Laurence D Hurst

Laurence D Hurst

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Laurence D Hurst

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A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences.

Mol Biol Evol 2020 Apr;37(4):1148-1164

Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1093/molbev/msz299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086181PMC
April 2020

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons.

PLoS Genet 2019 09 17;15(9):e1008386. Epub 2019 Sep 17.

Milner Centre for Evolution, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1008386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764699PMC
September 2019

Author Correction: Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.

Nat Protoc 2019 Aug;14(8):2596

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

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http://dx.doi.org/10.1038/s41596-018-0086-6DOI Listing
August 2019

A century of bias in genetics and evolution.

Authors:
Laurence D Hurst

Heredity (Edinb) 2019 07 12;123(1):33-43. Epub 2019 Jun 12.

The Milner Centre for Evolution, University of Bath, Bath, BA2 7AY, UK.

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http://dx.doi.org/10.1038/s41437-019-0194-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781121PMC
July 2019

The architecture of intra-organism mutation rate variation in plants.

PLoS Biol 2019 04 9;17(4):e3000191. Epub 2019 Apr 9.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1371/journal.pbio.3000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456163PMC
April 2019

Exonic splice regulation imposes strong selection at synonymous sites.

Genome Res 2018 10 24;28(10):1442-1454. Epub 2018 Aug 24.

The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.233999.117
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http://dx.doi.org/10.1101/gr.233999.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169883PMC
October 2018

Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout.

Proc Natl Acad Sci U S A 2018 08 23;115(32):E7559-E7567. Epub 2018 Jul 23.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210023 Nanjing, China;

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http://dx.doi.org/10.1073/pnas.1806110115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094097PMC
August 2018

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica.

Curr Biol 2018 07 18;28(13):2046-2057.e5. Epub 2018 Jun 18.

Group Systems Biology of Motor Proteins, Department of NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.04.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041473PMC
July 2018

Refining the Ambush Hypothesis: Evidence That GC- and AT-Rich Bacteria Employ Different Frameshift Defence Strategies.

Genome Biol Evol 2018 04;10(4):1153-1173

Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath, United Kingdom.

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http://dx.doi.org/10.1093/gbe/evy075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909447PMC
April 2018

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts.

Nat Ecol Evol 2018 02 8;2(2):388-394. Epub 2018 Jan 8.

The Milner Centre for Evolution, Department of Biology and Biochemistry, University Of Bath, Bath, UK.

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http://dx.doi.org/10.1038/s41559-017-0442-xDOI Listing
February 2018

Faster Evolving Primate Genes Are More Likely to Duplicate.

Mol Biol Evol 2018 01;35(1):107-118

Department of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

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https://academic.oup.com/mbe/article/35/1/107/4554431
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http://dx.doi.org/10.1093/molbev/msx270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850500PMC
January 2018

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias.

Nat Ecol Evol 2018 Jan 20;2(1):164-173. Epub 2017 Nov 20.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1038/s41559-017-0372-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733138PMC
January 2018

Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts.

Mol Biol Evol 2017 Dec;34(12):3064-3080

Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath, Bath, United Kingdom.

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https://academic.oup.com/mbe/article/34/12/3064/4093714
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http://dx.doi.org/10.1093/molbev/msx223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850271PMC
December 2017

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.

Circulation 2017 Nov 13;136(19):1824-1839. Epub 2017 Sep 13.

From Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (J.Z., M.S., F.H., N.H., D.N.M., Z.I.); Experimental and Clinical Research Center, a joint cooperation between the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité-Universitätsmedizin Berlin, Germany (J.Z., F.H., L.P., N.H., M.G., H.S., F.C.L., D.N.M., R.D.); Berlin Institute of Health, Germany (J.Z., F.H., L.P., N.H., M.G., F.C.L., D.N.M., R.D., Z.I.); Department of Obstetrics and Department of Gynecology, Charité-Universitätsmedizin Berlin, Germany (M.G.); German Centre for Cardiovascular Research, partner site Berlin, Germany (N.H., D.N.M.); Centre for Trophoblast Research, University of Cambridge, UK (H.W.Y.); Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria (B.H.); Molecular and Clinical Sciences Research Institute, St George's University of London, UK (J.E.C., G.W.); Division of Obstetrics and Gynaecology, Oslo University Hospital, Norway (G.M.J., A.C.S.); University of Oslo, Norway (G.M.J., A.C.S.); Évolution des Régulations Endocriniennes, Muséum Nationale d'Histoire Naturelle, Paris, France (G.L.); HELIOS-Klinikum, Berlin, Germany (A.I., R.D.); Cologne Center for Genomics, University of Cologne, Germany (H.S.); and Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, UK (L.D.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671803PMC
November 2017

Depletion of somatic mutations in splicing-associated sequences in cancer genomes.

Genome Biol 2017 11 7;18(1):213. Epub 2017 Nov 7.

Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/s13059-017-1337-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678748PMC
November 2017

Estimating the prevalence of functional exonic splice regulatory information.

Hum Genet 2017 09 12;136(9):1059-1078. Epub 2017 Apr 12.

The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK.

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http://dx.doi.org/10.1007/s00439-017-1798-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602102PMC
September 2017

It's easier to get along with the quiet neighbours.

Authors:
Laurence D Hurst

Mol Syst Biol 2017 09 26;13(9):943. Epub 2017 Sep 26.

The Milner Centre for Evolution Biology and Biochemistry, University of Bath, Bath, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615921PMC
http://dx.doi.org/10.15252/msb.20177961DOI Listing
September 2017

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency.

Curr Opin Virol 2017 08 24;25:49-58. Epub 2017 Jul 24.

Mobile DNA, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18796257173002
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http://dx.doi.org/10.1016/j.coviro.2017.07.001DOI Listing
August 2017

Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution.

Mol Biol Evol 2017 05;34(5):1110-1126

The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1093/molbev/msx061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400389PMC
May 2017

Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Species.

Genetics 2017 05 9;206(1):363-376. Epub 2017 Mar 9.

Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath, BA2 7AY, United Kingdom

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http://dx.doi.org/10.1534/genetics.116.195784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419481PMC
May 2017

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance.

PLoS Biol 2017 05 23;15(5):e2002255. Epub 2017 May 23.

The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, England.

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http://dx.doi.org/10.1371/journal.pbio.2002255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441579PMC
May 2017

Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects.

Mol Biol Evol 2017 01 20;34(1):119-130. Epub 2016 Oct 20.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China

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http://dx.doi.org/10.1093/molbev/msw226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854123PMC
January 2017

Mutation rate analysis via parent-progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation.

Proc Biol Sci 2016 10;283(1841)

The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK

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http://dx.doi.org/10.1098/rspb.2016.1785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095386PMC
October 2016

Open questions in the study of de novo genes: what, how and why.

Nat Rev Genet 2016 09 25;17(9):567-78. Epub 2016 Jul 25.

The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, Somerset BA2 7AY, UK.

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http://dx.doi.org/10.1038/nrg.2016.78DOI Listing
September 2016

Purifying Selection on Exonic Splice Enhancers in Intronless Genes.

Mol Biol Evol 2016 06 23;33(6):1396-418. Epub 2016 Jan 23.

Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1093/molbev/msw018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868121PMC
June 2016

Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs.

Mol Biol Evol 2016 Feb 5;33(2):518-29. Epub 2015 Nov 5.

Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, Somerset, United Kingdom

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http://dx.doi.org/10.1093/molbev/msv251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866546PMC
February 2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.

Nat Protoc 2016 Feb 21;11(2):327-46. Epub 2016 Jan 21.

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

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http://dx.doi.org/10.1038/nprot.2016.016DOI Listing
February 2016

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?

Bioessays 2016 Jan;38(1):109-17

Department of Biology and Biochemistry, University of Bath, Bath, Somerset, UK.

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http://dx.doi.org/10.1002/bies.201500096DOI Listing
January 2016

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.

PLoS Biol 2015 Dec 18;13(12):e1002315. Epub 2015 Dec 18.

The Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pbio.1002315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686125PMC
December 2015

Neighboring Genes Show Correlated Evolution in Gene Expression.

Mol Biol Evol 2015 Jul 4;32(7):1748-66. Epub 2015 Mar 4.

Department of Biology and Biochemisty, University of Bath, Bath, United Kingdom

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http://dx.doi.org/10.1093/molbev/msv053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476153PMC
July 2015

Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs.

Mol Biol Evol 2015 Jul 13;32(7):1847-61. Epub 2015 Mar 13.

Department of Biology and Biochemistry, University of Bath, Bath, Somerset, United Kingdom

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http://dx.doi.org/10.1093/molbev/msv069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476162PMC
July 2015

Parent-progeny sequencing indicates higher mutation rates in heterozygotes.

Nature 2015 Jul 15;523(7561):463-7. Epub 2015 Jul 15.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.

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http://dx.doi.org/10.1038/nature14649DOI Listing
July 2015

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs.

Mol Biol Evol 2014 Dec 25;31(12):3164-83. Epub 2014 Aug 25.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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http://dx.doi.org/10.1093/molbev/msu249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245815PMC
December 2014

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations.

Genome Res 2014 Nov 14;24(11):1821-9. Epub 2014 Oct 14.

Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;

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http://dx.doi.org/10.1101/gr.177659.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216923PMC
November 2014

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.

Sci Rep 2014 Aug 12;4:6036. Epub 2014 Aug 12.

State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, People's Republic of China.

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http://dx.doi.org/10.1038/srep06036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381403PMC
August 2014

Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp.

Mol Biol Evol 2014 Jan 28;31(1):70-84. Epub 2013 Sep 28.

Department of Biology and Biochemistry, University of Bath, Bath, Somerset, United Kingdom.

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http://dx.doi.org/10.1093/molbev/mst169DOI Listing
January 2014

Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving.

Mol Biol Evol 2013 Dec 10;30(12):2588-601. Epub 2013 Sep 10.

State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/mst148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840307PMC
December 2013

The form of a trade-off determines the response to competition.

Ecol Lett 2013 Oct 31;16(10):1267-76. Epub 2013 Jul 31.

G08-Biochemistry Building, School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1111/ele.12159DOI Listing
October 2013

Positively charged residues are the major determinants of ribosomal velocity.

PLoS Biol 2013 12;11(3):e1001508. Epub 2013 Mar 12.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1001508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595205PMC
September 2013

Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study.

Sci Rep 2013 ;3:2147

The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China.

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http://dx.doi.org/10.1038/srep02147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701898PMC
September 2013

Open questions: a logic (or lack thereof) of genome organization.

Authors:
Laurence D Hurst

BMC Biol 2013 May 28;11:58. Epub 2013 May 28.

Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1186/1741-7007-11-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665519PMC
May 2013

Great majority of recombination events in Arabidopsis are gene conversion events.

Proc Natl Acad Sci U S A 2012 Dec 3;109(51):20992-7. Epub 2012 Dec 3.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.

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http://dx.doi.org/10.1073/pnas.1211827110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529023PMC
December 2012

Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution.

Nucleic Acids Res 2012 May 11;40(9):4002-12. Epub 2012 Jan 11.

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/nar/gkr1312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351155PMC
May 2012

Direct and indirect consequences of meiotic recombination: implications for genome evolution.

Trends Genet 2012 Mar 7;28(3):101-9. Epub 2011 Dec 7.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S01689525110018
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http://dx.doi.org/10.1016/j.tig.2011.11.002DOI Listing
March 2012

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster.

Mol Biol Evol 2012 Feb 31;29(2):873-82. Epub 2011 Oct 31.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1093/molbev/msr265DOI Listing
February 2012

Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation.

Genome Biol 2011 17;12(3):R23. Epub 2011 Mar 17.

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

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http://dx.doi.org/10.1186/gb-2011-12-3-r23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129673PMC
January 2012

Error prevention and mitigation as forces in the evolution of genes and genomes.

Nat Rev Genet 2011 11 18;12(12):875-81. Epub 2011 Nov 18.

Centre for Genomic Regulation and UPF, Barcelona, Spain.

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http://www.nature.com/articles/nrg3092
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http://dx.doi.org/10.1038/nrg3092DOI Listing
November 2011

Atypical at skew in Firmicute genomes results from selection and not from mutation.

PLoS Genet 2011 Sep 15;7(9):e1002283. Epub 2011 Sep 15.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174206PMC
September 2011

Transcriptional coupling of neighboring genes and gene expression noise: evidence that gene orientation and noncoding transcripts are modulators of noise.

Genome Biol Evol 2011 14;3:320-31. Epub 2011 Mar 14.

Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.

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http://dx.doi.org/10.1093/gbe/evr025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654408PMC
August 2011

Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability.

Hum Mutat 2011 Aug 12;32(8):921-9. Epub 2011 Jul 12.

Centre for Rare Diseases and Personalised Medicine and Department of Medical & Molecular Genetics, School of Clinical and Experimental Medicine, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/humu.21519DOI Listing
August 2011

Metabolic trade-offs and the maintenance of the fittest and the flattest.

Nature 2011 Apr 27;472(7343):342-6. Epub 2011 Mar 27.

Department of Mathematics, Imperial College London, Huxley Building, 180 Queen's Gate, London SW7 2A7, UK.

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http://dx.doi.org/10.1038/nature09905DOI Listing
April 2011

Molecular genetics: The sound of silence.

Authors:
Laurence D Hurst

Nature 2011 Mar;471(7340):582-3

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http://dx.doi.org/10.1038/471582aDOI Listing
March 2011

Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness.

Genome Biol Evol 2010 5;2:636-45. Epub 2010 Aug 5.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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https://academic.oup.com/gbe/article/doi/10.1093/gbe/evq049/
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http://dx.doi.org/10.1093/gbe/evq049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941156PMC
December 2010

Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster.

J Mol Evol 2010 Dec 12;71(5-6):415-26. Epub 2010 Oct 12.

Department of Biology and Biochemistry, University of Bath, Bath, UK.

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http://dx.doi.org/10.1007/s00239-010-9395-2DOI Listing
December 2010

Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation.

Mol Syst Biol 2010 Dec;6:442

The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. China.

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http://dx.doi.org/10.1038/msb.2010.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018160PMC
December 2010

A mixture of "cheats" and "co-operators" can enable maximal group benefit.

PLoS Biol 2010 Sep 14;8(9). Epub 2010 Sep 14.

Department of Zoology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1371/journal.pbio.1000486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939026PMC
September 2010

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos.

J Anat 2010 Jun 14;216(6):683-91. Epub 2010 Apr 14.

Department of Biology & Biochemistry, University of Bath, Somerset, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952381PMC
June 2010

Timing of replication is a determinant of neutral substitution rates but does not explain slow Y chromosome evolution in rodents.

Mol Biol Evol 2010 May 21;27(5):1077-86. Epub 2009 Dec 21.

Department of Biology and Biochemistry, University of Bath, Somerset, United Kingdom.

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http://dx.doi.org/10.1093/molbev/msp314DOI Listing
May 2010

GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution.

Mol Syst Biol 2010 19;6:340. Epub 2010 Jan 19.

Department of Biology and Biochemistry, University of Bath, Bath, UK.

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http://dx.doi.org/10.1038/msb.2009.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824523PMC
February 2010

Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals.

Genome Biol 2009 13;10(7):R74. Epub 2009 Jul 13.

Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, South Chongqing Road, Shanghai 200025, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728528PMC
January 2010

Maternally-inherited Grb10 reduces placental size and efficiency.

Dev Biol 2010 Jan 13;337(1):1-8. Epub 2009 Oct 13.

Department of Biology and Biochemistry, University of Bath, Building 4 South, Bath BA27AY, UK.

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http://dx.doi.org/10.1016/j.ydbio.2009.10.011DOI Listing
January 2010

Monoallelic expression and tissue specificity are associated with high crossover rates.

Trends Genet 2009 Dec 21;25(12):519-22. Epub 2009 Oct 21.

Université de Lyon, Lyon, France.

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http://dx.doi.org/10.1016/j.tig.2009.10.001DOI Listing
December 2009

Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates.

Genome Biol Evol 2009 Sep 2;1:340-9. Epub 2009 Sep 2.

Department of Biology and Biochemistry, University of Bath, Bath, Somerset, UK.

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http://dx.doi.org/10.1093/gbe/evp033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817428PMC
September 2009

Evolutionary genomics and the reach of selection.

Authors:
Laurence D Hurst

J Biol 2009 23;8(2):12. Epub 2009 Feb 23.

Department of Biology and Biochemistry, University of Bath, Somerset, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687768PMC
September 2009

Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence.

Biochem Soc Trans 2009 Aug;37(Pt 4):756-61

Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

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August 2009

Does negative auto-regulation increase gene duplicability?

BMC Evol Biol 2009 Aug 7;9:193. Epub 2009 Aug 7.

Department of Biology & Biochemistry, University of Bath, UK.

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http://dx.doi.org/10.1186/1471-2148-9-193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739200PMC
August 2009

The price of silent mutations.

Sci Am 2009 Jun;300(6):46-53

Hurst's Laboratory, University of Bath, UK.

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http://dx.doi.org/10.1038/scientificamerican0609-46DOI Listing
June 2009

Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay.

BMC Biol 2009 May 14;7:23. Epub 2009 May 14.

Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697156PMC
May 2009

Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli.

PLoS Biol 2009 May 26;7(5):e1000115. Epub 2009 May 26.

Institute of Biochemistry, Biological Research Center, Szeged, Hungary.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684527PMC
May 2009

Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates.

Genome Biol Evol 2009 Apr 30;1:13-22. Epub 2009 Apr 30.

Department of Biology and Biochemistry, University of Bath, Bath, Somerset, United Kingdom.

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http://dx.doi.org/10.1093/gbe/evp001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817397PMC
April 2009

Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes.

Genome Biol 2008 2;9(12):R169. Epub 2008 Dec 2.

Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, 225 South Chong Qing Road, Shanghai 200025, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646273PMC
March 2009

Fundamental concepts in genetics: genetics and the understanding of selection.

Authors:
Laurence D Hurst

Nat Rev Genet 2009 Feb;10(2):83-93

Department of Biology and Biochemistry, University of Bath, Somerset, BA2 7AY, UK.

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http://www.nature.com/articles/nrg2506
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February 2009

Evolutionary genomics: A positive becomes a negative.

Authors:
Laurence D Hurst

Nature 2009 Jan;457(7229):543-4

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January 2009

The impact of the nucleosome code on protein-coding sequence evolution in yeast.

PLoS Genet 2008 Nov 7;4(11):e1000250. Epub 2008 Nov 7.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570795PMC
November 2008

Understanding the limits to generalizability of experimental evolutionary models.

Nature 2008 Sep;455(7210):220-3

Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1038/nature07152DOI Listing
September 2008

The determinants of gene order conservation in yeasts.

Genome Biol 2007 ;8(11):R233

Logic of Genomic Systems Laboratory, Spanish National Biotechnology Centre, Centro Superior de Investigaciones Científicas (CSIC), Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258174PMC
August 2008

Do Alu repeats drive the evolution of the primate transcriptome?

Genome Biol 2008 1;9(2):R25. Epub 2008 Feb 1.

Department of Biology and Biochemistry, University of Bath, Bath, BA4 7AY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374697PMC
May 2008

A test of the null model for 5' UTR evolution based on GC content.

Mol Biol Evol 2008 May 21;25(5):801-4. Epub 2008 Feb 21.

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http://dx.doi.org/10.1093/molbev/msn044DOI Listing
May 2008

Leukocyte tyrosine kinase functions in pigment cell development.

PLoS Genet 2008 Mar 7;4(3):e1000026. Epub 2008 Mar 7.

Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265441PMC
March 2008

Do Wolbachia-associated incompatibilities promote polyandry?

Evolution 2008 Jan 6;62(1):107-22. Epub 2007 Dec 6.

Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn, UK.

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http://dx.doi.org/10.1111/j.1558-5646.2007.00274.xDOI Listing
January 2008

Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster.

Mol Biol Evol 2007 Dec 28;24(12):2755-62. Epub 2007 Sep 28.

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom.

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December 2007