Lauren O Bakaletz

Lauren O Bakaletz

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Lauren O Bakaletz

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Identification of essential biofilm proteins in middle ear fluids of otitis media with effusion patients.

Laryngoscope 2020 Mar 25;130(3):806-811. Epub 2019 Apr 25.

Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

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http://dx.doi.org/10.1002/lary.28011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814449PMC
March 2020

Transcutaneous immunization with a nontypeable Haemophilus influenzae dual adhesin-directed immunogen induces durable and boostable immunity.

Vaccine 2020 Feb 27;38(10):2378-2386. Epub 2020 Jan 27.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; The Ohio State University College of Medicine, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2020.01.052DOI Listing
February 2020

Expression of the Nontypeable Haemophilus influenzae Type IV Pilus Is Stimulated by Coculture with Host Respiratory Tract Epithelial Cells.

Infect Immun 2019 12 18;87(12). Epub 2019 Nov 18.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/IAI.00704-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867834PMC
December 2019

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates.

Proc Natl Acad Sci U S A 2019 12 25;116(50):25068-25077. Epub 2019 Nov 25.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205;

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http://dx.doi.org/10.1073/pnas.1909017116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911203PMC
December 2019

Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms.

Laryngoscope 2019 Jul 17. Epub 2019 Jul 17.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

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http://dx.doi.org/10.1002/lary.28188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980231PMC
July 2019

Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae .

mSphere 2019 07 31;4(4). Epub 2019 Jul 31.

Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/mSphere.00254-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669334PMC
July 2019

Biofilm biology and vaccine strategies for otitis media due to nontypeable .

J Pediatr Infect Dis 2019 Feb 6;14(2):69-77. Epub 2018 Jul 6.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1055/s-0038-1660818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402341PMC
February 2019

High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

Microbiol Resour Announc 2019 Jan 10;8(2). Epub 2019 Jan 10.

Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.

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http://dx.doi.org/10.1128/MRA.01500-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328670PMC
January 2019

Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm.

mBio 2018 12 11;9(6). Epub 2018 Dec 11.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/mBio.02423-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299487PMC
December 2018

Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.

J Immunol 2018 10 17;201(7):2016-2027. Epub 2018 Aug 17.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205;

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http://dx.doi.org/10.4049/jimmunol.1800076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143431PMC
October 2018

The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans.

Biochem Biophys Res Commun 2018 09 27;503(2):1103-1107. Epub 2018 Jun 27.

Institute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.06.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095747PMC
September 2018

Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae.

mBio 2018 09 18;9(5). Epub 2018 Sep 18.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01682-18
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http://dx.doi.org/10.1128/mBio.01682-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143736PMC
September 2018

Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.

Trends Microbiol 2018 08 13;26(8):715-726. Epub 2018 Feb 13.

Institute for Glycomics, Griffith University, Gold Coast, Queensland, 4222, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2018.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054543PMC
August 2018

Nontypeable Haemophilus influenzae (NTHi).

Trends Microbiol 2018 08 21;26(8):727-728. Epub 2018 May 21.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; The Ohio State University College of Medicine, Department of Pediatrics, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.tim.2018.05.001DOI Listing
August 2018

The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure.

Microbiologyopen 2018 06 12;7(3):e00563. Epub 2017 Dec 12.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1002/mbo3.563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011942PMC
June 2018

Targeting the HUβ Protein Prevents Porphyromonas gingivalis from Entering into Preexisting Biofilms.

J Bacteriol 2018 06 9;200(11). Epub 2018 May 9.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/JB.00790-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952391PMC
June 2018

Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable .

mBio 2017 12 19;8(6). Epub 2017 Dec 19.

Center for Microbial Pathogenesis, The Research Institute at the Nationwide Children's Hospital, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/mBio.01466-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736908PMC
December 2017

Nontypeable releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

Proc Natl Acad Sci U S A 2017 08 10;114(32):E6632-E6641. Epub 2017 Jul 10.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205;

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http://dx.doi.org/10.1073/pnas.1705508114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559034PMC
August 2017

Impact of protein D-containing pneumococcal conjugate vaccines on non-typeable Haemophilus influenzae acute otitis media and carriage.

Expert Rev Vaccines 2017 07 7;16(7):1-14. Epub 2017 Jun 7.

a Department of Vaccine Research and Development, GSK Vaccines , Wavre , Belgium.

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http://dx.doi.org/10.1080/14760584.2017.1333905DOI Listing
July 2017

Transcutaneous Immunization with a Band-Aid Prevents Experimental Otitis Media in a Polymicrobial Model.

Clin Vaccine Immunol 2017 Jun 5;24(6). Epub 2017 Jun 5.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's and The Ohio State University College of Medicine, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/CVI.00563-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461379PMC
June 2017

The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.

Sci Rep 2017 06 9;7(1):3161. Epub 2017 Jun 9.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, 43205, USA.

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http://dx.doi.org/10.1038/s41598-017-03552-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466613PMC
June 2017

Panel 6: Vaccines.

Otolaryngol Head Neck Surg 2017 04;156(4_suppl):S76-S87

9 University at Buffalo, The State University of New York, Buffalo, New York, USA.

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http://dx.doi.org/10.1177/0194599816632178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505493PMC
April 2017

Enhanced Probiotic Potential of When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo.

Front Microbiol 2017 27;8:489. Epub 2017 Mar 27.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital Columbus, OH, USA.

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http://dx.doi.org/10.3389/fmicb.2017.00489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366311PMC
March 2017

Viral-bacterial co-infections in the respiratory tract.

Curr Opin Microbiol 2017 02 7;35:30-35. Epub 2016 Dec 7.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Department of Pediatrics, 700 Children's Drive, Columbus, OH, 43205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2016.11.003DOI Listing
February 2017

The Chinchilla Research Resource Database: resource for an otolaryngology disease model.

Database (Oxford) 2016 12;2016. Epub 2016 May 12.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI, USA Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1093/database/baw073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865329PMC
January 2017

Type IV Pilus Expression Is Upregulated in Nontypeable Haemophilus influenzae Biofilms Formed at the Temperature of the Human Nasopharynx.

J Bacteriol 2016 10 9;198(19):2619-30. Epub 2016 Sep 9.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/JB.01022-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019060PMC
October 2016

ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.

J Infect Dis 2016 09 10;214(5):817-24. Epub 2016 Jun 10.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital The Ohio State University College of Medicine, Columbus, Ohio.

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http://dx.doi.org/10.1093/infdis/jiw243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978376PMC
September 2016

Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.

Cell Microbiol 2016 08 26;18(8):1043-55. Epub 2016 Feb 26.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1111/cmi.12575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959963PMC
August 2016

Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo.

EBioMedicine 2016 Aug 16;10:33-44. Epub 2016 Jun 16.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA; The Ohio State University College of Medicine, Department of Pediatrics, 700 Children's Drive, Columbus, OH, 43205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006588PMC
August 2016

Identification of biofilms in post-tympanostomy tube otorrhea.

Laryngoscope 2016 08 4;126(8):1946-51. Epub 2016 Jan 4.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital.

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http://dx.doi.org/10.1002/lary.25826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955598PMC
August 2016

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention.

J Biol Chem 2016 Jun 21;291(24):12538-46. Epub 2016 Apr 21.

From the Departments of Microbial Infection and Immunity and the Center for Microbial Interface Biology, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205 Microbiology, Ohio State University, Columbus, Ohio 43210,

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http://dx.doi.org/10.1074/jbc.R115.707547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933457PMC
June 2016

Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.

PLoS One 2014 27;9(5):e98269. Epub 2014 May 27.

Center for Microbial Pathogenesis, Department of Pediatrics, College of Medicine, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098269PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035277PMC
August 2015

Therapeutic Transcutaneous Immunization with a Band-Aid Vaccine Resolves Experimental Otitis Media.

Clin Vaccine Immunol 2015 Aug 27;22(8):867-74. Epub 2015 May 27.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA

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http://dx.doi.org/10.1128/CVI.00090-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519716PMC
August 2015

DNABII proteins play a central role in UPEC biofilm structure.

Mol Microbiol 2015 Jun 16;96(6):1119-35. Epub 2015 Apr 16.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1111/mmi.12994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464964PMC
June 2015

Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media.

Mol Microbiol 2015 Apr 15;96(2):276-92. Epub 2015 Feb 15.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA; The Ohio State University College of Medicine, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1111/mmi.12934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423401PMC
April 2015

Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms.

Mol Microbiol 2014 Sep 19;93(6):1246-58. Epub 2014 Aug 19.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1111/mmi.12735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160410PMC
September 2014

Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.

Laryngoscope 2014 Mar 2;124(3):608-15. Epub 2013 Oct 2.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, U.S.A; Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

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http://dx.doi.org/10.1002/lary.24333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020599PMC
March 2014

Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein.

PLoS One 2013 14;8(6):e67629. Epub 2013 Jun 14.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067629PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682984PMC
January 2014

Haemophilus influenzae and oxidative stress.

Front Cell Infect Microbiol 2012 28;2:40. Epub 2012 Mar 28.

The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus OH, USA. alistair.harrison@ nationwidechildrens.org

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http://dx.doi.org/10.3389/fcimb.2012.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417577PMC
December 2013

Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.

Front Cell Infect Microbiol 2013 27;3:18. Epub 2013 May 27.

Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, College of Medicine, The Ohio State University Columbus, OH, USA.

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http://journal.frontiersin.org/article/10.3389/fcimb.2013.00
Publisher Site
http://dx.doi.org/10.3389/fcimb.2013.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664316PMC
December 2013

Antibodies directed against integration host factor mediate biofilm clearance from Nasopore.

Laryngoscope 2013 Nov 13;123(11):2626-32. Epub 2013 May 13.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

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http://dx.doi.org/10.1002/lary.24183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060527PMC
November 2013

Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity.

J Innate Immun 2013 22;5(1):24-38. Epub 2012 Aug 22.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, The Ohio State University, College of Medicine, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1159/000339961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640559PMC
July 2013

Replication of respiratory syncytial virus is inhibited by the host defense molecule viperin.

J Innate Immun 2013 25;5(1):60-71. Epub 2012 Sep 25.

Center for Microbial Pathogenesis, The Research Institute, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio 43205-2696, USA.

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http://dx.doi.org/10.1159/000342473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595061PMC
July 2013

Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization.

Vaccine 2013 Jul 22;31(34):3417-26. Epub 2012 Oct 22.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis and The Ohio State University College of Medicine, 700 Children's Drive, Columbus, OH 43205, United States.

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http://dx.doi.org/10.1016/j.vaccine.2012.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578125PMC
July 2013

Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.

Otolaryngol Head Neck Surg 2013 Apr;148(4 Suppl):E52-63

Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1177/0194599813479772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006668PMC
April 2013

Panel 6: Vaccines.

Otolaryngol Head Neck Surg 2013 Apr;148(4 Suppl):E90-101

Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1177/0194599812466535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029613PMC
April 2013

Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26.

Hum Vaccin Immunother 2013 Mar 4;9(3):625-35. Epub 2013 Jan 4.

Faculty of Medical Science; Naresuan University; Phitsanulok, Thailand.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891721PMC
http://dx.doi.org/10.4161/hv.23255DOI Listing
March 2013

Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.

PLoS One 2012 29;7(6):e40088. Epub 2012 Jun 29.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis and The Ohio State University College of Medicine, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040088PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387005PMC
November 2012

Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media.

Paediatr Respir Rev 2012 Sep 27;13(3):154-9. Epub 2012 May 27.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis and The Ohio State University College of Medicine, 700 Children's Drive, W591, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1016/j.prrv.2012.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509202PMC
September 2012

Biological roles of nontypeable Haemophilus influenzae type IV pilus proteins encoded by the pil and com operons.

J Bacteriol 2012 Apr 10;194(8):1927-33. Epub 2012 Feb 10.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1128/JB.06540-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318474PMC
April 2012

Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Mar 22;68(Pt 3):284-7. Epub 2012 Feb 22.

Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.

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http://dx.doi.org/10.1107/S1744309111043910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310531PMC
March 2012

Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function.

J Bacteriol 2011 May 25;193(10):2527-35. Epub 2011 Mar 25.

The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Department of Pediatrics, Center for Microbial Pathogenesis, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1128/JB.01313-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133164PMC
May 2011

Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media.

Vaccine 2011 Feb 16;29(6):1211-21. Epub 2010 Dec 16.

The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.vaccine.2010.12.003DOI Listing
February 2011

In vitro biofilm formation in an 8-well chamber slide.

J Vis Exp 2011 Jan 20(47). Epub 2011 Jan 20.

Center for Microbial Pathogenesis.

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http://dx.doi.org/10.3791/2481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182645PMC
January 2011

The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway.

PLoS One 2010 Oct 7;5(10):e13224. Epub 2010 Oct 7.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013224PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951362PMC
October 2010

Mapping the anatomy of respiratory syncytial virus infection of the upper airways in chinchillas (Chinchilla lanigera).

Comp Med 2010 Jun;60(3):225-32

Centers for Microbial Pathogenesis and Vaccines and Immunity, Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890398PMC
June 2010

Immunopathogenesis of polymicrobial otitis media.

J Leukoc Biol 2010 Feb 20;87(2):213-22. Epub 2009 Oct 20.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1189/jlb.0709518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812561PMC
February 2010

Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates.

Vaccine 2009 Dec 22;28(1):279-89. Epub 2009 Aug 22.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis and The Ohio State University College of Medicine, 700 Children's Drive, W591, Columbus, OH 43205, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X0901182
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http://dx.doi.org/10.1016/j.vaccine.2009.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787809PMC
December 2009

The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant.

Int J Med Microbiol 2009 Nov 17;299(7):479-88. Epub 2009 May 17.

Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/j.ijmm.2009.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749905PMC
November 2009

Microbial interactions in the respiratory tract.

Pediatr Infect Dis J 2009 Oct;28(10 Suppl):S121-6

Division of Infectious Diseases, The State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1097/INF.0b013e3181b6d7ecDOI Listing
October 2009

Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae.

Cell Microbiol 2009 Sep 2;11(9):1399-408. Epub 2009 Jun 2.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2009.01339.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741182PMC
September 2009

Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention.

Expert Rev Vaccines 2009 Aug;8(8):1063-82

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1586/erv.09.63DOI Listing
August 2009

Innate immune defenses: finding a new way to calm the storm.

Immunol Cell Biol 2008 Nov-Dec;86(8):639-40. Epub 2008 Sep 16.

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http://dx.doi.org/10.1038/icb.2008.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864189PMC
June 2009

Nontypeable Haemophilus influenzae as a pathogen in children.

Pediatr Infect Dis J 2009 Jan;28(1):43-8

University at Buffalo, the State University of New York, Buffalo, NY.

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http://dx.doi.org/10.1097/INF.0b013e318184dba2DOI Listing
January 2009

Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.

Infect Immun 2008 Mar 26;76(3):967-77. Epub 2007 Dec 26.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1128/IAI.01395-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258844PMC
March 2008

A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin.

Infect Immun 2008 Jan 15;76(1):48-55. Epub 2007 Oct 15.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Department of Pediatrics, 700 Children's Drive, Rm. W591, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1128/IAI.00980-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223670PMC
January 2008

Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation.

Infect Immun 2007 Dec 1;75(12):5559-64. Epub 2007 Oct 1.

Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA.

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http://iai.asm.org/content/75/12/5559.full.pdf
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http://iai.asm.org/cgi/doi/10.1128/IAI.00946-07
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http://dx.doi.org/10.1128/IAI.00946-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168369PMC
December 2007

Bacterial biofilms in otitis media: evidence and relevance.

Pediatr Infect Dis J 2007 Oct;26(10 Suppl):S17-9

College of Medicine, The Ohio State University, Center for Microbial Pathogenesis, Columbus Children's Research Institute, Columbus, Ohio, USA.

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http://dx.doi.org/10.1097/INF.0b013e318154b273DOI Listing
October 2007

The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.

Mol Microbiol 2007 Sep 23;65(5):1288-99. Epub 2007 Jul 23.

Columbus Children's Research Institute, The Ohio State University College of Medicine, Department of Pediatrics, Center for Microbial Pathogenesis, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2007.05864.xDOI Listing
September 2007

Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein.

J Bacteriol 2007 May 23;189(10):3868-75. Epub 2007 Feb 23.

Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, 700 Children's Drive, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1128/JB.01935-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913342PMC
May 2007

A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.

Mol Immunol 2007 Mar 20;44(9):2446-58. Epub 2006 Nov 20.

Columbus Children's Research Institute, Center for Microbial Pathogenesis and The Ohio State University College of Medicine & Public Health, 700 Children's Drive, Rm. W591, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1016/j.molimm.2006.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817667PMC
March 2007

The OxyR regulon in nontypeable Haemophilus influenzae.

J Bacteriol 2007 Feb 1;189(3):1004-12. Epub 2006 Dec 1.

Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine and Public Health, 700 Children's Drive, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1128/JB.01040-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797302PMC
February 2007

The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition.

Mol Microbiol 2006 Dec 25;62(5):1357-72. Epub 2006 Oct 25.

Columbus Children's Research Institute and The Ohio State University College of Medicine and Public Health, Columbus, OH, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2006.05460.xDOI Listing
December 2006

Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae.

Vaccine 2006 May 27;24(22):4804-11. Epub 2006 Mar 27.

Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine and Public Health, 700 Children's Drive, W591, 43205, USA.

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http://dx.doi.org/10.1016/j.vaccine.2006.03.021DOI Listing
May 2006

Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes.

FEMS Microbiol Lett 2006 Jan;254(2):226-31

Department of Food Science and Technology, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1111/j.1574-6968.2005.00030.xDOI Listing
January 2006

Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.

Infect Immun 2005 Jun;73(6):3210-8

Center for Microbial Pathogenesis, Columbus Children's Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children's Drive, Rm. W591, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1128/IAI.73.6.3210-3218.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1111813PMC
June 2005

Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus.

J Virol 2005 May;79(10):6035-42

Columbus Children's Research Institute, Rm. W591, The Ohio State University College of Medicine & Public Health, Department of Pediatrics, 700 Children's Drive, Columbus, OH 43205-2696, USA.

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http://dx.doi.org/10.1128/JVI.79.10.6035-6042.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1091680PMC
May 2005

Vaccines for otitis media: proposals for overcoming obstacles to progress.

Vaccine 2005 Apr;23(21):2696-702

Division of Infectious Diseases, Department of Medicine, University at Buffalo, SUNY, USA.

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http://dx.doi.org/10.1016/j.vaccine.2004.12.014DOI Listing
April 2005

Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae.

Infect Immun 2005 Mar;73(3):1635-43

Department of Pediatrics, Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine and Public Health, 700 Children's Dr., Columbus, OH 43205-2696, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.73.3.1635-1643.2005
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http://dx.doi.org/10.1128/IAI.73.3.1635-1643.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064948PMC
March 2005

Recent advances in otitis media. 5. Microbiology and immunology.

Ann Otol Rhinol Laryngol Suppl 2005 Jan;194:60-85

Department of Pediatrics, St Louis University School of Medicine, Missouri, USA.

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January 2005

Recent advances in otitis media. 6. Vaccine.

Ann Otol Rhinol Laryngol Suppl 2005 Jan;194:86-103

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA.

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January 2005