J Clin Aesthet Dermatol 2020 Dec 1;13(12):32-37. Epub 2020 Dec 1.
Ms. Coakley, Mr. Wu, Mr. Kumar, and Ms. Dadrass are with Loyola University Chicago Stritch School of Medicine at Loyola University Medical Center in Maywood, Illinois.
Arch Dermatol Res 2021 Jan 12. Epub 2021 Jan 12.
Departments of Dermatology, Otolaryngology and Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair Suite 1600, Chicago, IL, 60611, USA.
Cutis 2020 03;105(3):132-136
Division of Dermatology, Loyola University Medical Center, Maywood, Illinois, USA.
J Cutan Pathol 2020 Aug 30;47(8):675-680. Epub 2020 Mar 30.
Division of Dermatopathology, Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA, USA.
Clin Pediatr (Phila) 2020 03 1;59(3):310-313. Epub 2019 Nov 1.
Loyola University Chicago, Maywood, IL, USA.
J Clin Aesthet Dermatol 2019 Sep 1;12(9):42-45. Epub 2019 Sep 1.
Dr. Lyons is with the Department of Dermatology at Henry Ford Hospital in Detroit, Michigan.
J Clin Aesthet Dermatol 2019 May 1;12(5):20-26. Epub 2019 May 1.
Drs. May, Reservo, Tung, and Swan are with the Department of Dermatology at the Stritch School of Medicine at Loyola University Chicago in May wood, Illinois. Mses. Janeczek, Riopelle, and Vetter are with the Stritch School of Medicine at Loyola University Chicago in May wood, Illinois.
J Drugs Dermatol 2019 06;18(6):576
J Drugs Dermatol 2019 May;18(5):448-453
J Cutan Pathol 2019 Aug 25;46(8):555-562. Epub 2019 Apr 25.
Division of Dermatology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
J Clin Aesthet Dermatol 2018 Dec 1;11(12):42-47. Epub 2018 Dec 1.
Ms. Janeczek is with the Stritch School of Medicine, Loyola University Chicago in Maywood, Illinos.
Dermatol Surg 2019 06;45(6):768-771
Division of Dermatology, Loyola University Medical Center, Maywood, Illinois.
Scars Burn Heal 2018 Jan-Dec;4:2059513118758510. Epub 2018 Feb 23.
Division of Dermatology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
Dermatol Surg 2018 Sep;44(9):1216-1219
Division of Dermatology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Dermatol Surg 2017 Nov;43 Suppl 2:S203-S207
*Private Practice, Dermatology, Beverly Hills, California; †Loyola University Medical Center, Department of Dermatology, La Grange Park, Illinois.
J Drugs Dermatol 2017 Oct;16(10):1030-1034
J Drugs Dermatol. 2017;16(10):1030-1034.
J Drugs Dermatol 2017 Apr;16(4):322-326
BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.
OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color.
METHODS: A single-center clinical trial was performed on twelve healthy men and women (average age 32.5) with Fitzpatrick Type IV-V skin and evidence of facial grade II-IV atrophic acne scars. Subjects applied topical EGF serum to the full-face twice daily for 12 weeks. Scar improvement was investigated at each visit using an Investigator Global Assessment (IGA), a Goodman grade, clinical photography, and patient self-assessment.
RESULTS: Eleven subjects completed the trial. Compared to baseline, there was an improvement in mean IGA score from 3.36 (SEM = 0.15) to 2.18 (SEM = 0.33). Mean Goodman grade was reduced from 2.73 (SEM = 0.19) to 2.55 (SEM = 0.21). Of the eleven pairs of before and after photographs, nine were correctly chosen as the post-treatment image by a blind investigator. On self-assessment, 81% reported a "good" to "excellent" improvement in their scars compared to baseline (P = 0.004).
CONCLUSION: Topical EGF may improve the appearance of atrophic acne scars in skin of color. Additional, larger studies should be conducted to better characterize improvement.
J Drugs Dermatol. 2017;16(4):322-326.
J Invest Dermatol 2012 Jan 18;132(1):163-9. Epub 2011 Aug 18.
Division of Dermatology, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California 90502, USA.
J Drugs Dermatol 2010 Dec;9(12):1519-21
Department of Dermatology, David Geffen School of Medicine at UC LA, Los Angeles, CA, USA.