Publications by authors named "Laurence A Turka"

100Publications

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

Lancet 2020 05;395(10237):1627-1639

Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Division of Personalized Tumor Therapy, Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(20)30167-7DOI Listing
May 2020

The Untapped Opportunity and Challenge of Immunometabolism: A New Paradigm for Drug Discovery.

Cell Metab 2020 01 12;31(1):26-34. Epub 2019 Dec 12.

Rheos Medicines, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.11.014DOI Listing
January 2020

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets.

PLoS One 2019 6;14(6):e0217761. Epub 2019 Jun 6.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217761PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553739PMC
February 2020

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs.

Cell Rep 2018 10;25(5):1204-1213.e4

Department of Surgery and Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA; Program in Immunology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183156
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http://dx.doi.org/10.1016/j.celrep.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289175PMC
October 2018

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets.

J Immunol 2018 10 12;201(8):2215-2219. Epub 2018 Sep 12.

Department of Surgery and Center for Transplantation Sciences; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129;

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http://dx.doi.org/10.4049/jimmunol.1800311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179917PMC
October 2018

Maintenance of CD4 T cell fitness through regulation of Foxo1.

Nat Immunol 2018 08 9;19(8):838-848. Epub 2018 Jul 9.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41590-018-0157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289177PMC
August 2018

Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity.

Front Immunol 2018 2;9:100. Epub 2018 Feb 2.

Immune Tolerance Network, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801415PMC
February 2019

Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients.

Hum Immunol 2018 May 12;79(5):380-387. Epub 2018 Feb 12.

Center for Transplantation Sciences, Massachusetts General Hospital and the Immune Tolerance Network, United States.

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http://dx.doi.org/10.1016/j.humimm.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924709PMC
May 2018

Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells.

Front Immunol 2018 29;9:69. Epub 2018 Jan 29.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796885PMC
February 2019

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

J Immunol 2017 12 1;199(12):3972-3980. Epub 2017 Nov 1.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129;

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http://dx.doi.org/10.4049/jimmunol.1700409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716898PMC
December 2017

Reply to Christakoudi and Hernandez-Fuentes: We agree-Let's move on.

Am J Transplant 2018 01 18;18(1):273. Epub 2017 Nov 18.

Center for Transplantation Sciences and Immune Tolerance Network, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/ajt.14569DOI Listing
January 2018

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

Nat Commun 2017 10 16;8(1):951. Epub 2017 Oct 16.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-017-00982-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643371PMC
October 2017

Navigating T-Cell Immunometabolism in Transplantation.

Transplantation 2018 02;102(2):230-239

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/TP.0000000000001951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790597PMC
February 2018

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.

Immunol Rev 2017 03;276(1):192-212

Division of Blood and Marrow Transplantation, Department of Pediatrics and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1111/imr.12523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338458PMC
March 2017

A composite score associated with spontaneous operational tolerance in kidney transplant recipients.

Kidney Int 2017 06 24;91(6):1473-1481. Epub 2017 Feb 24.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; CIC Biotherapy, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432017PMC
June 2017

FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance.

Am J Kidney Dis 2017 May 31;69(5):667-674. Epub 2016 Dec 31.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2016.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403573PMC
May 2017

Foxp3 and Toll-like receptor signaling balance T cell anabolic metabolism for suppression.

Nat Immunol 2016 Dec 3;17(12):1459-1466. Epub 2016 Oct 3.

Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/ni.3577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215903PMC
December 2016

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency.

Blood 2016 09 2;128(10):1424-35. Epub 2016 Aug 2.

Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN;

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http://dx.doi.org/10.1182/blood-2016-05-714535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016708PMC
September 2016

Immunometabolism of regulatory T cells.

Nat Immunol 2016 05;17(6):618-25

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006394PMC
May 2016

Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival.

Transpl Int 2016 Aug 14;29(8):930-40. Epub 2016 Jun 14.

Center for Transplantation Science, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049733PMC
http://dx.doi.org/10.1111/tri.12788DOI Listing
August 2016

Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing.

J Immunol 2015 Nov 25;195(9):4154-61. Epub 2015 Sep 25.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115; and

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http://dx.doi.org/10.4049/jimmunol.1500945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610862PMC
November 2015

Transplant tolerance: a new role for IL-34.

J Clin Invest 2015 Oct 21;125(10):3751-3. Epub 2015 Sep 21.

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http://dx.doi.org/10.1172/JCI84010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607117PMC
October 2015

Tolerance signatures in transplant recipients.

Curr Opin Organ Transplant 2015 Aug;20(4):400-5

aDepartment of Surgery, Emory University, Atlanta, Georgia bDepartment of Surgery and Immune Tolerance Network, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOT.0000000000000207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524570PMC
August 2015

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

Sci Transl Med 2015 Mar;7(280):280rv2

Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aaa6853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425354PMC
March 2015

T-cell energy metabolism as a controller of cell fate in transplantation.

Curr Opin Organ Transplant 2015 Feb;20(1):21-8

Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOT.0000000000000149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387772PMC
February 2015

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Nat Immunol 2015 Feb 5;16(2):188-96. Epub 2015 Jan 5.

1] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA. [2] Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297515PMC
February 2015

Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.

Blood 2015 Jan 4;125(5):852-5. Epub 2014 Dec 4.

Department of Surgery and Center for Transplantation Sciences, Massachusetts General Hospital.

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http://dx.doi.org/10.1182/blood-2014-04-571372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729535PMC
January 2015

Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.

J Allergy Clin Immunol 2015 Apr 22;135(4):913-21.e9. Epub 2014 Nov 22.

Allergy and Clinical Immunology Section, Department of Leukocyte Biology, Division of National Heart and Lung Institute, Imperial College London, and MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.09.049DOI Listing
April 2015

Tolerance: one transplant for life.

Transplantation 2014 Jul;98(2):117-21

1 Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Department of Medicine, Northwestern University School of Medicine, Chicago, IL. 3 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 4 Department of Medicine, Stanford University School of Medicine, Palo Alto, CA. 5 Immune Tolerance Network, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 6 Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom. 7 Address correspondence to: Laurence A. Turka, M.D., Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, 149 13th St, Room 5101, Boston, MA 02129.

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http://dx.doi.org/10.1097/TP.0000000000000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101034PMC
July 2014

Homeostatic expansion as a barrier to lymphocyte depletion strategies.

Curr Opin Organ Transplant 2014 Aug;19(4):357-62

aDepartment of Medicine bDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOT.0000000000000096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476295PMC
August 2014

B cells with immune-regulating function in transplantation.

Nat Rev Nephrol 2014 Jul 20;10(7):389-97. Epub 2014 May 20.

Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/nrneph.2014.80DOI Listing
July 2014

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Cell 2014 Apr;157(3):595-610

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098792PMC
April 2014

TIM4 Regulates the Anti-Islet Th2 Alloimmune Response.

Cell Transplant 2015 7;24(8):1599-1614. Epub 2014 Mar 7.

Transplantation Research Center, Division of Nephrology, Boston Children's Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.3727/096368914X678571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280358PMC
June 2016

Signals and pathways controlling regulatory T cells.

Immunol Rev 2014 Mar;258(1):117-31

Division of Medical Sciences, Harvard Medical School, Boston, MA, USA; Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/imr.12148DOI Listing
March 2014

Transplantation immunology in 2013: New approaches to diagnosis of rejection.

Nat Rev Nephrol 2014 Feb 17;10(2):72-4. Epub 2013 Dec 17.

Transplantation Biology Research Center, Massachusetts General Hospital, Room 5102, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1038/nrneph.2013.262DOI Listing
February 2014

T-cell costimulatory blockade in organ transplantation.

Cold Spring Harb Perspect Med 2013 Dec 1;3(12):a015537. Epub 2013 Dec 1.

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/cshperspect.a015537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839597PMC
December 2013

A breath of fresh aire.

Immunity 2013 Sep;39(3):427-9

Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 149 13(th) Street, Room 5101, Boston, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.08.022DOI Listing
September 2013

Control of T cell tolerance by phosphatase and tensin homolog.

Ann N Y Acad Sci 2013 Mar;1280:27-9

Massachusetts General Hospital, Transplantation Biology Research Center MGH-East, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1111/nyas.12015DOI Listing
March 2013

MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.

Proc Natl Acad Sci U S A 2013 Feb 22;110(6):2270-5. Epub 2013 Jan 22.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1206048110
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http://dx.doi.org/10.1073/pnas.1206048110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568327PMC
February 2013

An obligate cell-intrinsic function for CD28 in Tregs.

J Clin Invest 2013 Feb 2;123(2):580-93. Epub 2013 Jan 2.

Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI65013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561819PMC
February 2013

Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes.

J Immunol Methods 2012 Oct 30;384(1-2):25-32. Epub 2012 Jun 30.

Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.jim.2012.06.013DOI Listing
October 2012

Regulation of T cell homeostasis and responses by pten.

Front Immunol 2012 15;3:151. Epub 2012 Jun 15.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.3389/fimmu.2012.00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375464PMC
August 2012

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.

J Clin Invest 2012 Jul 11;122(7):2395-404. Epub 2012 Jun 11.

Harvard Medical School, Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1172/JCI45138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386804PMC
July 2012

A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin.

J Invest Dermatol 2012 Jul 2;132(7):1869-76. Epub 2012 Feb 2.

Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/jid.2011.463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343174PMC
July 2012

Plus ça change, plus c'est la même chose.

Authors:
Laurence A Turka

J Clin Invest 2012 Feb 1;122(2):422-3. Epub 2012 Feb 1.

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http://dx.doi.org/10.1172/JCI62577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269165PMC
February 2012

New insights on OX40 in the control of T cell immunity and immune tolerance in vivo.

J Immunol 2012 Jan 5;188(2):892-901. Epub 2011 Dec 5.

Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.4049/jimmunol.1101373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262989PMC
January 2012

Regulatory cells and cell signatures in clinical transplantation tolerance.

Curr Opin Immunol 2011 Oct;23(5):655-9

Department of Surgery, Emory University, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1016/j.coi.2011.07.008DOI Listing
October 2011

There's a goat behind door number 3: from Monty Hall to medicine.

J Clin Invest 2011 Oct;121(10):3819-21

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1172/JCI60003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195486PMC
October 2011

CTLA-4: not all costimulation is stimulatory.

J Immunol 2011 Oct;187(7):3457-8

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1102316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178888PMC
October 2011

Immunogenetics and transplantation.

Curr Opin Immunol 2011 Oct 8;23(5):639-40. Epub 2011 Aug 8.

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http://dx.doi.org/10.1016/j.coi.2011.07.009DOI Listing
October 2011

What is the evidence for our standards of care?

J Clin Invest 2011 Jul 1;121(7):2530. Epub 2011 Jul 1.

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http://dx.doi.org/10.1172/JCI59185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127439PMC
July 2011

Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.

J Immunol 2011 Jul 10;187(2):870-8. Epub 2011 Jun 10.

Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.4049/jimmunol.1100538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131427PMC
July 2011

A role for IL-27 in limiting T regulatory cell populations.

J Immunol 2011 Jul 27;187(1):266-73. Epub 2011 May 27.

Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1004182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119737PMC
July 2011

Challenges in the pursuit of immune tolerance.

Immunol Rev 2011 May;241(1):49-62

Benaroya Research Institute, Seattle, WA 98101-2795, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01003.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092524PMC
May 2011

Innate immunity in transplant tolerance and rejection.

Immunol Rev 2011 May;241(1):39-48

Department of Medicine and The Transplant Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01009.xDOI Listing
May 2011

The Immune Tolerance Network at 10 years: tolerance research at the bedside.

Nat Rev Immunol 2010 Nov;10(11):797-803

Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nri2869DOI Listing
November 2010

EGR-2 is not required for in vivo CD4 T cell mediated immune responses.

PLoS One 2010 Sep 23;5(9):e12904. Epub 2010 Sep 23.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012904PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944839PMC
September 2010

A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model.

Transplantation 2010 Aug;90(3):260-9

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140399PMC
http://dx.doi.org/10.1097/tp.0b013e3181e64217DOI Listing
August 2010

An update on regulatory T cells in transplant tolerance and rejection.

Nat Rev Nephrol 2010 Oct 3;6(10):577-83. Epub 2010 Aug 3.

The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/nrneph.2010.101DOI Listing
October 2010

Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia.

Curr Opin Organ Transplant 2010 Aug;15(4):441-8

Transplant Institute, Beth-Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1097/MOT.0b013e32833bd371DOI Listing
August 2010

Ten years of the Immune Tolerance Network: an integrated clinical research organization.

Sci Transl Med 2010 Feb;2(19):19cm7

Immune Tolerance Network, University of California, San Francisco, San Francisco, CA 94107, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000672DOI Listing
February 2010

TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.

Blood 2010 Jun 29;115(23):4750-7. Epub 2010 Mar 29.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-09-242768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890173PMC
June 2010

Top priority.

Authors:
Laurence A Turka

J Clin Invest 2009 Sep 1;119(9):2436-7. Epub 2009 Sep 1.

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http://dx.doi.org/10.1172/JCI40681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735919PMC
September 2009

The contribution of direct TLR signaling to T cell responses.

Immunol Res 2009 ;45(1):25-36

Department of Medicine and Immunology Graduate Group, University of Pennsylvania, 111 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s12026-009-8113-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486050PMC
May 2010

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

Proc Natl Acad Sci U S A 2009 Jun 15;106(26):10734-9. Epub 2009 Jun 15.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0812538106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705547PMC
June 2009

Towards the identification of biomarkers of transplantation tolerance.

Nat Rev Immunol 2009 07;9(7):521-6

Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA.

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http://dx.doi.org/10.1038/nri2568DOI Listing
July 2009

After further review.

Authors:
Laurence A Turka

J Clin Invest 2009 May 1;119(5):1057. Epub 2009 May 1.

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http://dx.doi.org/10.1172/JCI39392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673854PMC
May 2009

Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells.

Immunity 2008 Nov 23;29(5):795-806. Epub 2008 Oct 23.

Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.immuni.2008.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746692PMC
November 2008

Senator, what is your policy on "Other"?

Authors:
Laurence A Turka

J Clin Invest 2008 Sep;118(9):2988

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http://dx.doi.org/10.1172/JCI37035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522364PMC
September 2008

Regulation of T-cell responses by PTEN.

Immunol Rev 2008 Aug;224:239-48

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00650.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876726PMC
August 2008