Publications by authors named "Laurence M Boon"

52Publications

Genetics of vascular anomalies.

Semin Pediatr Surg 2020 Oct 16;29(5):150967. Epub 2020 Sep 16.

Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium; Center for Vascular Anomalies, Division of Plastic Surgery, VASCERN VASCA European Reference Centre, Saint Luc University Hospital, Brussels, Belgium; WELBIO (Walloon Excellence in Lifesciences and Biotechnology), de Duve Institute, University of Louvain, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150967DOI Listing
October 2020

New and Emerging Targeted Therapies for Vascular Malformations.

Am J Clin Dermatol 2020 Oct;21(5):657-668

Center for Vascular Anomalies, Division of Plastic Surgery, VASCERN VASCA European Reference Centre, Saint Luc University Hospital, Avenue Hippocrate 10, 1200, Brussels, Belgium.

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http://dx.doi.org/10.1007/s40257-020-00528-wDOI Listing
October 2020

Theranostic Advances in Vascular Malformations.

J Invest Dermatol 2020 Apr;140(4):756-763

Centre for Vascular Anomalies, Division of Plastic Surgery, Cliniques universitaires Saint-Luc; European Reference Network for Rare Multisystemic Vascular Diseases Vascular Anomalies European Reference Centre, Brussels, Belgium; Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium; Walloon Excellence in Lifesciences and Biotechnology, de Duve Institute, University of Louvain, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.10.001DOI Listing
April 2020

The Infantile Hemangioma Referral Score: A Validated Tool for Physicians.

Pediatrics 2020 04 11;145(4). Epub 2020 Mar 11.

Centre for Laser and Vascular Anomalies, Department of Dermatology, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1542/peds.2019-1628DOI Listing
April 2020

mosaic mutations in patients with capillary malformation-arteriovenous malformation.

J Med Genet 2020 01 12;57(1):48-52. Epub 2019 Jul 12.

Center for Vascular Anomalies, Division of Plastic Surgery, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium; VASCERN VASCA European Reference Center.

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http://dx.doi.org/10.1136/jmedgenet-2019-106024DOI Listing
January 2020

Rapamycin and treatment of venous malformations.

Curr Opin Hematol 2019 05;26(3):185-192

Center for Vascular Anomalies, Division of Plastic Surgery.

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http://dx.doi.org/10.1097/MOH.0000000000000498DOI Listing
May 2019

Sirolimus is efficacious in treatment for extensive and/or complex slow-flow vascular malformations: a monocentric prospective phase II study.

Orphanet J Rare Dis 2018 10 29;13(1):191. Epub 2018 Oct 29.

Center for Vascular Anomalies, Division of Plastic Surgery, Cliniques universitaires Saint Luc, University of Louvain, 10 avenue Hippocrate, B-1200, Brussels, Belgium.

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0
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http://dx.doi.org/10.1186/s13023-018-0934-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206885PMC
October 2018

Angiosarcoma arising from congenital primary lymphedema.

Pediatr Dermatol 2018 Nov 14;35(6):e382-e388. Epub 2018 Sep 14.

Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1111/pde.13664DOI Listing
November 2018

Etiology and Genetics of Congenital Vascular Lesions.

Otolaryngol Clin North Am 2018 Feb;51(1):41-53

Human Molecular Genetics, de Duve Institute, University of Louvain, Avenue Hippocrate 74 (+5), Brussels B-1200, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.otc.2017.09.006DOI Listing
February 2018

Venous Malformations of the Head and Neck.

Otolaryngol Clin North Am 2018 Feb;51(1):173-184

Human Molecular Genetics, de Duve Institute, University of Louvain, Avenue Hippocrate 74, 1200 Brussels, Belgium; Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques Universitaires Saint Luc, University of Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.otc.2017.09.003DOI Listing
February 2018

Vascular Anomalies Caused by Abnormal Signaling within Endothelial Cells: Targets for Novel Therapies.

Semin Intervent Radiol 2017 Sep 11;34(3):233-238. Epub 2017 Sep 11.

Laboratory of Human Molecular Genetics, de Duve Institute, University of Louvain (UCL), Brussels, Belgium.

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http://dx.doi.org/10.1055/s-0037-1604296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615384PMC
September 2017

Germline Loss-of-Function Mutations in EPHB4 Cause a Second Form of Capillary Malformation-Arteriovenous Malformation (CM-AVM2) Deregulating RAS-MAPK Signaling.

Circulation 2017 Sep 7;136(11):1037-1048. Epub 2017 Jul 7.

From Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels, Belgium (M.A., R.H., M.V.); Center for Human Genetics, Cliniques Universitaires St Luc, Université catholique de Louvain, Brussels, Belgium (N.R.); Université catholique de Louvain, Brussels, Belgium (E.P.); Department of Dermatology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain (E.B.); Department of Dermatology, Hospital Garrahan, Buenos Aires, Argentina (M.C.); Strong Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY (M.C.); Departments of Pediatrics and Medicine, Columbia University, New York (W.C., A.B.); Department of Medical Imaging, Sainte-Justine Mother- Child University Hospital, Montreal, Canada (J.D.); Service de Dermatologie, Centre Hospitalo-Universitaire de Nice, France (J.-P.L.); Genética Molecular, Hospital Sant Joan de Déu, Barcelona, Spain (L.M.); Service de Dermatologie, Centre de Référence des Maladies rares de la peau, Hôpital Larrey, Toulouse, France (J.M.-H.); Departments of Medicine and Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (R.E.P.); Victorian Clinical Genetics Services, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia (D.J.A.); Department of Neuroradiology, Lariboisière Hospital, Paris, France (A.B.); Vascular Anomalies Program, Lenox Hill Hospital, New York (F.B.); Vascular Birthmark Institute of New York, Roosevelt Hospital (F.B.); Department of Pediatrics, Medical Genetics University of Iowa Carver College of Medicine, Iowa City (H.B.); Department of Dermatology, Université de Caen Basse Normandie, CHU Caen, France (A.D.); Department of Urology, Wake Forest School of Medicine, Winston Salem, NC (D.B.); Genetics Service, Paediatric Department, University Hospital Santa Maria, Lisbon, Portugal (J.D.); Department of Dermatology, Hospital Sant Joan de Deu, Barcelona, Spain (M.A.G.-E.); Departement of Dermatology, School of Medicine, University of California, San Francisco (I.P.); Department of Genetics, University Hospital, Caen, France (M.G.); Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden (M.K.); Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, CA (A.K.H.-K., L.H.); Hopital Pellegrin Enfants, Bordeaux, France (C.L.-L.); Hôpital Sainte-Justine, Montréal, Quebec, Canada (C.M.); Department of Dermatology, Texas Children's Hospital, Houston (D.M.); Département de Pédiatrie et Génétique Médicale, CHRU Hôpital Morvan, Brest, France (P.P.); Department of Dermatology, Paul Sabatier University, Toulouse, France (C.P.); Service de Génétique Clinique, Hôpital Jeanne de Flandre, Lille, France (F.P.); Pediatric Dermatology Unit, Claude Bernard-Lyon, University and Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, France (A.P.); Centre Hospitalier Universitaire, Montpellier, France (I.Q.); Dermatolgie, Faculté de Médecine d'Alger, Algeria (A.S.); Department of Medical Genetics, Sydney Children's Hospital, Randwick, New South Wales, Australia (A.T.); Service de Dermatologie, Centre Hospitalo-Universitaire Dijon-Bourgogne, France (P.V.); Department of Dermatology, Hospital Sant Joan de Deu, Barcelona, Spain (A.V.); Department of Paediatric Dermatology, Sydney Children's Hospital, School of Women's and Children's Health University of New South Wales, Sydney, Australia (O.W.); Department of Plastic and Reconstructive Surgery, University of Tokyo, Hongo, Japan (S.W.); Department of Pediatric Dermatology, University Children's Hospital Zurich, Switzerland (L.W.); Children's Hospital of New York (A.W.); University of Iowa Hospitals and Clinics, Iowa City (M.W.); Department of Pediatrics, Washington University, St. Louis, MO (M.W.); and Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, Boston, MA (L.M.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026886DOI Listing
September 2017

Risk Factors for Degree and Type of Sequelae After Involution of Untreated Hemangiomas of Infancy.

JAMA Dermatol 2016 11;152(11):1239-1243

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1001/jamadermatol.2016.2905DOI Listing
November 2016

[Rapamycin opens the era of targeted molecular therapy of venous malformations].

Med Sci (Paris) 2016 Jun-Jul;32(6-7):574-8. Epub 2016 Jul 12.

Génétique Moléculaire Humaine, institut de Duve, université catholique de Louvain, Bruxelles, DDUV, Avenue Hippocrate 75, 1200 Woluwe-Saint-Lambert, Belgique - Centre des anomalies vasculaires, division de chirurgie plastique, cliniques universitaires Saint-Luc, université catholique de Louvain, Bruxelles, Belgique.

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http://dx.doi.org/10.1051/medsci/20163206016DOI Listing
July 2017

Somatic Activating PIK3CA Mutations Cause Venous Malformation.

Am J Hum Genet 2015 Dec;97(6):914-21

Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678782PMC
December 2015

Blue bleb rubber nevus syndrome.

Handb Clin Neurol 2015 ;132:223-30

Laboratory of Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/B97804446270250
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http://dx.doi.org/10.1016/B978-0-444-62702-5.00016-0DOI Listing
August 2016

Dabigatran etexilate versus low-molecular weight heparin to control consumptive coagulopathy secondary to diffuse venous vascular malformations.

Blood Coagul Fibrinolysis 2016 Mar;27(2):216-9

aHaematology-Haemostasis Unit, University Hospital, Tours, France bHaemostasis and Thrombosis Unit, Haemophilia Clinic, Division of Haematology cHaemostasis Laboratory, Department of Biological Chemistry dDivision of Plastic and Reconstructive Surgery, Center for Vascular Anomalies, Clinic of the Saint-Luc University Hospital, Catholic University of Leuven, Brussels, Belgium.

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http://dx.doi.org/10.1097/MBC.0000000000000412DOI Listing
March 2016

Common and specific effects of TIE2 mutations causing venous malformations.

Hum Mol Genet 2015 Nov 28;24(22):6374-89. Epub 2015 Aug 28.

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland,

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http://dx.doi.org/10.1093/hmg/ddv349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614705PMC
November 2015

Treatment of infantile haemangiomas: recommendations of a European expert group.

Eur J Pediatr 2015 Jul 29;174(7):855-65. Epub 2015 May 29.

Department of Paediatrics and Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Liliencronstr. 130, Hamburg, 22149, Germany,

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http://dx.doi.org/10.1007/s00431-015-2570-0DOI Listing
July 2015

Surgical Treatment of Intra-articular Knee Venous Malformations: When and How?

J Pediatr Orthop 2016 Apr-May;36(3):316-22

*Department of Orthopaedic Surgery †Division of Plastic and Reconstructive Surgery, Center for Vascular Anomalies, Cliniques universitaires St-Luc, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1097/BPO.0000000000000432DOI Listing
November 2016

Genetics of vascular malformations.

Semin Pediatr Surg 2014 Aug 19;23(4):221-6. Epub 2014 Jun 19.

Laboratory of Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels, Belgium; Walloon Excellence in Lifesciences and Biotechnology (WELBIO), de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1053/j.sempedsurg.2014.06.014DOI Listing
August 2014

Reconstructive surgery in the management of a patient with CLOVES syndrome.

J Plast Reconstr Aesthet Surg 2013 Dec 16;66(12):1813-5. Epub 2013 Jul 16.

Center for Vascular Anomalies, Division of Plastic and Reconstructive Surgery, Cliniques universitaires St. Luc, Université catholique de Louvain, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bjps.2013.06.045DOI Listing
December 2013

Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB.

Hum Mol Genet 2013 Sep 30;22(17):3438-48. Epub 2013 Apr 30.

Laboratory of Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1093/hmg/ddt198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736867PMC
September 2013

Vascular anomalies: from genetics toward models for therapeutic trials.

Cold Spring Harb Perspect Med 2012 Aug 1;2(8). Epub 2012 Aug 1.

Laboratory of Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1101/cshperspect.a009688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405833PMC
August 2012

Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations.

Eur Radiol 2011 Dec 7;21(12):2647-56. Epub 2011 Aug 7.

Department of Dermatology, Université de Caen Basse Normandie, CHU Caen, Av Georges Clémenceau, 14033 Caen, France.

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http://dx.doi.org/10.1007/s00330-011-2213-4DOI Listing
December 2011

Pathogenesis of vascular anomalies.

Clin Plast Surg 2011 Jan;38(1):7-19

Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques Universitaires St Luc, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.cps.2010.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031181PMC
January 2011

Acute life-threatening presentation of unknown lymphatic malformation.

Am J Emerg Med 2010 Nov;28(9):1062.e1-3

Pediatric Intensive Care Unit, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ajem.2010.01.031DOI Listing
November 2010

Elevated D-dimer level in the differential diagnosis of venous malformations.

Arch Dermatol 2009 Nov;145(11):1239-44

Department of Dermatology, Université de Caen Basse, Normandie, Centre Hospitalier, Universitaire de Caen, Caen, France.

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http://dx.doi.org/10.1001/archdermatol.2009.296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561655PMC
November 2009

Sporadic in utero generalized edema caused by mutations in the lymphangiogenic genes VEGFR3 and FOXC2.

J Pediatr 2009 Jul 25;155(1):90-3. Epub 2009 Apr 25.

Laboratory of Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.jpeds.2009.02.023DOI Listing
July 2009

From germline towards somatic mutations in the pathophysiology of vascular anomalies.

Hum Mol Genet 2009 Apr;18(R1):R65-74

de Duve Institute, Division of Plastic Surgery, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1093/hmg/ddp002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657941PMC
April 2009

From blue jeans to blue genes.

J Craniofac Surg 2009 Mar;20 Suppl 1:703-6

Center for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

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https://insights.ovid.com/crossref?an=00001665-200903001-000
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http://dx.doi.org/10.1097/SCS.0b013e318193d7a0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901832PMC
March 2009

Congenital plaque-type glomuvenous malformations presenting in childhood.

Arch Dermatol 2006 Jul;142(7):892-6

Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1001/archderm.142.7.892DOI Listing
July 2006

A novel mutation in the MSX2 homeobox gene of a family with foramina parietalia permagna, headache and vascular anomaly.

Eur J Pediatr 2006 Oct 27;165(10):734-5. Epub 2006 Apr 27.

Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 74 (+5), 1200, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00431-006-0138-8DOI Listing
October 2006

RASA1: variable phenotype with capillary and arteriovenous malformations.

Curr Opin Genet Dev 2005 Jun;15(3):265-9

Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.gde.2005.03.004DOI Listing
June 2005

Glomuvenous malformation (glomangioma) and venous malformation: distinct clinicopathologic and genetic entities.

Arch Dermatol 2004 Aug;140(8):971-6

Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archderm.140.8.971DOI Listing
August 2004

Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations.

Am J Hum Genet 2003 Dec 24;73(6):1240-9. Epub 2003 Nov 24.

Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180390PMC
http://dx.doi.org/10.1086/379793DOI Listing
December 2003

A novel mutation in the SDHD gene in a family with inherited paragangliomas--implications of genetic diagnosis for follow up and treatment.

Head Neck 2003 Feb;25(2):146-51

Department of Radiation Oncology, Cliniques universitaires St Luc, Université catholique de Louvain, Brussels, Belgium.

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http://doi.wiley.com/10.1002/hed.10220
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http://dx.doi.org/10.1002/hed.10220DOI Listing
February 2003

Locus for susceptibility for familial capillary malformation ('port-wine stain') maps to 5q.

Eur J Hum Genet 2002 Jun;10(6):375-80

Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology & Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1038/sj.ejhg.5200817DOI Listing
June 2002

Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas").

Am J Hum Genet 2002 Apr 13;70(4):866-74. Epub 2002 Feb 13.

Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 74(+5), B-1200 Brussels, Belgium.

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http://dx.doi.org/10.1086/339492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379115PMC
April 2002