Epub 2012 Mar 3.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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September 2012

Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination.

PLoS One 2012 4;7(4):e33969. Epub 2012 Apr 4.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Insititutes of Health, Bethesda, Maryland, United States of America.

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August 2012

A prospective cohort study of partner testing for herpes simplex virus and sexual behavior during pregnancy.

J Infect Dis 2012 Aug 12;206(4):486-94. Epub 2012 Jun 12.

Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific St, Box 356460, Seattle, WA 98195-6460, USA.

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August 2012

Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations.

Antimicrob Agents Chemother 2012 May 13;56(5):2777-9. Epub 2012 Feb 13.

Department of Pharmacology and Molecular Sciences, Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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May 2012

HIV Vaccine Trials Network: activities and achievements of the first decade and beyond.

Clin Investig (Lond) 2012 Mar;2(3):245-254

HIV Vaccine Trials Network, Vaccine & Infectious Disease Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA.

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March 2012

Cytomegalovirus viremia as a risk factor for mortality prior to antiretroviral therapy among HIV-infected gold miners in South Africa.

PLoS One 2011 12;6(10):e25571. Epub 2011 Oct 12.

Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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February 2012

Detection of adeno-associated virus viremia in hematopoietic cell transplant recipients.

J Infect Dis 2011 Dec 17;204(11):1746-9. Epub 2011 Oct 17.

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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December 2011

Detailed analysis of mucosal herpes simplex virus-2 replication kinetics with and without antiviral therapy.

J Antimicrob Chemother 2011 Nov 24;66(11):2593-600. Epub 2011 Aug 24.

Department of Medicine, University of Washington, Seattle, WA 98102, USA.

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November 2011

Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome.

Diagn Microbiol Infect Dis 2011 Sep 26;71(1):66-71. Epub 2011 Jul 26.

Department of Laboratory Medicine, University of Washington, Seattle, WA 98105, USA.

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September 2011

Development of an interferon-gamma ELISPOT assay to detect human T cell responses to HSV-2.

Vaccine 2011 Sep 27;29(40):7058-66. Epub 2011 Jul 27.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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September 2011

The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions.

J Infect Dis 2011 Aug;204(4):554-61

Department of Medicine, University of Washington, Seattle, Washington, USA.

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August 2011