Publications by authors named "Laurent Decosterd"

100Publications

Population pharmacokinetic modelling to quantify the magnitude of drug-drug interactions between amlodipine and antiretroviral drugs.

Eur J Clin Pharmacol 2021 Jan 16. Epub 2021 Jan 16.

Centre for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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January 2021

Pharmacokinetic/Pharmacodynamic Modelling to Describe the Cholesterol Lowering Effect of Rosuvastatin in People Living with HIV.

Clin Pharmacokinet 2020 Oct 29. Epub 2020 Oct 29.

Centre for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 17, 1005, 1011, Lausanne, Switzerland.

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October 2020

Clinical Data Combined With Modeling and Simulation Indicate Unchanged Drug-Drug Interaction Magnitudes in the Elderly.

Clin Pharmacol Ther 2020 Aug 8. Epub 2020 Aug 8.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.

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August 2020

Effect of ageing on antiretroviral drug pharmacokinetics using clinical data combined with modelling and simulation.

Br J Clin Pharmacol 2020 May 29. Epub 2020 May 29.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.

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May 2020

The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib.

Front Pharmacol 2020 3;11:177. Epub 2020 Mar 3.

Service of Clinical Pharmacology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.

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March 2020

Polypharmacy, Drug-Drug Interactions, and Inappropriate Drugs: New Challenges in the Aging Population With HIV.

Open Forum Infect Dis 2019 Dec 21;6(12):ofz531. Epub 2019 Dec 21.

Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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December 2019

Therapeutic Drug Monitoring of Newer Antiepileptic Drugs: A Randomized Trial for Dosage Adjustment.

Ann Neurol 2020 01 26;87(1):22-29. Epub 2019 Nov 26.

Department of Clinical Neurosciences, Neurology Service, Lausanne University Hospital (Vaud University Hospital Center) and University of Lausanne, Lausanne, Switzerland.

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January 2020

Pharmacokinetic profiles of boosted darunavir, dolutegravir and lamivudine in aging people living with HIV.

AIDS 2020 01;34(1):103-108

aService of Clinical Pharmacology, University Hospital of Lausanne and University of Lausanne, Lausanne bDivision of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel cUniversity of Basel, Basel dInstitute of Pharmaceutical Sciences of Western Switzerland, Geneva eService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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January 2020

Population pharmacokinetics of dolutegravir: influence of drug-drug interactions in a real-life setting.

J Antimicrob Chemother 2019 09;74(9):2690-2697

Service of Clinical Pharmacology, University Hospital Centre and University of Lausanne, Bugnon 17, Lausanne, Switzerland.

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September 2019

Severe rosuvastatin accumulation with rhabdomyolysis due to drug interactions and low cardiac output syndrome.

Br J Clin Pharmacol 2019 07 3;85(7):1616-1618. Epub 2019 May 3.

Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.

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July 2019

Intravenous brivaracetam in status epilepticus: Correlation between loading dose, plasma levels and clinical response.

Epilepsy Res 2019 01 3;149:88-91. Epub 2018 Dec 3.

Department of Clinical Neurosciences, Neurology Service, University Hospital (CHUV) and Faculty of Biology and Medicine of Lausanne, Switzerland. Electronic address:

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January 2019

Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy.

Nat Commun 2018 11 19;9(1):4848. Epub 2018 Nov 19.

Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne, University of Geneva, CMU 5-6, Rue Michel-Servet 1, Geneva, 1211, Switzerland.

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November 2018

Levetiracetam circulating concentrations and response in status epilepticus.

Epilepsy Behav 2018 11 18;88:61-65. Epub 2018 Sep 18.

Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Switzerland. Electronic address:

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November 2018

Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania.

PLoS One 2018 7;13(9):e0202745. Epub 2018 Sep 7.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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February 2019

Comparison against current standards of a DNA aptamer for the label-free quantification of tobramycin in human sera employed for therapeutic drug monitoring.

J Pharm Biomed Anal 2018 Sep 30;159:341-347. Epub 2018 Jun 30.

Ecole Polytechnique Fédérale de Lausanne, Institute of Bioengineering, Station 17, CH-1015 Lausanne, Switzerland. Electronic address:

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September 2018

Efficacy and safety of continuous infusions with elastomeric pumps for outpatient parenteral antimicrobial therapy (OPAT): an observational study.

J Antimicrob Chemother 2018 09;73(9):2540-2545

Department of Ambulatory Care and Community Medicine, and Infectious Diseases Service, University Hospital of Lausanne, Av du Bugnon 44, 1011 Lausanne, Switzerland.

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September 2018

The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction.

Shock 2018 06;49(6):675-681

Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.

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June 2018

Lamotrigine serum levels: Ceiling effect in people with epilepsy in remission?

Epilepsy Behav 2017 09 4;74:41-44. Epub 2017 Jul 4.

Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland. Electronic address:

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September 2017

Intravenous lacosamide in status epilepticus: Correlation between loading dose, serum levels, and clinical response.

Epilepsy Res 2017 09 20;135:38-42. Epub 2017 May 20.

Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Switzerland. Electronic address:

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September 2017

Adequate plasma drug concentrations suggest that amoxicillin can be administered by continuous infusion using elastomeric pumps.

J Antimicrob Chemother 2017 09;72(9):2613-2615

Department of Ambulatory Care and Community Medicine, University Hospital of Lausanne, Lausanne, Switzerland.

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September 2017

Darunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir.

J Antimicrob Chemother 2017 09;72(9):2574-2577

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.

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September 2017

Free and total plasma concentrations of elvitegravir/cobicistat during pregnancy and postpartum: a case report.

Br J Clin Pharmacol 2017 12 16;83(12):2835-2838. Epub 2017 May 16.

Division of Clinical Pharmacology, Department of Laboratories, University Hospital of Lausanne, Lausanne, Switzerland.

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December 2017

Is Penicillin Plus Gentamicin Synergistic against Clinical Group B isolates?: An Study.

Front Microbiol 2016 21;7:1680. Epub 2016 Oct 21.

Institute for Infectious Diseases, University of BernBern, Switzerland; Department of Infectious Diseases, Bern University Hospital, University of BernBern, Switzerland.

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October 2016

Population Pharmacokinetics and Pharmacogenetics Analysis of Rilpivirine in HIV-1-Infected Individuals.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Division of Clinical Pharmacology, University Hospital Center, University of Lausanne, Lausanne, Switzerland

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January 2017

Is gentamicin necessary in the antimicrobial treatment for group B streptococcal infections in the elderly? An in vitro study with human blood products.

Infect Dis (Lond) 2017 Mar 21;49(3):185-192. Epub 2016 Oct 21.

a Institute for Infectious Diseases, University of Bern , Bern , Switzerland.

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March 2017

Therapeutic drug monitoring for sofosbuvir and daclatasvir in transplant recipients with chronic hepatitis C and advanced renal disease.

J Hepatol 2016 11 25;65(5):1063-1065. Epub 2016 Jul 25.

Division of Clinical Pharmacology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.

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November 2016

Population pharmacokinetic analysis of elvitegravir and cobicistat in HIV-1-infected individuals.

J Antimicrob Chemother 2016 07 29;71(7):1933-42. Epub 2016 Mar 29.

Division of Clinical Pharmacology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

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July 2016

Antitumoral Effect of Sunitinib-eluting Beads in the Rabbit VX2 Tumor Model.

Radiology 2016 08 26;280(2):425-35. Epub 2016 Feb 26.

From the Departments of Radiology (P.B., R.D., A.D.), Surgery (O.D.), and Clinical Pharmacology (L.A.D.), University Hospital of Lausanne, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland (K.F., O.J., E.D.); and Archimmed, Paris, France (J.N.).

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August 2016

In Vivo Profiling and Distribution of Known and Novel Phase I and Phase II Metabolites of Efavirenz in Plasma, Urine, and Cerebrospinal Fluid.

Drug Metab Dispos 2016 Jan 9;44(1):151-61. Epub 2015 Nov 9.

Laboratory of Clinical Pharmacology, Service of Biomedicine (M.A., B.T., M.R., L.A.D.), Division of Clinical Pharmacology, Service of Biomedicine (M.A., C.B., T.B.), Service of Infectious Diseases (B.T., M.C.), Institute of Microbiology (A.T., M.R.), and Innovation and Development, Service of Biomedicine (H.H.), University Hospital and University of Lausanne, Lausanne, Switzerland; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland (A.A., H.F.G.); Institute of Medical Virology, University of Zurich, Zurich, Switzerland (H.F.G.); Division of Infectious Diseases, Cantonal Hospital, St. Gallen, Switzerland (P.V.); Laboratory of Virology, University Hospital of Geneva, Geneva, Switzerland (S.Y.); and The J. Craig Venter Institute, La Jolla, California (A.T.)

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January 2016

Therapeutic drug monitoring of targeted anticancer therapy.

Biomark Med 2015 3;9(9):887-93. Epub 2015 Sep 3.

Division of Clinical Pharmacology, Service of Biomedicine, Lausanne University Hospital & University of Lausanne, Switzerland.

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July 2016

Sofosbuvir and ribavirin before liver re-transplantation for graft failure due to recurrent hepatitis C: a case report.

BMC Gastroenterol 2015 Mar 26;15:38. Epub 2015 Mar 26.

Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.

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March 2015

Label-free detection of tobramycin in serum by transmission-localized surface plasmon resonance.

Anal Chem 2015 May 28;87(10):5278-85. Epub 2015 Apr 28.

†Institute of Bioengineering, École polytechnique fédérale de Lausanne, Lausanne, CH-1015 Switzerland.

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May 2015

Pharmacokinetic modelling of dialytic clearance in a case of acyclovir intoxication.

Int J Antimicrob Agents 2015 Mar 17;45(3):325-7. Epub 2014 Dec 17.

Division of Clinical Pharmacology, Department of Laboratories, Centre hospitalier universitaire vaudois, Lausanne, Switzerland. Electronic address:

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March 2015

High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate.

J Chromatogr A 2014 Nov 2;1369:52-63. Epub 2014 Oct 2.

Division and Laboratory of Clinical Pharmacology, Service of Biomedicine, Department of Laboratories, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. Electronic address:

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November 2014

Shotgun ecotoxicoproteomics of Daphnia pulex: biochemical effects of the anticancer drug tamoxifen.

J Proteome Res 2015 Jan 13;14(1):279-91. Epub 2014 Nov 13.

Institute of Earth Surface Dynamics, Géopolis, University of Lausanne , 1015 Lausanne, Switzerland.

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January 2015

Population pharmacokinetics and clinical response for artemether-lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Tanzania.

Antimicrob Agents Chemother 2014 Aug 27;58(8):4583-92. Epub 2014 May 27.

Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland Department of Ambulatory Care and Community Medicine and Division of Infectious Diseases, University Hospital, Lausanne, Switzerland.

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August 2014

Erlotinib: another candidate for the therapeutic drug monitoring of targeted therapy of cancer? A pharmacokinetic and pharmacodynamic systematic review of literature.

Ther Drug Monit 2015 Feb;37(1):2-21

*Department of Pharmacy, Paul Strauss Cancer Center, Strasbourg, France; †Division of Clinical Pharmacology, University Hospital Center and University of Lausanne; ‡School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland; §Department of Pneumology; and ¶Department of Pharmacy, University Hospital Center and University of Strasbourg; ‖Translational Federation of Medicine and Faculty of Pharmacy, University of Strasbourg, Strasbourg, France; and **Pharmacy of Eastern Vaud Hospitals, Vevey, Switzerland.

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February 2015

Efavirenz intoxication due to a new CYP2B6 constellation.

Antivir Ther 2013 2;18(5):739-43. Epub 2013 May 2.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.

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June 2014

Multiplex liquid chromatography-tandem mass spectrometry assay for simultaneous therapeutic drug monitoring of ribavirin, boceprevir, and telaprevir.

Antimicrob Agents Chemother 2013 Jul 29;57(7):3147-58. Epub 2013 Apr 29.

Innovation & Development Laboratory, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.

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July 2013

Prediction of free imatinib concentrations based on total plasma concentrations in patients with gastrointestinal stromal tumours.

Br J Clin Pharmacol 2013 Apr;75(4):1007-18

Division of Clinical Pharmacology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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April 2013

Therapeutic drug monitoring of imatinib: Bayesian and alternative methods to predict trough levels.

Clin Pharmacokinet 2012 Mar;51(3):187-201

Division of Clinical Pharmacology and Toxicology, Laboratory Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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March 2012

Emission wavelength tuning by mechanical stressing of GaAs/Ge/Si microbeams.

Opt Express 2011 Aug;19(17):15732-8

Department of Materials Engineering, The University of Tokyo, 7-3-1, Hongo Bunkyo, Tokyo, 113-8656, Japan.

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August 2011

P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases.

Anticancer Res 2011 Jun;31(6):2121-8

Division of Clinical Pharmacology and Toxicology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University Hospital, BH18-218, CH-1011 Lausanne, Switzerland.

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June 2011

Cell disposition of raltegravir and newer antiretrovirals in HIV-infected patients: high inter-individual variability in raltegravir cellular penetration.

J Antimicrob Chemother 2011 Jul 19;66(7):1573-81. Epub 2011 Apr 19.

Division of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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July 2011

Antiretroviral drug toxicity in relation to pharmacokinetics, metabolic profile and pharmacogenetics.

Expert Opin Drug Metab Toxicol 2011 ;7(5):609-22

Department of Clinical Pharmacology and Toxicology, University Hospital and University of Lausanne, Beaumont, Lausanne, Switzerland.

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May 2016

Who is in charge of assessing therapeutic drug monitoring? The case of imatinib.

Lancet Oncol 2011 Jan 24;12(1):9-11. Epub 2010 Nov 24.

Division of Clinical Pharmacology and Toxicology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne 1011, Switzerland.

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January 2011

Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza: pharmacokinetic and pharmacodynamic characteristics.

Clin Pharmacokinet 2010 Nov;49(11):741-65

Division of Clinical Pharmacology and Toxicology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.

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November 2010

Ultra-performance liquid chromatography mass spectrometry and sensitive bioassay methods for quantification of posaconazole plasma concentrations after oral dosing.

Antimicrob Agents Chemother 2010 Dec 4;54(12):5074-81. Epub 2010 Oct 4.

Quantitative Mass Spectrometry Facility, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.

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December 2010