Lawrence A Leiter

Lawrence A Leiter

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Lawrence A Leiter

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Effect of vegetarian dietary patterns on cardiometabolic risk factors in diabetes: A systematic review and meta-analysis of randomized controlled trials.

Clin Nutr 2019 Jun 13;38(3):1133-1145. Epub 2018 Jun 13.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada; Division of Endocrinology & Metabolism, St. Michael's Hospital, Toronto, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2018.05.032DOI Listing
June 2019

Fixed-ratio combination of insulin degludec and liraglutide (IDegLira) improves cardiovascular risk markers in patients with type 2 diabetes uncontrolled on basal insulin.

Diabetes Obes Metab 2019 Jun 8;21(6):1506-1512. Epub 2019 Apr 8.

Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/dom.13675DOI Listing
June 2019

Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study.

Clin Cardiol 2019 May 9;42(5):498-505. Epub 2019 Apr 9.

FACT (French Alliance for Cardiovascular Trials), an F-CRIN Network, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Université Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1002/clc.23164DOI Listing
May 2019

The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Diabetes Care 2019 May 28;42(5):767-776. Epub 2019 Mar 28.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada

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http://dx.doi.org/10.2337/dc18-2270DOI Listing
May 2019

Efficacy and Safety of Degludec Compared to Glargine 300 Units/mL in Insulin-Experienced Patients With Type 2 Diabetes: Trial Protocol Amendment (NCT03078478).

J Diabetes Sci Technol 2019 May 11;13(3):498-506. Epub 2019 Apr 11.

4 Li Ka Shing Knowledge Institute, Division of Endocrinology and Metabolism, St Michael's Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1177/1932296819841585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501520PMC
May 2019

Important food sources of fructose-containing sugars and incident gout: a systematic review and meta-analysis of prospective cohort studies.

BMJ Open 2019 May 5;9(5):e024171. Epub 2019 May 5.

Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02417
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http://dx.doi.org/10.1136/bmjopen-2018-024171DOI Listing
May 2019

Residual cardiovascular risk among people with diabetes.

Diabetes Obes Metab 2019 Apr;21 Suppl 1:28-38

Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13646
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http://dx.doi.org/10.1111/dom.13646DOI Listing
April 2019

Effects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study.

Neurology 2019 Mar 27;92(13):e1435-e1446. Epub 2019 Feb 27.

From the Population Health Research Institute (J.B., M. O., B.S., E.M.L., M.S., S.F.L., J.M.P., R.H., S.Y.) and Hamilton Health Sciences (J.B.), School of Rehabilitation Science, McMaster University, Ontario; Institut Universitaire de Cardiologie et Pneumologie de Québec (G.D.), Université Laval, Québec; Li Ka Shing Knowledge Institute (L.A.L.), St. Michael's Hospital, University of Toronto, Ontario, Canada; Research Board Clinical Research Facility (M.O.), Department of Medicine, NUI Galway, Ireland; Instituto Cardiovascular de Rosario (R.D.), Argentina; Diabetes Research Centre (K.K.), University of Leicester; Department of Cardiovascular Sciences and the National Institute for Health Research (W.D.T.), Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, University of Leicester, UK; College of Medicine (A.D.), University of the Philippines, Manila, Philippines; Lady Davis Carmel Medical Center (B.S.L.), Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa; Dante Pazzanese Institute of Cardiology (A.A.), São Paulo, Brazil; Department of Medical Sciences (C.H.), Cardiology, Uppsala Clinical Research Center, Uppsala University, Sweden; Semmelweis University (M.K.), Budapest, Hungary; Monash University (C.R.), Melbourne, Victoria; School of Public Health (C.M.R.), Curtin University, Perth, Australia; and Hatter Institute for Cardiovascular Research in Africa (K.S.), Department of Medicine, University of Cape Town, Soweto Cardiovascular Research Group, South Africa.

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http://dx.doi.org/10.1212/WNL.0000000000007174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453765PMC
March 2019

Cost Effectiveness of Once-Weekly Semaglutide Versus Once-Weekly Dulaglutide in the Treatment of Type 2 Diabetes in Canada.

Pharmacoecon Open 2019 Mar 29. Epub 2019 Mar 29.

Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s41669-019-0131-6DOI Listing
March 2019

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2019 01 10;380(4):347-357. Epub 2018 Nov 10.

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital (S.D.W., M.P.B., T.A.Z., J.F.K., S.A.M., D.L.B., C.T.R., M.S.S.), and the Cardiology Division, Massachusetts General Hospital (M.G.S.) - both in Boston; the Diabetes Unit, Hadassah Hebrew University Hospital, Jerusalem (I.R., O.M., A.C.); the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (E.T.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (D.K.M.); Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom (J.P.H.W.); and AstraZeneca Gothenburg, Mölndal, Sweden (I.A.M.G.-N., M.F., P.A.J., A.-M.L.).

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http://dx.doi.org/10.1056/NEJMoa1812389DOI Listing
January 2019

Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial.

Diabetes Care 2019 01 28;42(1):173-176. Epub 2018 Nov 28.

Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/dc18-1491DOI Listing
January 2019

Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial.

Circulation 2019 Jan;139(3):366-375

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038341DOI Listing
January 2019

The Effect of Small Doses of Fructose and Its Epimers on Glycemic Control: A Systematic Review and Meta-Analysis of Controlled Feeding Trials.

Nutrients 2018 Nov 20;10(11). Epub 2018 Nov 20.

Toronto 3D (Diet, Digestive Tract, and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.

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http://dx.doi.org/10.3390/nu10111805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266436PMC
November 2018

Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.

BMJ 2018 11 21;363:k4644. Epub 2018 Nov 21.

Toronto 3D (Diet, Digestive Tract, and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, 61 Queen Street East, Toronto, ON, M5C 2T2, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247175PMC
http://dx.doi.org/10.1136/bmj.k4644DOI Listing
November 2018

Glycated Hemoglobin Level Goal Achievement in Adults With Type 2 Diabetes in Canada: Still Room for Improvement.

Can J Diabetes 2018 Nov 2. Epub 2018 Nov 2.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jcjd.2018.10.005DOI Listing
November 2018

The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: A double-blind, randomized, controlled, acute feeding, equivalence trial.

Diabetes Obes Metab 2018 10 25;20(10):2361-2370. Epub 2018 Jun 25.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada.

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http://dx.doi.org/10.1111/dom.13374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175314PMC
October 2018

Efficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials.

Diabetes Obes Metab 2018 10 2;20(10):2389-2398. Epub 2018 Jul 2.

Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/dom.13384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175384PMC
October 2018

Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study.

Atherosclerosis 2018 Oct 12;277:195-203. Epub 2018 Jun 12.

Division of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, 61 Queen St East #6121, Toronto, M5C 2T2, Ontario, Canada.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.002DOI Listing
October 2018

Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update.

CMAJ 2018 Oct;190(40):E1192-E1206

Libin Cardiovascular Institute, Cumming School of Medicine (Anderson), University of Calgary, Calgary, Alta.; Department of Health, Kinesiology, and Applied Physiology (Bacon), Concordia University, Montreal, Que. & Montreal Behavioural Medicine Centre, CIUSSS-NIM, Montreal, Que.; St. Michael's Hospital (Cheng), University of Toronto, Toronto, Ont.; McGill University (Daskalopoulou), Montreal, Que.; Department of Medicine (Ezekowitz), University of Alberta, Edmonton, Alta.; Institut de cardiologie de Montreal (Gregoire), Montreal, Que.; Universite de Montreal (Gubitz), Montreal, Que.; Sunnybrook Research Institute (Hua-Stewart), Toronto, Ont.; Department of Family and Community Medicine (Jain), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Keshavjee), University of Toronto, Toronto, Ont.; Department of Nutritional Sciences (L'Abbe), University of Toronto, Toronto, Ont.; Department of Medicine and Libin Cardiovascular Institute (Lau), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Li Ka Shing Knowledge Institute (Leiter), St. Michael's Hospital, University of Toronto, Toronto, Ont.; Heart and Stroke Foundation (Lindsay), Ottawa, Ont.; Ottawa Heart Institute (Liu), University of Ottawa, Ottawa, Ont.; Insitut de Cardiologie de Montreal (O'Meara), Universite de Montreal, Montreal, Que.; Division of Cardiology, Mazankowski Alberta Heart Institute; University of Alberta, Faculty of Medicine and Dentistry (Pearson), Edmonton, Alta.; Departments of Medicine, Community Health and Cardiac Sciences (Rabi), University of Calgary, Calgary, Alta.; Centre for Addiction and Mental Health, Departments of Family and Community Medicine, Psychiatry and Public Health Sciences (Selby), University of Toronto, Toronto, Ont.; School of Nursing and Health Research Methods, Evidence and Impact, Faculty of Health Sciences (Sherifali), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Stone), University of Calgary, Calgary, Alta.; Division of Nephrology (Tobe), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; ICES, Sunnybrook Research Institute (Tu), University of Toronto, Toronto, Ont.; St. Joseph's Health Care Centre (Walker), Toronto, Ont.; McMaster University (Wharton), Hamilton Ont.; York University (Wharton), Toronto, Ont.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.180194
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http://dx.doi.org/10.1503/cmaj.180194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175624PMC
October 2018

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins.

Circulation 2018 Sep;138(13):1304-1316

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, the Netherlands (R.M.S., J.J.P.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034710DOI Listing
September 2018

The place of gliclazide MR in the evolving type 2 diabetes landscape: A comparison with other sulfonylureas and newer oral antihyperglycemic agents.

Diabetes Res Clin Pract 2018 Sep 24;143:1-14. Epub 2018 May 24.

Diabetes Department, Hôpital Bichat-Claude Bernard, Assistance Publique des Hôpitaux de Paris, Université Denis Diderot Paris 7, and INSERM U1138, Paris, France.

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http://dx.doi.org/10.1016/j.diabres.2018.05.028DOI Listing
September 2018

Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients.

N Engl J Med 2018 09 26;379(12):1107-1117. Epub 2018 Aug 26.

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W., J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division, University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.); Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University, Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada; MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai, Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.); and the Translational Research Institute for Metabolism and Diabetes, Florida Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).

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http://dx.doi.org/10.1056/NEJMoa1808721DOI Listing
September 2018

Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes.

Metabolism 2018 08 13;85:32-37. Epub 2018 Feb 13.

Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Rd, Titusville, NJ 08560, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.02.002DOI Listing
August 2018

Inflammatory and Cholesterol Risk in the FOURIER Trial.

Circulation 2018 Jul 12;138(2):131-140. Epub 2018 Mar 12.

TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.B., R.P.G., J.-G.P., S.A.M., M.S.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034032DOI Listing
July 2018

DECLARE-TIMI 58: Participants' baseline characteristics.

Diabetes Obes Metab 2018 05 14;20(5):1102-1110. Epub 2018 Feb 14.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/dom.13217DOI Listing
May 2018

Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children.

Can J Cardiol 2018 05 1;34(5):506-525. Epub 2018 Mar 1.

Division of Internal Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2018.02.022DOI Listing
May 2018

Use of GLP-1 RAs in Cardiovascular Disease Prevention: A Practical Guide.

Circulation 2018 May;137(21):2200-2202

Division of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute of St. Michael's Hospital and Departments of Medicine and Nutritional Sciences, University of Toronto, Ontario, Canada (L.A.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032759DOI Listing
May 2018

Blood Pressure Management in Adults With Type 2 Diabetes: Insights From the Diabetes Mellitus Status in Canada (DM-SCAN) Survey.

Can J Diabetes 2018 Apr 25;42(2):130-137. Epub 2017 May 25.

Division of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcjd.2017.01.005DOI Listing
April 2018

Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy.

Diabetes Obes Metab 2018 04 8;20(4):889-897. Epub 2018 Jan 8.

Department of Ophthalmology, Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://doi.wiley.com/10.1111/dom.13172
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http://dx.doi.org/10.1111/dom.13172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888154PMC
April 2018

Dyslipidemia.

Can J Diabetes 2018 Apr;42 Suppl 1:S178-S185

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http://dx.doi.org/10.1016/j.jcjd.2017.10.019DOI Listing
April 2018

Effectiveness of gliclazide MR 60 mg in the management of type 2 diabetes: analyses from the EASYDia trial.

Diabetol Metab Syndr 2018 10;10:30. Epub 2018 Apr 10.

3Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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https://dmsjournal.biomedcentral.com/articles/10.1186/s13098
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http://dx.doi.org/10.1186/s13098-018-0331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894204PMC
April 2018

Insights Into the Current Management of Older Adults With Type 2 Diabetes in the Ontario Primary Care Setting.

Can J Diabetes 2018 Feb 2;42(1):23-30. Epub 2017 Jun 2.

Division of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jcjd.2017.03.003DOI Listing
February 2018

Metabolic Surgery: Weight Loss, Diabetes, and Beyond.

J Am Coll Cardiol 2018 Feb;71(6):670-687

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.12.014DOI Listing
February 2018

Questioning the safety and benefits of evolocumab - Authors' reply.

Lancet Diabetes Endocrinol 2018 01;6(1):11-12

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S2213-8587(17)30403-5DOI Listing
January 2018

Efficacy and safety of alirocumab in insulin-treated individuals with type 1 or type 2 diabetes and high cardiovascular risk: The ODYSSEY DM-INSULIN randomized trial.

Diabetes Obes Metab 2017 12 10;19(12):1781-1792. Epub 2017 Oct 10.

University of California San Diego School of Medicine, and Center for Metabolic Research, Veterans Affairs, San Diego Healthcare System, San Diego, California.

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http://dx.doi.org/10.1111/dom.13114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698740PMC
December 2017

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Am Heart Assoc 2017 Dec 20;6(12). Epub 2017 Dec 20.

Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada

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http://dx.doi.org/10.1161/JAHA.117.006659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779002PMC
December 2017

Efficacy and safety of lixisenatide in patients with type 2 diabetes and renal impairment.

Diabetes Obes Metab 2017 11 7;19(11):1594-1601. Epub 2017 Jun 7.

Internal Medicine Department, University Regional Hospital, Malaga, Spain.

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http://dx.doi.org/10.1111/dom.12986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655920PMC
November 2017

CANTOS Ushers in a New Calculus of Inflammasome Targeting for Vascular Protection-and Maybe More.

Cell Metab 2017 Nov 19;26(5):703-705. Epub 2017 Oct 19.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.cmet.2017.09.022DOI Listing
November 2017

Cancer risks of anti-hyperglycemic drugs for type 2 diabetes treatment - a clinical appraisal.

J Diabetes Complications 2017 Sep 15;31(9):1451-1457. Epub 2017 Jun 15.

Division of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, 61 Queen St. East #6121, Toronto, ON, M5C 2T2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2017.06.003DOI Listing
September 2017

Efficacy and Safety of GLP-1 Receptor Agonists Across the Spectrum of Type 2 Diabetes Mellitus.

Exp Clin Endocrinol Diabetes 2017 Jul 19;125(7):419-435. Epub 2017 Jul 19.

Division of Diabetology, Medical Department I, St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr. 56, Bochum, Germany.

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http://dx.doi.org/10.1055/s-0043-103969DOI Listing
July 2017

Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults.

Can J Cardiol 2017 05 10;33(5):557-576. Epub 2017 Mar 10.

Departments of Medicine, Community Health and Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.03.005DOI Listing
May 2017

Gaps and barriers in the control of blood glucose in people with type 2 diabetes.

Diab Vasc Dis Res 2017 05 1;14(3):172-183. Epub 2017 Feb 1.

6 Diabetes, Metabolism and Endocrinology Center, Quakenbrück Hospital, Quakenbrück, Germany.

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http://dx.doi.org/10.1177/1479164116679775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418936PMC
May 2017

Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies.

CMAJ 2017 May;189(20):E711-E720

Toronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.160706
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http://dx.doi.org/10.1503/cmaj.160706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436961PMC
May 2017

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol.

N Engl J Med 2017 04 17;376(15):1430-1440. Epub 2017 Mar 17.

From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.), and Knowle House Surgery, Plymouth (T.H.) - both in the United Kingdom; the Department of Cardiology, Charité-Universitätsmedizin Berlin, Berlin Institute of Health and German Center for Cardiovascular Research, Berlin (U.L.), and University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg (M.K.) - all in Germany; the Division of Endocrinology and Metabolism, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Medicines Company, Parsippany, NJ (D.K., P.W.); Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal (R.D.); the Department of Cardiology and Interventional Cardiology, VieCuri Medical Center for Northern Limburg, Venlo (R.P.T.T.), University Medical Center, Utrecht (F.L.J.V.), and the Department of Vascular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam (J.J.P.K.) - all in the Netherlands; the Metabolic and Atherosclerosis Research Center, Medpace, Cincinnati (T.T.); and the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.).

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http://dx.doi.org/10.1056/NEJMoa1615758DOI Listing
April 2017

Diabetes for Cardiologists: Practical Issues in Diagnosis and Management.

Can J Cardiol 2017 03 26;33(3):366-377. Epub 2016 Jul 26.

Division of Endocrinology, McGill University Health Centre, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.07.512DOI Listing
March 2017

Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis.

CMAJ Open 2017 Jan-Mar;5(1):E152-E177. Epub 2017 Feb 24.

Divisions of Cardiac Surgery (Verma, Quan, Teoh), Endocrinology and Metabolism (Teoh, Leiter) and Cardiology (Connelly), and Departments of Surgery (Verma), Medicine (Connelly, Leiter, Friedrich) and Critical Care (Friedrich), Li Ka Shing Knowledge Institute of St. Michael's Hospital; Departments of Surgery (Verma), Medicine (Farkouh, Connelly, Leiter, Friedrich), Nutritional Sciences (Leiter) and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; LMC Diabetes & Endocrinology (Goldenberg), Thornhill, Ont.; Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School (Bhatt), Boston, Mass.; Peter Munk Cardiac Centre (Farkouh), University Health Network, Toronto, Ont.

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http://cmajopen.ca/lookup/doi/10.9778/cmajo.20160058
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http://dx.doi.org/10.9778/cmajo.20160058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403656PMC
February 2017

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.

N Engl J Med 2016 11 15;375(19):1834-1844. Epub 2016 Sep 15.

From the Research Medical Center, Kansas City, MO (S.P.M.); School of Medicine, Swansea University, Swansea, United Kingdom (S.C.B.); Department of Medicine and Aging Science and Center of Excellence on Aging and Translational Medicine, G. d'Annunzio University, Chieti-Pescara, Italy (A.C.); CPClin Research Center/Hospital Israelita Albert Einstein, São Paulo (F.G.E.); Hospital Universitario Quirón Salud Madrid, Facultad de Ciencias de la Salud, Universidad Europea de Madrid, Madrid (E.J.); Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.), and the University of Manitoba, Winnipeg (V.W.) - both in Canada; University of Texas Southwestern Medical Center (I.L.) and Dallas Diabetes Research Center at Medical City (J.R.) - both in Dallas; University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany (J.S.); Physicians East, Greenville, NC (M.L.W.); and Novo Nordisk, Søborg (O.H., A.G.H., J.P.), and the Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup (T.V.) - both in Denmark.

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http://dx.doi.org/10.1056/NEJMoa1607141DOI Listing
November 2016

Fructose intake and risk of gout and hyperuricemia: a systematic review and meta-analysis of prospective cohort studies.

BMJ Open 2016 10 3;6(10):e013191. Epub 2016 Oct 3.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/bmjopen-2016-013191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073537PMC
October 2016

Secondary Prevention Beyond Hospital Discharge for Acute Coronary Syndrome: Evidence-Based Recommendations.

Can J Cardiol 2016 07 10;32(7 Suppl):S15-34. Epub 2016 Mar 10.

St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.03.002DOI Listing
July 2016

LEADER-4: blood pressure control in patients with type 2 diabetes and high cardiovascular risk: baseline data from the LEADER randomized trial.

J Hypertens 2016 06;34(6):1140-50

aInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK bDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern, Dallas, Texas, USA cInstitute of Life Science, College of Medicine, Swansea University Medical School, Swansea, UK dMossakowski Medical Research Centre, Polish Academy of Sciences eDepartment of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital MSW, Warsaw, Poland fKardio Metabolischen Instituts, Villingen-Schwenningen, Germany gEndocrinology and Nutrition Department, Hospital Son Llàtzer, University Institute of Health Science Research (IUNICS)-Universitat de les Illes Balears, Palma de Mallorca, Spain hDivisions of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Ontario, Canada i1st Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic jDivision of Endocrinology and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey kDepartment of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, University of KwaZulu Natal, South Africa lEndocrinology Research Centre, Diabetes Institute mI.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation nFaculty of Medicine, Antwerp University Hospital, Antwerp, Belgium oDepartment of Nephrology, Hypertension & Rheumatology, Friedrich Alexander University of Erlangen, Munchen, Germany pNovo Nordisk, A/S, Bagsvaerd, Denmark qLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada rInternational Centre for Circulatory Health, Imperial College London, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856174PMC
June 2016

Effects of dietary pulse consumption on body weight: a systematic review and meta-analysis of randomized controlled trials.

Am J Clin Nutr 2016 May 30;103(5):1213-23. Epub 2016 Mar 30.

Department of Nutritional Sciences, Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Li Ka Shing Knowledge Institute, and Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Canada;

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http://ajcn.nutrition.org/content/early/2016/03/30/ajcn.115.
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http://ajcn.nutrition.org/cgi/doi/10.3945/ajcn.115.124677
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May 2016

Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease.

N Engl J Med 2016 May 2;374(21):2032-43. Epub 2016 Apr 2.

From the Population Health Research Institute, Hamilton Health Sciences (S.Y., E.L., J.B., R.M., J.P., H.J.), Department of Medicine (S.Y., E.L., R.M.), School of Rehabilitation Science (J.B.), Department of Clinical Epidemiology and Biostatistics (J.P.), McMaster University, Hamilton, ON, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.), and Institut Universitaire de Cardiologie et Pneumologie de Québec, Université Laval, Quebec, QC (G.D.) - all in Canada; St. John's Research Institute (P.P., D.X.), and St. John's Medical College (D.X.), Bangalore, India; Fundacion Oftalmológica de Santander and Instituto Masira, Medical School, Universidad de Santander, Bucaramanga (P.L.-J.), and Universidad del Norte, Barranquilla (J.L.A.) - both in Colombia; Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.Z., L.L.); Dante Pazzanese Institute of Cardiology (A.A.) and HCor-Heart Hospital (L.S.P.), Sao Paulo; Institute of Cardiology, Kiev, Ukraine (A.P.); Hungarian Institute of Cardiology, Semmelweis University, Budapest, Hungary (M.K., K. Keltai); Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town, Soweto Cardiovascular Research Group, Cape Town, South Africa (K.S.); Institute of Clinical Cardiology in the Russian Cardiology Research Complex, Moscow (I.C.); the Department of Cardiology, Academic Medical Center, Amsterdam (R.J.G.P.); the Department of Medical Sciences, Cardiology, Clinical Research Center, Uppsala University, Uppsala, Sweden (C.H.); Universiti Teknologi Majlis Amansh Rakyat, Selayang, and University College Sedaya International University, Kuala Lumpur (K.Y.) - both in Malaysia; Lady Davis Carmel Medical Center, Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (B.S.L.); University Hospital Motol, Prague, Czech Repu

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http://dx.doi.org/10.1056/NEJMoa1600177DOI Listing
May 2016

Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease.

N Engl J Med 2016 May 2;374(21):2021-31. Epub 2016 Apr 2.

From the Population Health Research Institute, Hamilton Health Sciences (S.Y., J.B., R.M., J.P., H.J., P.G., E.L.), Departments of Medicine (S.Y., R.M., E.L.) and Clinical Epidemiology and Biostatistics (J.P.), and School of Rehabilitation Science (J.B.), McMaster University, Hamilton, ON, Institut Universitaire de Cardiologie et Pneumologie de Québec, Université Laval, Quebec, QC (G.D.), and Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.) - all in Canada; Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.Z., L.L.); St. John's Medical College (D.X.) and St. John's Research Institute (D.X., P.P.), Bangalore, India; Fundacion Oftalmológica de Santander and Instituto Masira, Medical School, Universidad de Santander, Bucaramanga (P.L.-J.), and University of Quindio, Armenia (G.S.-V.) - both in Colombia; College of Medicine, University of the Philippines, Manila (A.D.); Dante Pazzanese Institute of Cardiology (A.A.) and HCor-Heart Hospital (L.S.P.), São Paulo; Institute of Cardiology, Kiev, Ukraine (A.P.); Hungarian Institute of Cardiology, Semmelweis University, Budapest (K. Keltai, M.K.); Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town, Soweto Cardiovascular Research Group, Cape Town, South Africa (K.S.); Department of Cardiology, Academic Medical Center, Amsterdam (R.J.G.P); Department of Medical Sciences, Cardiology, Clinical Research Center, Uppsala University, Uppsala, Sweden (C.H.); Institute of Clinical Cardiology in the Russian Cardiology Research Complex, Moscow (I.C.); Universiti Teknologi Majlis Amansh Rakyat, Selayang, and University College Sedaya International University, Kuala Lumpur - both in Malaysia (K.Y.); Lady Davis Carmel Medical Center, Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa (B.S.L.); Universi

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http://dx.doi.org/10.1056/NEJMoa1600176DOI Listing
May 2016

Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.

N Engl J Med 2016 May 2;374(21):2009-20. Epub 2016 Apr 2.

From the Population Health Research Institute, Hamilton Health Sciences (E.M.L., J.B., R.M., J.P., J.W., H.J., S.Y.), the Department of Medicine (E.M.L., R.M., S.Y.), the School of Rehabilitation Science (J.B.), and the Department of Clinical Epidemiology and Biostatistics (J.P.), McMaster University, Hamilton, ON, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.), and Institut Universitaire de Cardiologie et Pneumologie de Québec, Université Laval, Quebec, QC (G.D.) - all in Canada; Fundacion Oftalmológica de Santander and Instituto Masira, Medical School, Universidad de Santander, Bucaramanga (P.L.-J.), and University of Caldas and Institución Prestadora de Salud Internistas de Caldas, Manizales (D.I.M.S.) - both in Colombia; Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.Z., L.L.); St. John's Research Institute (P.P., D.X.) and St. John's Medical College (D.X.), Bangalore, India; Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.); Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town, Soweto Cardiovascular Research Group, Cape Town, South Africa (K.S.); College of Medicine, University of the Philippines, Manila (A.D.); Dante Pazzanese Institute of Cardiology (A.A.) and HCor-Heart Hospital (L.S.P.) - both in São Paulo; Hungarian Institute of Cardiology, Semmelweis University, Budapest, Hungary (K. Keltai, M.K.); Institute of Clinical Cardiology in the Russian Cardiology Research Complex, Moscow (I.C.); the Department of Cardiology, Academic Medical Center, Amsterdam (R.J.G.P.); the Department of Medical Sciences, Cardiology, Clinical Research Center, Uppsala University, Uppsala, Sweden (C.H.); Universiti Teknologi Majlis Amansh Rakyat, Selayang, and University College Sedaya International University, Kuala Lumpur (K.Y.) - both in Malaysia; Lady Davis Ca

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http://dx.doi.org/10.1056/NEJMoa1600175DOI Listing
May 2016

Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension.

Can J Cardiol 2016 05 10;32(5):569-88. Epub 2016 Mar 10.

Departments of Medicine, Community Health and Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.02.066DOI Listing
May 2016

Implementing an optimized glucose-lowering strategy with a novel once daily modified release gliclazide formulation.

Diabetes Res Clin Pract 2016 Feb 23;112:50-56. Epub 2015 Nov 23.

Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.diabres.2015.11.001DOI Listing
February 2016

The Role of the Kidney and SGLT2 Inhibitors in Type 2 Diabetes.

Can J Diabetes 2015 Dec;39 Suppl 5:S167-75

Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S14992671150062
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http://dx.doi.org/10.1016/j.jcjd.2015.09.001DOI Listing
December 2015

Cardiovascular Implications of Hypoglycemia in Diabetes Mellitus.

Circulation 2015 Dec;132(24):2345-50

From Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada (K.A.C., A.T.Y., L.A.L., S.V.); and the Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA (D.L.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.015946DOI Listing
December 2015