Lawrence A Leiter

Lawrence A Leiter

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Lawrence A Leiter

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Cardiovascular and renal benefits of dapagliflozin in patients with short and long-standing type 2 diabetes: Analysis from the DECLARE-TIMI 58 trial.

Diabetes Obes Metab 2020 Jul 12;22(7):1122-1131. Epub 2020 Mar 12.

Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1111/dom.14011DOI Listing
July 2020

Association of Major Food Sources of Fructose-Containing Sugars With Incident Metabolic Syndrome: A Systematic Review and Meta-analysis.

JAMA Netw Open 2020 Jul 1;3(7):e209993. Epub 2020 Jul 1.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamanetworkopen.2020.9993DOI Listing
July 2020

Latest Evidence on Sulfonylureas: What's New?

Diabetes Ther 2020 Jun 22;11(Suppl 1):15-22. Epub 2020 Apr 22.

Division of Endocrinology and Metabolism, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s13300-020-00812-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261305PMC
June 2020

Glucose-lowering drugs or strategies, atherosclerotic cardiovascular events, and heart failure in people with or at risk of type 2 diabetes: an updated systematic review and meta-analysis of randomised cardiovascular outcome trials.

Lancet Diabetes Endocrinol 2020 05;8(5):418-435

Women's College Research Institute and Cardiovascular Division, Women's College Hospital, Toronto, ON, Canada; Department of Medicine, St Michael's Hospital, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(20)30038-3DOI Listing
May 2020

Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.

Can J Cardiol 2020 May;36(5):596-624

Division of Internal Medicine, Department of Medicine, McGill University, and Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2020.02.086DOI Listing
May 2020

Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial.

Circulation 2020 Apr 27;141(15):1227-1234. Epub 2020 Jan 27.

TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.A.Z., M.P.B., R.H.M.F., J.F.K., S.A.M., D.L.B., M.S.S., S.D.V.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044183DOI Listing
April 2020

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.

N Engl J Med 2020 04 18;382(16):1507-1519. Epub 2020 Mar 18.

From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Zurich, Switzerland (D.K.); Deutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm - all in Germany (W.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg (F.J.R.); the Medicines Company, Parsippany, NJ (J.A.B., T.R., P.L.J.W.); Summit Analytical, Denver (M.J.), and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).

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http://dx.doi.org/10.1056/NEJMoa1912387DOI Listing
April 2020

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia.

N Engl J Med 2020 Apr 18;382(16):1520-1530. Epub 2020 Mar 18.

From the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (F.J.R.); the Medicines Company, Zurich, Switzerland (D.K.); the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College, London (K.K.R.); Medpace Reference Laboratories, Cincinnati (T.T.); Deutsches Herzzentrum München, Technische Universität München, and German Center for Cardiovascular Research, Munich Heart Alliance, Munich (W.K.), and the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm (W.K.) - all in Germany; the Division of Preventive Cardiology and the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.); the Medicines Company, Parsippany, NJ (P.L.J.W., D.C.); Summit Analytical, Denver (M.J.J.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); and the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.).

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http://dx.doi.org/10.1056/NEJMoa1913805DOI Listing
April 2020

Effect of inclisiran, the siRNA against PCSK9, on platelets, immune cells and immunological biomarkers - a pre-specified analysis from ORION-1.

Cardiovasc Res 2020 Apr 3. Epub 2020 Apr 3.

Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1093/cvr/cvaa077DOI Listing
April 2020

A LEADER in the management of type 2 diabetes and cardiorenal disease.

J Thorac Cardiovasc Surg 2020 03 19;159(3):978-984. Epub 2019 Jun 19.

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jtcvs.2019.03.134DOI Listing
March 2020

GOAL Canada: Physician Education and Support Can Improve Patient Management.

CJC Open 2020 Mar 28;2(2):49-54. Epub 2019 Dec 28.

Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjco.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067689PMC
March 2020

Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.

Diabetes Care 2020 02 16;43(2):468-475. Epub 2019 Dec 16.

Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.

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http://dx.doi.org/10.2337/dc19-1476DOI Listing
February 2020

Cost Effectiveness of Once-Weekly Semaglutide Versus Once-Weekly Dulaglutide in the Treatment of Type 2 Diabetes in Canada.

Pharmacoecon Open 2019 Dec;3(4):537-550

Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s41669-019-0131-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861407PMC
December 2019

Relation of Total Sugars, Sucrose, Fructose, and Added Sugars With the Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.

Mayo Clin Proc 2019 12;94(12):2399-2414

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Risk Factor Modification Center, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mayocp.2019.05.034DOI Listing
December 2019

Important Food Sources of Fructose-Containing Sugars and Incident Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.

J Am Heart Assoc 2019 12 12;8(24):e010977. Epub 2019 Dec 12.

Toronto 3D Knowledge Synthesis and Clinical Trials Unit Clinical Nutrition and Risk Factor Modification Centre St. Michael's Hospital Toronto Ontario Canada.

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http://dx.doi.org/10.1161/JAHA.118.010977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951071PMC
December 2019

Correctly understanding the diabetes data in FOURIER.

Diabetes Obes Metab 2019 10 4;21(10):2342-2343. Epub 2019 Jul 4.

Departments of Medicine and Nutritional Sciences, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/dom.13812DOI Listing
October 2019

Ticagrelor in Patients with Stable Coronary Disease and Diabetes.

N Engl J Med 2019 Oct 1;381(14):1309-1320. Epub 2019 Sep 1.

From the French Alliance for Cardiovascular Trials, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Université de Paris, INSERM Unité 1148 (P.G.S.), Assistance Publique-Hôpitaux de Paris (P.G.S., T.S.), Hôpital Saint Antoine, Department of Clinical Pharmacology, Unité de Recherche Clinique (T.S.), and Sorbonne Université (T.S.) - all in Paris; the National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London (P.G.S., K.F.); Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B.) and Baim Institute for Clinical Research (Y.L.) - both in Boston; the Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON (S.R.M.), and Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada; Stanford University, Stanford, CA (R.A.H.); the Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala (C.H.), and AstraZeneca BioPharmaceuticals Research and Development, Mölndal (M.A., A.H., W.R., M.L.-Z.) - both in Sweden; the Department of Cardiology, Medical University of Warsaw, Warsaw, Poland (G.O.); City Clinical Hospital No. 51, State Health Care Agency, Moscow (D.Z.); Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China (J.G.); Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (J.C.N.); Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile (R.C.); Northwest Clinics, Department of Cardiology, Alkmaar, Dutch Network for Cardiovascular Research, Utrecht, and Department of Cardiology, Radboud University Medical Center, Nijmegen - all in the Netherlands (J.H.C.); and Cardiocenter Charles University, Third Faculty of Medicine, University Hospital Kralovske Vinohrady, Prague, Czech Republic (P.W.).

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http://dx.doi.org/10.1056/NEJMoa1908077DOI Listing
October 2019

SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus.

Cell Metab 2019 10 30;30(4):609-613. Epub 2019 Aug 30.

Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.08.015DOI Listing
October 2019

Cardiovascular Outcome Trials in Type 2 Diabetes: What Do They Mean for Clinical Practice?

Clin Diabetes 2019 Oct;37(4):316-337

Li Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/cd19-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794224PMC
October 2019

Glycated Hemoglobin Level Goal Achievement in Adults With Type 2 Diabetes in Canada: Still Room for Improvement.

Can J Diabetes 2019 Aug 2;43(6):384-391. Epub 2018 Nov 2.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jcjd.2018.10.005DOI Listing
August 2019

Effect of vegetarian dietary patterns on cardiometabolic risk factors in diabetes: A systematic review and meta-analysis of randomized controlled trials.

Clin Nutr 2019 06 13;38(3):1133-1145. Epub 2018 Jun 13.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada; Division of Endocrinology & Metabolism, St. Michael's Hospital, Toronto, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2018.05.032DOI Listing
June 2019

Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study.

Clin Cardiol 2019 May 9;42(5):498-505. Epub 2019 Apr 9.

FACT (French Alliance for Cardiovascular Trials), an F-CRIN Network, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Université Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1002/clc.23164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522985PMC
May 2019

The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Diabetes Care 2019 05 28;42(5):767-776. Epub 2019 Mar 28.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada

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http://dx.doi.org/10.2337/dc18-2270DOI Listing
May 2019

Efficacy and Safety of Degludec Compared to Glargine 300 Units/mL in Insulin-Experienced Patients With Type 2 Diabetes: Trial Protocol Amendment (NCT03078478).

J Diabetes Sci Technol 2019 05 11;13(3):498-506. Epub 2019 Apr 11.

4 Li Ka Shing Knowledge Institute, Division of Endocrinology and Metabolism, St Michael's Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1177/1932296819841585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501520PMC
May 2019

Residual cardiovascular risk among people with diabetes.

Diabetes Obes Metab 2019 04;21 Suppl 1:28-38

Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13646
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http://dx.doi.org/10.1111/dom.13646DOI Listing
April 2019

Effects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study.

Neurology 2019 03 27;92(13):e1435-e1446. Epub 2019 Feb 27.

From the Population Health Research Institute (J.B., M. O., B.S., E.M.L., M.S., S.F.L., J.M.P., R.H., S.Y.) and Hamilton Health Sciences (J.B.), School of Rehabilitation Science, McMaster University, Ontario; Institut Universitaire de Cardiologie et Pneumologie de Québec (G.D.), Université Laval, Québec; Li Ka Shing Knowledge Institute (L.A.L.), St. Michael's Hospital, University of Toronto, Ontario, Canada; Research Board Clinical Research Facility (M.O.), Department of Medicine, NUI Galway, Ireland; Instituto Cardiovascular de Rosario (R.D.), Argentina; Diabetes Research Centre (K.K.), University of Leicester; Department of Cardiovascular Sciences and the National Institute for Health Research (W.D.T.), Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, University of Leicester, UK; College of Medicine (A.D.), University of the Philippines, Manila, Philippines; Lady Davis Carmel Medical Center (B.S.L.), Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa; Dante Pazzanese Institute of Cardiology (A.A.), São Paulo, Brazil; Department of Medical Sciences (C.H.), Cardiology, Uppsala Clinical Research Center, Uppsala University, Sweden; Semmelweis University (M.K.), Budapest, Hungary; Monash University (C.R.), Melbourne, Victoria; School of Public Health (C.M.R.), Curtin University, Perth, Australia; and Hatter Institute for Cardiovascular Research in Africa (K.S.), Department of Medicine, University of Cape Town, Soweto Cardiovascular Research Group, South Africa.

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http://dx.doi.org/10.1212/WNL.0000000000007174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453765PMC
March 2019

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2019 01 10;380(4):347-357. Epub 2018 Nov 10.

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital (S.D.W., M.P.B., T.A.Z., J.F.K., S.A.M., D.L.B., C.T.R., M.S.S.), and the Cardiology Division, Massachusetts General Hospital (M.G.S.) - both in Boston; the Diabetes Unit, Hadassah Hebrew University Hospital, Jerusalem (I.R., O.M., A.C.); the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (E.T.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (D.K.M.); Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom (J.P.H.W.); and AstraZeneca Gothenburg, Mölndal, Sweden (I.A.M.G.-N., M.F., P.A.J., A.-M.L.).

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http://dx.doi.org/10.1056/NEJMoa1812389DOI Listing
January 2019

Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial.

Diabetes Care 2019 01 28;42(1):173-176. Epub 2018 Nov 28.

Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/dc18-1491DOI Listing
January 2019

Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial.

Circulation 2019 01;139(3):366-375

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (B.M.S., E.A.B., A.Q., S.A.M., K.I., M.P.B., C.T.R., M.S.S., S.D.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038341DOI Listing
January 2019

The Effect of Small Doses of Fructose and Its Epimers on Glycemic Control: A Systematic Review and Meta-Analysis of Controlled Feeding Trials.

Nutrients 2018 Nov 20;10(11). Epub 2018 Nov 20.

Toronto 3D (Diet, Digestive Tract, and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.

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http://dx.doi.org/10.3390/nu10111805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266436PMC
November 2018

Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.

BMJ 2018 11 21;363:k4644. Epub 2018 Nov 21.

Toronto 3D (Diet, Digestive Tract, and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, 61 Queen Street East, Toronto, ON, M5C 2T2, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247175PMC
http://dx.doi.org/10.1136/bmj.k4644DOI Listing
November 2018

The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: A double-blind, randomized, controlled, acute feeding, equivalence trial.

Diabetes Obes Metab 2018 10 25;20(10):2361-2370. Epub 2018 Jun 25.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada.

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http://dx.doi.org/10.1111/dom.13374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175314PMC
October 2018

Efficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials.

Diabetes Obes Metab 2018 10 2;20(10):2389-2398. Epub 2018 Jul 2.

Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/dom.13384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175384PMC
October 2018

Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study.

Atherosclerosis 2018 10 12;277:195-203. Epub 2018 Jun 12.

Division of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, 61 Queen St East #6121, Toronto, M5C 2T2, Ontario, Canada.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.002DOI Listing
October 2018

Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update.

CMAJ 2018 10;190(40):E1192-E1206

Libin Cardiovascular Institute, Cumming School of Medicine (Anderson), University of Calgary, Calgary, Alta.; Department of Health, Kinesiology, and Applied Physiology (Bacon), Concordia University, Montreal, Que. & Montreal Behavioural Medicine Centre, CIUSSS-NIM, Montreal, Que.; St. Michael's Hospital (Cheng), University of Toronto, Toronto, Ont.; McGill University (Daskalopoulou), Montreal, Que.; Department of Medicine (Ezekowitz), University of Alberta, Edmonton, Alta.; Institut de cardiologie de Montreal (Gregoire), Montreal, Que.; Universite de Montreal (Gubitz), Montreal, Que.; Sunnybrook Research Institute (Hua-Stewart), Toronto, Ont.; Department of Family and Community Medicine (Jain), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Keshavjee), University of Toronto, Toronto, Ont.; Department of Nutritional Sciences (L'Abbe), University of Toronto, Toronto, Ont.; Department of Medicine and Libin Cardiovascular Institute (Lau), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Li Ka Shing Knowledge Institute (Leiter), St. Michael's Hospital, University of Toronto, Toronto, Ont.; Heart and Stroke Foundation (Lindsay), Ottawa, Ont.; Ottawa Heart Institute (Liu), University of Ottawa, Ottawa, Ont.; Insitut de Cardiologie de Montreal (O'Meara), Universite de Montreal, Montreal, Que.; Division of Cardiology, Mazankowski Alberta Heart Institute; University of Alberta, Faculty of Medicine and Dentistry (Pearson), Edmonton, Alta.; Departments of Medicine, Community Health and Cardiac Sciences (Rabi), University of Calgary, Calgary, Alta.; Centre for Addiction and Mental Health, Departments of Family and Community Medicine, Psychiatry and Public Health Sciences (Selby), University of Toronto, Toronto, Ont.; School of Nursing and Health Research Methods, Evidence and Impact, Faculty of Health Sciences (Sherifali), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Stone), University of Calgary, Calgary, Alta.; Division of Nephrology (Tobe), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; ICES, Sunnybrook Research Institute (Tu), University of Toronto, Toronto, Ont.; St. Joseph's Health Care Centre (Walker), Toronto, Ont.; McMaster University (Wharton), Hamilton Ont.; York University (Wharton), Toronto, Ont.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.180194
Publisher Site
http://dx.doi.org/10.1503/cmaj.180194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175624PMC
October 2018

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Prespecified Secondary End Points in ORION 1.

Circulation 2018 09;138(13):1304-1316

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, the Netherlands (R.M.S., J.J.P.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034710DOI Listing
September 2018

The place of gliclazide MR in the evolving type 2 diabetes landscape: A comparison with other sulfonylureas and newer oral antihyperglycemic agents.

Diabetes Res Clin Pract 2018 Sep 24;143:1-14. Epub 2018 May 24.

Diabetes Department, Hôpital Bichat-Claude Bernard, Assistance Publique des Hôpitaux de Paris, Université Denis Diderot Paris 7, and INSERM U1138, Paris, France.

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http://dx.doi.org/10.1016/j.diabres.2018.05.028DOI Listing
September 2018

Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients.

N Engl J Med 2018 09 26;379(12):1107-1117. Epub 2018 Aug 26.

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W., J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division, University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.); Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University, Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada; MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai, Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.); and the Translational Research Institute for Metabolism and Diabetes, Florida Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).

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http://dx.doi.org/10.1056/NEJMoa1808721DOI Listing
September 2018

Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes.

Metabolism 2018 08 13;85:32-37. Epub 2018 Feb 13.

Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Rd, Titusville, NJ 08560, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.02.002DOI Listing
August 2018

Inflammatory and Cholesterol Risk in the FOURIER Trial.

Circulation 2018 07 12;138(2):131-140. Epub 2018 Mar 12.

TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.B., R.P.G., J.-G.P., S.A.M., M.S.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034032DOI Listing
July 2018

DECLARE-TIMI 58: Participants' baseline characteristics.

Diabetes Obes Metab 2018 05 14;20(5):1102-1110. Epub 2018 Feb 14.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/dom.13217DOI Listing
May 2018

Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children.

Can J Cardiol 2018 05 1;34(5):506-525. Epub 2018 Mar 1.

Division of Internal Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2018.02.022DOI Listing
May 2018

Use of GLP-1 RAs in Cardiovascular Disease Prevention: A Practical Guide.

Circulation 2018 05;137(21):2200-2202

Division of Endocrinology & Metabolism, Li Ka Shing Knowledge Institute of St. Michael's Hospital and Departments of Medicine and Nutritional Sciences, University of Toronto, Ontario, Canada (L.A.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032759DOI Listing
May 2018

Dyslipidemia.

Can J Diabetes 2018 Apr;42 Suppl 1:S178-S185

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http://dx.doi.org/10.1016/j.jcjd.2017.10.019DOI Listing
April 2018

Effectiveness of gliclazide MR 60 mg in the management of type 2 diabetes: analyses from the EASYDia trial.

Diabetol Metab Syndr 2018 10;10:30. Epub 2018 Apr 10.

3Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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https://dmsjournal.biomedcentral.com/articles/10.1186/s13098
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http://dx.doi.org/10.1186/s13098-018-0331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894204PMC
April 2018

Metabolic Surgery: Weight Loss, Diabetes, and Beyond.

J Am Coll Cardiol 2018 02;71(6):670-687

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.12.014DOI Listing
February 2018

Questioning the safety and benefits of evolocumab - Authors' reply.

Lancet Diabetes Endocrinol 2018 01;6(1):11-12

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S2213-8587(17)30403-5DOI Listing
January 2018

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Am Heart Assoc 2017 Dec 20;6(12). Epub 2017 Dec 20.

Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada

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http://dx.doi.org/10.1161/JAHA.117.006659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779002PMC
December 2017