Publications by authors named "Laurence Lafanechère"

50Publications

Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation.

Eur J Med Chem 2020 Oct 4;209:112873. Epub 2020 Oct 4.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112873DOI Listing
October 2020

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells.

Cancers (Basel) 2020 Aug 6;12(8). Epub 2020 Aug 6.

INSERM U1209, CNRS UMR5309, Team Regulation and Pharmacology of the Cytoskeleton, Department of Microenvironment, Cell Plasticity and Signaling, Institute for Advanced Biosciences, Université Grenoble Alpes, 38000 Grenoble, France.

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http://dx.doi.org/10.3390/cancers12082196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463452PMC
August 2020

A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval.

Front Pharmacol 2020 30;11:543. Epub 2020 Apr 30.

Institute for Advanced Biosciences, Team Regulation and Pharmacology of the Cytoskeleton, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France.

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http://dx.doi.org/10.3389/fphar.2020.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204994PMC
April 2020

Marginal band microtubules are acetylated by αTAT1.

Platelets 2020 May 2:1-5. Epub 2020 May 2.

Institute for Advanced Biosciences, University Grenoble Alpes, INSERM, CNRS, Grenoble, France.

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http://dx.doi.org/10.1080/09537104.2020.1759791DOI Listing
May 2020

Live imaging of single platelets at work.

Platelets 2020 Jul 27;31(5):551-558. Epub 2019 Dec 27.

Institute for Advanced Biosciences, University Grenoble Alpes , Grenoble, France.

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http://dx.doi.org/10.1080/09537104.2019.1708886DOI Listing
July 2020

[On the road to deciphering the tubulin code: focus on acetylation and detyrosination].

Med Sci (Paris) 2018 Dec 9;34(12):1047-1055. Epub 2019 Jan 9.

Régulation et pharmacologie du cytosquelette, Institut pour l'avancée des biosciences, Université Grenoble Alpes ; Inserm U 1209 ; CNRS 5309, Allée des Alpes, 38700 La Tronche, France.

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https://www.medecinesciences.org/10.1051/medsci/2018295
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http://dx.doi.org/10.1051/medsci/2018295DOI Listing
December 2018

The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo.

Biochem Pharmacol 2019 02 7;160:1-13. Epub 2018 Dec 7.

Cancer Target and Experimental Therapeutics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.12.004DOI Listing
February 2019

LIM kinases: cofilin and beyond.

Oncotarget 2017 Jun;8(25):41749-41763

Institute for Advanced Biosciences, INSERM, CNRS UMR, Université Grenoble Alpes, Grenoble, France.

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http://dx.doi.org/10.18632/oncotarget.16978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522193PMC
June 2017

Targeting LIM kinases in taxane resistant tumors.

Oncotarget 2016 08;7(32):50816-50817

Université Grenoble Alpes, INSERM U823, Institut Albert Bonniot, Team "Polarity, Development and Cancer", Grenoble, France.

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http://dx.doi.org/10.18632/oncotarget.10816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239435PMC
August 2016

LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.

Sci Rep 2016 04 27;6:24925. Epub 2016 Apr 27.

Institut Curie, PSL Research University, CNRS UMR 144, Membrane and Cytoskeleton Dynamics, 75248 cedex 05, Paris, France.

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http://dx.doi.org/10.1038/srep24925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847008PMC
April 2016

β3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner.

J Cell Biol 2016 Mar 7;212(6):693-706. Epub 2016 Mar 7.

Institut National de la Santé et de la Recherche Médicale U823, Institut Albert Bonniot, 38042 Grenoble, France Centre National de la Recherche Scientifique, Equipe de Recherche Labellisée 5284, 38042 Grenoble, France Université Grenoble Alpes, 38041 Grenoble, France.

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http://dx.doi.org/10.1083/jcb.201508018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792076PMC
March 2016

Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations.

Cancer Chemother Pharmacol 2015 Feb 30;75(2):431-7. Epub 2014 Dec 30.

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia, Pretoria, Gauteng, 0007, South Africa,

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http://dx.doi.org/10.1007/s00280-014-2653-zDOI Listing
February 2015

Novel synthetic pharmacophores inducing a stabilization of cellular microtubules.

Curr Cancer Drug Targets 2015 ;15(1):2-13

Centre de Recherche INSERM-UJF U823, Institut Albert Bonniot, Team 3 "Polarity, Development and Cancer", UJF Site Sante, BP 170-La Tronche-38042 Grenoble Cedex 9 - France.

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http://dx.doi.org/10.2174/1568009615666141215154149DOI Listing
November 2015

[Chemical biology: cross-border strategies].

Med Sci (Paris) 2014 Dec 24;30(12):1059-60. Epub 2014 Dec 24.

AFMB (architecture et fonction des macromolécules biologiques), Polytech-Marseille, Campus de Luminy, 13288 Marseille Cedex 09, France.

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http://dx.doi.org/10.1051/medsci/20143012001DOI Listing
December 2014

Improving detection of rare biological events in high-throughput screens.

J Biomol Screen 2015 Feb 4;20(2):230-41. Epub 2014 Sep 4.

McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada Department of Human Genetics, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1177/1087057114548853DOI Listing
February 2015

[Phenotypic screens or one stone to kill two birds: discover the target and its pharmacological regulator].

Med Sci (Paris) 2013 Oct 18;29(10):897-905. Epub 2013 Oct 18.

Institut Albert Bonniot, CRI Inserm/Université Joseph Fourier (UJF) U823, équipe 3 Polarité, développement et cancer, rond-point de la Chantourne, 38706 La Tronche Cedex, France.

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http://dx.doi.org/10.1051/medsci/20132910018DOI Listing
October 2013

Single assay-wide variance experimental (SAVE) design for high-throughput screening.

Bioinformatics 2013 Dec 20;29(23):3067-72. Epub 2013 Sep 20.

McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 0G1, Canada, McGill Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada, Equipe Criblage pour des Molécules Bio-Actives (CMBA), CEA Grenoble, Grenoble Cedex 09, France, INSERM, U823, Université Joseph Fourier-Grenoble 1 and Institut Albert Bonniot, Grenoble F-38706, France.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btt538DOI Listing
December 2013

Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells.

Cancer Cell Int 2013 Aug 27;13(1):87. Epub 2013 Aug 27.

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia, 0007 Gauteng, Pretoria, South Africa.

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http://dx.doi.org/10.1186/1475-2867-13-87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766685PMC
August 2013

Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells.

Mol Ther Nucleic Acids 2013 Aug 20;2:e116. Epub 2013 Aug 20.

Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, UCBL1, IFR128, 46 allée d'Italie, Lyon Cedex 07, France.

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http://dx.doi.org/10.1038/mtna.2013.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759739PMC
August 2013

Intensity quantile estimation and mapping--a novel algorithm for the correction of image non-uniformity bias in HCS data.

Bioinformatics 2012 Oct 22;28(20):2632-9. Epub 2012 Aug 22.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/bioinformatics/bts491DOI Listing
October 2012

Preparation of pure tyrosinated or detyrosinated tubulin isoforms.

Methods Mol Biol 2011 ;777:71-86

Albert Bonniot Institute, CRI INSERM/UJF U823, Grenoble, France.

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http://dx.doi.org/10.1007/978-1-61779-252-6_5DOI Listing
November 2011

High-content screening for the discovery of pharmacological compounds: advantages, challenges and potential benefits of recent technological developments.

Expert Opin Drug Discov 2010 Feb 9;5(2):135-44. Epub 2010 Jan 9.

CEA-Grenoble, Institut de Recherche en Technologies et Sciences pour le Vivant, Centre de Criblage pour des Molécules Bioactives, Département des Sciences du Vivant, 17 rue des Martyrs, Grenoble Cedex 9, 38054, France.

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http://dx.doi.org/10.1517/17460440903544456DOI Listing
February 2010

Motor-dependent microtubule disassembly driven by tubulin tyrosination.

J Cell Biol 2009 Jun;185(7):1159-66

Institut National de la Santé et de la Recherche Medicale Unité 836, Institut des Neurosciences de Grenoble, 38042 Grenoble, Cedex 9, France.

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http://dx.doi.org/10.1083/jcb.200902142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712961PMC
June 2009

Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases.

Cell Cycle 2009 Mar 18;8(5):765-72. Epub 2009 Mar 18.

INSERM: U823 Institut Albert Bonniot, Université Joseph Fourier, La Tronche, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325905PMC
http://dx.doi.org/10.4161/cc.8.5.7879DOI Listing
March 2009

Chemogenomics and cancer chemotherapy: cell-based assays to screen for small molecules that impair microtubule dynamics.

Comb Chem High Throughput Screen 2008 Sep;11(8):617-23

Centre National de la Recherche Scientifique, UMR 5168, 17 rue des Martyrs, Grenoble, France.

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http://dx.doi.org/10.2174/138620708785739943DOI Listing
September 2008

Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.

Biochim Biophys Acta 2008 Dec 7;1780(12):1412-20. Epub 2008 Jul 7.

INSERM, U873, Grenoble, F-38054, France; CEA, iRTSV/LTS, Grenoble, F-38054, France; Université Joseph Fourier, Grenoble, France.

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http://dx.doi.org/10.1016/j.bbagen.2008.06.010DOI Listing
December 2008

Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.

Chem Biol 2008 Jul;15(7):683-92

Laboratoire de Transduction du Signal, Institut de Recherche en Technologies et Sciences pour le Vivant, CEA, 17 Rue des Martyrs 38054 Grenoble, France.

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http://dx.doi.org/10.1016/j.chembiol.2008.05.018DOI Listing
July 2008

A revised nomenclature for the human and rodent alpha-tubulin gene family.

Genomics 2007 Aug 1;90(2):285-9. Epub 2007 Jun 1.

HUGO Gene Nomenclature Committee, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.

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http://dx.doi.org/10.1016/j.ygeno.2007.04.008DOI Listing
August 2007

Parthenolide inhibits tubulin carboxypeptidase activity.

Cancer Res 2007 Apr;67(7):3371-8

Centre de Criblage pour Molécules Bio-Actives, institut de Recherches en Technologies et Sciences pour le Vivant, Commissariat à l'Energie Atomique-Grenoble, Grenoble, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3732DOI Listing
April 2007

Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.

J Cell Biol 2006 Sep 5;174(6):839-49. Epub 2006 Sep 5.

Laboratoire du Cytosquelette, Institut National de la Santé et de la Recherche Médicale U366, Département Réponse et Dynamique Cellulaire, Commisariat à l'Energie Atomique Grenoble, 38054 Grenoble, France.

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http://dx.doi.org/10.1083/jcb.200512058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064338PMC
September 2006

Identification of proteins binding the native tubulin dimer.

Biochem Biophys Res Commun 2005 Feb;327(1):35-42

INSERM Unité 366, DRDC/CS, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1016/j.bbrc.2004.11.138DOI Listing
February 2005