Laurence Klotz

Laurence Klotz

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Laurence Klotz

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Comparison of MRI- and TRUS-Informed Prostate Biopsy for Prostate Cancer Diagnosis in Biopsy-Naive Men: A Systematic Review and Meta-Analysis.

J Urol 2019 Oct 14:101097JU0000000000000595. Epub 2019 Oct 14.

Urology Division, Surgical Oncology Department, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JU.0000000000000595DOI Listing
October 2019

Apalutamide for Metastatic, Hormone-Responsive Prostate Cancer.

Authors:
Laurence Klotz

N Engl J Med 2019 07;381(1):84-86

From the Sunnybrook Health Sciences Centre, Toronto.

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http://dx.doi.org/10.1056/NEJMe1905891DOI Listing
July 2019

Re: Prostate Cancer-specific Mortality Across Gleason Scores in Black vs Nonblack Men.

Eur Urol 2019 Jun 26;75(6):1036-1037. Epub 2019 Feb 26.

Department of Surgery, Division of Urology, Medical College of Georgia at Augusta University, Augusta, GA, USA; Georgia Cancer Center at Augusta University, Augusta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2019.02.019DOI Listing
June 2019

A Phase 1 Pilot Study of Preoperative Radiation Therapy for Prostate Cancer: Long-Term Toxicity and Oncologic Outcomes.

Int J Radiat Oncol Biol Phys 2019 May 6;104(1):61-66. Epub 2019 Jan 6.

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Techna Institute, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.054DOI Listing
May 2019

Combining urinary DNA methylation and cell-free microRNA biomarkers for improved monitoring of prostate cancer patients on active surveillance.

Urol Oncol 2019 05 16;37(5):297.e9-297.e17. Epub 2019 Feb 16.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2019.01.031DOI Listing
May 2019

Consistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies.

Eur Urol Oncol 2019 May 13;2(3):333-336. Epub 2018 Sep 13.

Erasmus Medical Center, Rotterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S25889311183013
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http://dx.doi.org/10.1016/j.euo.2018.08.017DOI Listing
May 2019

Value of Increasing Biopsy Cores per Target with Cognitive MRI-targeted Transrectal US Prostate Biopsy.

Radiology 2019 Apr 29;291(1):83-89. Epub 2019 Jan 29.

From the Department of Medical Imaging (M.Z., L.M., M.A.H.), Division of Anatomic Pathology (L.S., M.D.), and Department of Surgery (L.K.), Sunnybrook Health Sciences Centre, Toronto, Canada; Sunnybrook Research Institute, Toronto, Canada (L.M., F.K., S.M.B., L.K.); Ontario Institute for Cancer Research, Toronto, Canada (M.A.H.); Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, 600 University Ave, 5th Floor, Toronto, ON, Canada M5G 1X5 (M.A.H.); and Lunenfeld Tanenbaum Research Institute, Toronto, Canada (M.A.H.).

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http://pubs.rsna.org/doi/10.1148/radiol.2019180712
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http://dx.doi.org/10.1148/radiol.2019180712DOI Listing
April 2019

Contemporary approach to active surveillance for favorable risk prostate cancer.

Authors:
Laurence Klotz

Asian J Urol 2019 Apr 15;6(2):146-152. Epub 2018 Dec 15.

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S22143882183009
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http://dx.doi.org/10.1016/j.ajur.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488691PMC
April 2019

Active surveillance in intermediate risk prostate cancer.

Arch Esp Urol 2019 Mar;72(2):157-166

Division of Urology. Sunnybrook Health Sciences Centre. Toronto. ON. Canada.

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March 2019

Cannabinoid WIN 55,212-2 induces cell cycle arrest and apoptosis, and inhibits proliferation, migration, invasion, and tumor growth in prostate cancer in a cannabinoid-receptor 2 dependent manner.

Prostate 2019 02 21;79(2):151-159. Epub 2018 Sep 21.

Department of Surgery (Urology), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.23720DOI Listing
February 2019

Oncologic and Functional Outcomes of Partial Gland Ablation with High Intensity Focused Ultrasound for Localized Prostate Cancer.

J Urol 2019 01;201(1):113-119

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto , Toronto , Ontario , Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00225347184355
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http://dx.doi.org/10.1016/j.juro.2018.07.040DOI Listing
January 2019

Oncologic and Functional Outcomes of Partial Gland Ablation with High Intensity Focused Ultrasound for Localized Prostate Cancer.

J Urol 2019 01;201(1):113-119

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00225347184355
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http://dx.doi.org/10.1016/j.juro.2018.07.040DOI Listing
January 2019

Combining Desmopressin and Docetaxel for the Treatment of Castration-Resistant Prostate Cancer in an Orthotopic Model.

Anticancer Res 2019 Jan;39(1):113-118

Department of Surgery, Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.21873/anticanres.13086DOI Listing
January 2019

Stratifying Risk for Men With Low-Volume Intermediate-Risk Prostate Cancer.

Authors:
Laurence Klotz

JAMA Oncol 2018 08;4(8):1133

Division of Urology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaoncol.2018.0748DOI Listing
August 2018

Advanced Androgen Blockage in Nonmetastatic Castration-resistant Prostate Cancer: An Indirect Comparison of Apalutamide and Enzalutamide.

Eur Urol Oncol 2018 08 15;1(3):238-241. Epub 2018 May 15.

Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada; Division of Urology, Department of Surgery, Princess Margaret Hospital, University Health Network, Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S25889311183003
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http://dx.doi.org/10.1016/j.euo.2018.04.004DOI Listing
August 2018

Total energy expenditure and vigorous-intensity physical activity are associated with reduced odds of reclassification among men on active surveillance.

Prostate Cancer Prostatic Dis 2018 06 14;21(2):187-195. Epub 2017 Dec 14.

Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41391-017-0010-0DOI Listing
June 2018

Assessment of Serum microRNA Biomarkers to Predict Reclassification of Prostate Cancer in Patients on Active Surveillance.

J Urol 2018 06 12;199(6):1475-1481. Epub 2017 Dec 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00225347177806
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http://dx.doi.org/10.1016/j.juro.2017.12.006DOI Listing
June 2018

MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis.

N Engl J Med 2018 May 18;378(19):1767-1777. Epub 2018 Mar 18.

From University College London (UCL) and UCL Hospitals NHS Foundation Trust (V.K., C.A., F.G., A.F., S.M., S.P., M.E., C.M.M.), London North West Healthcare NHS Trust (G.H.), Whittington Health NHS Trust (M.G.), Royal Free London NHS Foundation Trust (P.B.S.), and UCL Surgical and Interventional Trials Unit (N.R.W., C.B.-G.), London, Hampshire Hospitals NHS Foundation Trust, Basingstoke (R.G.H.), Princess Alexandra Hospital NHS Trust, Harlow (J.V.), and the Institute of Applied Health Research and the NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham (J.D., Y.T.) - all in the United Kingdom; Helsinki University and Helsinki University Hospital, Helsinki (A.S.R.), and Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu (M.H.V.) - all in Finland; Centro de Urología, Buenos Aires (M.B.); Sapienza University, Rome (V.P.), and IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan (A.B.) - all in Italy; Mayo Clinic, Rochester, MN (L.A.M.); Martini Klinik, Hamburg (L.B.), University Hospital Essen, Essen (B.A.H.), and University Hospital Heidelberg, Heidelberg (B.A.H.) - all in Germany; Erasmus University Medical Center, Rotterdam (M.J.R.), and Radboud University Medical Center, Nijmegen (W.V.) - both in the Netherlands; University of Chicago, Chicago (S.E.); Université de Lille and Centre Hospitalier Universitaire Lille, Lille (A.V.), Université de Bordeaux and Bordeaux Pellegrin University Hospital, Bordeaux (G.R.), and Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud (A.R.), and Hospices Civils de Lyon of the Hôpital Edouard Herriot (S.C.), Lyon - all in France; Jewish General Hospital, Montreal (F.B.), and Sunnybrook Health Sciences Centre, Toronto (L.K.) - both in Canada; Ghent University Hospital, Ghent, Belgium (G.M.V.); University Hospital Bern, Bern, Switzerland (S.B.); Weill Cornell Medicine, New York-Presbyterian Hospital (J.C.H., D.M.), and New York University Langone Medical Center (S.S.T.), New York; National Institutes of Health, Bethesda, MD (P.P.); and the University of Southern California Institute of Urology, Keck School of Medicine, Los Angeles (I.G.).

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http://dx.doi.org/10.1056/NEJMoa1801993DOI Listing
May 2018

Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part II: Recommended Approaches and Details of Specific Care Options.

J Urol 2018 04 10;199(4):990-997. Epub 2018 Jan 10.

American Urological Association Education and Research, Inc., Linthicum, Maryland; ASTRO, Arlington, Virginia; Society of Urologic Oncology, Schamburg, Illinois.

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http://dx.doi.org/10.1016/j.juro.2018.01.002DOI Listing
April 2018

Prostate cancer prevention: proof is elusive.

Authors:
Laurence Klotz

BJU Int 2018 04;121(4):487-488

Division of Urology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bju.14184DOI Listing
April 2018

The future of active surveillance.

Authors:
Laurence Klotz

Transl Androl Urol 2018 Apr;7(2):256-259

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.21037/tau.2018.01.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911542PMC
April 2018

Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part I: Risk Stratification, Shared Decision Making, and Care Options.

J Urol 2018 03 15;199(3):683-690. Epub 2017 Dec 15.

American Urological Association Education and Research, Inc., Linthicum, Maryland; ASTRO, Arlington, Virginia; Society of Urologic Oncology, Schamburg, Illinois.

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http://dx.doi.org/10.1016/j.juro.2017.11.095DOI Listing
March 2018

A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA 'grey zone'.

World J Urol 2018 Mar 16;36(3):341-348. Epub 2017 Dec 16.

Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00345-017-2152-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846823PMC
March 2018

Personal prostate-specific antigen screening and treatment choices for localized prostate cancer among expert physicians.

Can Urol Assoc J 2018 Feb 1;12(2):E59-E63. Epub 2017 Dec 1.

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.5489/cuaj.4736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937408PMC
February 2018

Comparative Analysis of Biopsy Upgrading in Four Prostate Cancer Active Surveillance Cohorts.

Ann Intern Med 2018 01 28;168(1):1-9. Epub 2017 Nov 28.

From University of Washington, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, Washington; Technical University of Munich, Garching, Germany; The James Buchanan Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland; University of California, San Francisco, San Francisco, California; University of Toronto, Toronto, Ontario, Canada; and Vanderbilt University, Nashville, Tennessee.

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http://dx.doi.org/10.7326/M17-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752581PMC
January 2018

Evaluating Metformin as a Potential Chemosensitizing Agent when Combined with Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Cells.

Anticancer Res 2017 12;37(12):6601-6607

Division of Urology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

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http://dx.doi.org/10.21873/anticanres.12117DOI Listing
December 2017

Contemporary Active Surveillance: Candidate Selection, Follow-up Tools, and Expected Outcomes.

Urol Clin North Am 2017 Nov;44(4):565-574

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue. # MG 408, Toronto, Ontario M4N3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ucl.2017.07.005DOI Listing
November 2017

Prostatectomy versus Observation for Early Prostate Cancer.

N Engl J Med 2017 09;377(13):1301-2

Sunnybrook Health Sciences Centre, Toronto, ON, Canada

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http://dx.doi.org/10.1056/NEJMc1710384DOI Listing
September 2017

Active Surveillance for Intermediate Risk Prostate Cancer.

Authors:
Laurence Klotz

Curr Urol Rep 2017 Aug 11;18(10):80. Epub 2017 Aug 11.

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave. #MG408, Toronto, Ontario, M4N 3M5, Canada.

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http://link.springer.com/10.1007/s11934-017-0726-3
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http://dx.doi.org/10.1007/s11934-017-0726-3DOI Listing
August 2017

Active surveillance for low-risk prostate cancer.

Authors:
Laurence Klotz

Curr Opin Urol 2017 May;27(3):225-230

Division of Urology Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOU.0000000000000393DOI Listing
May 2017

Active Surveillance for Prostate Cancer: How to Do It Right.

Oncology (Williston Park) 2017 05;31(5):333-40, 345

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May 2017

The Effect of Metformin Use during Docetaxel Chemotherapy on Prostate Cancer Specific and Overall Survival of Diabetic Patients with Castration Resistant Prostate Cancer.

J Urol 2017 04 28;197(4):1068-1075. Epub 2016 Oct 28.

Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.10.069DOI Listing
April 2017

The drama of prostate cancer diagnostics.

Lancet Oncol 2017 03 2;18(3):e132. Epub 2017 Mar 2.

Department of Urology/CamPARI Clinic, Cambridge University Hospitals, Cambridge, UK; Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S1470-2045(17)30121-3DOI Listing
March 2017

Urinary DNA Methylation Biomarkers for Noninvasive Prediction of Aggressive Disease in Patients with Prostate Cancer on Active Surveillance.

J Urol 2017 02 18;197(2):335-341. Epub 2016 Aug 18.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.08.081DOI Listing
February 2017

Maximal testosterone suppression in the management of recurrent and metastatic prostate cancer.

Can Urol Assoc J 2017 Jan-Feb;11(1-2):E62-E63. Epub 2017 Feb 20.

Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.

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http://dx.doi.org/10.5489/cuaj.4494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403685PMC
February 2017

10-Year Outcomes in Localized Prostate Cancer.

N Engl J Med 2017 01;376(2):178

Brigham and Women’s Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1614342DOI Listing
January 2017

Intermittent Androgen Deprivation Therapy-An Important Treatment Option for Prostate Cancer.

JAMA Oncol 2016 Dec;2(12):1531-1532

Division of Medical Oncology, Departments of Medicine and Urology, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2016.3138DOI Listing
December 2016

Active Surveillance for Intermediate Risk Prostate Cancer: Survival Outcomes in the Sunnybrook Experience.

J Urol 2016 12 26;196(6):1651-1658. Epub 2016 Aug 26.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Measurement and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.06.102DOI Listing
December 2016

The uptake of active surveillance for the management of prostate cancer: A population-based analysis.

Can Urol Assoc J 2016 Sep-Oct;10(9-10):333-338

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto.

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http://dx.doi.org/10.5489/cuaj.3684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085913PMC
November 2016

Testosterone Therapy Can be Given to Men with No Concern that it will Promote Prostate Cancer Development or Progression: Con.

J Urol 2016 10 9;196(4):985-8. Epub 2016 Aug 9.

Department of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2016.08.010DOI Listing
October 2016

The uptake of active surveillance for the management of prostate cancer: A population-based analysis.

Can Urol Assoc J 2016 Sep-Oct;10(9-10):E342-E346. Epub 2016 Oct 13.

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto.

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http://dx.doi.org/10.5489/cuaj.4207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085922PMC
October 2016

Surgery Provides Better Oncologic Outcomes than Radiation for the Treatment of Prostate Cancer.

J Urol 2016 08 7;196(2):309-11. Epub 2016 May 7.

Department of Urology, University of California, Davis School of Medicine, Sacramento, California.

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http://dx.doi.org/10.1016/j.juro.2016.05.008DOI Listing
August 2016

Laurence Klotz on the Controversy Surrounding Screening for Prostate Cancer.

Authors:
Laurence Klotz

Oncology (Williston Park) 2016 08;30(8):694, 764

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August 2016

Pharmacokinetic and pharmacodynamic profile of degarelix for prostate cancer.

Authors:
Laurence Klotz

Expert Opin Drug Metab Toxicol 2015 29;11(11):1795-802. Epub 2015 Oct 29.

a Sunnybrook Health Sciences Centre , 2075 Bayview Ave, Room MG 204, Toronto, ON, M4N 3M5, Canada +1 416 480 610 ;

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http://dx.doi.org/10.1517/17425255.2015.1085506DOI Listing
June 2016

Overtreatment in cancer - is it a problem?

Expert Opin Pharmacother 2016 20;17(1):1-5. Epub 2016 Jan 20.

a Division of Urology , Sunnybrook Health Sciences Centre , Toronto , ON , Canada.

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http://dx.doi.org/10.1517/14656566.2016.1115481DOI Listing
June 2016

New Rates of Interventions to Manage Complications of Modern Prostate Cancer Treatment in Older Men.

Eur Urol 2016 05 11;69(5):933-41. Epub 2015 Nov 11.

Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.10.043DOI Listing
May 2016

Metastatic Prostate Cancer in Men Initially Treated with Active Surveillance.

J Urol 2016 May 18;195(5):1409-1414. Epub 2015 Dec 18.

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology (BM, DV, GG, AL), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.11.075DOI Listing
May 2016

Editorial Comment.

Authors:
Laurence Klotz

Urology 2015 Nov;86(5):996

Division of Urology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.urology.2015.07.043DOI Listing
November 2015

Identification and Validation of a Five MicroRNA Signature Predictive of Prostate Cancer Recurrence and Metastasis: A Cohort Study.

J Cancer 2015 15;6(11):1160-71. Epub 2015 Sep 15.

2. Department of Anatomic Pathology, Platform Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave., Toronto, ON, M4N3M5, Canada.

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http://dx.doi.org/10.7150/jca.13397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615353PMC
October 2015

Survivorship and improving quality of life in men with prostate cancer.

Eur Urol 2015 Sep 1;68(3):374-83. Epub 2015 May 1.

Vanderbilt University Department of Urologic Surgery and VA Tennessee Valley Healthcare System, Nashville, TN, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03022838150032
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http://dx.doi.org/10.1016/j.eururo.2015.04.023DOI Listing
September 2015

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model.

Prostate 2015 Sep 5;75(12):1300-11. Epub 2015 Jun 5.

Department of Surgery (Urology), Sunnybrook Health Sciences Center, Toronto, Ontario.

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http://dx.doi.org/10.1002/pros.23013DOI Listing
September 2015

A combination of desmopressin and docetaxel inhibit cell proliferation and invasion mediated by urokinase-type plasminogen activator (uPA) in human prostate cancer cells.

Biochem Biophys Res Commun 2015 Aug 13;464(3):848-54. Epub 2015 Jul 13.

Division of Urology, Sunnybrook Health Sciences Center, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.07.050DOI Listing
August 2015

Gleason Upgrading with Time in a Large Prostate Cancer Active Surveillance Cohort.

J Urol 2015 Jul 4;194(1):79-84. Epub 2015 Feb 4.

Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.juro.2015.01.102DOI Listing
July 2015

Management of low- and intermediate-risk prostate cancer.

World J Urol 2015 Jul;33(7):905-6

Department of Urology, Netherlands Cancer Institute, Postbus 90203, 1006 BE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00345-015-1618-0DOI Listing
July 2015

Active surveillance for the management of localized prostate cancer: Guideline recommendations.

Can Urol Assoc J 2015 May-Jun;9(5-6):171-8

Department of Pathology and Laboratory, Faculty of Medicine, University of Toronto, Toronto, ON.

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http://dx.doi.org/10.5489/cuaj.2806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479637PMC
July 2015

Active Surveillance for Prostate Cancer: Debate over the Application, Not the Concept.

Authors:
Laurence Klotz

Eur Urol 2015 Jun 24;67(6):1006-1008. Epub 2015 Jan 24.

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.01.007DOI Listing
June 2015

Active surveillance and focal therapy for low-intermediate risk prostate cancer.

Authors:
Laurence Klotz

Transl Androl Urol 2015 Jun;4(3):342-54

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Canada.

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http://dx.doi.org/10.3978/j.issn.2223-4683.2015.06.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708232PMC
June 2015

Defining 'progression' and triggers for curative intervention during active surveillance.

Authors:
Laurence Klotz

Curr Opin Urol 2015 May;25(3):258-66

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOU.0000000000000158DOI Listing
May 2015

The effects of serum from prostate cancer patients with elevated body mass index on prostate cancer cells in vitro.

Lipid Insights 2015 19;8:11-9. Epub 2015 Apr 19.

Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://journals.sagepub.com/doi/10.4137/LPI.S23135
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http://dx.doi.org/10.4137/LPI.S23135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404997PMC
May 2015

Active surveillance for low-risk prostate cancer: developments to date.

Eur Urol 2015 Apr 27;67(4):646-8. Epub 2014 Nov 27.

Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.eururo.2014.11.004DOI Listing
April 2015

Magnetic resonance imaging in active surveillance of prostate cancer: a systematic review.

Eur Urol 2015 Apr 15;67(4):627-36. Epub 2014 Nov 15.

Division of Surgical and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospital Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.10.050DOI Listing
April 2015

Nadir testosterone within first year of androgen-deprivation therapy (ADT) predicts for time to castration-resistant progression: a secondary analysis of the PR-7 trial of intermittent versus continuous ADT.

J Clin Oncol 2015 Apr 2;33(10):1151-6. Epub 2015 Mar 2.

Laurence Klotz, Sunnybrook Health Sciences Centre, University of Toronto; Mary Gospodarowicz, Princess Margaret Hospital, Toronto; Chris O'Callaghan and Keyue Ding, Queen's University, Kingston; Shawn Malone, Ottawa Regional Cancer Centre, Ottawa, Ontario; Paul Toren, Larry Goldenberg, and Juanita M. Crook, University of British Columbia, Vancouver, British Columbia, Canada; David Dearnaley, Royal Marsden Hospital, London, United Kingdom; Celestia S. Higano, Fox Chase Cancer Center, Philadelphia, PA; and Eric Horwitz, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2014.58.2973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372851PMC
April 2015

Active surveillance for low-risk prostate cancer.

Authors:
Laurence Klotz

Curr Urol Rep 2015 Apr;16(4):24

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave. #MG408, Toronto, ON, M4N 3M5, Canada,

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http://dx.doi.org/10.1007/s11934-015-0492-zDOI Listing
April 2015

Complications after radical prostatectomy or radiotherapy for prostate cancer: results of a population-based, propensity score-matched analysis.

Urology 2015 Mar;85(3):621-7

Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2014.11.037DOI Listing
March 2015

Capsaicin: a novel radio-sensitizing agent for prostate cancer.

Prostate 2015 Feb 13;75(2):113-25. Epub 2014 Oct 13.

Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.22896DOI Listing
February 2015

Active surveillance for prostate cancer: the role of the pathologist.

Pathology 2015 Jan;47(1):1-3

1Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand 2Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA 3Department of Oncology and Pathology, Karolinska University Hospital, Solna, Stockholm, Sweden 4Aquesta Pathology and University of Queensland, Brisbane, Qld, Australia 5Trillium Health Partners, Mississauga and McMaster University, Hamilton, ON, Canada 6Department of Pathology, Yale University School of Medicine, New Haven, CT, USA 7Institute for Precision Medicine and the Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell, University and New York-Presbyterian Hospital, New York, NY, USA 8Department of Pathology, Urology and Oncology, Johns Hopkins School of Medicine, Baltimore, MA, USA 9Department of Urology, University of Washington, Seattle, WA, USA 10Department of Surgery, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand 11Division of Urology, Sunnybrook Health Sciences, Centre, University of Toronto, Toronto, ON, Canada 12Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA 13Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA 14Department of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA 15Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche Region (Ancona), Ancona, Italy 16University Health Network, University of Toronto, Toronto, Ontario, Canada 17Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH, USA 18Department of Cellular Pathology, The Royal London Hospital, London, UK 19Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA 20Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA 2

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http://dx.doi.org/10.1097/PAT.0000000000000186DOI Listing
January 2015

Long-term follow-up of a large active surveillance cohort of patients with prostate cancer.

J Clin Oncol 2015 Jan 15;33(3):272-7. Epub 2014 Dec 15.

Laurence Klotz, Danny Vesprini, Perakaa Sethukavalan, Vibhuti Jethava, Liying Zhang, Suneil Jain, Toshihiro Yamamoto, and Andrew Loblaw, Sunnybrook Health Sciences Centre, University of Toronto; and Alexandre Mamedov, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2014.55.1192DOI Listing
January 2015

World Urologic Oncology Federation Bladder Cancer Prevention Program: a global initiative.

Urol Oncol 2015 Jan;33(1):25-29

Ausl Modena, Nuovo Ospedale Civile-S. Agostino Estense, Modena, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S10781439140027
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http://dx.doi.org/10.1016/j.urolonc.2014.07.017DOI Listing
January 2015

Testosterone therapy and prostate cancer--safety concerns are well founded.

Authors:
Laurence Klotz

Nat Rev Urol 2015 01;12(1):48-54

University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, #MG 408, Toronto, ON M4N 3M5, Canada.

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http://dx.doi.org/10.1038/nrurol.2014.338DOI Listing
January 2015

Reply by the authors.

Urology 2014 Nov 24;84(5):1250-1. Epub 2014 Oct 24.

Division of Urology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.urology.2014.08.004DOI Listing
November 2014

Low-risk and very-low-risk prostate cancer: is there a role for focal therapy in the era of active surveillance? Yes, the two approaches complement each other.

Oncology (Williston Park) 2014 Nov;28(11):950-C3

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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November 2014

Practice patterns of post-radical prostatectomy incontinence surgery in Ontario.

Can Urol Assoc J 2014 Sep;8(9-10):E670-4

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON;

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http://dx.doi.org/10.5489/cuaj.1959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216297PMC
September 2014