Publications by authors named "Laurie L Parker"

37 Publications

Multiplexable fluorescence lifetime imaging (FLIM) probes for Abl and Src-family kinases.

Chem Commun (Camb) 2020 Nov 9;56(87):13409-13412. Epub 2020 Oct 9.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, University of Minnesota, Minneapolis, 55455, USA.

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November 2020

Substrate binding to Src: A new perspective on tyrosine kinase substrate recognition from NMR and molecular dynamics.

Protein Sci 2020 02 21;29(2):350-359. Epub 2019 Nov 21.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.

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February 2020

Assays for tyrosine phosphorylation in human cells.

Methods Enzymol 2019 24;626:375-406. Epub 2019 Jul 24.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States. Electronic address:

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June 2020

High-throughput Identification of FLT3 Wild-type and Mutant Kinase Substrate Preferences and Application to Design of Sensitive In Vitro Kinase Assay Substrates.

Mol Cell Proteomics 2019 Mar 22;18(3):477-489. Epub 2020 Sep 22.

University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics, 420 Washington Avenue SE, Minneapolis, Minnesota 55455;. Electronic address:

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March 2019

A Gradient in Metaphase Tension Leads to a Scaled Cellular Response in Mitosis.

Dev Cell 2019 04 21;49(1):63-76.e10. Epub 2019 Feb 21.

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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April 2019

Multiomic Profiling of Tyrosine Kinase Inhibitor-Resistant K562 Cells Suggests Metabolic Reprogramming To Promote Cell Survival.

J Proteome Res 2019 04 21;18(4):1842-1856. Epub 2019 Feb 21.

Department of Biochemistry, Molecular Biology and Biophysics , University of Minnesota , Minneapolis , Minnesota 55455 , United States.

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April 2019

High-throughput Identification of FLT3 Wild-type and Mutant Kinase Substrate Preferences and Application to Design of Sensitive Kinase Assay Substrates.

Mol Cell Proteomics 2019 03 12;18(3):477-489. Epub 2018 Dec 12.

From the ‡University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics, 420 Washington Avenue SE, Minneapolis, Minnesota 55455;

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March 2019

In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates.

Biochemistry 2018 03 12;57(12):1847-1851. Epub 2018 Mar 12.

Department of Biochemistry, Molecular Biology and Biophysics , University of Minnesota , 420 Washington Avenue Southeast , Minneapolis , Minnesota 55455 , United States.

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March 2018

N-methyladenine is an epigenetic marker of mammalian early life stress.

Sci Rep 2017 12 22;7(1):18078. Epub 2017 Dec 22.

Department of Psychology, University of Wisconsin-Madison, University of Wisconsin-Madison, Madison, WI, 53706, United States.

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December 2017

A Cell-Based Assay for Measuring Endogenous BcrAbl Kinase Activity and Inhibitor Resistance.

PLoS One 2016 6;11(9):e0161748. Epub 2016 Sep 6.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana, United States of America.

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August 2017

Modular, Antibody-free Time-Resolved LRET Kinase Assay Enabled by Quantum Dots and Tb(3+)-sensitizing Peptides.

Sci Rep 2016 07 18;6:28971. Epub 2016 Jul 18.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 7-194 MCB Building, 420 Washington Ave SE, Minneapolis, MN 55455 USA.

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July 2016

Time-Resolved Proteomic Visualization of Dendrimer Cellular Entry and Trafficking.

J Am Chem Soc 2015 Oct 5;137(40):12772-12775. Epub 2015 Oct 5.

Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, United States.

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October 2015

Multicolored, Tb³⁺-Based Antibody-Free Detection of Multiple Tyrosine Kinase Activities.

Anal Chem 2015 Aug 24;87(15):7555-8. Epub 2015 Jul 24.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and Purdue Center for Cancer Research, Purdue University, 201 S. University Street, West Lafayette, Indiana 47907, United States.

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August 2015

KINATEST-ID: a pipeline to develop phosphorylation-dependent terbium sensitizing kinase assays.

J Am Chem Soc 2015 Feb 17;137(7):2484-94. Epub 2015 Feb 17.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907.

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February 2015

A time-resolved luminescence biosensor assay for anaplastic lymphoma kinase (ALK) activity.

Chem Commun (Camb) 2015 18;51(2):362-5. Epub 2014 Nov 18.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

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August 2015

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Curr Biol 2014 Mar 13;24(5):473-83. Epub 2014 Feb 13.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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March 2014

A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions.

Anal Chem 2013 May 8;85(10):5071-7. Epub 2013 May 8.

Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, United States.

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May 2013

Fluorescence lifetime imaging of biosensor peptide phosphorylation in single live cells.

Angew Chem Int Ed Engl 2013 Apr 28;52(14):3931-4. Epub 2013 Feb 28.

Department of Agricultural and Biological Engineering, Bindley Bioscience Center, Purdue Center for Cancer Research, Purdue University, 225 S. University Street, West Lafayette, IN 47907, USA.

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April 2013

A multiple reaction monitoring (MRM) method to detect Bcr-Abl kinase activity in CML using a peptide biosensor.

PLoS One 2013 20;8(2):e56627. Epub 2013 Feb 20.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA.

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September 2013

Time-resolved luminescence detection of spleen tyrosine kinase activity through terbium sensitization.

Anal Chem 2013 Mar 15;85(5):2582-8. Epub 2013 Feb 15.

Department of Medicinal Chemistry and Molecular Pharmacology and Purdue Center for Cancer Research, Purdue University, 201 S. University Street, West Lafayette, Indiana 47907, United States.

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March 2013

A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition.

Biochemistry 2012 Sep 12;51(38):7515-24. Epub 2012 Sep 12.

Department of Medicinal Chemistry and Molecular Pharmacology and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

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September 2012

Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.

Chembiochem 2012 Mar 14;13(5):665-73. Epub 2012 Feb 14.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

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March 2012

Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.

Cell Signal 2012 May 11;24(5):1064-73. Epub 2012 Jan 11.

Department of Medicinal Chemistry and Molecular Pharmacology and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, USA.

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May 2012

Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine.

J Biol Chem 2012 Jan 23;287(3):1662-9. Epub 2011 Nov 23.

Department of Biochemistry, Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.

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January 2012

Peptide reporters of kinase activity in whole cell lysates.

Biopolymers 2010 ;94(4):475-86

Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USA.

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September 2010

A peptide biosensor for detecting intracellular Abl kinase activity using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Anal Biochem 2010 Feb 7;397(1):73-8. Epub 2009 Oct 7.

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Center for Cancer Research, Purdue University, West Lafayette, IN 47904, USA.

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February 2010

A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates.

Anal Biochem 2008 Apr 25;375(1):18-26. Epub 2007 Dec 25.

Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA.

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April 2008