Publications by authors named "Laurens Wiel"

10Publications

MetaDome: Pathogenicity analysis of genetic variants through aggregation of homologous human protein domains.

Hum Mutat 2019 08 18;40(8):1030-1038. Epub 2019 Jun 18.

Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/humu.23798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772141PMC
August 2019

Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts.

Nucleic Acids Res 2017 Oct;45(18):10634-10648

Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkx704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737536PMC
October 2017

Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes.

Am J Hum Genet 2017 Sep 31;101(3):478-484. Epub 2017 Aug 31.

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591029PMC
September 2017

Aggregation of population-based genetic variation over protein domain homologues and its potential use in genetic diagnostics.

Hum Mutat 2017 11 31;38(11):1454-1463. Epub 2017 Aug 31.

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, GA, 6525, The Netherlands.

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http://doi.wiley.com/10.1002/humu.23313
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http://dx.doi.org/10.1002/humu.23313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656839PMC
November 2017